A Database of Drosophila Genes & Genomes

FB2008_06, released July 3, 2008
 

Allele Dmel\AdhnB

General Information
SymbolDmel\AdhnBSpeciesD. melanogaster
NameFlyBase IDFBal0000348
Feature typealleleCreated / Updated2006-05-31/2006-05-31
Associated geneDmel\Adh
Allele classloss of function
Mutagenethyl methanesulfonate
hide Nature of the Allele
Allele class
loss of function
 
Mutagen
ethyl methanesulfonate
(Martin et al., 1985)
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      AdhF
       
      Nature of the lesion
      Statement
      Reference
      Amino acid replacement: W235@. Polypeptide shorter than normal (24 kilodaltons).
       
      UGA codon at 234 suppressible in vitro with yeast ochre suppressor tRNA.
      (Kubli et al., 1982)
      TGG Trp codon at amino acid 235 replaced by a TGA termination codon.
      (Martin et al., 1985)
      Steady state level of Adh mRNA is reduced to 60% of control.
      (Brogna, 1999)
      Assay mode
      Carried on aberration
      CyO-vOb
      (FlyBase Curators, 2006-, O'Donnell et al., 1975)
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      electrophoretic variant
       
      hide Phenotype Manifest In
      hide Detailed Description
      Statement
      Reference
      hide Interactions
      hide Phenotypic Class
      hide Phenotype Manifest In
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Comments
      hide Stocks ( 53 )
      Bloomington
      1719
      Df(2R)X3/CyO, AdhnB
      3583
      Df(2L)fn2/CyO, AdhnB
      6069
      Df(2L)Sco7/CyO, AdhnB
      6056
      Df(2L)64j, L2/CyO, AdhnB
      1702
      Df(2R)X1, Mef2X1/CyO, AdhnB
      6065
      Df(2L)fn1, pr1 cn1/CyO, AdhnB
      6066
      Df(2L)fn5, pr1 cn1/CyO, AdhnB
      Kyoto
      106468
      Df(2R)X3/CyO, AdhnB
      107110
      Df(2L)fn2/CyO, AdhnB
      108583
      Df(2L)Sco7/CyO, AdhnB
      108570
      Df(2L)64j, L2/CyO, AdhnB
      106718
      Df(2R)X1, Mef2X1/CyO, AdhnB
      hide Notes on Origin
      Discoverer
      Sofer.
      Induced on: In(2LR)O. Selected as: Pentenol resistant adult.
       
      hide Comments
      CRM positive.
       
      hide Synonyms & Secondary IDs ( 1 )
      Reported As
      Symbol Synonym
      AdhnB
       
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 9 )
        Research paper
        Brogna, 1999, RNA, N.Y. 5(4): 562--573
        Nonsense mutations in the alcohol dehydrogenase gene of Drosophila melanogaster correlate with an abnormal 3' end processing of the corresponding pre-mRNA. [FBrf0107626]
        Garza et al., 1990, Genetics 126: 625--637
        Drosophila nonsense suppressors: functional analysis in Saccharomyces cerevisiae, Drosophila tissue culture cells and Drosophila melanogaster. [FBrf0051961]
        Martin et al., 1985, J. molec. Biol. 184: 221--229
        UGA nonsense mutation in the alcohol dehydrogenase gene of Drosophila melanogaster. [FBrf0043104]
        Kubli et al., 1982, Nucleic Acids Res. 10: 7145--7152
        In vitro suppression of a nonsense mutant of Drosophila melanogaster. [FBrf0038565]
        Schwartz and Sofer, 1976, Genetics 83: 125--136
        Alcohol dehydrogenase-negative mutants in Drosophila: defects at the structural locus? [FBrf0028744]
        O'Donnell et al., 1975, Genetics 79: 73--83
        Chemical selection of mutants that affect alcohol dehydrogenase in Drosophila. [FBrf0027526]
        Gerace and Sofer, 1972, D. I. S. 49: 39
        [New mutants report.] [FBrf0063455]
        FlyBase analysis
        FlyBase Curators, 2006-, Balancer summary information.
        Balancer summary information. [FBrf0189689]
        Stock list
        The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Russia, 1997, D. I. S. 80: 109--130
        Stock list. [FBrf0098381]