Open Close
General Information
Symbol
Dmel\adp60
Species
D. melanogaster
Name
FlyBase ID
FBal0000386
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
complex substitution
Comment:

Reported as a 23bp deletion which cause a frameshift and early termination. The published sequence show that a 25bp region is missing and TA is inserted in the gap, resulting in a frameshift and early termination.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

23bp deletion, resulting in a frameshift that produces two changed amino acid residues followed by a premature stop codon.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous adp60 mutants have decreased mobility compared with heterozygotes.

Homo- and heterozygous adp60 mutant flies deprived of food survive longer than wild-type controls under the same conditions. Survival is adp60 > adp60/+ > +/+. Triglyceride content of the flies follows the same trend.

After 1 week of ad libitum feeding, the fat body cells of adp60 flies contain greatly enlarged lipid droplets compared to controls. In addition, the mutant animals show a twofold higher accumulation of triglycerides, and a variable, slight reduction of glycogen levels to 70-80% of normal levels.

adp60 adults show increased resistance to starvation compared to control flies.

Homozygous females are heavier than control females. Heterozygous females are not significantly different in weight from control females.

Adults are obese.

Corpus allatum hypertrophies in mated females. Females are fertile but egg hatchability is reduced. Adult emergence is low.

Adult fat body hypertrophies as cells become distorted by enormous oil globules. Lipid accumulated at expense of glycogen in fat body; yolk deposition retarded (FBrf0065652; FBrf0034729). Lipid content and fatty acid profiles compared for various developmental stages in adp60 and wild type (FBrf0044927). Abnormal fat bodies visible through body wall of 6-day-old and older adults when submerged in 95% alcohol and then water. Corpus allatum of mated females hypertrophies. Females fertile but egg hatchability reduced to 45-90%, depending on residual genome; dorsal appendages of chorion convoluted or fused (FBrf0015801); adult emergence lowered to 33-85%. (FBrf0015272).Heterozygotes show desiccation tolerance superior to that of wild type or adp60 homozygotes (FBrf0039608). RK3.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

adp60/Df(2L)C28 double heterozygous females are significantly heavier (approximately 21% heavier) than control females.

adp60/Df(2L)C28 double heterozygotes eclose at the same rate as adp60/+ flies.

The weight of adp60/tocP and adp60/Mad12 double heterozygous flies is not significantly different from that of control flies.

adp60/Df(2L)C28 double heterozygous females expressing Hydr2Scer\UAS.cWa under the control of Scer\GAL4hs.PB (using heat shock) show no significant difference in weight compared to control females.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Doane, 1960.

Arose in: Kaduna wild population maintained at Edinburgh. Identified in 1960.

Isolated from: Kaduna, Nigeria population.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (15)