|Feature type||allele||Associated gene||Dmel\amx|
|Allele class||amorphic allele - genetic evidence, hypomorphic allele - genetic evidence|
|Mutagen||X ray, ethyl methanesulfonate|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Phenotype Manifest In|
Embryos from amx1/Df(1)10-70d females die and show the hypertrophy of the central nervous system characteristic of amx1/amx1 progeny.
Displays locomotor activity rhythm with an approximately 24h period.
Hyperplasia of replicating sensory precursors: due to an increased number of ectodermal cells being recruited as sensory precursor cells.
amx1 shows neural hypertrophy, a 2-5 fold increase in nau expressing cells per cluster relative to wild type.
Increase in SMCs per cluster in embryos lacking the maternal product.
Variable embryonic neurogenic phenotype.
Most homozygotes are indistinguishable from wild-type, but some flies have smaller eyes than normal with disarranged facets, giving a rough eye phenotype.
Eyes slightly reduced, narrower below; trident pattern stronger than in lz. Studies by Shannon (FBrf0023892) show that amx1 progeny and many amx1/+ progeny of amx1 mothers are embryonic lethals. Ovaries and egg production of amx1 females normal. General disorganization of early embryo with amx1/+ progeny of amx1 mothers less extreme than amx1 progeny (FBrf0025447) amx1/+ daughters show 0.2% survival; amx1/Dp(1;1)lz-2 show considerably higher survival (FBrf0040181); Lethal embryos exhibit hypertrophy of central nervous system at the expense of epidermal tissue (FBrf0037306; FBrf0040185). Similarly peripheral nervous elements, the sensilla, exhibit increased numbers and abnormal morphology; cells diverted from epidermal to neurological pathway (FBrf0045357). Embryonic phenotype locally rescuable by injections of ooplasm from wild-type or pcxunspecified ova during preblastoderm stages (FBrf0040181; FBrf0042361). lz/amx1 is wild type. Mosaics in amx1/+ daughters of +/+ or amx1/+ females show that ventral tissues are sensitive to reduced amx+ activity; no clones of amx1 tissue found in cuticle of amx1/+ daughters of amx1 mothers (FBrf0041016). RK2.
|Phenotype Manifest In|
|NOT suppressed by|
|Complementation & Rescue Data|
|Stocks ( 2 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 22 )|
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|Recent research papers (0)|
|All research papers listed in FlyBase were published before 2011|