Allele Dmel\amx¹

General Information
Symbol	Dmel\amx¹	Species	D. melanogaster
Name		FlyBase ID	FBal0000504
Feature type	allele	Associated gene	Dmel\amx

Allele class	amorphic allele - genetic evidence, hypomorphic allele - genetic evidence
Mutagen	X ray, ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (de la Concha et al., 1988) hypomorphic allele - genetic evidence (Lehmann et al., 1983)
Mutagen	ethyl methanesulfonate (Santamaria and Randsholt, 1995) X ray
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	female sterile \| recessive lethal \| embryonic stage \| neurogenic phenotype (with Df(1)10-70d) (Santamaria and Randsholt, 1995) lethal \| neurogenic phenotype (Corbin et al., 1991, Goriely et al., 1991) lethal \| rescuable maternal effect visible \| recessive (Green and Green, 1956, )
Phenotype Manifest In
	ectoderm (Bodmer et al., 1993) embryonic epidermis (Lehmann et al., 1983) epidermis (Corbin et al., 1991, Santamaria and Randsholt, 1995) epidermis (with Df(1)10-70d) (Santamaria and Randsholt, 1995) epidermis \| rescuable maternal effect eye (Green and Green, 1956, ) nervous system (Corbin et al., 1991, Santamaria and Randsholt, 1995) nervous system (with Df(1)10-70d) (Santamaria and Randsholt, 1995) nervous system \| rescuable maternal effect ommatidium (Green and Green, 1956) sensory mother cell (Goriely et al., 1991) thorax
Detailed Description
	Statement Reference Embryos from amx¹/Df(1)10-70d females die and show the hypertrophy of the central nervous system characteristic of amx¹/amx¹ progeny. (Santamaria and Randsholt, 1995) Displays locomotor activity rhythm with an approximately 24h period. (Vosshall and Young, 1995) Hyperplasia of replicating sensory precursors: due to an increased number of ectodermal cells being recruited as sensory precursor cells. (Bodmer et al., 1993) amx¹ shows neural hypertrophy, a 2-5 fold increase in nau expressing cells per cluster relative to wild type. (Corbin et al., 1991) Increase in SMCs per cluster in embryos lacking the maternal product. (Goriely et al., 1991) Variable embryonic neurogenic phenotype. (Lehmann et al., 1983) Most homozygotes are indistinguishable from wild-type, but some flies have smaller eyes than normal with disarranged facets, giving a rough eye phenotype. (Green and Green, 1956) Eyes slightly reduced, narrower below; trident pattern stronger than in lz. Studies by Shannon (FBrf0023892) show that amx¹ progeny and many amx¹/+ progeny of amx¹ mothers are embryonic lethals. Ovaries and egg production of amx¹ females normal. General disorganization of early embryo with amx¹/+ progeny of amx¹ mothers less extreme than amx¹ progeny (FBrf0025447) amx¹/+ daughters show 0.2% survival; amx¹/Dp(1;1)lz-2 show considerably higher survival (FBrf0040181); Lethal embryos exhibit hypertrophy of central nervous system at the expense of epidermal tissue (FBrf0037306; FBrf0040185). Similarly peripheral nervous elements, the sensilla, exhibit increased numbers and abnormal morphology; cells diverted from epidermal to neurological pathway (FBrf0045357). Embryonic phenotype locally rescuable by injections of ooplasm from wild-type or pcx^unspecified ova during preblastoderm stages (FBrf0040181; FBrf0042361). lz/amx¹ is wild type. Mosaics in amx¹/+ daughters of +/+ or amx¹/+ females show that ventral tissues are sensitive to reduced amx⁺ activity; no clones of amx¹ tissue found in cuticle of amx¹/+ daughters of amx¹ mothers (FBrf0041016). RK2.
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Statement Reference amx¹ has phenotype, non-suppressible by su(Hw)² (Lindsley and Grell, 1968)
Additional Comments
Genetic Interactions
Statement Reference No effect on the faf eye phenotype. (Huang and Fischer-Vize, 1996)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	10 amx¹ lz^g v¹/C(1)DX, y¹ f¹
Kyoto	105672 amx¹ lz^g v¹/C(1)DX, y¹ f¹
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	amx (Green and Green, 1956) amx¹ (Christensen et al., 2008.12.28, Popodi et al., 2010-)
Name Synonym
Secondary FlyBase IDs

References ( 22 )

Generate a list of	All references relating to this allele ( 22 )

List References by type	Research paper ( 16 ) Personal communication to FlyBase ( 2 ) Abstract ( 2 ) Book ( 2 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...

Allele Dmel\amx1

Allele Dmel\amx¹