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General Information
Symbol
Dmel\Antp73b
Species
D. melanogaster
Name
FlyBase ID
FBal0000573
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Antp73
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference
Inversion breakpoint in Antp.
Inversion breakpoint is 45kb upstream of the P2 start site.
Inversion between Doc{}sasDoc (in first intron of sas) and Doc{}AntpDoc (in first intron of Antp) causes an exchange between the proximal exons of Antp and sas.
Proximal inversion breakpoint is at map position +178-182.
Insertion components
Doc{}Antp73b
Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
100% of heterozygotes show transformation of antenna to leg.
Mutants show extensive transformation of antenna to leg.
Only 55% of heterozygotes show normal arista development.
100% of mutant flies show an antenna to leg transformation.
Heterozygous males do not show any change in the level of monoene cuticular hydrocarbons compared to wild-type males. Heterozygous females do not show any significant change in the level of monoene or 7,11-diene cuticular hydrocarbons compared to wild-type females.
Heterozygous flies show transformation of antenna to leg. This phenotype is not suppressed by one copy of osa1 or osa2.
No gross morphological defects in the brain are seen in homozygous embryos.
Antenna to leg transformation. Heterozygotes display minaturised maxillary palps, characterised by fewer bristles. Heterozygotes exhibit reduced compound eye and ommatidia are replaced by micro- and macrochaetae.
Heterozygotes show differentiation of leg structures in the antennae. The penetrance and expressivity of this phenotype is unaffected if the flies are also heterozygous for mor1 or mor2.
None of the ash2 alleles affect the expressivity or penetrance of the antenna to leg transformation.
pbhs.PB cannot redirect phenotype of antennae from ectopic leg to maxillary palp.
Shows a small patch of untransformed antennal tissue remaining on the homeotic femur. Size of this patch varies 6-fold across different genetic backgrounds. Effects of maternal parent, sex and sex-linkage have been observed.
Transformation of head to thoracic tissue.
Homeotic transformation of antennae to mesothoracic legs.
Antennae to leg transformation.
Transformation of antenna to prothoracic leg identity.
A strong allele.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Antp73b has visible phenotype, enhanceable by tsh17
Antp73b has visible phenotype, enhanceable by tsh8
Antp73b has visible phenotype, enhanceable by tsh75
NOT suppressed by
Statement
Reference
Antp73b has visible | dominant phenotype, non-suppressible by Bap60[+]/Bap601
Antp73b has visible | dominant phenotype, non-suppressible by Gug[+]/Gug1757
Antp73b has visible | dominant phenotype, non-suppressible by Gug2295/Gug[+]
Antp73b has visible | dominant phenotype, non-suppressible by Gug3333/Gug[+]
Antp73b has visible | dominant phenotype, non-suppressible by Gug519/Gug[+]
Antp73b has visible phenotype, non-suppressible by tna[+]/tnarI075
Antp73b has visible phenotype, non-suppressible by tna[+]/tna1
Antp73b has visible phenotype, non-suppressible by Df(3L)vin2/+
NOT Suppressor of
Statement
Reference
Antp73b is a non-suppressor of visible | somatic clone phenotype of bowl1
Other
Phenotype Manifest In
Enhanced by
Statement
Reference
Antp73b has antenna phenotype, enhanceable by tsh17
Antp73b has eye phenotype, enhanceable by tsh75
Antp73b has leg | ectopic phenotype, enhanceable by tsh17
Antp73b has antenna phenotype, enhanceable by tsh8
Antp73b has leg | ectopic phenotype, enhanceable by tsh8
Antp73b has antenna phenotype, enhanceable by tsh75
Antp73b has leg | ectopic phenotype, enhanceable by tsh75
Antp73b has ommatidium phenotype, enhanceable by tsh75
NOT suppressed by
Statement
Reference
Antp73b has antenna phenotype, non-suppressible by Bap60[+]/Bap601
Antp73b has leg | ectopic phenotype, non-suppressible by Bap60[+]/Bap601
Antp73b has arista phenotype, non-suppressible by Gug[+]/Gug1757
Antp73b has arista phenotype, non-suppressible by Gug2295/Gug[+]
Antp73b has arista phenotype, non-suppressible by Gug3333/Gug[+]
Antp73b has arista phenotype, non-suppressible by Gug519/Gug[+]
Antp73b has leg | ectopic phenotype, non-suppressible by Df(3L)vin2/+
Antp73b has antenna phenotype, non-suppressible by tna[+]/tnarI075
Antp73b has leg | ectopic phenotype, non-suppressible by tna[+]/tnarI075
Antp73b has antenna phenotype, non-suppressible by tna[+]/tna1
Antp73b has leg | ectopic phenotype, non-suppressible by tna[+]/tna1
Antp73b has antenna phenotype, non-suppressible by Df(3L)vin2/+
NOT Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference
Antp73b toyD2 mutants show eye-to-wing transformations.
Somatic mutant bowl1 clones induced in the ventral region of the antennal imaginal disc during stage L1 in Antp73b mutant larvae result in the formation of ectopic, supernumerary appendages.
The antenna to leg transformation phenotype seen in Antp73b/+ flies is not suppressed by Bap601/+.
obk1, Antp73b (or AntpNs), hthdtl-S142204 triple mutants produce biramous antenna/legs in place of single antennae.
Eye phenotype is enhanced in a tsh75 mutant background.
Not enhanced or suppressed by brm1.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (4)
Notes on Origin
Discoverer
Green.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (41)