A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Allele Dmel\AntpB

General Information
SymbolDmel\AntpBSpeciesD. melanogaster
Nameof BaconFlyBase IDFBal0000580
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\Antp
Allele classamorph, loss of function, gain of function
MutagenX ray
hide Nature of the Allele
Allele class
amorph
(Abbott and Kaufman, 1986)
loss of function
(McKenna et al., 1989)
gain of function
 
Mutagen
X ray
(Scott et al., 1983)
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
      Distal inversion breakpoint is at map position +138.
      (Scott et al., 1983)
      Inversion breakpoint is 10.5kb upstream of the P2 cap site.
      (Boulet and Scott, 1988)
      Assay mode
      Caused by aberration
      In(3R)AntpB
      (Scott et al., 1983, Vazquez et al., 1999, Gutierrez et al., 2003, Southworth and Kennison, 2002, Duncan and Kaufman, 1975, Kaufman et al., 1980, Lewis et al., 1980, Garber et al., 1983, Abbott and Kaufman, 1986, Boulet and Scott, 1988, Lewis et al., 1980)
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      viable (with Antp1)
      (Southworth and Kennison, 2002)
      viable (with Antp23)
      (Southworth and Kennison, 2002)
      lethal (with AntpNs-rv2)
      (Duncan and Kaufman, 1975)
      lethal | recessive
      (Duncan and Kaufman, 1975, Kaufman et al., 1980, Scott et al., 1983)
      lethal | larval stage
      (Abbott and Kaufman, 1986)
      visible (with Antp1)
      (Vazquez et al., 1999)
      visible (with Antp23)
      (Vazquez et al., 1999)
      visible | dominant
      (Gutierrez et al., 2003)
      visible | dominant | homeotic
       
      visible | homeotic
      (Abbott and Kaufman, 1986, McKenna et al., 1989)
      hide Phenotype Manifest In
      antenna
      (Cribbs et al., 1995, Lewis et al., 1980, Abbott and Kaufman, 1986, Duncan and Kaufman, 1975, McKenna et al., 1989, Scott et al., 1983)
      mesothoracic leg | ectopic
      (Cribbs et al., 1995)
      wing
      (Gutierrez et al., 2003)
      wing (with Antp1)
      (Vazquez et al., 1999)
      wing (with Antp23)
      (Vazquez et al., 1999)
      hide Detailed Description
      Statement
      Reference
      Antenna partially leglike but less extreme than AntpYu and may overlap wild type. Enhanced by Pc. Enhanced by Pc2. Enhanced by ssa. AntpB ssa/+ ssa has virtually complete antennal leg including coxa, tibia, femur, and tarsus but no sex comb in the male (B. Holloway, cited in FBrf0020044). RK3A.
       
      Lethal with AntpYu, Antp49, Antp50, and Scr.
      (Hannah and Stromnaes, 1955)
      Antenna are leg-like.
      (Duncan and Kaufman, 1975)
      Transformation of antenna to prothoracic leg identity.
      (Lewis et al., 1980)
      Antennae to leg transformation.
      (Scott et al., 1983)
      Enhanced by ph-d2.
      (Dura et al., 1985)
      Homeotic transformation of antennae to mesothoracic legs.
      (Abbott and Kaufman, 1986)
      Partial transformation of antennae into legs. Flies exhibit diminished chemosensory jump behaviour to ethyl acetate but no change in the jump response to a visual stimulus.
      (McKenna et al., 1989)
      58% of Antp1/AntpB flies and 70% of Antp23/AntpB flies have a held-out wings phenotype.
      (Vazquez et al., 1999)
      8% of heterozygotes have a held-out wings phenotype.
      (Gutierrez et al., 2003)
      hide Interactions
      hide Phenotypic Class
      hideEnhanced by
      Statement
      Reference
      Antp1/AntpB has visible phenotype, enhanceable by brm[+]/brm2
      (Vazquez et al., 1999)
      Antp23/AntpB has visible phenotype, enhanceable by brm[+]/brm2
      (Vazquez et al., 1999)
      AntpB has visible | dominant phenotype, enhanceable by tna1
      (Gutierrez et al., 2003)
      hide Phenotype Manifest In
      hideEnhanced by
      Statement
      Reference
      AntpB has phenotype, enhanceable by art1
      (Ouweneel, 1970, )
      Antp1/AntpB has wing phenotype, enhanceable by brm[+]/brm2
      (Vazquez et al., 1999)
      Antp23/AntpB has wing phenotype, enhanceable by brm[+]/brm2
      (Vazquez et al., 1999)
      AntpB has wing phenotype, enhanceable by tna1
      (Gutierrez et al., 2003)
      hideOther
      Statement
      Reference
      AntpB, pbhs.PB has maxillary palpus | ectopic phenotype
      (Cribbs et al., 1995)
      AntpB, pbhs.PB has antenna phenotype
      (Cribbs et al., 1995)
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      Homeotic transformation of antennae to T2 leg seen in AntpB flies can be redirected by pbhs.PB from ectopic leg to maxillary palp.
      (Cribbs et al., 1995)
      The penetrance of the held-out wing phenotype of Antp1/AntpB and Antp23/AntpB flies is increased if the flies are also heterozygous for brm2.
      (Vazquez et al., 1999)
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Fails to complement
      Antp49
      (Hannah and Stromnaes, 1955, Lindsley and Grell, 1968)
      Antp50
      (Hannah and Stromnaes, 1955)
      AntpNs-rv2
      (Duncan and Kaufman, 1975)
      AntpNs-rv3
      (Duncan and Kaufman, 1975)
      AntpNs-rv6
      (Duncan and Kaufman, 1975)
      AntpNs-rv8
      (Duncan and Kaufman, 1975)
      AntpNs-rv13
      (Duncan and Kaufman, 1975)
      AntpNs-rv16
      (Duncan and Kaufman, 1975)
      AntpNs-rv18
      (Duncan and Kaufman, 1975)
      AntpNs-rv19
      (Duncan and Kaufman, 1975)
      AntpNs-rv72
      (Talbert and Garber, 1994)
      AntpScx
      (Hannah and Stromnaes, 1955)
      AntpYu
      (Hannah and Stromnaes, 1955)
      Comments
      hide Stocks ( 3 )
      Bloomington
      3511
      In(3R)AntpB, AntpB Ubxbx-34e Ubxbxd-121/TM1
      2229
      In(3R)AntpB, AntpB pp Ubxbx-1/TM2, pp
      Kyoto
      101665
      In(3R)AntpB, AntpB / TM1, Me1 kniri-1 Sbsbd-l
      hide Notes on Origin
      Discoverer
      Bacon, July 1950.
      hide Synonyms & Secondary IDs ( 2 )
      Reported As
      Symbol Synonym
      AntpB
       
      Name Synonym
      of Bacon
       
      Secondary FlyBase IDs
        hide References ( 20 )
        Research paper
        Gutierrez et al., 2003, Development 130(2): 343--354
        The Drosophila trithorax group gene tonalli(tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger protein. [FBrf0155711]
        Southworth and Kennison, 2002, Genetics 161(2): 733--746
        Transvection and silencing of the Scr homeotic gene of Drosophila melanogaster. [FBrf0149025]
        Vazquez et al., 1999, Development 126(4): 733--742
        The trithorax group gene osa encodes an ARID-domain protein that genetically interacts with the brahma chromatin-remodeling factor to regulate transcription. [FBrf0107412]
        Cribbs et al., 1995, EMBO J. 14(4): 767--778
        Levels of homeotic protein function can determine developmental identity: Evidence from low-level expression of the Drosophila homeotic gene proboscipedia under Hsp70 control. [FBrf0079960]
        Talbert and Garber, 1994, Genetics 138(3): 709--720
        The Drosophila homeotic mutation Nasobemia (AntpNs) and its revertants: an analysis of mutational reversion. [FBrf0080434]
        McKenna et al., 1989, Proc. Natl. Acad. Sci. USA 86: 8118--8122
        A simple chemosensory response in Drosophila and the isolation of acj mutants in which it is affected. [FBrf0050866]
        Boulet and Scott, 1988, Genes Dev. 2: 1600--1614
        Control elements of the P2 promoter of the Antennapedia gene. [FBrf0048102]
        Abbott and Kaufman, 1986, Genetics 114: 919--942
        The relationship between the functional complexity and the molecular organization of the Antennapedia locus of Drosophila melanogaster. [FBrf0044490]
        Dura et al., 1985, Molec. gen. Genet. 198: 213--220
        Polyhomeotic: a gene of Drosophila melanogaster required for correct expression of segmental identity. [FBrf0043249]
        Garber et al., 1983, EMBO J. 2(11): 2027--2036
        Genomic and cDNA clones of the homeotic locus Antennapedia in Drosophila. [FBrf0039287]
        Scott et al., 1983, Cell 35: 763--776
        The molecular organization of the Antennapedia locus of Drosophila. [FBrf0039012]
        Kaufman et al., 1980, Genetics 94(1): 115--133
        Cytogenetic analysis of chromosome 3 in Drosophila melanogaster: the homoeotic gene complex in polytene chromosome interval 84A-B. [FBrf0034841]
        Lewis et al., 1980, Genetics 95(2): 367--381
        Genetic analysis of the Antennapedia gene complex (ANT-C) and adjacent chromosomal regions of Drosophila melanogaster. [FBrf0034853]
        Lewis et al., 1980, Genetics 95(2): 383--397
        Genetic analysis of the Antennapedia gene complex (ANT-C) and adjacent chromosomal regions of Drosophila melanogaster. [FBrf0073734]
        Duncan and Kaufman, 1975, Genetics 80: 733--752
        Cytogenetic analysis of chromosome 3 in Drosophila melanogaster: mapping of the proximal portion of the right arm. [FBrf0027527]
        Ouweneel, 1970, D. I. S. 45: 35
        [New mutants report.] [FBrf0063772]
        Lewis, 1956, D. I. S. 30: 76--77
        [New mutants report.] [FBrf0063639]
        Hannah and Stromnaes, 1955, D. I. S. 29: 121--123
        Extra sex comb mutants in Drosophila melanogaster. [FBrf0010085]
        Abstract
        Haynie and Rubeck, 1999, A. Dros. Res. Conf. 40: 191A
        Polycomb influences phenotypic expression in three alleles of the homoeotic gene Antennapedia in Drosophila melanogaster. [FBrf0106632]
        Book
        Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp
        Genetic variations of Drosophila melanogaster. [FBrf0020044]