Open Close
General Information
Symbol
Dmel\AntpCtx
Species
D. melanogaster
Name
FlyBase ID
FBal0000582
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Complex rearrangement.

breakpoint is at map position +165-166.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

AntpCtx mutants exhibit ectopic wing and thoracic outgrowths on the dorsal rim of the eye, head capsule-to-thorax, and antenna-to-leg transformations, and general eye reduction. The eye disc in AntpCtx flies is transformed into different parts of the wing disc, indicating a more general homeotic transformation toward T2.

Transformation of head to thoracic tissue.

Posterior dorsal head structures are transformed to dorsal mesothoracic structures.

Occasionally antennae to leg transformation. Dorsal head is transformed to dorsal thoracic tissue.

Strong allele.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

AntpCtx has wing | ectopic phenotype, enhanceable by ciD/ci[+]

AntpCtx has eye phenotype, enhanceable by ciD/ci[+]

AntpCtx has eye phenotype, enhanceable by bip2[+]/Taf34

Other
Additional Comments
Genetic Interactions
Statement
Reference

Approximately 14% of AntpCtx/+;ciD/+ flies exhibit ectopic wings on the head as compared to 4% in AntpCtx/+;bip24/+ transheterozygous flies. Flies showing an ectopic wing on the head almost always show a normal or slightly reduced eye, whereas flies with a head capsule-to-thorax transformation mostly have reduced or lost eyes.

AntpCtx/+;bip24/+ flies show stronger eye-reduction/eye-loss phenotypes compared to AntpCtx/+;ciD/+ flies. Ninety percent of the eyes of AntpCtx/+;ciD/+ flies show a normal to weakly reduced eye phenotype, whereas only 34% of the eyes of AntpCtx/+;bip24/+ flies show an eye-loss phenotype, compared with 2% without the bip24 mutation.

Homeotic transformation of antennae to T2 leg seen in AntpCtx flies can be redirected by pbhs.PB from ectopic leg to maxillary palp.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Lewis.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
AntpCephalothorax
Secondary FlyBase IDs
    References (7)