FlyBase Allele Report: Dmel\Antp[Ns]

General Information

Symbol

Dmel\Antp^Ns

Species

D. melanogaster

Name

Nasobemia

FlyBase ID

FBal0000587

Feature type

allele

Associated gene

Dmel\Antp

Associated Insertion(s)

roo{}Antp^Ns

Carried in Construct

Key Links

Allele class

neomorphic allele - genetic evidence

gain of function allele

Mutagen

spontaneous

Nature of the Allele

Allele class

gain of function allele

(Bhojwani et al., 1997, Adamson and Shearn, 1996, Talbert and Garber, 1994, McKenna et al., 1989, Jorgensen and Garber, 1987, Scott et al., 1983)

neomorphic allele - genetic evidence

(Denell, 1994)

Mutagen

spontaneous

(Scott et al., 1983)

Progenitor genotype

Associated Insertion(s)

roo{}Antp^Ns

Cytology

Polytene chromosomes normal.

(Kaufman et al., 1980, Lewis et al., 1980)

Description

Internal 25kb partial duplication from position 46 to 71 and a complex insertion of more than 40kb including two roo elements. Truncated roo element has inserted at position 71 within intron sequences in opposite transcriptional orientation. The 5' half of a roo element has inserted at position 46 in opposite transcriptional orientation. The duplication gives the gene three promoters, P1, P2A and P2B. Dominant mutant phenotype due to ectopic expression from promoter Antp P2A.

(Talbert and Garber, 1994)

25kb duplication of the exon 3 region with a roo transposon separating the duplicated sequences.

(Jorgensen and Garber, 1987)

Insertion of an 8kb roo element at map position +128.

(Scott et al., 1983)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Heterozygous flies show antenna to leg transformations.

(Bantignies et al., 2011)

Heterozygous adults show transformation of antenna to leg and the eyes are smaller than normal.

(Yazdani et al., 2008)

Heterozygotes lack the arista, but appear to have normal maxillary palps.

The locomotor activity of heterozygous flies in an open field arena is not significantly different from that of wild-type flies.

(Liu et al., 2007)

Antp^Ns/+ mutants show ectopic transformation of antennae into leg tissue.

(Ragab et al., 2006)

100% of heterozygotes show transformation of antenna to leg.

(Möller et al., 2005)

Only 15% of heterozygotes show normal arista development.

(Kankel et al., 2004)

95% of mutant flies show an antenna to leg transformation.

(Gutierrez et al., 2003)

Heterozygotes show transformation of antenna to leg.

(Zraly et al., 2003)

96% of heterozygous flies show transformation of antenna to leg.

(Vazquez et al., 1999)

Antenna to leg transformation. Heterozygotes exhibit reduced compound eye and ommatidia are replaced by micro- and macrochaetae.

(Bhojwani et al., 1997)

96-99% of heterozygotes show differentiation of leg structures in the antennae.

(Brizuela and Kennison, 1997)

A viable dominant leg to antenna transformation.

(Denell, 1994)

Antp^Ns derepresses the Antp P2 promoter in the eye-antennal disc. The penetrance of antennae to leg transformations of Antp^Ns mutations is greatly reduced in brm¹ heterozygotes.

(Tamkun et al., 1992)

Partial transformation of antennae into legs. Flies exhibit diminished chemosensory jump behaviour to ethyl acetate but no change in the jump response to a visual stimulus.

(McKenna et al., 1989)

Transformation of head to thoracic tissue.

(Jorgensen and Garber, 1987)

Antennae to leg transformation.

(Scott et al., 1983)

Transformation of antenna to prothoracic leg identity.

(Lewis et al., 1980)

Antenna are leg-like.

(Duncan and Kaufman, 1975)

In extreme cases, Antp^Ns/+ forms, in place of an antenna, a complete leg that includes sternopleura, coxa, trochanter, femur, tibia, and tarsus. Antennal leg has no sex comb in male, and bristle pattern is that of a middle leg. Eyes smaller; whole head tends to be malformed. Antp^Ns ss^a/+ ss^a indistinguishable from Antp^Ns/+. Antp^Ns/Antp^B viable; phenotype like extreme Antp^Ns/+. Expression variable but penetrance complete. RK1.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Antp^Ns has visible phenotype, enhanceable by tsh¹⁷

(Bhojwani et al., 1997)

Antp^Ns, Pc² has visible | homeotic phenotype, enhanceable by Pcl[+]/Pcl¹⁸

(Kennison and Tamkun, 1988)

Suppressed by

Statement

Reference

Antp^Ns has visible | dominant phenotype, suppressible by Df(3R)swp2^MICAL/+

(Yazdani et al., 2008)

Antp^Ns has visible | homeotic phenotype, suppressible by osa²

(Ragab et al., 2006)

Antp^Ns has visible | homeotic phenotype, suppressible by Df(2R)ED3921

(Ragab et al., 2006)

Antp^Ns has visible | dominant phenotype, suppressible by Bap60[+]/Bap60¹

(Möller et al., 2005)

Antp^Ns has visible | dominant phenotype, suppressible by Gug[+]/Gug¹⁷⁵⁷

(Kankel et al., 2004)

Antp^Ns has visible | dominant phenotype, suppressible by Gug³³³³/Gug[+]

(Kankel et al., 2004)

Antp^Ns has visible | dominant phenotype, suppressible by Gug⁵¹⁹/Gug[+]

(Kankel et al., 2004)

Antp^Ns has visible phenotype, suppressible by Df(3L)vin2/+

(Gutierrez et al., 2003)

Antp^Ns has visible phenotype, suppressible by tna[+]/tna^rI075

(Gutierrez et al., 2003)

Antp^Ns has visible phenotype, suppressible by tna[+]/tna¹

(Gutierrez et al., 2003)

Antp^Ns has visible | dominant phenotype, suppressible by Snr1^R3

(Zraly et al., 2003)

Antp^Ns has visible | dominant | homeotic phenotype, suppressible by osa¹/osa[+]

(Vazquez et al., 1999)

Antp^Ns has visible | dominant | homeotic phenotype, suppressible by osa²/osa[+]

(Vazquez et al., 1999)

Antp^Ns has visible | dominant phenotype, suppressible by mor¹

(Brizuela and Kennison, 1997)

Antp^Ns has visible | dominant phenotype, suppressible by mor²

(Brizuela and Kennison, 1997)

Antp^Ns, Pc² has visible | homeotic phenotype, suppressible by brm¹/brm[+]

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has visible | homeotic phenotype, suppressible by mor[+]/mor¹

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has visible | homeotic phenotype, suppressible by mor²/mor[+]

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has visible | homeotic phenotype, suppressible by osa¹/osa[+]

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has visible | homeotic phenotype, suppressible by osa²/osa[+]

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has visible | homeotic phenotype, suppressible by osa[+]/osa³

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has visible | homeotic phenotype, suppressible by osa[+]/osa⁴

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has visible | homeotic phenotype, suppressible by trx^E3/trx[+]

(Kennison and Tamkun, 1988)

NOT suppressed by

Statement

Reference

Antp^Ns has visible | dominant phenotype, non-suppressible by Gug²²⁹⁵/Gug[+]

(Kankel et al., 2004)

Other

Statement

Reference

Antp^Ns, hth^dtl-S142204, obk¹ has visible phenotype

(Dworkin et al., 2001)

Antp^Ns, tsh¹⁷ has visible | dominant phenotype

(Bhojwani et al., 1997)

Antp^Ns, Pc² has visible | homeotic phenotype

(Kennison and Tamkun, 1988)

Phenotype Manifest In

Enhanced by

Statement

Reference

Antp^Ns has ommatidium phenotype, enhanceable by tsh¹⁷

(Bhojwani et al., 1997)

Antp^Ns has eye phenotype, enhanceable by tsh¹⁷

(Bhojwani et al., 1997)

Antp^Ns has phenotype, enhanceable by ash2¹⁸

(Adamson and Shearn, 1996)

Antp^Ns has phenotype, enhanceable by ash2¹

(Adamson and Shearn, 1996)

Antp^Ns has phenotype, enhanceable by ash2²

(Adamson and Shearn, 1996)

Antp^Ns has phenotype, enhanceable by ash2⁴

(Adamson and Shearn, 1996)

Antp^Ns has phenotype, enhanceable by ash2⁹

(Adamson and Shearn, 1996)

Antp^Ns has phenotype, enhanceable by ash2¹¹

(Adamson and Shearn, 1996)

Antp^Ns has phenotype, enhanceable by ash2¹²

(Adamson and Shearn, 1996)

Antp^Ns, Pc² has antenna phenotype, enhanceable by Pcl[+]/Pcl¹⁸

(Kennison and Tamkun, 1988)

Antp^Ns has phenotype, enhanceable by dachs¹

(Mikuta and Mglinetz, 1979)

Antp^Ns has phenotype, enhanceable by al¹

(Mikuta and Mglinets, 1978)

Suppressed by

Statement

Reference

Antp^Ns has antenna phenotype, suppressible by Df(3R)swp2^MICAL/+

(Yazdani et al., 2008)

Antp^Ns has eye phenotype, suppressible by Df(3R)swp2^MICAL/+

(Yazdani et al., 2008)

Antp^Ns has leg | ectopic phenotype, suppressible by Df(3R)swp2^MICAL/+

(Yazdani et al., 2008)

Antp^Ns has antenna phenotype, suppressible by osa²

(Ragab et al., 2006)

Antp^Ns has antenna phenotype, suppressible by Df(2R)ED3921

(Ragab et al., 2006)

Antp^Ns has leg | ectopic phenotype, suppressible by osa²

(Ragab et al., 2006)

Antp^Ns has leg | ectopic phenotype, suppressible by Df(2R)ED3921

(Ragab et al., 2006)

Antp^Ns has antenna phenotype, suppressible by Bap60[+]/Bap60¹

(Möller et al., 2005)

Antp^Ns has leg | ectopic phenotype, suppressible by Bap60[+]/Bap60¹

(Möller et al., 2005)

Antp^Ns has arista phenotype, suppressible by Gug[+]/Gug¹⁷⁵⁷

(Kankel et al., 2004)

Antp^Ns has arista phenotype, suppressible by Gug³³³³/Gug[+]

(Kankel et al., 2004)

Antp^Ns has arista phenotype, suppressible by Gug⁵¹⁹/Gug[+]

(Kankel et al., 2004)

Antp^Ns has antenna phenotype, suppressible by Df(3L)vin2/+

(Gutierrez et al., 2003)

Antp^Ns has antenna phenotype, suppressible by tna[+]/tna¹

(Gutierrez et al., 2003)

Antp^Ns has antenna phenotype, suppressible by tna[+]/tna^rI075

(Gutierrez et al., 2003)

Antp^Ns has leg | ectopic phenotype, suppressible by Df(3L)vin2/+

(Gutierrez et al., 2003)

Antp^Ns has leg | ectopic phenotype, suppressible by tna[+]/tna¹

(Gutierrez et al., 2003)

Antp^Ns has leg | ectopic phenotype, suppressible by tna[+]/tna^rI075

(Gutierrez et al., 2003)

Antp^Ns has antenna phenotype, suppressible by Snr1^R3

(Zraly et al., 2003)

Antp^Ns has leg | ectopic phenotype, suppressible by Snr1^R3

(Zraly et al., 2003)

Antp^Ns has antenna phenotype, suppressible by osa¹/osa[+]

(Vazquez et al., 1999)

Antp^Ns has leg | ectopic phenotype, suppressible by osa¹/osa[+]

(Vazquez et al., 1999)

Antp^Ns has antenna phenotype, suppressible by osa²/osa[+]

(Vazquez et al., 1999)

Antp^Ns has leg | ectopic phenotype, suppressible by osa²/osa[+]

(Vazquez et al., 1999)

Antp^Ns has antenna phenotype, suppressible by mor¹

(Brizuela and Kennison, 1997)

Antp^Ns has antenna phenotype, suppressible by mor²

(Brizuela and Kennison, 1997)

Antp^Ns has phenotype, suppressible by skd²

(Lindsley and Zimm, 1992)

Antp^Ns, Pc² has antenna phenotype, suppressible by brm¹/brm[+]

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has antenna phenotype, suppressible by mor[+]/mor¹

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has antenna phenotype, suppressible by mor²/mor[+]

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has antenna phenotype, suppressible by osa¹/osa[+]

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has antenna phenotype, suppressible by osa²/osa[+]

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has antenna phenotype, suppressible by osa[+]/osa³

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has antenna phenotype, suppressible by osa[+]/osa⁴

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has antenna phenotype, suppressible by trx^E3/trx[+]

(Kennison and Tamkun, 1988)

NOT suppressed by

Statement

Reference

Antp^Ns has arista phenotype, non-suppressible by Gug²²⁹⁵/Gug[+]

(Kankel et al., 2004)

Other

Statement

Reference

Antp^Ns, hth^dtl-S142204, obk¹ has leg | ectopic phenotype

(Dworkin et al., 2001)

Antp^Ns, hth^dtl-S142204, obk¹ has antenna phenotype

(Dworkin et al., 2001)

Antp^Ns, tsh¹⁷ has ommatidium phenotype

(Bhojwani et al., 1997)

Antp[+]/Antp^Ns, Pc², Pcl¹⁸ has sex comb phenotype

(Kennison and Tamkun, 1988)

Antp^Ns, Pc² has antenna phenotype

(Kennison and Tamkun, 1988)

Antp[+]/Antp^Ns, Pc², Scm^K1 has sex comb phenotype

(Kennison and Tamkun, 1988)

Additional Comments

Genetic Interactions

Statement

Reference

The Antp^Ns/+ antenna-to-leg transformation phenotype is exacerbated by Abd-B^Fab7-12 (which deletes the Fab-7 element) after a Antp^Ns Abd-B^Fab7-12 stock has been maintained for several generations; no difference in the Antp^Ns phenotype is seen immediately after the establishment of the Antp^Ns Abd-B^Fab7-12 stock, however, an exacerbation of the Antp^Ns phenotype emerges in subsequent generations of the stock, reaching a plateau after 3 to 5 generations.

(Bantignies et al., 2011)

Df(3R)swp2^MICAL/+ suppresses the antenna-to-leg transformation and the reduction in eye size seen in Antp^Ns heterozygotes.

(Yazdani et al., 2008)

The Df(2R)ED3921 deficiency causes a 21% suppression of the Antp^Ns homeotic transformation. The osa² mutation suppresses this phenotype by 87%.

(Ragab et al., 2006)

The penetrance of the antenna to leg transformation phenotype seen in Antp^Ns/+ flies is slightly suppressed by Bap60¹/+ from 100% to 92%.

(Möller et al., 2005)

The mutant arista phenotype seen in Antp^Ns/+ adults is partially suppressed if they are also heterozygous for Gug⁵¹⁹ (36% of flies have normal arista development), Gug¹⁷⁵⁷ (26% of flies have normal arista development) or Gug³³³³ (28% of flies have normal arista development), but is unaffected if they are also heterozygous for Gug²²⁹⁵.

(Kankel et al., 2004)

The Antp^Ns/+ antenna to leg transformation is suppressed about 50% by Snr1^R3.

(Zraly et al., 2003)

obk¹, Antp^73b (or Antp^Ns), hth^dtl-S142204 triple mutants produce biramous antenna/legs in place of single antennae.

(Dworkin et al., 2001)

Eye phenotype is enhanced in a tsh¹⁷ mutant background.

(Bhojwani et al., 1997)

The penetrance of Antp^Ns/+ phenotype is greatly reduced if the flies are also heterozygous for mor¹ or mor².

(Brizuela and Kennison, 1997)

ash2 alleles affect the expressivity or penetrance of the antenna to leg transformation. ash2¹, ash2⁹, ash2¹¹, ash2¹² and ash2¹⁸ enhance the transformation phenotype, ash2² and ash2⁴ suppress the transformation phenotype.

(Adamson and Shearn, 1996)

Suppressed by brm¹.

(Tamkun et al., 1992)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Antp^B

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

2235

106749

Notes on Origin

Discoverer

Gehring.

Comments

Etymology: mutation is named "Nasobemia" after an imaginary animal that can walk on its nose in a poem by Christian Morgenstern; mutant flies show transformation of antenna to leg.

(Walter, 2002)

Etymology: W. Gehring believed this variant to be a separate locus from Antp and named it "Nasobemia" after Morgenstern's mythological creature that walked on its nose.

(Denell, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Antp^NS

(Liu et al., 2007, Möller et al., 2005, Cummins et al., 2003, Amoros et al., 2002, Yao et al., 1999)

Antp^Ns

(Yung et al., 2015, Bantignies et al., 2011, Yazdani et al., 2008)

Name Synonyms

Nasobemia

(Walter, 2002, McKenna et al., 1989)

Secondary FlyBase IDs

References (33)

Report Sections

Open Close