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General Information
Symbol
Dmel\AntpNs
Species
D. melanogaster
Name
Nasobemia
FlyBase ID
FBal0000587
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Polytene chromosomes normal.
Nature of the lesion
Statement
Reference
Internal 25kb partial duplication from position 46 to 71 and a complex insertion of more than 40kb including two roo elements. Truncated roo element has inserted at position 71 within intron sequences in opposite transcriptional orientation. The 5' half of a roo element has inserted at position 46 in opposite transcriptional orientation. The duplication gives the gene three promoters, P1, P2A and P2B. Dominant mutant phenotype due to ectopic expression from promoter Antp P2A.
25kb duplication of the exon 3 region with a roo transposon separating the duplicated sequences.
Insertion of an 8kb roo element at map position +128.
Insertion components
roo{}AntpNs
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Heterozygous flies show antenna to leg transformations.
Heterozygous adults show transformation of antenna to leg and the eyes are smaller than normal.
Heterozygotes lack the arista, but appear to have normal maxillary palps. The locomotor activity of heterozygous flies in an open field arena is not significantly different from that of wild-type flies.
AntpNs/+ mutants show ectopic transformation of antennae into leg tissue.
100% of heterozygotes show transformation of antenna to leg.
Only 15% of heterozygotes show normal arista development.
95% of mutant flies show an antenna to leg transformation.
Heterozygotes show transformation of antenna to leg.
96% of heterozygous flies show transformation of antenna to leg.
Antenna to leg transformation. Heterozygotes exhibit reduced compound eye and ommatidia are replaced by micro- and macrochaetae.
96-99% of heterozygotes show differentiation of leg structures in the antennae.
A viable dominant leg to antenna transformation.
AntpNs derepresses the Antp P2 promoter in the eye-antennal disc. The penetrance of antennae to leg transformations of AntpNs mutations is greatly reduced in brm1 heterozygotes.
Partial transformation of antennae into legs. Flies exhibit diminished chemosensory jump behaviour to ethyl acetate but no change in the jump response to a visual stimulus.
Transformation of head to thoracic tissue.
Antennae to leg transformation.
Transformation of antenna to prothoracic leg identity.
Antenna are leg-like.
In extreme cases, AntpNs/+ forms, in place of an antenna, a complete leg that includes sternopleura, coxa, trochanter, femur, tibia, and tarsus. Antennal leg has no sex comb in male, and bristle pattern is that of a middle leg. Eyes smaller; whole head tends to be malformed. AntpNs ssa/+ ssa indistinguishable from AntpNs/+. AntpNs/AntpB viable; phenotype like extreme AntpNs/+. Expression variable but penetrance complete. RK1.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
AntpNs has visible phenotype, enhanceable by tsh17
AntpNs, Pc2 has visible | homeotic phenotype, enhanceable by Pcl[+]/Pcl18
Suppressed by
Statement
Reference
AntpNs has visible | dominant phenotype, suppressible by Antp[+]/AntpNs
AntpNs has visible | homeotic phenotype, suppressible by osa2
AntpNs has visible | homeotic phenotype, suppressible | partially by Df(2R)ED3921
AntpNs has visible | dominant phenotype, suppressible | partially by Bap60[+]/Bap601
AntpNs has visible | dominant phenotype, suppressible | partially by Gug[+]/Gug1757
AntpNs has visible | dominant phenotype, suppressible | partially by Gug3333/Gug[+]
AntpNs has visible | dominant phenotype, suppressible | partially by Gug519/Gug[+]
AntpNs has visible phenotype, suppressible | partially by Df(3L)vin2/+
AntpNs has visible phenotype, suppressible | partially by tna[+]/tnarI075
AntpNs has visible phenotype, suppressible | partially by tna[+]/tna1
AntpNs has visible | dominant phenotype, suppressible | partially by Snr1R3
AntpNs has visible | dominant | homeotic phenotype, suppressible by osa1/osa[+]
AntpNs has visible | dominant | homeotic phenotype, suppressible by osa2/osa[+]
AntpNs has visible | dominant phenotype, suppressible by mor1
AntpNs has visible | dominant phenotype, suppressible by mor2
AntpNs, Pc2 has visible | homeotic phenotype, suppressible by mor2/mor[+]
AntpNs, Pc2 has visible | homeotic phenotype, suppressible by osa1/osa[+]
AntpNs, Pc2 has visible | homeotic phenotype, suppressible by osa2/osa[+]
AntpNs, Pc2 has visible | homeotic phenotype, suppressible by osa[+]/osa3
AntpNs, Pc2 has visible | homeotic phenotype, suppressible by osa[+]/osa4
AntpNs, Pc2 has visible | homeotic phenotype, suppressible by trxE3/trx[+]
AntpNs, Pc2 has visible | homeotic phenotype, suppressible by brm1/brm[+]
AntpNs, Pc2 has visible | homeotic phenotype, suppressible by mor[+]/mor1
NOT suppressed by
Statement
Reference
AntpNs has visible | dominant phenotype, non-suppressible by Gug2295/Gug[+]
Suppressor of
Statement
Reference
Antp[+]/AntpNs is a suppressor of visible | dominant phenotype of AntpNs
Other
Phenotype Manifest In
Enhanced by
Statement
Reference
AntpNs has ommatidium phenotype, enhanceable by tsh17
AntpNs has eye phenotype, enhanceable by tsh17
AntpNs has phenotype, enhanceable by ash218
AntpNs has phenotype, enhanceable by ash21
AntpNs has phenotype, enhanceable by ash22
AntpNs has phenotype, enhanceable by ash24
AntpNs has phenotype, enhanceable by ash29
AntpNs has phenotype, enhanceable by ash211
AntpNs has phenotype, enhanceable by ash212
AntpNs, Pc2 has antenna phenotype, enhanceable by Pcl[+]/Pcl18
AntpNs has phenotype, enhanceable by d1
AntpNs has phenotype, enhanceable by al1
Suppressed by
Statement
Reference
AntpNs has antenna phenotype, suppressible by Antp[+]/AntpNs
AntpNs has eye phenotype, suppressible by Antp[+]/AntpNs
AntpNs has leg | ectopic phenotype, suppressible by Antp[+]/AntpNs
AntpNs has antenna phenotype, suppressible by osa2
AntpNs has leg | ectopic phenotype, suppressible by osa2
AntpNs has antenna phenotype, suppressible | partially by Df(2R)ED3921
AntpNs has leg | ectopic phenotype, suppressible | partially by Df(2R)ED3921
AntpNs has antenna phenotype, suppressible | partially by Bap60[+]/Bap601
AntpNs has leg | ectopic phenotype, suppressible | partially by Bap60[+]/Bap601
AntpNs has arista phenotype, suppressible | partially by Gug[+]/Gug1757
AntpNs has arista phenotype, suppressible | partially by Gug3333/Gug[+]
AntpNs has arista phenotype, suppressible | partially by Gug519/Gug[+]
AntpNs has antenna phenotype, suppressible | partially by Df(3L)vin2/+
AntpNs has leg | ectopic phenotype, suppressible | partially by Df(3L)vin2/+
AntpNs has antenna phenotype, suppressible | partially by tna[+]/tnarI075
AntpNs has leg | ectopic phenotype, suppressible | partially by tna[+]/tnarI075
AntpNs has antenna phenotype, suppressible | partially by tna[+]/tna1
AntpNs has leg | ectopic phenotype, suppressible | partially by tna[+]/tna1
AntpNs has antenna phenotype, suppressible | partially by Snr1R3
AntpNs has leg | ectopic phenotype, suppressible | partially by Snr1R3
AntpNs has antenna phenotype, suppressible by osa1/osa[+]
AntpNs has leg | ectopic phenotype, suppressible by osa1/osa[+]
AntpNs has antenna phenotype, suppressible by osa2/osa[+]
AntpNs has leg | ectopic phenotype, suppressible by osa2/osa[+]
AntpNs has antenna phenotype, suppressible by mor1
AntpNs has antenna phenotype, suppressible by mor2
AntpNs has phenotype, suppressible by skd2
AntpNs, Pc2 has antenna phenotype, suppressible by mor[+]/mor1
AntpNs, Pc2 has antenna phenotype, suppressible by mor2/mor[+]
AntpNs, Pc2 has antenna phenotype, suppressible by osa1/osa[+]
AntpNs, Pc2 has antenna phenotype, suppressible by osa2/osa[+]
AntpNs, Pc2 has antenna phenotype, suppressible by osa[+]/osa3
AntpNs, Pc2 has antenna phenotype, suppressible by osa[+]/osa4
AntpNs, Pc2 has antenna phenotype, suppressible by trxE3/trx[+]
AntpNs, Pc2 has antenna phenotype, suppressible by brm1/brm[+]
NOT suppressed by
Statement
Reference
AntpNs has arista phenotype, non-suppressible by Gug2295/Gug[+]
Suppressor of
Statement
Reference
Antp[+]/AntpNs is a suppressor of antenna phenotype of AntpNs
Antp[+]/AntpNs is a suppressor of eye phenotype of AntpNs
Antp[+]/AntpNs is a suppressor of leg | ectopic phenotype of AntpNs
Other
Additional Comments
Genetic Interactions
Statement
Reference
The AntpNs/+ antenna-to-leg transformation phenotype is exacerbated by Abd-BFab7-12 (which deletes the Fab-7 element) after a AntpNs Abd-BFab7-12 stock has been maintained for several generations; no difference in the AntpNs phenotype is seen immediately after the establishment of the AntpNs Abd-BFab7-12 stock, however, an exacerbation of the AntpNs phenotype emerges in subsequent generations of the stock, reaching a plateau after 3 to 5 generations.
Df(3R)swp2MICAL/+ suppresses the antenna-to-leg transformation and the reduction in eye size seen in AntpNs heterozygotes.
The Df(2R)ED3921 deficiency causes a 21% suppression of the AntpNs homeotic transformation. The osa2 mutation suppresses this phenotype by 87%.
The penetrance of the antenna to leg transformation phenotype seen in AntpNs/+ flies is slightly suppressed by Bap601/+ from 100% to 92%.
The mutant arista phenotype seen in AntpNs/+ adults is partially suppressed if they are also heterozygous for Gug519 (36% of flies have normal arista development), Gug1757 (26% of flies have normal arista development) or Gug3333 (28% of flies have normal arista development), but is unaffected if they are also heterozygous for Gug2295.
The AntpNs/+ antenna to leg transformation is suppressed about 50% by Snr1R3.
obk1, Antp73b (or AntpNs), hthdtl-S142204 triple mutants produce biramous antenna/legs in place of single antennae.
Eye phenotype is enhanced in a tsh17 mutant background.
The penetrance of AntpNs/+ phenotype is greatly reduced if the flies are also heterozygous for mor1 or mor2.
ash2 alleles affect the expressivity or penetrance of the antenna to leg transformation. ash21, ash29, ash211, ash212 and ash218 enhance the transformation phenotype, ash22 and ash24 suppress the transformation phenotype.
Suppressed by brm1.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Complements
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Gehring.
Comments
Comments
Etymology: mutation is named "Nasobemia" after an imaginary animal that can walk on its nose in a poem by Christian Morgenstern; mutant flies show transformation of antenna to leg.
Etymology: W. Gehring believed this variant to be a separate locus from Antp and named it "Nasobemia" after Morgenstern's mythological creature that walked on its nose.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (32)