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General Information
Symbol
Dmel\aop1
Species
D. melanogaster
Name
FlyBase ID
FBal0000622
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
aopIP
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C2159540T

Reported nucleotide change:

G952A

Amino acid change:

Q318term | aop-PA; Q318term | aop-PB; Q318term | aop-PC; Q318term | aop-PD; Q318term | aop-PE

Reported amino acid change:

Q318term

Comment:

The nucleotide change was reported as G952A, presumably relative to the noncoding strand. The nucleotide change required for the nonsense mutation is C952T (nucleotide position relative to the aop CDS).

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: G952A.

Amino acid replacement: Q318term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

aop1/Df(2L)Exel6006 mutant embryos present significant decreases in the number of cardioblasts (both generic cardioblasts and ostial cardioblasts), as compared to controls.

aop1 mutant embryos display anterior holes in the cuticle and fault dorsal closure.

Homozygous border cell clones show defects in migration. The clones are rarely recovered and defects are seen in other follicle cells and in germline cells.

Homozygous embryos show an increase in the number of scolopidia in the lch5 chordotonal organs.

Mutant embryos have an increased number of eve-expressing progenitors and their derivatives (eve-expressing pericardial cells and muscle DA1) in the mesoderm.

Embryos have 1 or 2 additional chordotonal organs per abdominal hemisegment compared to wild-type.

Embryonic dorsal cuticle lacks dorsal hairs and has a convoluted appearance. Examination of the lateral epithelium reveals the cells to stretch but they are disorganised and variable in size.

Transheterozygote aop1/aoppok-x8 adult escapers have small rough eyes.

Homozygous embryos have anterior dorsal hole in epidermis. Brain and sometimes gut extrude through hole. Head involution normal. Visible during dorsal closure.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

aop[+]/aop1 is a non-enhancer of visible phenotype of CycEJP

aop1 is a non-enhancer of visible phenotype of Pp2B-14Dact.GMR

aop1 is a non-enhancer of visible phenotype of CanBGMR.PS, Pp2B-14Dact.GMR

Suppressor of
Statement
Reference

aop1 is a suppressor | partially of lethal phenotype of lncRNA:acal5

aop[+]/aop1 is a suppressor of visible | heat sensitive phenotype of peb1

aop[+]/aop1 is a suppressor of visible | heat sensitive phenotype of HC2.hs

NOT Suppressor of
Statement
Reference

aop[+]/aop1 is a non-suppressor of visible phenotype of CycEJP

aop1 is a non-suppressor of visible phenotype of Pp2B-14Dact.GMR

aop1 is a non-suppressor of visible phenotype of CanBGMR.PS, Pp2B-14Dact.GMR

Other
Phenotype Manifest In
Enhanced by
Suppressed by
Statement
Reference
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

aop[+]/aop1 is a non-enhancer of eye phenotype of CycEJP

aop1 is a non-enhancer of eye phenotype of CanBGMR.PS, Pp2B-14Dact.GMR

aop1 is a non-enhancer of eye phenotype of Pp2B-14Dact.GMR

aop1 is a non-enhancer of phenotype of Rho1rev220

Suppressor of
Statement
Reference

aop[+]/aop1 is a suppressor | partially of eye phenotype of HScer\UAS.cMa/HUAS.cMa, Scer\GAL4GMR.PU

aop[+]/aop1 is a suppressor of eye | heat sensitive phenotype of peb1

aop[+]/aop1 is a suppressor of wing vein | ectopic | heat sensitive phenotype of HC2.hs

aop[+]/aop1 is a suppressor of wing | heat sensitive phenotype of HC2.hs

aop1 is a suppressor of photoreceptor cell R7 phenotype of SosJC2, sev6

NOT Suppressor of
Statement
Reference

aop[+]/aop1 is a non-suppressor of eye phenotype of CycEJP

aop1 is a non-suppressor of eye phenotype of Pp2B-14Dact.GMR

aop1 is a non-suppressor of eye phenotype of CanBGMR.PS, Pp2B-14Dact.GMR

aop1 is a non-suppressor of phenotype of Rho1rev220

Additional Comments
Genetic Interactions
Statement
Reference

The decreased number of cardioblasts observed in aop1/Df(2L)Exel6006 and edlk06602 single mutant embryos is slightly more severe in the double mutants.

One copy of acal5 almost completely rescues the dorsal closure defects and lethality seen in aop1 mutant embryos.

One copy of aop1 does not rescue the dorsal closure defects and lethality seen in acal5 mutant embryos.

The small-eye phenotype observed in animals expressing HScer\UAS.cMa in the eye under the control of Scer\GAL4GMR.PU is partially suppressed in a aop1/+ mutant background.

Introduction of Df(2R)edl-L19 into an aop1 background causes a clear reduction in the number of scolopidia formed in the lch5 chordotonal organs.

sev6/sev+; SosJC2/aop1 exhibit an increase in the number of R7 cells compared to sev6/SosJC2 mutants with two functional aop copies.

Xenogenetic Interactions
Statement
Reference

The rough eye phenotype caused by expression of Hsap\MAPTV337M.Scer\UAS under the control of Scer\GAL4GMR.PF is not modified if the flies are also carrying aop1.

Complementation and Rescue Data
Partially complements
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
References (34)