Allele Dmel\aop²

General Information
Symbol	Dmel\aop²	Species	D. melanogaster
Name		FlyBase ID	FBal0000623
Feature type	allele	Associated gene	Dmel\aop
Also Known As	aop^IIS

Allele class	amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Rogge et al., 1995)
Mutagen	ethyl methanesulfonate (Tearle and Nusslein-Volhard, 1987)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	partially lethal - majority die (with aop^pok-x8) (Rogge et al., 1995)
Phenotype Manifest In
	ommatidium (with aop^pok-x8) (Rogge et al., 1995) photoreceptor cell R7 \| ectopic (with aop^pok-x8) (Rogge et al., 1995) pigment cell (with aop^pok-x8) (Rogge et al., 1995)
Detailed Description
	Statement Reference Transheterozygote aop²/aop^pok-x8 adult escapers have small rough eyes. (Rogge et al., 1995)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement Reference aop[+]/aop² is an enhancer of ommatidium phenotype of Egfr^E1 (Rogge et al., 1995)
Suppressor of
Statement Reference aop² is a suppressor of photoreceptor cell R7 phenotype of Sos^JC2, sev⁶ (Rogge et al., 1995)
Additional Comments
Genetic Interactions
Statement Reference Has no effect on the eye phenotype produced by activated arm constructs. (either arm^S44Y.GMR or arm^S56F.GMR). (Freeman and Bienz, 2001) sev⁶/sev⁺; Sos^JC2/aop² exhibit an increase in the number of R7 cells compared to sev⁶/Sos^JC2 mutants with two functional aop copies. (Rogge et al., 1995)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially complements	aop^pok-x8 (Rogge et al., 1995)
Fails to complement	aop^e2d (Rogge et al., 1995)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	aop² aop^II5 (Gabay et al., 1996) aop^IIS (Smith et al., 2002, O'Keefe et al., 1997, Tearle and Nusslein-Volhard, 1987, ) aop-IIs (Rogge et al., 1995)
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Smith et al., 2002, Development 129(13): 3255--3267 daughterless coordinates somatic cell proliferation, differentiation and germline cyst survival during follicle formation in Drosophila. [FBrf0148972] Freeman and Bienz, 2001, EMBO Rep. 2(2): 157--162 EGF receptor/Rolled MAP kinase signalling protects cells against activated Armadillo in the Drosophila eye. [FBrf0134599] O'Keefe et al., 1997, Development 124(23): 4837--4845 Spitz and Wingless, emanating from distinct borders, cooperate to establish cell fate across the Engrailed domain in the Drosophila epidermis. [FBrf0099888] Gabay et al., 1996, Development 122(11): 3355--3362 EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm. [FBrf0090562] Rogge et al., 1995, Development 121(12): 3947--3958 The role of yan in mediating the choice between cell division and differentiation. [FBrf0085837]
Stock list	Tearle and Nusslein-Volhard, 1987, D. I. S. 66: 209--269 Tubingen mutants and stock list. [FBrf0045941]

Allele Dmel\aop2

Allele Dmel\aop²