|Feature type||allele||Associated gene||Dmel\ap|
|Allele class||hypomorphic allele - genetic evidence|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Phenotype Manifest In|
ap[56f]/Df(2R)DG mutant flies show wing phenotypes. Wing defects are seen in ap[loxP.MCP-PRE.MM]/ap[56f] mutant flies, but they are significantly less severe than those seen in ap[loxP.MCP-PRE.MM] homozygotes. Wing defects are seen in Df(2R)DG-Mcp/ap[56f] mutant flies, but they are less severe than those seen in Df(2R)DG-Mcp homozygotes. Wing defects are seen in Df(2R)DG/ap[56f] mutant flies, but they are less severe than those seen in Df(2R)DG homozygotes.
The wing pouch is absent in mutant third larval instar discs.
One day-old ap56f mutant females have a significantly reduced heat stress reactivity as judged by juvenile hormone, octopamine and dopamine metabolism. In contrast, mutant males have a stress reactivity that is similar to wild-type. The initiation of heat shock response appears normal in ap56f females. In normal conditions, ap56f females lay eggs two days later and produce about five times fewer progeny than wild-type females. Egg-counting indicates that the lower rate of fertility in mutants occurs prior to oviposition. Heat stress causes a significant reduction in fertility for only two days in ap56f females, while the fertility of wild-type females is in sharp decline for three days. In normal conditions the viability of both male and female ap56f mutants is reduced (by around 10-15%) compared to wild-type. In wild-type flies survival under heat stress is higher in females, while in ap56f mutants survival is higher in males. Survival of ap56f females under heat stress is sharply decreased compared to wild-type (around 20% survival in 6-day-old ap56f females vs around 50% in wild-type), while survival of mutant males is similar to wild-type.
Mutant females show a delay in vitellogenic development which can be rescued by the application of juvenile hormone III.
Mutant males have smaller accessory glands than normal.
Levels of ecdysteroid production and content in homozygous ovaries are approximately double that of wild-type.
Heterozygotes have normal wings.
Homozygotes exhibit a loss of wing phenotype.
Homozygotes and hemizygotes exhibit nubbin wings. Transheterozygotes with apUG-2106A exhibit wings of nearly normal size with mildly serrated margins.
Ultrastructure of the corpus allatum studied.
Histolysis of the larval fat body is normal in homozygous females.
Homozygous ap56f males have a mating rate 1% of wild type levels, this rate increases with age. If allowed sufficient time with females progeny are produced. For mating success ap56f is an amorph. Homozygous ap56f males showed significantly less nonwing courtship than wild type even though the males were normally active, this is attributable to the ap locus. Homozygous ap56f males had higher sex appeal and orientation component of courtship at 2--3 days old than wild type flies. 2 day old hemizygous ap56f males have a 10--60 fold higher sex appeal than hemizygous ap+ males.
No egg maturation defect. Glands are defective in hormone production.
Homozygous flies have virtually no wing blade and have only 29% female receptivity to mature male ap+ flies. The receptivity is lower for flies heterozygous with Df(2R)M41A4B. Females have a low courtship intensity.
Wings and halteres reduced to vestiges. Scutellar and dorsocentral bristles missing (FBrf0017003). Rear and middle legs occasionally twisted, more frequently in female than in male. Both sexes fertile and long lived when homozygous and in combination with other ap alleles. ap56f/Df(2R)M41A4 have normal complement of dorsocentral and scutellar bristles (FBrf0017003).
|NOT suppressed by|
|Phenotype Manifest In|
|NOT Enhanced by|
|NOT suppressed by|
|NOT Enhancer of|
z partially suppresses the wing phenotypes seen in ap[56f]/Df(2R)DG mutant flies. z[a] does not suppress the wing phenotypes seen in ap[56f]/Df(2R)DG mutant flies.
Expression of N[intra.-FRT.Scer\UAS] under the control of Scer\GAL4[αTub84B.PC] in ap[56f]/ap[56f] wing discs rescues wing growth. Expression of N[ECN.Scer\UAS] under the control of Scer\GAL4[αTub84B.PC] in ap[56f]/ap[56f] wing discs rescues wing growth. Clones expressing vg[αTub84B.PZa] autonomously rescue wing growth in ap[56f]/ap[56f] wing discs.
No wing scalloping is seen when combined with SsdpKG03600, SsdpBG01663, Ssdpneo48, Ssdp31 or Ssdp11.
|Complementation & Rescue Data|
|Stocks ( 2 )|
|Notes on Origin|
Thompson, June 1956.
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 26 )|
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|Recent research papers (0)|
|All research papers listed in FlyBase were published before 2011|