A Database of Drosophila Genes & Genomes

FB2008_06, released July 3, 2008
 

Allele Dmel\apXa

General Information
SymbolDmel\apXaSpeciesD. melanogaster
NameXastaFlyBase IDFBal0000663
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\ap
Allele class
MutagenX ray
hide Nature of the Allele
Allele class
Mutagen
X ray
 
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
       
       
      Assay mode
      Caused by aberration
      T(2;3)apXa
      (Jack and DeLotto, 1992, Sturtevant, 1934)
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      lethal | recessive
       
      visible | dominant
      (Stevens, 1991, Jack and DeLotto, 1992)
      fertile
       
      hide Phenotype Manifest In
      wing
      (Stevens, 1991, Jack and DeLotto, 1992)
      scutum
       
      mesothoracic tergum
      (Stevens, 1991)
      hide Detailed Description
      Statement
      Reference
      Combination of NX1 and apXa produces small wings, like vg1 and lower viability. Wings reduced in length to about 70% normal; irregular in outline with a V-shaped incision with apex at L2, uniformly present giving wing a mitten-like shape with the thumb between marginal vein and L2. Usually lethal in homozygous conditions, but occasionally ecloses very late as pale dwarf with wings and balancers like vg. Deep notch visible in tip of wing fold in prepupa (FBrf0004792; FBrf0005070). In homozygotes and in combination with ap4, ap6, or Df(2R)M41A4, wings are straplike and 30-70% normal length, and haltere length is 25-50% normal; longevity and fertility like ap4/ap4 except for an occasional long-lived apXa/Df(2R)M41A4 female that may be fertile (FBrf0017003). In heterozygous combination with apID, duplications of the notum occur frequently. Wing disc cell death found in both apXa/+ (FBrf0020826) and apXa/apID (FBrf0031010).
       
      apXa/ap+ flies produce a mitten-shaped wing. Duplications of the notum are often seen accompanied by loss of wing tissue, the duplications resemble notum duplications produced by wg mutations.
      (Stevens, 1991)
      Homozygotes exhibit loss of a large portion of the wing distal half removing the wing tip. The margin of the remaining wing is intact. The phenotype is unchanged in double homozygote combinations with ct46l and ct53d.
      (Jack and DeLotto, 1992)
      hide Interactions
      hide Phenotypic Class
      hideOther
      Statement
      Reference
      NX1, apXa has visible phenotype
         
      hide Phenotype Manifest In
      hideOther
      Statement
      Reference
      NX1, apXa has wing phenotype
         
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Comments
      hide Stocks ( 52 )
      Bloomington
      3141
      T(2;3)apXa, apXa/SM5
      517
      H2/T(2;3)apXa, apXa
      561
      Pw1/T(2;3)apXa, apXa
      4252
      NX1/T(2;3)apXa, apXa
      548
      Abd-BMc/T(2;3)apXa, apXa
      3419
      Ubxbx-3/T(2;3)apXa, apXa
      3433
      UbxCbx-1/T(2;3)apXa, apXa
      3449
      Ubxpbx-1/T(2;3)apXa, apXa
      4067
      T(2;3)apXa, apXa/l(3)XaR1
      1788
      T(2;3)apXa, apXa/TM6B, Tb1
      3192
      w*; T(2;3)apXa, apXa/CyO; TM6
      Kyoto
      105957
      H2/T(2;3)apXa, apXa
      hide Notes on Origin
      Discoverer
      Serebrovsky, Jan. 1928.
      hide Comments
      Excellent dominant with no overlap with wild-type.
       
      The phenotype of apXa resembles that of aphs.PB adults developing from larvae that have been treated with heat shocks overnight.
      (Blair et al., 1994)
      hide Synonyms & Secondary IDs ( 3 )
      Reported As
      Symbol Synonym
      apXa
       
      Xa
       
      Name Synonym
      Xasta
       
      Secondary FlyBase IDs
        hide References ( 8 )
        Research paper
        Blair et al., 1994, Development 120(7): 1805--1815
        The role of apterous in the control of dorsoventral compartmentalization and PS integrin gene expression in the developing wing of Drosophila. [FBrf0072642]
        Jack and DeLotto, 1992, Genetics 131(2): 353--363
        Effect of wing scalloping mutations on cut expression and sense organ differentiation in the Drosophila wing margin. [FBrf0056217]
        Stevens, 1991, D. I. S. 70: 219--220
        The phenotype produced by two dominant apterous mutations. [FBrf0053604]
        Stevens and Bryant, 1985, Genetics 110: 281--297
        Apparent genetic complexity generated by developmental thresholds: the apterous locus in Drosophila melanogaster. [FBrf0042632]
        Waddington, 1940, J. Genet. 41: 75--139
        The genetic control of wing development in Drosophila. [FBrf0005070]
        Serebrovsky and Dubinin, 1930, J. Hered. 21: 259--265
        X-ray experiments with Drosophila. [FBrf0001995]
        Stock list
        Sturtevant, 1934, D. I. S. 2: 11--20
        Stock list. [FBrf0063892]
        Book
        Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp
        Genetic variations of Drosophila melanogaster. [FBrf0020044]