Q404term | aret-PA; Q610term | aret-PB; Q161term | aret-PD; Q404term | aret-PE; Q404term | aret-PF; Q610term | aret-PG; Q373term | aret-PH; Q373term | aret-PI; Q373term | aret-PJ; Q373term | aret-PK
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
germ cell & egg chamber
germ cell & egg chamber | supernumerary
Oogenesis arrests at about stage 3 in S1 aretPD/aretQB females and no oocyte is specified. Df(3R)M-Kx1 dominantly suppresses the ovary phenotype of aretPD/aretQB females; the arrest in oogenesis occurs later in the double mutants than in the single mutant females. Expression of Lk6EP886 under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 enhances the ovary phenotype of aretPD/aretQB females (oogenesis arrests at 3), while in the absence of an Scer\GAL4 driver, Lk6EP886 suppresses the ovary phenotype of aretPD/aretQB females (oogenesis arrests at stage 9). The stage at which oogenesis arrests in aretQB homozygous females is extended to stage 3 or 4 when Lk6EP886 is present. aretPD/aretQB eIF-4ES251D ; Lk6EP886/+ females arrest oogenesis at the same stage (stage 9) as aretPD/aretQB ; Lk6EP886/+ females. eIF-4ES251D suppresses the aretPD/aretQB ovary phenotype, delaying arrest of oogenesis until stage 9. The oogenesis arrest phenotype of aretQB homozygous females is suppressed by Df(3R)mbc-R1. Ovarioles in aretQB/aretQB ; Dl9P/+ females form a single large egg chambers with many germline cells. The fusome appears as dots. Most egg chambers have more than 16 germline cells in aretQB/aretPD ; Dl9P/+ ovaries. Three classes of abnormal egg chambers are seen, which are present in roughly equal numbers. In the first class, a large number of germline cells of roughly equal size are enveloped by a single epithelium of follicle cells. The remaining two classes arise from partial fusion of separate cysts; no stalk cells can be detected and the follicle cell layers of different egg chambers remain in contact with each other. In the "anterior/posterior fusion" class, a well-defined linear organisation within individual ovarioles is maintained, and adjacent egg chambers are fused with each other at their anterior and posterior boundaries. In the "random fusion" class, egg chambers are positioned irregularly and can be closely apposed to multiple different egg chambers on lateral as well as on anterior and posterior surfaces. In both the partial fusion classes, each egg chamber contains an oocyte. In the anterior/posterior fusion class the oocyte is present at the posterior of the cyst and in the random fusion class the oocyte is either lateral or posterior relative to the overall polarity of the ovariole.
Embryos derived from a cross of wild-type males to females heterozygous for aretQB and also heterozygous for either apt41, apt167, apt09049, apttdf-PΔ3 or apttdf-PΔ4 occasionally have head defects (these defects are not seen in embryos derived from females singly heterozygous for aretQB, apt41, apt167, apt09049, apttdf-PΔ3 or apttdf-PΔ4). This phenotype is largely suppressed (except in the case of aretQB apt09049 double heterozygotes) if the females are also heterozygous for nosL7.