FlyBase Allele Report: Dmel\arm[3]

Embryos maternally and zygotically mutant for arm³ show weak staining for and improper localisation of the shg, arm and α-Cat gene products, suggesting little or no adherens junction formation.

Embryos maternally and zygotically mutant for arm³ contain cells of normal shape after cellularization. However, mutant embryos form a disorganized ventral furrow during early gastrulation and much of the ectoderm breaks into rounded, dissociated cells soon afterward. Nevertheless, cells make roughly correct cell fate choices, and some cells retain residual epithelial character and undergo limited morphogenesis.

Embryos maternally and zygotically mutant for arm³ form more epithelial folds than wild type embryos.

Cells in epithelial folds and rosettes of embryos maternally and zygotically mutant for arm³ are pear-shaped with a constricted and extended apical domain, whereas wild type epithelial cells adopt a columnar shape.

Basic cytoskeletal polarity appears to be maintained in the epithelial folds of embryos maternally and zygotically mutant for arm³, although actin and microtubules are disorganised in rounded dissociated mutant cells.

In embryos maternally and zygotically mutant for arm³, most neuroblasts fail to be internalized and divide laterally or orthogonally on the embryo surface, rather than in the apical-basal orientation as in wild type. However, as in wild type, neuroblasts divide asymmetrically and epithelial cells divide symmetrically in arm³ mutants.

(Harris and Peifer, 2004)

arm³ maternal mutants have defects in spindle attachment to the cortex during syncytial divisions but do not have defects in pseudocleavage furrows. There is no evidence for multinucleate cells during cellularisation of arm³ maternal mutant embryos.

(Grevengoed et al., 2003)

arm³ somatic stem cell (SSC) clones in the ovary are lost more rapidly than wild-type clones. Follicle cells in mutant clones do not have the wild-type regular columnar shape.

(Song and Xie, 2003)

arm³ hemizygous embryos fail to form the second midgut constriction.

(Takemaru et al., 2003)

Leading edge cells fail to elongate uniformly in mutant embryos as dorsal closure is initiated.

(Grevengoed et al., 2001)

Homozygous embryos derived from homozygous female germline clones show loss of nuclei from the surface of the embryo during syncytial development.

(McCartney et al., 2001)

arm³/Y mutant cuticles are shorter than wild type, with a lawn of ventral denticles, no naked cuticle and incomplete dorsal closure. Embryos with a range of phenotypes is seen. In embryos with the most severe phenotype, the cuticle is much shorter than normal and is open dorsally. In less severe embryos, dorsal closure is partially complete and the cuticle is longer. At a very low frequency (0.5%), the cuticle is nearly wild type in length, has greater denticle diversity and is dorsally closed (the embryos retain an anterior hole).

(Cox et al., 2000)

Mutant embryos show dorsal closure defects and ventral defects revealed by loss of naked cuticle between denticle belts. At the end of germ band retraction the dorsal leading edge cells initiate cell shape cheanges, but in an uncoordinated fashion. A subset of more lateral cells fail to elongate. Most embryos fail to initiate dorsal closure and leading edge cells often curl under their more lateral neighbors. Amnioserosa eventually rips away from the leading edge cells with detached leading edge cells resuming a cuboidal shape.

(McEwen et al., 2000)

Large follicle cell clones mutant for arm³ form a follicular epithelium. The mutant cells in most cases have a normal cuboidal to columnar shape.

(Tanentzapf et al., 2000)

Affected embryos show a strong segment polarity phenotype: reduced size, lawn of denticles and missing head structures.

(Cavallo et al., 1998)

All surviving ventral cells of hemizygous embryos secrete denticles.

(Loureiro and Peifer, 1998)

Homozygotes show a strong zygotic segment polarity phenotype. Females with homozygous germlines can complete oogenesis, but homozygous embryos derived from these females are abnormal.

(White et al., 1998)

Embryos that are zygotically and maternally mutant for arm³ have a disrupted epithelium, and only patches of cuticle are secreted. The integrity of the cuticle is dramatically improved if these embryos are also expressing arm^{S10.Scer\UAS.T:Hsap\MYC} (using Scer\GAL4^e22c), and the secreted cuticle is naked. The integrity of the cuticle is dramatically improved if these embryos are also expressing arm^{S2.Scer\UAS.T:Hsap\MYC} (using Scer\GAL4^e22c), some of the secreted cuticle has denticles.

(Pai et al., 1997)

Germline mosaics cause failure in adhesion between follicle and germ cells in the egg chambers. Nurse cell cortical actin cytoskeleton is often disorganised with abnormal inclusions of actin present. Centripetal follicle cells frequently fail to migrate and separate the oocyte from the nurse cells and nurse cells often fail to transfer their contents into the oocyte. At a low frequency normal egg chambers are seen producing fertilizable eggs but egg production is greatly reduced. Of the eggs laid 23% are flat or half-filled. Of the full eggs 94% do not develop, the remaining 6% are fertilised and begin embryonic development. Half of the developing embryos arrest before secreting cuticle ("no cuticle" class). Deviation from normal development occurs before the cellular blastoderm stage. A quarter hatch or have a nearly normal cuticle ("wild-type" class). The remaining have a more dramatic cuticle phenotype secreting only a few cuticle scraps ("crumbs-like" class), due to lack of maternal and zygotic arm. Embryos cellularise normally but morphogenetic movements are disrupted at the onset of gastrulation, there is little or no germ band extension and the ventral furrow and posterior midgut fail to invaginate normally. Cell polarity is rapidly disrupted due to disruptions in adherens junctions. The epithelial monolayer of cells at the cellular blastoderm stage rapidly becomes a disordered, multilayered mesenchyme, the cells in this mesenchyme round up. Cell-cell adhesion is severely disrupted. "crumbs-like" class can be rescued by paternal arm correspondingly increasing the number of wild type embryos. Paternal arm cannot rescue the "no cuticle" class.

(Cox et al., 1996)

Females bearing germline clones lay some eggs, homozygous embryos develop normally, hemizygotes show poor differentiation of the larval cuticle. A rare class of hemizygotes shows very early defects, before and during cellularisation, due a disruption of zonula adherens formation. Other embryos develop normally until early gastrulation and then the monolayered epithelium becomes disordered and in some regions multilayered.

(Muller and Wieschaus, 1996)

Embryos secrete only small portion of cuticle, due to disruption of adherens junction function.

(Orsulic and Peifer, 1996)

Embryos arising from germ-line clones dissociate at the onset of gastrulation. Additional defects are evident in the egg and cellularization/early gastrulation of the embryo. Embryos deficient for both maternal and zygotic arm product have a crb like phenotype forming only scraps of cuticle.

(Cox and Peifer, 1995)

Females with homozygous arm³ germlines lay eggs that are often flaccid, perhaps because residual nurse cells prevent proper closure of the egg cell at the anterior end. Those eggs that are laid have normal anterior-posterior and dorso-ventral patterning.

(Peifer et al., 1993)

Homozygous clone tissue dies in the imaginal discs of larvae suggesting that arm⁺ activity is required in late larval and pupal stages.

(Peifer et al., 1991)

Shows effects on segment polarity, head development and dorsal closure.

(Peifer and Wieschaus, 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

arm³/arm[+] is an enhancer of partially lethal phenotype of lqfR⁰³⁶⁸⁵/lqfR^Δ117

(Lee and Fischer, 2012)

Suppressor of

Statement

Reference

arm³/arm[+] is a suppressor | partially of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU

(Dupont et al., 2012)

arm³/arm[+] is a suppressor | partially of decreased cell number | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU

(Dupont et al., 2012)

arm³/arm[+] is a suppressor | partially of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR

(Dupont et al., 2012)

arm³/arm[+] is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU

(Dupont et al., 2012)

arm³/arm[+] is a suppressor of bang sensitive phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU

(Dupont et al., 2012)

arm³ is a suppressor of visible phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

Other

Statement

Reference

arm³/arm[+], lqfR⁰³⁶⁸⁵/lqfR^Δ117 has lethal - all die during P-stage phenotype

(Lee and Fischer, 2012)

ASPP^d, arm³/arm[+] has visible phenotype

(Langton et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

arm³ has embryonic epidermis | dorsal phenotype, enhanceable by Scer\GAL4^LE/Tak1^K46R.UAS

(McEwen et al., 2000)

arm³ has embryonic epidermis | dorsal phenotype, enhanceable by puc^A251.1F3/puc^A251.1F3

(McEwen et al., 2000)

NOT Enhanced by

Statement

Reference

arm³ has embryonic midgut constriction 2 phenotype, non-enhanceable by Cby^dsRNA.cTa

(Takemaru et al., 2003)

Suppressed by

Statement

Reference

arm³ has embryonic/larval cuticle | embryonic stage phenotype, suppressible | partially by Arp3^EP3640/Arp3[+]

(Sarpal et al., 2012)

arm³ has phenotype, suppressible by Df(3R)Hu/+

(Cox et al., 2000)

arm³ has phenotype, suppressible by Df(3R)WIN11/+

(Cox et al., 2000)

arm³ has phenotype, suppressible by Df(3R)crb87-5/+

(Cox et al., 2000)

arm³ has phenotype, suppressible by Df(4)M101-62f/+

(Cox et al., 2000)

arm³ has phenotype, suppressible by T(Y;3)B81/+

(Cox et al., 2000)

arm³ has phenotype, suppressible by pan^unspecified

(Cox et al., 2000)

arm³ has phenotype, suppressible by spi¹

(Cox et al., 2000)

arm³ has phenotype, suppressible by hid^rvX1

(Cox et al., 2000)

arm³ has phenotype, suppressible by Dp(2;2)M(2)m⁺/Df(2L)M36F-S5

(Cox et al., 2000)

arm³ has phenotype, suppressible by Df(2L)sc19-8/Dp(2;1)B19

(Cox et al., 2000)

arm³ has phenotype, suppressible by In(2LR)Gla/In(2R)bw^VDe2LCy^R

(Cox et al., 2000)

arm³ has embryonic epidermis phenotype, suppressible by Dp(2;2)M(2)m⁺/Df(2L)TW137

(Cox et al., 2000)

arm³ has embryonic epidermis phenotype, suppressible by Df(2L)sc19-5/Dp(2;1)B19

(Cox et al., 2000)

arm³ has denticle | segment polarity expression pattern phenotype, suppressible by Df(2R)E2/+

(Cox et al., 2000)

arm³ has embryonic epidermis | segment polarity expression pattern phenotype, suppressible by Df(2R)E2/+

(Cox et al., 2000)

arm³ has embryo | dorsal closure stage phenotype, suppressible by Df(2R)E2/+

(Cox et al., 2000)

arm³ has embryonic epidermis phenotype, suppressible by C(4)RM/+

(Cox et al., 2000)

arm³ has embryonic epidermis phenotype, suppressible by Df(2L)TE29Aa-11/+

(Cox et al., 2000)

arm³ has embryonic epidermis phenotype, suppressible by Df(2L)spd/+

(Cox et al., 2000)

arm³ has embryonic epidermis phenotype, suppressible by Df(2R)017/+

(Cox et al., 2000)

arm³ has embryonic epidermis phenotype, suppressible by Df(2R)PC4/+

(Cox et al., 2000)

arm³ has embryonic epidermis phenotype, suppressible by Df(2R)ST1/+

(Cox et al., 2000)

arm³ has embryonic epidermis phenotype, suppressible by Df(3L)Cat/+

(Cox et al., 2000)

arm³ has embryonic epidermis phenotype, suppressible by Df(3L)Pc-MK/+

(Cox et al., 2000)

arm³ has embryonic epidermis phenotype, suppressible by Df(3L)W10/+

(Cox et al., 2000)

arm³ has embryonic epidermis phenotype, suppressible by +/Df(3R)Dl-BX12

(Cox et al., 2000)

arm³ has embryonic epidermis phenotype, suppressible by Df(3R)Scr/+

(Cox et al., 2000)

arm³ has embryonic epidermis phenotype, suppressible by Df(3R)p712/+

(Cox et al., 2000)

arm³ has embryonic epidermis phenotype, suppressible by Psn¹⁰/Psn[+]

(Cox et al., 2000)

arm³ has embryonic epidermis phenotype, suppressible by hid⁰⁵⁰¹⁴/W[+]

(Cox et al., 2000)

arm³ has phenotype, suppressible by puc^A251.1F3

(Cox et al., 2000)

arm³ has embryonic epidermis phenotype, suppressible by Scer\GAL4^arm.PS/BacA\p35^UAS.cHa

(Cox et al., 2000)

arm³ has phenotype, suppressible by Df(2L)H20/+

(Cox et al., 2000)

arm³ has phenotype, suppressible by Df(2L)JS32/+

(Cox et al., 2000)

arm³ has phenotype, suppressible by Df(2L)N22-3/+

(Cox et al., 2000)

arm³ has phenotype, suppressible by Df(2L)TW84/+

(Cox et al., 2000)

arm³ has phenotype, suppressible by Df(2L)al/+

(Cox et al., 2000)

arm³ has phenotype, suppressible by Df(2L)cl-h3/+

(Cox et al., 2000)

arm³ has phenotype, suppressible by +/Df(2L)prd1.7

(Cox et al., 2000)

arm³ has phenotype, suppressible by Df(2L)r10/+

(Cox et al., 2000)

arm³ has phenotype, suppressible by Df(2R)ES1/+

(Cox et al., 2000)

arm³ has phenotype, suppressible by +/Df(2R)M41A4

(Cox et al., 2000)

arm³ has phenotype, suppressible by Df(2R)Px2/+

(Cox et al., 2000)

arm³ has phenotype, suppressible by Df(2R)vg135/+

(Cox et al., 2000)

arm³ has phenotype, suppressible by Df(3L)H99/+

(Cox et al., 2000)

arm³ has phenotype, suppressible by Df(3L)ZN47/+

(Cox et al., 2000)

arm³ has phenotype, suppressible by Df(3L)fz-GF3b/+

(Cox et al., 2000)

arm³ has phenotype, suppressible by Df(3R)CA3/+

(Cox et al., 2000)

arm³ has phenotype, suppressible by Df(3R)D7/+

(Cox et al., 2000)

arm³ has embryonic epidermis | ventral phenotype, suppressible | partially by bsk^UAS.cBa/Scer\GAL4^VP16.arm

(McEwen et al., 2000)

arm³ has embryonic epidermis | dorsal phenotype, suppressible by Scer\GAL4^LE/Tak1^UAS.cTa

(McEwen et al., 2000)

arm³ has embryonic epidermis | dorsal phenotype, suppressible by dpp^UAS.cHa/Scer\GAL4^LE

(McEwen et al., 2000)

arm³ has embryonic epidermis | dorsal phenotype, suppressible by Scer\GAL4^LE/tkv^{Q199D.UAS.Tag:HA}

(McEwen et al., 2000)

arm³ has embryonic epidermis | dorsal phenotype, suppressible | partially by hep^UAS.cBa/Scer\GAL4^VP16.arm

(McEwen et al., 2000)

arm³ has embryonic epidermis | ventral phenotype, suppressible | partially by hep^UAS.cBa/Scer\GAL4^VP16.arm

(McEwen et al., 2000)

arm³ has embryonic epidermis | ventral phenotype, suppressible | partially by Scer\GAL4^prd.RG1/Tak1^UAS.cTa

(McEwen et al., 2000)

arm³ has denticle belt phenotype, suppressible | partially by puc¹/puc[+]

(McEwen et al., 2000)

arm³ has embryonic epidermis | dorsal phenotype, suppressible by puc¹/puc[+]

(McEwen et al., 2000)

arm³ has embryonic epidermis | ventral phenotype, suppressible | partially by puc¹/puc[+]

(McEwen et al., 2000)

arm³ has denticle belt phenotype, suppressible | partially by puc^A251.1F3/puc[+]

(McEwen et al., 2000)

arm³ has embryonic epidermis | dorsal phenotype, suppressible by puc^A251.1F3/puc[+]

(McEwen et al., 2000)

arm³ has embryonic epidermis | ventral phenotype, suppressible | partially by puc^A251.1F3/puc[+]

(McEwen et al., 2000)

arm³ has phenotype, suppressible by ci^D

(Cavallo et al., 1998)

arm³ has phenotype, suppressible by gro^E48

(Cavallo et al., 1998)

arm³ has embryonic epidermis phenotype, suppressible by Df(4)M101-62f

(Cavallo et al., 1998)

arm³ has embryonic epidermis phenotype, suppressible by Df(3R)Espl22

(Cavallo et al., 1998)

arm³ has denticle belt phenotype, suppressible by Df(3R)Espl22

(Cavallo et al., 1998)

arm³ has embryonic epidermis phenotype, suppressible by pan¹

(Cavallo et al., 1998)

arm³ has denticle belt phenotype, suppressible by pan¹

(Cavallo et al., 1998)

arm³ has embryonic epidermis phenotype, suppressible by pan²

(Cavallo et al., 1998)

arm³ has denticle belt phenotype, suppressible by pan²

(Cavallo et al., 1998)

arm³ has embryonic epidermis phenotype, suppressible by pan³

(Cavallo et al., 1998)

arm³ has denticle belt phenotype, suppressible by pan³

(Cavallo et al., 1998)

arm³ has embryonic/first instar larval cuticle | ventral phenotype, suppressible by shg²

(Loureiro and Peifer, 1998)

arm³ has denticle belt phenotype, suppressible by shg²

(Loureiro and Peifer, 1998)

arm³ has embryonic/first instar larval cuticle | ventral phenotype, suppressible by Df(3L)st100.62

(Loureiro and Peifer, 1998)

arm³ has denticle belt phenotype, suppressible by Df(3L)st100.62

(Loureiro and Peifer, 1998)

arm³ has cuticle phenotype, suppressible | partially by Hsap\JUP^arm.PW

(White et al., 1998)

arm³ has cuticle phenotype, suppressible | partially by Mmus\Ctnnb1^arm.PW

(White et al., 1998)

NOT suppressed by

Statement

Reference

arm³ has embryonic midgut constriction 2 phenotype, non-suppressible by Cby^dsRNA.cTa

(Takemaru et al., 2003)

arm³ has phenotype, non-suppressible by Tp(3;3)Dfd^rv1/Df(3R)Tpl10

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by Ras85D^e1B

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by vn^147-2

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by 18w^unspecified

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by Df(2L)J-H/+

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by Df(2L)TW50/+

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by Df(2L)tkv2/+

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by Df(2R)AA21/+

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by Df(2R)P34/+

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by Df(2R)Pcl11B/+

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by Df(2R)cn9/+

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by Df(3L)Pc/+

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by Df(3L)rdgC-co2

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by Df(3L)ri-79c

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by Df(3R)Cha7/+

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by Df(3R)MAP2/+

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by Egfr^C18

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by Jra¹

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by aop^XE-12

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by aos²⁵⁷

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by bsk^unspecified

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by dpp^e87

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by ena^unspecified

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by hh^AC

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by hh^unspecified

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by kkv¹

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by mbc^C1

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by qua^unspecified

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by rl^C18

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by scra⁸

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by scra^unspecified

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by scw^I1

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by sro¹

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by stck^3R-17

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by tor¹

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by tsh^unspecified

(Cox et al., 2000)

arm³ has phenotype, non-suppressible by wg^unspecified

(Cox et al., 2000)

arm³ has denticle belt phenotype, non-suppressible by puc^E69/puc[+]

(McEwen et al., 2000)

arm³ has embryonic epidermis | dorsal phenotype, non-suppressible by puc^E69/puc[+]

(McEwen et al., 2000)

arm³ has embryonic epidermis | ventral phenotype, non-suppressible by Ras85D^e1B

(McEwen et al., 2000)

arm³ has embryonic epidermis | dorsal phenotype, non-suppressible by bsk^UAS.cBa/Scer\GAL4^VP16.arm

(McEwen et al., 2000)

arm³ has embryonic epidermis | dorsal phenotype, non-suppressible by rl^unspecified

(McEwen et al., 2000)

arm³ has embryonic epidermis | ventral phenotype, non-suppressible by rl^unspecified

(McEwen et al., 2000)

arm³ has embryonic epidermis | dorsal phenotype, non-suppressible by vn^147-2

(McEwen et al., 2000)

arm³ has embryonic epidermis | ventral phenotype, non-suppressible by vn^147-2

(McEwen et al., 2000)

arm³ has embryonic epidermis | ventral phenotype, non-suppressible by puc^E69/puc[+]

(McEwen et al., 2000)

arm³ has embryonic epidermis | dorsal phenotype, non-suppressible by Ras85D^e1B

(McEwen et al., 2000)

arm³ has phenotype, non-suppressible by ci^Ce-1

(Cavallo et al., 1998)

arm³ has embryonic epidermis phenotype, non-suppressible by Df(4)M101-63a

(Cavallo et al., 1998)

Enhancer of

Statement

Reference

arm³/arm[+] is an enhancer of adherens junction | somatic clone | pupal stage phenotype of Magi^ex214

(Zaessinger et al., 2015)

arm³/arm[+] is an enhancer of eye disc | somatic clone | pupal stage phenotype of Magi^ex214

(Zaessinger et al., 2015)

arm³/arm[+] is an enhancer of ventral furrow phenotype of Traf4³

(Mathew et al., 2011)

NOT Enhancer of

Statement

Reference

arm³ is a non-enhancer of phenotype of Rho1^rev220

(Magie et al., 1999)

Suppressor of

Statement

Reference

arm³/arm[+] is a suppressor | partially of eye photoreceptor cell phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU

(Dupont et al., 2012)

arm³ is a suppressor of eye phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

arm³ is a suppressor of embryonic midgut constriction 1 phenotype of Cby^dsRNA.cTa

(Takemaru et al., 2003)

NOT Suppressor of

Statement

Reference

arm³ is a non-suppressor of phenotype of Rho1^rev220

(Magie et al., 1999)

Other

Statement

Reference

arm³/arm[+], lqfR⁰³⁶⁸⁵/lqfR^Δ117 has wing | P-stage phenotype

(Lee and Fischer, 2012)

arm³/arm[+], lqfR⁰³⁶⁸⁵/lqfR^Δ117 has eye | P-stage phenotype

(Lee and Fischer, 2012)

arm³/arm[+], lqfR⁰³⁶⁸⁵/lqfR^Δ117 has head capsule | P-stage phenotype

(Lee and Fischer, 2012)

arm³/arm[+], lqfR⁰³⁶⁸⁵/lqfR^Δ117 has leg | P-stage phenotype

(Lee and Fischer, 2012)

ASPP^d, arm³/arm[+] has eye phenotype

(Langton et al., 2009)

arm³, puc^A251.1F3/puc[+] has embryonic epidermis | dorsal phenotype

(McEwen et al., 2000)

arm³, puc^A251.1F3 has embryonic epidermis | dorsal phenotype

(McEwen et al., 2000)

Scer\GAL4^e22c, arm³, pan^ΔN.UAS has embryonic epidermis phenotype

(Cavallo et al., 1998)

Scer\GAL4^e22c, arm³, pan^ΔN.UAS has denticle belt phenotype

(Cavallo et al., 1998)

Abl¹, arm³ has longitudinal connective phenotype

(Loureiro and Peifer, 1998)

Hsap\JUP^arm.PW, arm³ has epidermis | ventral phenotype

(White et al., 1998)

Mmus\Ctnnb1^arm.PW, arm³ has epidermis | ventral phenotype

(White et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The high frequency of gaps in the structure of adherens junctions observed in somatic clones of Magi^ex214 homozygous cells in the pupal eye disc is strongly enhanced by combination with a single copy of the arm³ allele.

(Zaessinger et al., 2015)

arm³/+ ; lqfR⁰³⁶⁸⁵/lqfR^Δ117 animals die in the pupal case. They have small or absent eyes, small head capsules and also have morphological defects in the head cuticle, wings and legs.

(Lee and Fischer, 2012)

One copy of Arp3^EP3640 partially suppresses the cuticle defects seen in arm³ mutant embryos.

(Sarpal et al., 2012)

p130CAS¹ homozygotes in combination with heterozygous arm³ severely reduces viability.

(Tikhmyanova et al., 2010)

arm³/+ ; ASPP^d/ASPP^d flies have enlarged eyes.

(Langton et al., 2009)

Cby^dsRNA.cTa injected arm³ hemizygous embryos are indistinguishable from uninjected arm³ hemizygous embryos.

(Takemaru et al., 2003)

The arm³/Y phenotype is suppressed by one copy of Df(2R)E2; the cuticle is longer, the dorsal closure defect is substantially reduced and denticle diversity is partially restored. Expression of dsh^Scer\UAS.cAa under the control of Scer\GAL4^{arm.T:Hsim\VP16} in an arm³ background gives rise to a cuticle with many small denticles, but with the length of an arm³ single mutant.

(Cox et al., 2000)

puc^A251.1F3 and puc¹ dominantly suppress the dorsal closure defects of arm³, and partially suppress the ventral patterning defects, restoring naked cuticle. arm³,puc^A251.1F3 double mutants show a novel loss of dorsal cuticle phenotype.

(McEwen et al., 2000)

The arm² segment polarity phenotype is suppressed by heterozygosity for Df(4)M101-62f but not Df(4)M101-63a, and by suppressed by a reduction in maternal, but not paternal, contribution from Df(3R)Espl22.

(Cavallo et al., 1998)

The arm³ segment polarity phenotype is suppressed by one copy of shg² or Df(3L)st100.62. arm³; Abl¹/Abl¹ embryos show disruptions in axonogenesis, including segmental gaps along the longitudinal nerves.

(Loureiro and Peifer, 1998)

Xenogenetic Interactions

Statement

Reference

arm³/+ significantly partially suppresses the decreased lifespan seen in flies with expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} driven by Scer\GAL4^elav.PU or Scer\GAL4^Eaat1.PR. arm³/+ significantly suppresses photoreceptor loss seen in flies with expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} driven by Scer\GAL4^elav.PU. arm³/+ significantly suppresses the locomotor defects and bang sensitivity seen in Scer\GAL4^repo.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS} flies.

(Dupont et al., 2012)

The integrity of the cuticle in homozygous embryos derived from females with homozygous germlines is rescued by Hsap\JUP^arm.PW or Mmus\Catnb^arm.PW provided paternally, but has patterning defects; the ventral epidermis forms a denticle lawn in these partially rescued embryos.

(White et al., 1998)

Complementation and Rescue Data

Rescued by

arm³ is rescued by arm^S12.Tag:MYC

(Orsulic and Peifer, 1996)

arm³ is rescued by arm^S6.Tag:MYC

(Orsulic and Peifer, 1996)

Partially rescued by

arm³ is partially rescued by arm^{Tag:MYC,Tag:PM(hKRAS)}

(Cox et al., 1999)

arm³ is partially rescued by arm^S5.Tag:MYC

(Orsulic and Peifer, 1996)

arm³ is partially rescued by arm^S14.Tag:MYC

(Orsulic and Peifer, 1996)

Not rescued by

arm³ is not rescued by Scer\GAL4^e22c/arm^{S2.UAS.Tag:MYC}

(Cox et al., 1999)

arm³ is not rescued by arm^S11.Tag:MYC

(Orsulic and Peifer, 1996)

arm³ is not rescued by arm^S15.Tag:MYC

(Orsulic and Peifer, 1996)

Comments

Embryos maternally and zygotically mutant for arm³ have a fragmented cuticle. This cuticle phenotype is completely rescued by arm^{T:Hsap\MYC,T:Hsap\CAAX}, but the resulting embryos have a wg null-like phenotype.

(Cox et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

68160

y¹ arm³ P{neoFRT}19A/FM7a

Notes on Origin

Discoverer

Comments

Strong mutant allele.

Moderate allele.

(Peifer et al., 1993)

Intermediate allele.

(Cox and Peifer, 1995)

Association of arm protein with α-Cat and shg in vivo is assayed by SDS-PAGE and immunoblotting.

(Pai et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

arm³

(Wang and Baker, 2019, Zaessinger et al., 2015, Dupont et al., 2012, Lee and Fischer, 2012, Xu et al., 2011, Popodi et al., 2010-, Tikhmyanova et al., 2010, Langton et al., 2009)

arm^XP33

(Sarpal et al., 2012, Sawyer et al., 2009, Beronja et al., 2005, Langevin et al., 2005, Harris and Peifer, 2004, Tolwinski and Wieschaus, 2004, Bienz and Clevers, 2003, Bilder et al., 2003, Farge, 2003, Grevengoed et al., 2003, Takemaru et al., 2003, Grevengoed et al., 2001, Kumar et al., 2001, McCartney et al., 2001, Cox et al., 2000, McEwen et al., 2000, Muller, 2000, Tanentzapf et al., 2000, Cox et al., 1999, Cox et al., 1999, Magie et al., 1999, McEwen et al., 1999, Yu et al., 1999, Cavallo et al., 1998, Loureiro and Peifer, 1998, White et al., 1998, Pai et al., 1997, Tepass, 1997, Cox et al., 1996, Cox et al., 1996, Miller and Moon, 1996, Muller and Wieschaus, 1996, Orsulic and Peifer, 1996, Pai et al., 1996, Cox and Peifer, 1995, Peifer, 1995, Peifer et al., 1993, Peifer and Wieschaus, 1990, Riggleman et al., 1989)

Name Synonyms

Secondary FlyBase IDs

References (52)

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