FlyBase Allele Report: Dmel\arm[4]

The position of the contractile ring at the end of constriction is unbiased along the apical-basal axis in mutant clones in the follicle cells, in contrast to wild type. The final position of the midbody ring is also disrupted in the mutant cells. At the clone border, wild-type cells always direct the midbody towards the wild-type neighbour.

(Morais-de-Sá and Sunkel, 2013)

The area of naked cuticle of arm⁴ mutant embryos is decreased compared to wild-type controls.

(Jones et al., 2010)

Hemizygous embryos have a strongly shortened cuticle which lacks anterior and head structures.

(Kessler and Müller, 2009)

Myosin activity (assayed through a sqh antibody) is clearly restricted in arm⁴ follicle cell clones.

(Wang and Riechmann, 2007)

arm⁴ mutant clones sort away from wild-type cells and display epithelial integrity defects.

During oogenesis, arm⁴ mutant germ line clones cause oocyte mis-positioning. Also, in the follicular epithelium, arm⁴ mutant cells sort away from the wild-type cells and lose their epithelial integrity. arm⁴ mutant border cells do not migrate. Migration in arm⁴ mutant nurse cells is strongly blocked, although not inhibited.

(Pacquelet and Rorth, 2005)

Virtually all arm⁴/+ embryos show normal dorsal closure.

(Takahashi et al., 2005)

Embryos expressing arm^{S6.T:Hsap\MYC} in a arm⁴ background have a "lawn of denticles" cuticle phenotype. Embryos expressing arm^{S12.T:Hsap\MYC} in a arm⁴ background have a "lawn of denticles" cuticle phenotype.

(Thompson, 2004)

Tube fusion at the adherens junction in the dorsal trunk is defective in mutants, fusion cells do not form E-cadherin contacts and associated fusion tracks.

(Lee et al., 2003)

arm⁴ somatic stem cell (SSC) clones in the ovary are lost more rapidly than wild-type clones. arm⁴ follicle cell clones form large patches similar to those formed by marked wild-type clones. The mutant follicle cells do not have the wild-type regular columnar shape. Mislocalisation of the oocyte can also be seen.

(Song and Xie, 2003)

The addition of arm⁴ suppresses the eye phenotype seen in Hsap\MAPT^GMR.Ex.PJ animals almost to wild-type, except for the anterior margin.

(Jackson et al., 2002)

arm⁴ severely affects germline stem cell (GSC) maintenance in the ovary; more than 80% of mutant GSCs are lost 3 weeks after clone induction.

(Song et al., 2002)

Posterior spiracles are present, but in an abnormal location, in mutant embryos and the tracheal dorsal trunk branch, dorsal branch 10 and spiracular branch 10 are absent.

(Takaesu et al., 2002)

Has no effect on the eye phenotype produced by activated arm constructs. (either arm^S44Y.GMR or arm^S56F.GMR).

(Freeman and Bienz, 2001)

Mutant embryos show a dramatic failure in epidermal patterning.

(Zervas et al., 2001)

The size of the primary branches of the tracheal system is largely unaffected in embryos carrying arm^{S14.T:Hsap\MYC} in an arm⁴ background, even though segments of the dorsal trunk are disconnected.

(Beitel and Krasnow, 2000)

Invagination of tracheal primordia is normal in zygotic arm⁴ embryos. The dorsal trunk is completely lost in these embryos and branch fusion does not occur.

(Chihara and Hayashi, 2000)

Large follicle cell clones mutant for arm⁴ form a follicular epithelium. The follicle cells often develop a squamous cell morphology or show a multilayered structure.

(Tanentzapf et al., 2000)

Dorsal trunk branches are completely missing zygotic mutants.

(Oda and Tsukita, 1999)

Embryos that are zygotically arm⁴ but have wild-type maternal arm function have a partial set of RP2 neurons (70% of the normal number are formed). arm⁴ embryos have subtle ventral nervous system defects, including segmental gaps in the MP1 pathway. The pCC/MP2 pathway, although usually complete, undulates less than in wild-type embryos. The phenotype is not altered if the embryos also carry arm^{S14.T:Hsap\MYC}. Hemizygous embryos have a segment polarity phenotype.

(Loureiro and Peifer, 1998)

Germline clones generate mutant germ cells that are frequently altered in position in the egg chamber, position of the oocyte is altered, cell shape and size are irregular and cells are multinucleated. No gaps are visible between the germ cells. Cell-cell adhesion by shg protein is not lost but the shg protein has lost its normal connection to the actin network.

(Oda et al., 1997)

Embryos have a strong segment polarity defect and show defects in dorsal closure. The lethality and cuticle phenotype of arm⁴ embryos is rescued by arm^{S2.Scer\UAS.T:Hsap\MYC} expressed using Scer\GAL4^e22c. arm⁴ embryos expressing arm^{S10.Scer\UAS.T:Hsap\MYC} (using Scer\GAL4^e22c) differentiate essentially only naked cuticle, similar to the phenotype of embryos expressing arm^{S10.Scer\UAS.T:Hsap\MYC} (using Scer\GAL4^e22c) in a wild-type background. These embryos are shorter than wild-type.

(Pai et al., 1997)

arm⁴; crb² and arm⁴; crb^D88-3 double mutants exhibit a severe crb-like cuticle phenotype.

(Cox et al., 1996)

Tracheal system is defective in the embryo, though Malpighian tubules are normal. Dorsal trachea trunks are missing, and lateral trunks do not link up.

(Uemura et al., 1996)

Clonal analysis revealed that arm function within the germ line is not required for polarization of the follicle cells, however nurse cells and oocyte have altered shape and position. Cortical actin cytoskeleton, cytoplasmic actin filaments and ring canals are all disrupted in arm mutant germlines, the nurse cells' nuclei may be mis-positioned and there may be large aggregates of actin in both nurse cells and oocyte. In some mutant egg chambers border cell migration is perturbed. Unlaid eggs become surrounded by eggshells with normally positioned dorsal/anterior chorionic appendages and with a micropyle at the anterior end.

(Peifer et al., 1993)

Strong segment polarity phenotype. Homozygous clone tissue dies in the imaginal discs of larvae suggesting that arm⁺ activity is required in late larval and pupal stages. Flies carrying one copy of P{arm10.5} die as pupae with a wg-like phenotype.

(Peifer et al., 1991)

No protein. Embryos fail to close dorsally and much of the dorsal cuticle is missing. Segments are still recognizable but their segment polarity phenotype is very severe.

(Peifer and Wieschaus, 1990)

Strong arm allele. Mutant phenotype can be rescued to full adult viability and fertility by arm^+t10.5.

(Riggleman et al., 1989)

Clones of homozygous arm⁴ induced by mitotic recombination form denticles with reversed polarity. Changes in cell fate are autonomous at the level of single cells.

(Wieschaus and Riggleman, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

arm⁴ has cell migration defective | somatic clone phenotype, suppressible by Scer\GAL4^{FRT.Rnor\Cd2.αTub84B}/α-Cat::shg^UASp.fl

(Pacquelet and Rorth, 2005)

Enhancer of

Statement

Reference

arm⁴/arm[+] is an enhancer of planar polarity defective phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

arm⁴/arm[+] is an enhancer of visible phenotype of Scer\GAL4^en-e16E, crol^UAS.cMa

(Mitchell et al., 2008)

arm⁴ is an enhancer of cell polarity defective phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

arm⁴ is an enhancer of visible phenotype of Scer\GAL4^unspecified, nkd^UAS.cZa

(Zeng et al., 2000)

NOT Enhancer of

Statement

Reference

arm⁴/arm[+] is a non-enhancer of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Suppressor of

Statement

Reference

arm⁴/arm[+] is a suppressor | partially of cell polarity defective phenotype of CadN^UAS.cIa, Scer\GAL4^hs.2sev

(Mirkovic and Mlodzik, 2006)

arm⁴/arm[+] is a suppressor of visible phenotype of CycE^JP

(Brumby et al., 2004)

arm⁴ is a suppressor of visible phenotype of Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

NOT Suppressor of

Statement

Reference

arm⁴/arm[+] is a non-suppressor of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

arm⁴ has phenotype, enhanceable by Abl⁴

(Loureiro and Peifer, 1998)

arm⁴ has phenotype, enhanceable by Abl¹

(Loureiro and Peifer, 1998)

arm⁴ has commissure phenotype, enhanceable by Abl⁴/Abl¹

(Loureiro and Peifer, 1998)

arm⁴ has presumptive embryonic/larval central nervous system phenotype, enhanceable by Abl⁴/Abl¹

(Loureiro and Peifer, 1998)

NOT Enhanced by

Statement

Reference

Scer\GAL4^e22c, arm⁴ has abdominal ventral denticle belt | embryonic stage phenotype, non-enhanceable by pav[+]/pav^B200

(Jones et al., 2010)

arm⁴ has abdominal ventral denticle belt | embryonic stage phenotype, non-enhanceable by tum[+]/tum^AR2

(Jones et al., 2010)

arm⁴ has phenotype, non-enhanceable by nkd²

(Rousset et al., 2001)

arm⁴ has phenotype, non-enhanceable by nkd³

(Rousset et al., 2001)

arm⁴ has wing phenotype, non-enhanceable by Atg4b^P0997/Atg4b^P0997

(Thumm and Kadowaki, 2001)

Suppressed by

Statement

Reference

arm⁴ has contractile ring | somatic clone phenotype, suppressible by α-Cat::shg^GFP

(Morais-de-Sá and Sunkel, 2013)

arm⁴ has midbody | somatic clone phenotype, suppressible by α-Cat::shg^GFP

(Morais-de-Sá and Sunkel, 2013)

arm⁴ has epithelial cell | somatic clone phenotype, suppressible by Scer\GAL4^{FRT.Rnor\Cd2.αTub84B}/α-Cat::shg^UASp.fl

(Pacquelet and Rorth, 2005)

arm⁴ has cytoskeleton | somatic clone phenotype, suppressible by Scer\GAL4^{FRT.Rnor\Cd2.αTub84B}/α-Cat::shg^UASp.fl

(Pacquelet and Rorth, 2005)

arm⁴ has nurse cell | somatic clone phenotype, suppressible by Scer\GAL4^{FRT.Rnor\Cd2.αTub84B}/α-Cat::shg^UASp.fl

(Pacquelet and Rorth, 2005)

arm⁴ has oocyte | somatic clone phenotype, suppressible by Scer\GAL4^{FRT.Rnor\Cd2.αTub84B}/α-Cat::shg^UASp.fl

(Pacquelet and Rorth, 2005)

arm⁴, arm^S12.Tag:MYC has denticle | ectopic phenotype, suppressible | partially by pan::pygo^{pygoΔPHD-ΔNTCF.UAS.Tag:HA}/Scer\GAL4^arm.PS

(Thompson, 2004)

arm⁴, arm^S12.Tag:MYC has embryonic/first instar larval cuticle phenotype, suppressible | partially by pan::pygo^{pygoΔPHD-ΔNTCF.UAS.Tag:HA}/Scer\GAL4^arm.PS

(Thompson, 2004)

arm⁴ has embryonic epidermis phenotype, suppressible by p120ctn³⁰⁸/p120ctn³⁰⁸

(Myster et al., 2003)

arm⁴ has phenotype, suppressible by hid⁰⁵⁰¹⁴

(Cox et al., 2000)

arm⁴ has phenotype, suppressible by Psn¹⁰/Psn[+]

(Cox et al., 2000)

arm⁴ has phenotype, suppressible by gro^E48

(Cavallo et al., 1998)

arm⁴ has embryonic epidermis phenotype, suppressible by Df(3R)Espl22

(Cavallo et al., 1998)

arm⁴ has denticle belt phenotype, suppressible by Df(3R)Espl22

(Cavallo et al., 1998)

arm⁴ has embryonic epidermis phenotype, suppressible by pan²

(Cavallo et al., 1998)

arm⁴ has denticle belt phenotype, suppressible by pan²

(Cavallo et al., 1998)

arm⁴ has embryonic epidermis phenotype, suppressible by pan³

(Cavallo et al., 1998)

arm⁴ has denticle belt phenotype, suppressible by pan³

(Cavallo et al., 1998)

arm⁴ has phenotype, suppressible by Abl⁴

(Loureiro and Peifer, 1998)

arm⁴ has phenotype, suppressible by Abl¹/Df(3L)st-j7

(Loureiro and Peifer, 1998)

arm⁴ has phenotype, suppressible by Abl¹

(Loureiro and Peifer, 1998)

NOT suppressed by

Statement

Reference

Scer\GAL4^e22c, arm⁴ has abdominal ventral denticle belt | embryonic stage phenotype, non-suppressible by pav[+]/pav^B200

(Jones et al., 2010)

arm⁴ has abdominal ventral denticle belt | embryonic stage phenotype, non-suppressible by tum[+]/tum^AR2

(Jones et al., 2010)

arm⁴ has phenotype, non-suppressible by eRF1[+]/eRF1^F2

(Chao et al., 2003)

arm⁴ has phenotype, non-suppressible by nkd³

(Rousset et al., 2001)

arm⁴ has phenotype, non-suppressible by nkd²

(Rousset et al., 2001)

arm⁴ has wing phenotype, non-suppressible by Atg4b^P0997/Atg4b^P0997

(Thumm and Kadowaki, 2001)

arm⁴ has embryonic/larval dorsal trunk phenotype, non-suppressible by Scer\GAL4^btl.PS/Dl^UAS.cDa

(Chihara and Hayashi, 2000)

Enhancer of

Statement

Reference

arm⁴/arm[+] is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

arm⁴/arm[+] is an enhancer of wing blade posterior compartment phenotype of Scer\GAL4^en-e16E, crol^UAS.cMa

(Mitchell et al., 2008)

arm⁴ is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

arm⁴ is an enhancer of wing margin phenotype of Scer\GAL4^en-e16E, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Bauer et al., 2000)

NOT Enhancer of

Statement

Reference

arm⁴/arm[+] is a non-enhancer of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

arm⁴, Scer\GAL4^30A is a non-enhancer of wing phenotype of Pka-C1^UAS.cKa, Scer\GAL4^30A

(Kiger et al., 2001)

arm⁴/arm[+] is a non-enhancer of ommatidium phenotype of faf^FO8/faf^BX3

(Chen et al., 2000)

arm⁴/arm[+] is a non-enhancer of phenotype of ct^L188

(Jackson and Berg, 1999)

arm⁴/arm[+] is a non-enhancer of phenotype of ct^C145

(Jackson and Berg, 1999)

arm⁴ is a non-enhancer of phenotype of ct^C145

(Jackson and Berg, 1999)

Suppressor of

Statement

Reference

arm⁴/arm[+] is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, miple1^UAS.Tag:HA

(Muñoz-Soriano et al., 2013)

arm⁴/arm[+] is a suppressor of eye phenotype of Scer\GAL4^hs.2sev, miple1^UAS.Tag:HA

(Muñoz-Soriano et al., 2013)

arm⁴/arm[+] is a suppressor of wing pouch | somatic clone phenotype of crol^k05205

(Mitchell et al., 2008)

arm⁴/arm[+] is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2004)

arm⁴ is a suppressor of eye | anterior phenotype of Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

arm⁴ is a suppressor of eye phenotype of Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

arm⁴ is a suppressor of ommatidium phenotype of Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

arm⁴ is a suppressor of eye photoreceptor cell phenotype of Apc^Q8

(Ahmed et al., 1998)

NOT Suppressor of

Statement

Reference

arm⁴/arm[+] is a non-suppressor of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

arm⁴, Scer\GAL4^30A is a non-suppressor of wing phenotype of Pka-C1^UAS.cKa, Scer\GAL4^30A

(Kiger et al., 2001)

Other

Statement

Reference

CadN^UAS.cIa, Scer\GAL4^hs.2sev, arm⁴/arm[+] has ommatidium phenotype

(Mirkovic and Mlodzik, 2006)

Src42A^6-1, arm⁴ has embryo | dorsal closure stage phenotype

(Takahashi et al., 2005)

Src42A^6-1, arm⁴/arm[+] has embryo | dorsal closure stage phenotype

(Takahashi et al., 2005)

arm⁴, ena²¹⁰ has embryonic/first instar larval cuticle | dorsal phenotype

(Grevengoed et al., 2001)

Scer\GAL4^e22c, arm⁴, pan^ΔN.UAS has embryonic epidermis phenotype

(Cavallo et al., 1998)

Scer\GAL4^e22c, arm⁴, pan^ΔN.UAS has denticle belt phenotype

(Cavallo et al., 1998)

Abl⁴/Abl¹, arm⁴ has commissure phenotype

(Loureiro and Peifer, 1998)

Abl⁴/Abl¹, arm⁴ has presumptive embryonic/larval central nervous system phenotype

(Loureiro and Peifer, 1998)

Additional Comments

Genetic Interactions

Statement

Reference

α-Cat::shg^T:Avic\GFP rescues the defects in contractile ring and midbody ring positioning along the apical-basal axis which is seen in arm⁴ follicle cell clones.

(Morais-de-Sá and Sunkel, 2013)

An arm⁴ heterozygous mutant background suppresses the eye roughness seen in flies expressing miple1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

An arm⁴ heterozygous mutant background enhances the ommatidial rotation phenotype seen in flies expressing miple1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^hs.2sev.

(Muñoz-Soriano et al., 2013)

The delays in ventral furrow formation seen in homozygous Traf4³ embryos are more severe if they are derived from females heterozygous for arm⁴.

(Mathew et al., 2011)

arm⁴/+ enhances the ommatidial over-rotation phenotype which is caused by expression of nmo^Scer\UAS.cUa under the control of Scer\GAL4^hs.2sev.

(Mirkovic et al., 2011)

The elimination of naked cuticle observed in arm⁴ mutant embryos is unchanged in either a pav^B200/+ or a tum^AR2/+ mutant background.

(Jones et al., 2010)

The reduced size of the posterior compartment of the wing that is seen in animals expressing crol^Scer\UAS.cMa under the control of Scer\GAL4^en-e16E is enhanced is they are also heterozygous for arm⁴.

Analysis of 120 hour larval wing discs indicates that the growth of crol^k05205 clones is restored if they are induced in a arm⁴/+ background compared to when they are induced in an otherwise wild-type background.

(Mitchell et al., 2008)

Approximately 58.2% of arm⁴/+ ; SoxN^GA1192/+ double mutants appear phenotypically wild-type. Approximately 17.4% of mutants exhibit a 'lawn of denticles' phenotype, typical of arm mutants. The SoxN^GA1192 mutation disrupts the dorsal pattern and reduces the size of the embryos. A SoxN-like phenotype is observed in approximately 17.6% of the double mutants. Approximately 6.8% of the double mutants exhibit a severe arm phenotype.

Approximately 55.2% of arm⁴/+ ; SoxN^NC14/+ double mutants appear phenotypically wild-type. Approximately 19.9% of mutants exhibit a 'lawn of denticles' phenotype, typical of arm mutants. The SoxN^NC14 mutation disrupts the dorsal pattern and reduces the size of the embryos. A SoxN-like phenotype is observed in approximately 17.5% of the double mutants. Approximately 7.4% of the double mutants exhibit a severe arm phenotype.

(Chao et al., 2007)

The Scer\GAL4^hs.2sev>shg^{dCR3h.Scer\UAS.T:Avic\GFP-rs} eye phenotype is enhanced in a arm⁴ background, both in terms of the under-rotation of ommatidia and in defects associated with ommatidial architecture and adhesion, such as the appearance of gaps between the ommatidia.

The ommatidial rotation phenotype of Scer\GAL4^hs.2sev>shg^{dCR3h.Scer\UAS.T:Avic\GFP-rs} mutants is partially suppressed in an arm⁴/+ background but gaps appear between ommatidia due to decreased adhesion.

(Mirkovic and Mlodzik, 2006)

The "lawn of denticles" cuticle phenotype seen in embryos carrying arm^{S12.T:Hsap\MYC} in an arm⁴ background is substantially rescued by expression of pan::pygo^{pygoΔPHD-ΔNTCF.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^arm.PS; a segmented pattern of denticle bands and naked cuticle is restored.

(Thompson, 2004)

The dorsal side of arm⁴/Y ; ena²¹⁰/ena²¹⁰ embryos is completely open.

(Grevengoed et al., 2001)

The addition of nkd² or nkd³ to arm⁴ embryos has no effect on the arm phenotype.

(Rousset et al., 2001)

Expression of Dl^Scer\UAS.cDa under the control of Scer\GAL4^btl.PS does not rescue tracheal dorsal trunk formation in arm⁴ embryos.

(Chihara and Hayashi, 2000)

Many photoreceptors are rescued from death in Apc^Q8 homozygotes carrying one copy of arm⁴.

(Ahmed et al., 1998)

Suppressed by a reduction in maternal, but not paternal, contribution from Df(3R)Espl22.

(Cavallo et al., 1998)

arm⁴; Abl¹/Abl⁴ embryos show disruptions in axonogenesis, including fused or missing commissures. The defects become more severe as development proceeds, such that, by stage 16, the central nervous system is dramatically disrupted. Abl^+mTnabl significantly reduces the central nervous system defects of arm⁴; Abl¹/In(3L)std11 embryos. The segment polarity phenotype of hemizygous embryos is suppressed by two copies of Abl⁴, or by Abl¹/Df(3L)st-j7.

(Loureiro and Peifer, 1998)

N, wg¹ and arm⁴ triple mutants display, with about 10-20% penetrance, a perfect duplication of the notum charcateristic of wg mutations.

(Couso and Martinez Arias, 1994)

Xenogenetic Interactions

Statement

Reference

Heterozygosity for arm⁴ partially abolishes the protective effect of Li[+] with respect to photoreceptor loss in Hsap\HTT^GMR.Q120 flies.

(Berger et al., 2005)

Expression of shg::α-Cat^Scer\UAS.fl in arm⁴/+ mutant follicle cells using the MARCM system and Scer\GAL4^{Scer\FRT.Rnor\CD2.αTub84B} fully rescues oocyte positioning, sorting, and integrity of follicular epithelia, as well as border cell migration.

(Pacquelet and Rorth, 2005)

Complementation and Rescue Data

Rescued by

arm⁴ is rescued by arm^UASp.Y667F/Scer\GAL4^{FRT.Rnor\Cd2.αTub84B}/arm^{Y667F.Scer\UAS}

(Pacquelet and Rorth, 2005)

arm⁴ is rescued by arm^Y667F.PP

(Pacquelet and Rorth, 2005)

arm⁴ is rescued by arm^WT.PP

(Pacquelet and Rorth, 2005)

arm⁴ is rescued by Scer\GAL4^{FRT.Rnor\Cd2.αTub84B}/arm^UAS.cPa

(Pacquelet and Rorth, 2005)

arm⁴ is rescued by arm^{S10.UAS.Tag:MYC}/Scer\GAL4^btl.PS

(Chihara and Hayashi, 2000)

arm⁴ is rescued by Scer\GAL4^e22c/arm^{S2.UAS.Tag:MYC}

(Pai et al., 1997)

arm⁴ is rescued by arm^S2.Tag:MYC

(Orsulic and Peifer, 1996)

arm⁴ is rescued by arm^S4.Tag:MYC

(Orsulic and Peifer, 1996)

arm⁴ is rescued by arm^+t10.5

(Riggleman et al., 1989)

Partially rescued by

arm⁴ is partially rescued by arm^ΔN-88.UAS/Scer\GAL4^arm.PS

(Kessler and Müller, 2009)

arm⁴ is partially rescued by arm^UAS.cKa/Scer\GAL4^arm.PS

(Kessler and Müller, 2009)

arm⁴ is partially rescued by arm^S14.Tag:MYC

(Loureiro and Peifer, 1998)

arm⁴ is partially rescued by arm^S8

(Orsulic and Peifer, 1996)

Not rescued by

arm⁴/arm^S12.Tag:MYC is not rescued by Scer\GAL4^arm.PS/arm^{UAS.Tag:M(sev)}

(Thompson, 2004)

arm⁴/arm^S6.Tag:MYC is not rescued by Scer\GAL4^arm.PS/arm^{UAS.Tag:M(sev)}

(Thompson, 2004)

Comments

Expression of arm^Y667F.PP in nurse cells, or arm^{Y667F.Scer\UAS} in follicle and border cells clones, using the MARCM system, in a arm⁴ mutant clone, rescues migration defects caused by the absence of endogenous arm in border and nurse cells, along with both the sorting and follicular epithelium integrity.

Expression of arm^WT.PP in nurse cells, or arm^Scer\UAS.cPa in follicle and border cells clones, using the MARCM system, in a arm⁴ mutant clone, rescues migration defects caused by the absence of endogenous arm in border and nurse cells, along with both the sorting and follicular epithelium integrity.

Expression of shg::α-Cat^Scer\UAS.fl can suppress arm⁴ clone phenotypes such as follicle cell sorting, loss of epithelial integrity, and oocyte mis-positioning, as well as the migration defects of arm⁴ mutant border cell clones.

(Pacquelet and Rorth, 2005)

The "lawn of denticles" cuticle phenotype seen in embryos carrying arm^{S6.T:Hsap\MYC} in an arm⁴ background is not rescued by ubiquitous expression of arm^{Scer\UAS.T:sev-TM} using Scer\GAL4^arm.PS. The "lawn of denticles" cuticle phenotype seen in embryos carrying arm^{S12.T:Hsap\MYC} in an arm⁴ background is not rescued by ubiquitous expression of arm^{Scer\UAS.T:sev-TM} using Scer\GAL4^arm.PS. Ubiquitous expression of arm^{S10.Scer\UAS.T:Hsap\MYC} using Scer\GAL4^arm.PS produces ectopic naked cuticle in embryos carrying arm^{S6.T:Hsap\MYC} in an arm⁴ background. Ubiquitous expression of arm^{S10.Scer\UAS.T:Hsap\MYC} using Scer\GAL4^arm.PS produces ectopic naked cuticle in embryos carrying arm^{S12.T:Hsap\MYC} in an arm⁴ background.

(Thompson, 2004)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^btl.PS rescues the formation of the tracheal dorsal trunk in arm⁴ embryos.

(Chihara and Hayashi, 2000)

The phenotype seen in RP2 neurons in embryos that are zygotically arm⁴ but have wild-type maternal arm is rescued by arm^{S14.T:Hsap\MYC}.

(Loureiro and Peifer, 1998)

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

68161

y¹ arm⁴ P{neoFRT}19A/FM0

616

y¹ arm⁴ w^*/FM7c, P{ftz-lacC}YH1

Kyoto

106010

y¹ arm⁴ w^*/FM7c, P{ftz-lacC}YH1

Notes on Origin

Discoverer

Comments

Strong mutant allele.

Used as cuticular marker to aid in identifying rescue of the N epidermal defect in embryos.

(Struhl and Adachi, 1998)

Even when the oocyte is mispositioned it enlarges relative to the nurse cells, and follicle cells retract from nurse cells and become columnar atop the oocyte. There is a phenotypic series in the clonal germline phenotype that parallels the affect in embryos.

(Peifer et al., 1993)

Association of arm protein with α-Cat and shg in vivo is assayed by SDS-PAGE and immunoblotting.

(Pai et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

arm4m

(Uddin et al., 2011)

arm^35YD

(Kumar et al., 2001)

arm⁴

(Morais-de-Sá and Sunkel, 2013, Muñoz-Soriano et al., 2013, Mathew et al., 2011, Mirkovic et al., 2011, Djiane and Mlodzik, 2010, Jones et al., 2010, Chao et al., 2007, Berger et al., 2005, Pacquelet and Rorth, 2005)

arm^YD35

(Jones et al., 2010, Kessler and Müller, 2009, Mitchell et al., 2008, Chao et al., 2007, Wang and Riechmann, 2007, Mirkovic and Mlodzik, 2006, Fox et al., 2005, Langevin et al., 2005, Takahashi et al., 2005, Bauer et al., 2004, Brumby et al., 2004, Chao et al., 2003, Kubota et al., 2003, Lee et al., 2003, Myster et al., 2003, Geisbrecht and Montell, 2002, Grevengoed et al., 2001, Rousset et al., 2001, Thumm and Kadowaki, 2001, Zervas et al., 2001, Beitel and Krasnow, 2000, Chihara and Hayashi, 2000, Cox et al., 2000, Tanentzapf et al., 2000, Zeng et al., 2000, Magie et al., 1999, Oda and Tsukita, 1999, Ahmed et al., 1998, Cavallo et al., 1998, Loureiro and Peifer, 1998, Struhl and Adachi, 1998, Oda et al., 1997, Pai et al., 1997, Cox et al., 1996, Miller and Moon, 1996, Orsulic and Peifer, 1996, Pai et al., 1996, Uemura et al., 1996, Peifer, 1995, Couso and Martinez Arias, 1994, Hooper, 1994, Peifer et al., 1994, Peifer et al., 1993, Peifer et al., 1993, Hoppe and Greenspan, 1990, Riggleman et al., 1989)

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