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General Information
Symbol
Dmel\ash14
Species
D. melanogaster
Name
FlyBase ID
FBal0000734
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ash1RE418
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

A19595552T

Reported nucleotide change:

A3369T

Amino acid change:

K875term | ash1-PB; K875term | ash1-PC

Reported amino acid change:

K875term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: K875term.

Nucleotide substitution: A3369T.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Double heterozygotes with Ubxabx-1, trxel2 or brm2 exhibit transformation of third leg to second leg identity and haltere to wing transformation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhancer of
Statement
Reference

ash14 is a non-enhancer of wing vein | ectopic phenotype of Snr1R3/Snr1E1

ash14 is a non-enhancer of wing phenotype of Snr1R3/Snr1E1

NOT Suppressor of
Statement
Reference

ash14 is a non-suppressor of wing vein | ectopic phenotype of Snr1R3/Snr1E1

ash14 is a non-suppressor of wing phenotype of Snr1R3/Snr1E1

Other
Additional Comments
Genetic Interactions
Statement
Reference

ash14 sktlk07505 double heterozygotes show a homeotic transformation of third leg to second leg (7.1% penetrance).

Double heterozygotes with Df(2L)Mdh, Df(2R)or-BR6, Df(3L)Ar14-8, Df(2L)cl-h3, Df(2R)Pu-D17, Df(2R)en-A, Df(2R)vg-C, Df(2R)CX1, Df(2R)trix or Df(3R)by62 show T3 to T2 transformations. Double heterozygotes with Df(2R)eve, Df(2R)en30, Df(2R)Jp1 or Df(3R)M-Kx1 do not show T3 to T2 transformations. Double heterozygotes with Df(2R)en-A show a frequency of T3 to T2 transformations that is indistinguishable from ash14/+ single heterozygotes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Range of lethality for transheterozygotes extends from the third larval instar for the most severe alleles to the pharate adult stage for the least severe alleles.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)