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General Information
Symbol
Dmel\ash117
Species
D. melanogaster
Name
FlyBase ID
FBal0000749
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ash1VF101
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion of 451 bases between nucleotide 2483 and 2934.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Double heterozygotes with Ubxabx-1, trxel2 or brm2 exhibit transformation of third leg to second leg identity and haltere to wing transformation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by AsxXF23/Asx[+]

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by E(Pc)[+]/E(Pc)1

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by E(z)[+]/E(z)5

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Psc[+]/Psc1

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Sce[+]/SceD1

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by ScmD1/Scm[+]

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by ScmM56/Scm[+]

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Su(z)21/Su(z)2[+]

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Su(z)4[+]/Su(z)41

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Su(z)6[+]/Su(z)61

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Su(z)7[+]/Su(z)71

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Trl[+]/TrlR85

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by mxc[+]/mxcG48

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by sxc[+]/sxc1

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Kdm5k06801/lid[+]

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Asx3/Asx[+]

ash1[+]/ash117, trxB11 has visible | dominant | homeotic phenotype, enhanceable by lawcp1/lawc[+]

ash117, trxB11 has visible | homeotic phenotype, enhanceable by lawcEF520

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by lawcp1/lawc[+]

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by lawc[+]/lawcEF520

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, enhanceable by Df(1)RA2/+

ash1[+]/ash117, trxB11 has visible | dominant | homeotic phenotype, enhanceable by lawc[+]/lawcEF520

ash1[+]/ash117, trxB11 has visible | dominant | homeotic phenotype, enhanceable by Df(1)RA2/+

ash117, mod(mdg4)T16/mod(mdg4)[+] has visible | dominant | homeotic phenotype, enhanceable by trxB11/trx[+]

ash1[+]/ash117, trxB11 has visible | dominant | homeotic phenotype, enhanceable by mod(mdg4)[+]/mod(mdg4)ul

ash1[+]/ash117, trxB11 has visible | dominant | homeotic phenotype, enhanceable by mod(mdg4)[+]/mod(mdg4)T6

ash1[+]/ash117, trxB11 has visible | dominant | homeotic phenotype, enhanceable by mod(mdg4)T16/mod(mdg4)[+]

NOT Enhanced by
Statement
Reference

ash117 has visible | dominant | homeotic phenotype, non-enhanceable by Df(1)RA2

ash117 has visible | dominant | homeotic phenotype, non-enhanceable by lawcp1

ash117 has visible | dominant | homeotic phenotype, non-enhanceable by lawcEF520

ash117 has visible | dominant | homeotic phenotype, non-enhanceable by lawc+10

Suppressed by
Statement
Reference

ash117, trxB11/trx[+] has visible | dominant phenotype, suppressible | partially by His2Av05146

ash117, trxB11/trx[+] has visible | dominant phenotype, suppressible | partially by His2Av810

ash1[+]/ash117, trxB11 has visible | dominant | homeotic phenotype, suppressible by dom14/dom[+]

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, suppressible by dom14/dom[+]

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, suppressible by Pc3/Pc[+]

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, suppressible by Pcl7/Pcl[+]

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, suppressible by Psc[+]/PscArp1

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, suppressible by ScmSuz302/Scm[+]

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, suppressible by esc10/esc[+]

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, suppressible by esc21/esc[+]

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, suppressible by esc5/esc[+]

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, suppressible by esc9/esc[+]

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, suppressible by mxc[+]/mxc1

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, suppressible by mxc[+]/mxcM1

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, suppressible by ph-d[+]/ph-d503

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, suppressible by phob/pho[+]

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, suppressible by sxc[+]/sxc4

ash117, trxB11/trx[+] has visible | dominant | homeotic phenotype, suppressible by sxc[+]/sxc5

Enhancer of
Statement
Reference

trxB11, trx[+], ash1[+], ash117 is an enhancer of visible | homeotic phenotype of lawcp1

ash1[+]/ash117 is an enhancer of visible | dominant | homeotic phenotype of mod(mdg4)T6, trxB11

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, enhanceable by Asx3/Asx[+]

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, enhanceable by AsxXF23/Asx[+]

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, enhanceable by E(Pc)[+]/E(Pc)1

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, enhanceable by E(z)[+]/E(z)5

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, enhanceable by Psc[+]/Psc1

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, enhanceable by Sce[+]/SceD1

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, enhanceable by ScmD1/Scm[+]

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, enhanceable by ScmM56/Scm[+]

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, enhanceable by Su(z)21/Su(z)2[+]

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, enhanceable by Su(z)4[+]/Su(z)41

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, enhanceable by Su(z)6[+]/Su(z)61

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, enhanceable by Su(z)7[+]/Su(z)71

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, enhanceable by Trl[+]/TrlR85

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, enhanceable by mxc[+]/mxcG48

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, enhanceable by sxc[+]/sxc1

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, enhanceable by Kdm5k06801/lid[+]

ash117, trxB11/trx[+] has haltere phenotype, enhanceable by lawcp1/lawc[+]

ash1[+]/ash117, trxB11 has haltere phenotype, enhanceable by lawcp1/lawc[+]

ash117, trxB11/trx[+] has metathoracic leg phenotype, enhanceable by lawcp1/lawc[+]

ash117, trxB11/trx[+] has haltere phenotype, enhanceable by lawc[+]/lawcEF520

ash1[+]/ash117, trxB11 has metathoracic leg phenotype, enhanceable by lawcp1/lawc[+]

NOT Enhanced by
Statement
Reference

ash117 has phenotype, non-enhanceable by Df(1)RA2

Suppressed by
Statement
Reference

ash117, trxB11/trx[+] has metathoracic leg phenotype, suppressible | partially by His2Av810

ash117, trxB11/trx[+] has abdominal segment 6 phenotype, suppressible by dom14/dom[+]

ash1[+]/ash117, trxB11 has abdominal segment 6 phenotype, suppressible by dom14/dom[+]

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, suppressible by Pc3/Pc[+]

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, suppressible by Pcl7/Pcl[+]

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, suppressible by Psc[+]/PscArp1

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, suppressible by ScmSuz302/Scm[+]

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, suppressible by esc10/esc[+]

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, suppressible by esc21/esc[+]

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, suppressible by esc5/esc[+]

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, suppressible by esc9/esc[+]

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, suppressible by mxc[+]/mxc1

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, suppressible by mxc[+]/mxcM1

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, suppressible by ph-d[+]/ph-d503

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, suppressible by phob/pho[+]

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, suppressible by sxc[+]/sxc4

ash117, trxB11/trx[+] has adult metathoracic segment phenotype, suppressible by sxc[+]/sxc5

Enhancer of
Statement
Reference

ash1[+]/ash117 is an enhancer of wing vein | ectopic phenotype of Snr1E1

trxB11, trx[+], ash1[+], ash117 is an enhancer of arista phenotype of lawcp1

trxB11, trx[+], ash1[+], ash117 is an enhancer of phenotype of mod(mdg4)ul

ash1[+]/ash117 is an enhancer of haltere phenotype of mod(mdg4)T6, trxB11

Suppressor of
Statement
Reference

ash1[+]/ash117 is a suppressor of wing vein | ectopic phenotype of Snr1E1

Other
Additional Comments
Genetic Interactions
Statement
Reference

ash117 trxB11 double heterozygotes show transformations of third leg into second leg; an apical bristle appears on the third leg in 66% of cases. The frequency of the appearance of an apical bristle on the third leg decreases to 37% in ash117 trxB11 His2Av05146 triple heterozygotes and to 29% in ash117 trxB11 His2Av810 triple heterozygotes.

At 29oC, ash117 suppresses the ectopic vein that extends distally from the posterior crossvein in Snr1E1 animals. but enhances the extra vein material seen posterior of the L5 wing vein.

The abdominal segment A6 to A5 transformation of ash117/+, trxB11/+ is dominantly suppressed by dom14.

52.1% of trxB11 ash117 double heterozygotes show T3 to T2 transformations. The penetrance of this phenotype is enhanced by one copy of lidk06801, E(Pc)1, Su(z)21, Psc1, AsxXF23, Asx3, mxcG48, sxc1, SceD1, E(z)5, TrlR85, Su(z)41, Su(z)71, Su(z)61, ScmD1 or ScmM56 and suppressed by one copy of Pc3, ph-d503, Pcl7, phob, mxcM1, mxc1, esc5, esc9, esc10, esc21, sxc4, sxc5, PscArp1 or ScmSuz302.

The frequency of homeotic transformations in heterozygotes is not enhanced by lawcp1, lawcEF520, lawc+10 or Df(1)RA2. The frequency and severity of homeotic transformations (such as haltere to wing or third leg to second leg transformations) in trxB11 ash117 double heterozygotes is dominantly enhanced by lawcp1. The enhancement is stronger in a lawcp1 maternal background. The arista to leg transformation characteristic of lawcp1 is also enhanced in these flies. The frequency of homeotic transformations in trxB11 ash117 double heterozygotes is dominantly enhanced by lawcEF520 or Df(1)RA2. lawcp1/lawcEF520 females are viable. However, in combination with ash117, lawcp1/lawcEF520 results in lethality. lawcp1/Df(1)RA2 females are viable. However, in combination with ash117, lawcp1/Df(1)RA2 results in lethality.

14.1% of trxB11 ash117 double heterozygous adults show a homeotic phenotype. This is increased to 77.7% if the flies are also heterozygous for mod(mdg4)T16, 50.4% if the flies are also heterozygous for mod(mdg4)ul and 32.6% if the flies are also heterozygous for mod(mdg4)T6. The combination ash117 trxB11 dominantly enhances the effect of mod(mdg4)ul on the y2 phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Range of lethality for transheterozygotes extends from the third larval instar for the most severe alleles to the pharate adult stage for the least severe alleles.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (11)