FlyBase Allele Report: Dmel\Asx[1]

General Information

Symbol

Dmel\Asx¹

Species

D. melanogaster

Name

FlyBase ID

FBal0000784

Feature type

allele

Associated gene

Dmel\Asx

Associated Insertion(s)

Carried in Construct

Also Known As

Asx^IIF51

Key Links

Allele class

gain of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

gain of function allele

(Milne et al., 1999, Cheng et al., 1994)

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w^+mW.hs allele at the telomeres of the second and third chromosomes.

(Cryderman et al., 1999)

Dominantly enhances position effect variegation (PEV) at the w locus caused by In(1)w^m4, PEV at the B locus caused by Dp(1;Y)B^SCV and PEV at the Sb locus caused by T(2;3)Sb^V.

(Sinclair et al., 1998)

Asx¹/+ ; Df(3L)fz-GS1a embryos completely lack the head, thorax and ventral denticle belts.

(Landecker et al., 1994)

Embryonic lethal or semi-lethal when heterozygous with ph-d². Unhatched larvae carry segmentation defects or polarity defects.

(McKeon et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Asx[+]/Asx¹ is an enhancer of visible phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Ji et al., 2012)

Asx[+]/Asx¹ is an enhancer of abnormal eye color phenotype of Hsap\MECP2^R294X.UAS, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

NOT Enhancer of

Statement

Reference

Asx[+]/Asx¹ is a non-enhancer of visible phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Suppressor of

Statement

Reference

Asx[+]/Asx¹ is a suppressor of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Asx[+]/Asx¹ is a suppressor of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Asx[+]/Asx¹ is a suppressor of visible phenotype of E2f1^{dsRNA.UAS.cJa}, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Asx[+]/Asx¹ is a suppressor | partially of visible phenotype of E2f1^{dsRNA.UAS.cJa}, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

NOT Suppressor of

Statement

Reference

Asx[+]/Asx¹ is a non-suppressor of visible phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Phenotype Manifest In

Enhancer of

Statement

Reference

Asx[+]/Asx¹ is an enhancer of wing phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Ji et al., 2012)

Asx[+]/Asx¹ is an enhancer of eye phenotype of Hsap\MECP2^UAS.FL, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

Asx[+]/Asx¹ is an enhancer of eye phenotype of Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

Asx¹ is an enhancer of sex comb phenotype of Pc⁴

(Milne et al., 1999)

NOT Enhancer of

Statement

Reference

Asx[+]/Asx¹ is a non-enhancer of eye phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Asx¹ is a non-enhancer of eye phenotype of CycE^JP

(Brumby et al., 2002)

Suppressor of

Statement

Reference

Asx[+]/Asx¹ is a suppressor of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Asx[+]/Asx¹ is a suppressor of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Asx[+]/Asx¹ is a suppressor of eye phenotype of E2f1^{dsRNA.UAS.cJa}, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Asx[+]/Asx¹ is a suppressor | partially of 1st posterior cell phenotype of E2f1^{dsRNA.UAS.cJa}, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

Asx[+]/Asx¹ is a suppressor of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

NOT Suppressor of

Statement

Reference

Asx[+]/Asx¹ is a non-suppressor of eye phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Asx¹ is a non-suppressor of eye phenotype of CycE^JP

(Brumby et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU is ameliorated by combination with a single copy of Asx¹.

(Morimoto et al., 2016)

Asx¹/Snr1^E1 wings have an extra vein between veins L3 and L4 in 11% of cases.

(Marenda et al., 2004)

Enhances the trx-G homeotic transformations of Df(3R)red1. Strongly enhances the extra sex comb phenotype of Pc⁴.

(Milne et al., 1999)

The addition of heterozygous Asx¹ can suppress the Pairing sensitive silencing effect seen in w^Mcp.scs'.11. The addition of heterozygous Asx¹ has no effect on the Pairing sensitive silencing effect seen in w^Mcp.10, w^Mcp.11, w^Mcp.13, w^Mcp.scs'.14 and w^{Mcp.scs'.12:15}. The addition of heterozygous Asx¹ has no effect on the Pairing sensitive silencing effect seen in w^Mcp.scs'.11 (P{Mcp-w#11}16/+, P{Mcp-w#11}102/+) double heterozygous insertions. The addition of heterozygous Asx¹ has no effect on the Pairing sensitive silencing effect seen in w^Mcp.scs'.14/ w^Mcp.13 (P{Mcp-w#14}AP-2^stummelbein/+, P{Mcp-w#13}116/+) double heterozygous insertions.

(Muller et al., 1999)

Xenogenetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 is ameliorated by combination with a single copy of Asx¹.

(Morimoto et al., 2016)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

4198

cn¹ Asx¹ bw¹ speck¹/CyO

Kyoto

107625

cn¹ Asx¹ bw¹ speck¹/CyO

Notes on Origin

Discoverer

Comments

Isolated as an embryonic lethal mutation causing head defects.

(Jurgens, 1985)

Weak derepression of en expression.

(Moazed and O'Farrell, 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Asx¹

(Ji et al., 2012, Christensen et al., 2008.12.28, Christensen and Cook, 2007.10.29, Halachmi et al., 2007)

Asx^IIF51

(Muller et al., 1999, Moazed and O'Farrell, 1992, McKeon and Brock, 1991, Jurgens, 1985)

Asx^IIF

(Tearle and Nusslein-Volhard, 1987)

Name Synonyms

Secondary FlyBase IDs

References (22)

Report Sections

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