FlyBase Allele Report: Dmel\Asx[3]

General Information

Symbol

Dmel\Asx³

Species

D. melanogaster

Name

FlyBase ID

FBal0000786

Feature type

allele

Associated gene

Dmel\Asx

Associated Insertion(s)

Carried in Construct

Also Known As

Asx^XT129

Key Links

Allele class

gain of function allele

Mutagen

X ray

Nature of the Allele

Allele class

gain of function allele

(Milne et al., 1999, Sinclair et al., 1998)

Mutagen

X ray

(Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

1.3kb deletion. Resulting protein includes approximately the first 80-0 amino acids of the native protein.

(Milne et al., 1999)

1.3kb deletion.

(Sinclair et al., 1998)

1.2kb deletion in the middle of the coding region.

(Soto et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdominal tergite 4 | male

(Mollaaghababa et al., 2001)

adult abdominal segment 4

(Mollaaghababa et al., 2001)

adult abdominal segment 5 | ectopic

(Mollaaghababa et al., 2001)

anaphase | embryonic stage

(O'Dor et al., 2006)

sex comb | ectopic

(Mollaaghababa et al., 2001)

telophase | embryonic stage

(O'Dor et al., 2006)

Detailed Description

Statement

Reference

Asx³ embryos from heterozygous mothers show segregation defects in anaphase and telophase as judged by the presence of chromatin bridges. Most of these chromatin bridges are probably resolved because large irregularly-shaped nuclei and polyploid nuclei are only seen at a low penetrance. Asx³ embryos also show a higher level of "nuclear fallout", a process that removes nuclei with abnormal mitoses, than wild-type embryos. Fallout nuclei tend to be observed in pairs or clusters and have a late telophase appearance. There is no evidence of metaphase defects in these embryos although a small number show chromatin bridges that persist to the prometaphase stage.

(O'Dor et al., 2006)

Somatic mitotic clones of Asx³ do not induce ovarian defects.

(Narbonne et al., 2004)

10% of heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 0% of heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). There is an average of 0.1 extra sex combs (average total number of extra sex comb teeth on the four posterior legs of a male).

(Mollaaghababa et al., 2001)

Embryonic lethal or semi-lethal when heterozygous with ph-d². Unhatched larvae carry segmentation defects or polarity defects.

(McKeon et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Asx³/Asx[+] is an enhancer of visible | dominant | homeotic phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

Asx³/Asx[+] is an enhancer of visible | dominant | homeotic phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

Suppressor of

Statement

Reference

Asx³/Asx[+] is a suppressor of visible phenotype of tant¹

(Dietrich et al., 2001)

Asx³/Asx[+] is a suppressor of visible phenotype of tant²

(Dietrich et al., 2001)

Other

Statement

Reference

Asx³, P{hsp26-pt-T}39C-5, ph-p⁴¹⁰ has suppressor of variegation phenotype

(Boivin et al., 2003)

Asx³, Hsc70-4^54.1 has visible | dominant | homeotic phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4[+]/Hsc70-4^54.1 has visible | dominant | homeotic phenotype

(Mollaaghababa et al., 2001)

Asx³, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx³, ash1²² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx³, brm² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx³/Asx[+], ash1²² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx³/Asx[+], brm² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx³/Asx[+], trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

Asx³ has sex comb | ectopic phenotype, enhanceable by Hsc70-4[+]/Hsc70-4^54.1

(Mollaaghababa et al., 2001)

Enhancer of

Statement

Reference

Asx³/Asx[+] is an enhancer of adult metathoracic segment phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

Asx³/Asx[+] is an enhancer of adult metathoracic segment phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

Asx³ is an enhancer of abdominal segment phenotype of Pc⁴

(Milne et al., 1999)

Asx³ is an enhancer of sex comb phenotype of Pc⁴

(Milne et al., 1999)

NOT Enhancer of

Statement

Reference

Asx³ is a non-enhancer of phenotype of trx^B11

(Milne et al., 1999)

Suppressor of

Statement

Reference

Asx³/Asx[+] is a suppressor of interocellar bristle phenotype of tant¹

(Dietrich et al., 2001)

Asx³/Asx[+] is a suppressor of interocellar bristle phenotype of tant²

(Dietrich et al., 2001)

NOT Suppressor of

Statement

Reference

Asx³ is a non-suppressor of phenotype of trx^B11

(Milne et al., 1999)

Other

Statement

Reference

Asx³, Hsc70-4^54.1 has adult abdominal segment 4 phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4^54.1 has adult abdominal segment 6 phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4^54.1 has adult abdominal segment 5 | ectopic phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4^54.1 has abdominal tergite 6 | male phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4^54.1 has abdominal tergite 4 | male phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4^54.1 has adult abdominal segment 7 | ectopic phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4[+]/Hsc70-4^54.1 has adult abdominal segment 4 phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4[+]/Hsc70-4^54.1 has adult abdominal segment 6 phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4[+]/Hsc70-4^54.1 has adult abdominal segment 5 | ectopic phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4[+]/Hsc70-4^54.1 has abdominal tergite 6 | male phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4[+]/Hsc70-4^54.1 has abdominal tergite 4 | male phenotype

(Mollaaghababa et al., 2001)

Asx³, Hsc70-4[+]/Hsc70-4^54.1 has adult abdominal segment 7 | ectopic phenotype

(Mollaaghababa et al., 2001)

Asx³, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx³, ash1²² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx³, brm² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx³/Asx[+], ash1²² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx³/Asx[+], brm² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx³/Asx[+], trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

26% of Hsc70-4^54.1 Asx³ double heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 7% of Hsc70-4^54.1 Asx³ double heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). There is an average of 0.8 extra sex combs (average total number of extra sex comb teeth on the four posterior legs of a male) in Hsc70-4^54.1 Asx³ double heterozygotes.

(Mollaaghababa et al., 2001)

Does not significantly enhance the trx-G homeotic transformations of Df(3R)red1 or trx^B11, nor suppress anterior transformations due to Df(3R)red1 or trx^B11. Strongly enhances both the extra sex comb and abdominal segment transformation phenotypes of Pc⁴.

(Milne et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Weak derepression of en expression.

(Moazed and O'Farrell, 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Asx³

(Li et al., 2017, de Ayala Alonso et al., 2007, O'Dor et al., 2006)

Asx^XT129

(Narbonne et al., 2004, Boivin et al., 2003, Beuchle et al., 2001, Mollaaghababa et al., 2001, Mallin et al., 1998, Soto et al., 1995, Moazed and O'Farrell, 1992, Tearle and Nusslein-Volhard, 1987)

Asx^xt129

(Mollaaghababa et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (17)

Report Sections

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