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General Information
Symbol
Dmel\aurA87Ac-3
Species
D. melanogaster
Name
FlyBase ID
FBal0000804
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
aur87Ac-3
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

aurA949/aurA87Ac-3 transheterozygous third instar larval brain neuroblasts show some chromosomal aberrations and aneuploidy/polyploidy, which are almost absent in controls.

aur3/aur87Ac-3 embryos have a reduced number of pole cells compared to controls and the pole cells that do form often have greatly reduced germ plasm.

aur37/aur87Ac-3 larval brain neuroblasts show overproliferation.

aur87Ac-5/aur87Ac-3 larval brain neuroblasts show very few normal metaphase and anaphase figures, and many circular mitotic figures.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Suppressor of
Statement
Reference
Other
Phenotype Manifest In
Suppressed by
Enhancer of
Suppressor of
Statement
Reference

aurA87Ac-3/aur[+] is a suppressor of centrosome | somatic clone phenotype of jubE1

aurA87Ac-3/aur[+] is a suppressor of spindle | somatic clone phenotype of jubE1

aurA87Ac-3/aur[+] is a suppressor of neuroblast | somatic clone phenotype of jubE1

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The proportion of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage is significantly increased in wtsx1/+;aurA87Ac-3/+ double heterozygous embryos compared to either of the single heterozygotes or wild type.

The percentage of abnormal spindles in jubE1 mutants is suppressed by removing one copy of aur because in jubE1, aur87Ac-3 double mutant cells the total number of spindle defects is decreased from 45% to 34%.

The overproliferation of larval brain neuroblasts seen in aur37/aur87Ac-3 animals is suppressed by expression of bazScer\UAS.P\T.T:Avic\GFP under the control of Scer\GAL41407.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially complements
Fails to complement
Comments

aur37/aur87Ac-3 is a lethal combination.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (8)
References (16)