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General Information
Symbol
Dmel\Dll3
Species
D. melanogaster
Name
FlyBase ID
FBal0001001
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

antennal segment 2 & macrochaeta

femur & macrochaeta

tibia & macrochaeta

Detailed Description
Statement
Reference

Dll17/Dll3 mutant larvae show a significantly impaired behavioural response to an attractive odorant (EtOAc). Some larvae show dorsal organ malformations but there appears to be no correlation between the larvae with cuticular defects and those with olfactory impairment. Motor activity appears normal, and allowing more time for the larva to respond (10 minutes rather than 5 minutes) does not change the response indices.

Dll3/Dll7 mutant stage 12 embryos show disruption to the mushroom body peduncles. The Kenyon cell clusters are reduced in size by at least 50%, the calyces are markedly smaller, the dorsal and medial lobes are thinned and the relative position of the peduncle and the dorsal lobe are abnormal.

Dll1/Dll3 mutant larvae have malformed dorsal organs. Larvae exhibit a normal behavioural response to an attractive odorant.

Dll3/Dll7 animals display antenna to leg transformations and deletion of tarsal segments 3-5 and the claw.

About 3% of Dllmd23/Dll3 animals emerge as adults, with all escapers displaying partial transformation of the antenna to leg structures and deletion of distal leg structures.

The distal antennal segment 3 (a3) and the arista of Dll3/Dll7 transheterozygotes are transformed towards leg. The circular outline of the joint between antennal segments 2 and 3 is also missing. Dllmd23/Dll3 animals results in the loss of the arista and transformation of antennal segment 3 towards leg. Antennal segment 2 is present and has a normal cuticle.

Dll3/Dll7 animals show partial transformation of the antenna into leg. The distal part of antennal segment 3 and the proximal part of the arista are transformed towards tibia. Tarsal segment deletions and fusions in the legs are seen. Dll1/Dll3 animals die as pharate adults. They show both a transformation of the antenna towards leg and distal truncations. What remains of antennal segment 3 resembles leg tissue and the arista is deleted. A complete loss of the tarsal segments and shortening of both the femur and tibia is seen in the legs. Dll3/Dll17 animals die as pharate adults. They show truncations of the antenna, such as deletion of antennal segment 3 and the arista. A complete loss of the tarsal segments and shortening of both the femur and tibia is seen in the legs.

In Dll3/Df(2R)Dll-MP adults, the hindgut is enlarged at the expense of the anal plates in both males and females. In females, the vaginal plates are disorganised. A few anal bristles surrounded by hindgut tissue may be observed. The internal and external genitalia appear normal in both males and females.

Homozygotes lack all of the tarsus and the tibia and femur are reduced in size.

Homozygous adults have legs that are truncated at the tibia. The tibia, femur and trochanter are shorter than wild-type and are deformed.

Severe leg reductions: deletion of all distal tarsal segments, tibia and femur very reduced.

Greatly reduced femur and tibia, associated with normal trochanter and coxa.

Heterozygotes are wild-type. Homozygotes die as pharate adults in which the most distal part of the arista is sometimes present, but there is no evidence of a third antennal segment. The second segment has a large number of ectopic bristles, some of which are bracted. The thoracic legs are distorted and lack all elements distal to the tibia. Duplications are sometimes seen in the femur which have a large number of ectopic bristles that are not bracted. Hemizygous but not homozygous embryos sometimes lack Keilin's organs and the labial sense organ.

Dll3/+ wild type; Dll3/Dll1 fail to eclose; pharate adults lack third antennal segment; second segment transformed to leg; distal arista normal. Legs lack all structures distal to tibiae; tibiae enlarge and bear ectopic bristles; no remaining leg bristles are bracted. recessive pharate-adult lethal

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
Phenotype Manifest In
Suppressed by
Additional Comments
Genetic Interactions
Statement
Reference

Scer\GAL4Dll-md23-mediated expression of discoScer\UAS.cDa partially rescues the lethality associated with Dllmd23/Dll3, and nearly completely rescues the antenna and leg phenotypes of this mutant.

Scer\GAL4Dll-md23-mediated expression of discodsRNA.Scer\UAS reduces the number of Dllmd23/Dll3 escapers to nearly zero.

No effect on the eye pigment phenotype of wT81.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Sunkel.

Comments
Comments

Strong Dll allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (21)