FB2025_01 , released February 20, 2025
Allele: Dmel\Dll7
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General Information
Symbol
Dmel\Dll7
Species
D. melanogaster
Name
FlyBase ID
FBal0001004
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous Dll7 mutant embryos have fewer neurons and fewer support cells in the dorsal organ (DO) and terminal organ than wild type animals. No cell death is seen (TUNEL staining) and the remaining neurons exhibit aberrant morphologies. The DO dendrites are loosely associated rather than tightly bundled.

Dll3/Dll7 mutant stage 12 embryos show disruption to the mushroom body peduncles. The Kenyon cell clusters are reduced in size by at least 50%, the calyces are markedly smaller, the dorsal and medial lobes are thinned and the relative position of the peduncle and the dorsal lobe are abnormal.

Dll3/Dll7 animals display antenna to leg transformations and deletion of tarsal segments 3-5 and the claw.

The distal antennal segment 3 (a3) and the arista of Dll3/Dll7 transheterozygotes are transformed towards leg. The circular outline of the joint between antennal segments 2 and 3 is also missing.

Dll3/Dll7 animals show partial transformation of the antenna into leg. The distal part of antennal segment 3 and the proximal part of the arista are transformed towards tibia. Tarsal segment deletions and fusions in the legs are seen.

Reduced distal tarsal elements, the metatarsus is fused to the tibia, and there is a decrease in pattern elements on both segments.

Moderate reduction of tarsal structures and fusion between tarsal and tibial elements.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
  • FBal0029047
References (7)