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General Information
Symbol
Dmel\Dll9
Species
D. melanogaster
Name
FlyBase ID
FBal0001006
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
BaM, DllM
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

About 3% of Dllmd23/Dll9 animals emerge as adults, with all escapers displaying partial transformation of the antenna to leg structures and deletion of distal leg structures.

Homozygote has a very mild leg phenotype: males have a decrease in number of sex comb teeth. Entire arista and distal most portion of AIII are transformed into a distally complete tarsus.

Minor reductions in the tarsal region.

Heterozygotes are wild-type. Homozygotes show a transformation of antenna to leg. Hemizygous embryos but not homozygous embryos lack the Keilin's organs, and sometimes lack the labial sense organ, antennal sense organ and maxillary sense organ.

Homozygotes show partial transformation of antennae to legs as well as deletions of some leg structures. Tarsal tissue, sometimes including claws, develops in place of arista and part of third antennal segment. Third segment usually contains patchwork of incompletely differentiated leg tissue; first and second segments normal. Leg effects distal to mid-tibia; legs proximal to mid-tibia normal. In extreme cases number of tarsal segments reduced to two or three; basitarsus and distal tibia may be missing; in most extreme cases claws may also be missing. In the case of mild expression abnormal bristle patterns, including polarity reversal, occur around basitarsus-tibia joint, where there may also develop cuticular hyperplasia. Penetrance greater in females than males, in antennae than legs and in metathoracic than other legs.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
Enhancer of
Statement
Reference

Dll9/Dll[+] is an enhancer of visible phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS

Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressed by
Enhancer of
Statement
Reference

Dll9/Dll[+] is an enhancer of eye phenotype of DrefUAS.cSa, Scer\GAL4GMR.PS

NOT Enhancer of
Statement
Reference

Dll9/Dll[+] is a non-enhancer of wing vein | ectopic phenotype of Snr1E1

NOT Suppressor of
Statement
Reference

Dll9/Dll[+] is a non-suppressor of wing vein | ectopic phenotype of Snr1E1

Additional Comments
Genetic Interactions
Statement
Reference

Scer\GAL4Dll-md23-mediated expression of discoScer\UAS.cDa partially rescues the lethality associated with Dllmd23/Dll9, and nearly completely rescues the antenna and leg phenotypes of this mutant.

Scer\GAL4Dll-md23-mediated expression of discodsRNA.Scer\UAS reduces the number of Dllmd23/Dll9 escapers to nearly zero.

Dll9 flies expressing Nf-YAScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ey.PH show 86% viability.

Genetic crossing of the DrefScer\UAS.cSa expressing strain with Dll9 results in a weakly enhanced rough eye phenotype.

The rough eye phenotype caused by expression of BEAF-32Scer\UAS.cYa under the control of Scer\GAL4GMR.PS is weakly enhanced by Dll9.

Has little or no effect on the phenotype of E2fGMR.PD DpGMR.PD BacA\p35GMR.PH flies.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

Sato.

Comments
Comments

Weak Dll allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (13)