FB2025_01 , released February 20, 2025
Allele: Dmel\bcd8
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General Information
Symbol
Dmel\bcd8
Species
D. melanogaster
Name
FlyBase ID
FBal0001082
Feature type
allele
Associated gene
Dmel\bcd
Associated Insertion(s)
Carried in Construct
Also Known As
bcdE3
Key Links
Genomic Maps

Allele class

heat sensitive loss of function allele

Mutagen
Nature of the Allele
Allele class

heat sensitive loss of function allele

(Frohnhofer and Nusslein-Volhard, 1987)
Mutagen
ethyl methanesulfonate
(Driever and Nusslein-Volhard, 1988, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C2406T. Amino acid replacement: S131L. Within the homeobox.

(Struhl et al., 1989)

2406 C --> T; 131 ser --> leu

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:6,758,281..6,758,281 [-]
Nucleotide change:

C6758281T

Reported nucleotide change:

C2406T

Amino acid change:

S126L | bcd-PD; S55L | bcd-PE; S50L | bcd-PF; S131L | bcd-PG

Reported amino acid change:

S131L

(Struhl et al., 1989)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos derived from homozygous females have defects in the head and anterior abdomen. At 29oC, the phenotype is almost amorphic, whereas at 18oC, the thorax is only slightly reduced and head structures are still prominent. The phenocritical temperature-sensitive period begins around pole cell formation and lasts until the formation of cell membranes between the blastoderm nuclei during stage 5. Embryos derived from bcd8/bcd10 females have strong pattern defects in the thorax and anterior abdomen while the head is rather complete, as seen by the presence of a labrum.

      (Frohnhofer and Nusslein-Volhard, 1987)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      bcd8 has segment phenotype, enhanceable by Chig96.1

      (Torigoi et al., 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Embryos laid by bcd8/bcd8; Chig96.1/+ mothers produce on average nearly one segment less than bcd8/bcd8 mothers.

      (Torigoi et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      bcd8 is rescued by bcdp2107

      (Ruez et al., 1998)
      Partially rescued by

      bcd8 is partially rescued by bcdp2107B-

      (Ruez et al., 1998)
      Not rescued by

      bcd8 is not rescued by bcdp2107A-

      (Ruez et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Intermediate bcd allele.

      (Driever and Nusslein-Volhard, 1988)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (10)