FlyBase Allele Report: Dmel\bi[omb-1]

General Information

Symbol

Dmel\bi^omb-1

Species

D. melanogaster

Name

FlyBase ID

FBal0001122

Feature type

allele

Associated gene

Dmel\bi

Associated Insertion(s)

Carried in Construct

Also Known As

omb^H31, omb^bi

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Hoube and Fischbach, 1992)

Mutagen

ethyl methanesulfonate

Progenitor genotype

Caused by aberration

In(1)omb^H31

Cytology

Description

40kb of regulatory DNA, downstream from the transcription unit, are removed from the bi gene.

(Poeck et al., 1993)

Deletion of sequences proximal to +30kb.

(Pflugfelder et al., 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult optic lobe

(Hoube and Fischbach, 1992)

eye (with bi^omb-282)

(Tsai et al., 2015)

horizontal system neuron

(Bulthoff and Buchner, 1985)

lobula

(Pflugfelder et al., 1992)

lobula (with bi^D1Tp)

(Brunner et al., 1992)

lobula plate

(Brunner et al., 1992, Bulthoff and Buchner, 1985)

lobula plate | adult stage

(Bulthoff, 1982)

ommatidium | adult stage | increased number (with bi^omb-282)

(Tsai et al., 2015)

optic chiasma (with bi^D1Tp)

(Brunner et al., 1992)

wing

(Adachi-Yamada et al., 1999, Adachi-Yamada et al., 1999)

wing disc

(Adachi-Yamada et al., 1999)

wing vein

(Adachi-Yamada et al., 1999)

Detailed Description

Statement

Reference

Hemizygous males show fusion of veins at the base of the wing and a small amount of notching at the wing tip.

(Adachi-Yamada et al., 1999)

bi^omb-1/Y flies show a small notching of the wing tip in less than 10% of cases. A cluster of dying cells appears in the primordial wing tip in the late third larval instar bi^omb-1/Y wing disc.

(Adachi-Yamada et al., 1999)

Disruption of visual input can unmask CaMKII-dependent memory formation. Locomotor activity shows no defects in white or dim red light.

(Joiner and Griffith, 1997)

Proximal fusion of all longitudinal veins and variable defects at the tip of the wing. These defects become more severe over null mutations and are dominantly enhanced by mutations in ap and dpp. Impaired in the large field optomotor response in flight and walking.

(Kerscher et al., 1993)

Reduction in fibre number in the anterior optic tracts.

(Hoube and Fischbach, 1992)

Normal external morphology but with discrete defects in optic lobes and behaviour. Reduction in wing size and increase in tergite pigmentation.

(Pflugfelder et al., 1992)

Flies have an increased reflectance on the wing surface, indicative of the lac phenotype. The lac phenotype is caused by position effect or second site mutation rather than directly at the breakpoint.

(Pflugfelder et al., 1990)

ERG defect, slow return of the potential to base light at light off.

(Banga et al., 1986)

The optomotor yaw response is reduced to 12% of the wild-type response. The lobula plate is reduced in thickness. The giant VS- and HS-cells are present but are reduced in size. The distribution of metabolic activity (measured by 3H-deoxyglucose autoradiography) in the optic lobes does not differ substantially from wild-type.

(Bulthoff and Buchner, 1985)

Mushroom bodies have normal size and shape. Normal olfactory learning. Structural defects are restricted to visual system.

(Heisenberg et al., 1985)

Defects in the lobula plate giant neurones of the visual system.

(Bulthoff, 1982)

Adults impaired in optomotor turning responses in tests involving tethered or freely moving flies (FBrf0032046; FBrf0038345; FBrf0048204; FBrf0050160). The mutant is also aberrant in orientation to vertical stripe (FBrf0032046). More detailed examination of 'yaw torque' optomotor responses show that mutant is restricted in responses to stimulation of 'frontal visual field', with mutant behavior summarized as retaining 'object responses' but missing 'large field responses' (FBrf0044893). The mutant is relatively normal in 'lift/thrust' response to vertical pattern movement and in regard to landing response elicited by front-to-back horizontal motion. Slow phototaxis, using Y-tube, was markedly subnormal (FBrf0050160). Mutants show anomalous avoidance reaction, i.e., 'antifixation' to objects in Y-maze test (FBrf0063339); courting males exhibit diminished tracking responses of and turning responses to moving females (FBrf0034187; FBrf0037487). Visual stimulus-induced metabolic activity in the optic lobes

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

bi^omb-1 has visible | recessive phenotype, enhanceable by p38b^DN.UAS/Scer\GAL4^69B

(Adachi-Yamada et al., 1999)

bi^omb-1 has visible | recessive phenotype, enhanceable by p38b^a.UAS/Scer\GAL4^69B

(Adachi-Yamada et al., 1999)

bi^omb-1 has visible | recessive phenotype, enhanceable by puc^E69/puc[+]

(Adachi-Yamada et al., 1999)

bi^omb-1 has visible | recessive phenotype, enhanceable by hep[+]/hep^CA

(Adachi-Yamada et al., 1999)

Suppressed by

Statement

Reference

bi^omb-1, puc^E69 has increased cell death phenotype, suppressible by fu¹

(Adachi-Yamada and O'Connor, 2002)

Other

Statement

Reference

bi^omb-1, puc^E69 has increased cell death phenotype

(Adachi-Yamada and O'Connor, 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

bi^omb-1 has wing vein phenotype, enhanceable by p38b^a.UAS/Scer\GAL4^69B

(Adachi-Yamada et al., 1999)

bi^omb-1 has wing phenotype, enhanceable by p38b^DN.UAS/Scer\GAL4^69B

(Adachi-Yamada et al., 1999)

bi^omb-1 has wing vein phenotype, enhanceable by p38b^DN.UAS/Scer\GAL4^69B

(Adachi-Yamada et al., 1999)

bi^omb-1 has wing phenotype, enhanceable by p38b^a.UAS/Scer\GAL4^69B

(Adachi-Yamada et al., 1999)

bi^omb-1 has wing phenotype, enhanceable by puc^E69/puc[+]

(Adachi-Yamada et al., 1999)

bi^omb-1 has wing phenotype, enhanceable by hep[+]/hep^CA

(Adachi-Yamada et al., 1999)

bi^omb-1 has wing disc phenotype, enhanceable by wg[+]/wg^l-16

(Adachi-Yamada et al., 1999)

Suppressed by

Statement

Reference

bi^omb-1, puc^E69 has wing phenotype, suppressible by fu¹

(Adachi-Yamada and O'Connor, 2002)

Enhancer of

Statement

Reference

bi^omb-1/bi^omb-1 is an enhancer of wing vein L5 phenotype of ab¹

(Cook et al., 2004)

bi^omb-1/bi[+] is an enhancer of wing vein L5 phenotype of ab¹

(Cook et al., 2004)

Other

Statement

Reference

ab¹, bi^omb-1 has wing vein L5 phenotype

(Cook et al., 2004)

ab¹, bi^omb-1 has posterior crossvein phenotype

(Cook et al., 2004)

ab¹, bi^omb-1/bi[+] has wing vein L5 phenotype

(Cook et al., 2004)

ab¹/ab[+], bi^omb-1 has wing vein L5 phenotype

(Cook et al., 2004)

bi^omb-1, puc^E69 has wing phenotype

(Adachi-Yamada and O'Connor, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Wing vein L5 is distally truncated in the wings of ab¹/+; bi^omb-1/+ flies, but not in those of either single heterozygote. In addition, bi^omb-1/+ enhances the distal truncation of L5 seen in ab¹ homozygotes.

(Cook et al., 2004)

bi^omb-1, puc^E69 double heterozygotes exhibit a strong wing notch and cell death increase phenotype. These phenotypes are suppressed by the addition of fu¹.

(Adachi-Yamada and O'Connor, 2002)

The wing notching phenotype of bi^omb-1/Y flies is significantly enhanced by a single copy of puc^E69 or hep^CA, and in the case of hep^CA a wide region of the wing blade is lost, leaving only the base of the wing. The appearance of this apoptotic cluster in the primordial wing tip of late third larval instar bi^omb-1/Y wing discs is more apparent if the larvae are also heterozygous for wg^l-16.

(Adachi-Yamada et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Flies will avoid the visual object within the Y-maze.

(Bulthoff, 1982)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

H31

(Pflugfelder and Heisenberg, 1995)

In(1)omb^H31

(Hofmeyer et al., 2008)

bi^omb-1

l(1)omb^H31

(Sen et al., 2010, Meinertzhagen and Hanson, 1993)

omb¹

(Cook et al., 2004)

omb^H31

(Rutila et al., 1998, Stanewsky et al., 1998, Heisenberg, 1997, Joiner and Griffith, 1997, Kerscher et al., 1995, Pflugfelder, 1995, Balles and Pflugfelder, 1994, Kerscher et al., 1993, Brunner et al., 1992, Hoube and Fischbach, 1992, Pflugfelder et al., 1992, Pflugfelder et al., 1990, Kulkarni et al., 1988, Banga et al., 1986, Bulthoff and Buchner, 1985, Heisenberg et al., 1985, Bulthoff, 1982)

omb^bi

(Tsai et al., 2015, Miotto et al., 2006, del Alamo Rodriguez et al., 2004, Adachi-Yamada, 2002, Adachi-Yamada and O'Connor, 2002, Adachi-Yamada et al., 1999, Adachi-Yamada et al., 1999)

opm31

(Pflugfelder and Heisenberg, 1995)

Name Synonyms

Secondary FlyBase IDs

References (34)

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