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General Information
Symbol
Dmel\biomb-1
Species
D. melanogaster
Name
FlyBase ID
FBal0001122
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ombH31, ombbi
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

40kb of regulatory DNA, downstream from the transcription unit, are removed from the bi gene.

Deletion of sequences proximal to +30kb.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Hemizygous males show fusion of veins at the base of the wing and a small amount of notching at the wing tip.

biomb-1/Y flies show a small notching of the wing tip in less than 10% of cases. A cluster of dying cells appears in the primordial wing tip in the late third larval instar biomb-1/Y wing disc.

Disruption of visual input can unmask CaMKII-dependent memory formation. Locomotor activity shows no defects in white or dim red light.

Proximal fusion of all longitudinal veins and variable defects at the tip of the wing. These defects become more severe over null mutations and are dominantly enhanced by mutations in ap and dpp. Impaired in the large field optomotor response in flight and walking.

Reduction in fibre number in the anterior optic tracts.

Normal external morphology but with discrete defects in optic lobes and behaviour. Reduction in wing size and increase in tergite pigmentation.

Flies have an increased reflectance on the wing surface, indicative of the lac phenotype. The lac phenotype is caused by position effect or second site mutation rather than directly at the breakpoint.

ERG defect, slow return of the potential to base light at light off.

The optomotor yaw response is reduced to 12% of the wild-type response. The lobula plate is reduced in thickness. The giant VS- and HS-cells are present but are reduced in size. The distribution of metabolic activity (measured by 3H-deoxyglucose autoradiography) in the optic lobes does not differ substantially from wild-type.

Mushroom bodies have normal size and shape. Normal olfactory learning. Structural defects are restricted to visual system.

Defects in the lobula plate giant neurones of the visual system.

Adults impaired in optomotor turning responses in tests involving tethered or freely moving flies (FBrf0032046; FBrf0038345; FBrf0048204; FBrf0050160). The mutant is also aberrant in orientation to vertical stripe (FBrf0032046). More detailed examination of 'yaw torque' optomotor responses show that mutant is restricted in responses to stimulation of 'frontal visual field', with mutant behavior summarized as retaining 'object responses' but missing 'large field responses' (FBrf0044893). The mutant is relatively normal in 'lift/thrust' response to vertical pattern movement and in regard to landing response elicited by front-to-back horizontal motion. Slow phototaxis, using Y-tube, was markedly subnormal (FBrf0050160). Mutants show anomalous avoidance reaction, i.e., 'antifixation' to objects in Y-maze test (FBrf0063339); courting males exhibit diminished tracking responses of and turning responses to moving females (FBrf0034187; FBrf0037487). Visual stimulus-induced metabolic activity in the optic lobes

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

biomb-1 has visible | recessive phenotype, enhanceable by pucE69/puc[+]

biomb-1 has visible | recessive phenotype, enhanceable by hep[+]/hepCA

Suppressed by
Statement
Reference
Other
Phenotype Manifest In
Enhanced by
Statement
Reference

biomb-1 has wing phenotype, enhanceable by pucE69/puc[+]

biomb-1 has wing phenotype, enhanceable by hep[+]/hepCA

biomb-1 has wing disc phenotype, enhanceable by wg[+]/wgl-16

Suppressed by
Statement
Reference

biomb-1, pucE69 has wing phenotype, suppressible by fu1

Enhancer of
Statement
Reference

biomb-1/biomb-1 is an enhancer of wing vein L5 phenotype of ab1

biomb-1/bi[+] is an enhancer of wing vein L5 phenotype of ab1

Other
Additional Comments
Genetic Interactions
Statement
Reference

Wing vein L5 is distally truncated in the wings of ab1/+; biomb-1/+ flies, but not in those of either single heterozygote. In addition, biomb-1/+ enhances the distal truncation of L5 seen in ab1 homozygotes.

biomb-1, pucE69 double heterozygotes exhibit a strong wing notch and cell death increase phenotype. These phenotypes are suppressed by the addition of fu1.

The wing notching phenotype of biomb-1/Y flies is significantly enhanced by a single copy of pucE69 or hepCA, and in the case of hepCA a wide region of the wing blade is lost, leaving only the base of the wing. The appearance of this apoptotic cluster in the primordial wing tip of late third larval instar biomb-1/Y wing discs is more apparent if the larvae are also heterozygous for wgl-16.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Flies will avoid the visual object within the Y-maze.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (8)
References (34)