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General Information
Symbol
Dmel\BicC4
Species
D. melanogaster
Name
FlyBase ID
FBal0001138
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Bic-CWC45, BicCWC45
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

5% of eggs laid by heterozygous females have shortened or fused dorsal appendages.

A zone along the anterior region of the oocyte shows a significantly higher concentration of microtubules in BicC3/BicC4 egg chambers compared to wild type.

BicC3/BicC4 egg chambers often show incomplete nurse cell dumping. The actin cables that normally restrain the nurse cell nuclei are absent in the mutant egg chambers, and nurse cell nuclei are often seen to have entered the ring canals.

Dominant haplo-insufficient phenotype. All egg chambers are open ended, heterozygous females produce low frequency of bicaudal embryos.

Phenotypically wild type embryos from heterozygous mothers localize vas protein normally throughout embryogenesis. In phenotypically bicaudal embryos the pole cells fail to coalesce into gonads.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

BicC4 has dorsal appendage | maternal effect phenotype, enhanceable by me31BΔ1/me31B[+]

BicC4 has dorsal appendage | maternal effect phenotype, enhanceable by exu1/exu[+]

NOT Enhanced by
Statement
Reference

BicC4 has dorsal appendage | maternal effect phenotype, non-enhanceable by swa[+]/swa1

Additional Comments
Genetic Interactions
Statement
Reference

The penetrance of the mutant dorsal appendage phenotype seen in eggs laid by BicC4/+ females (5%) is dramatically increased if the females also carry tralKG08052/+ (97%), tral1Δ1/+ (65%), me31BΔ1/+ (79%) or exu1/+ (24%).

cupΔ212/+ has a very weak effect on the penetrance of the mutant dorsal appendage phenotype seen in eggs laid by BicC4/+ females, increasing it from 5% to 9% in the double heterozygous flies.

swa1/+ does not increase the penetrance of the mutant dorsal appendage phenotype seen in eggs laid by BicC4/+ females.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Schupbach.

T. Schupbach.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
References (15)