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General Information
Symbol
Dmel\br1
Species
D. melanogaster
Name
FlyBase ID
FBal0001189
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

412 element insertion at 164.4 kb.

Insertion components
412{}br1
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

br1 mutants persist as third instar larvae for days or even weeks.

br1 females show slightly reduced levels of oviposition compared to wild-type females. The susceptibility of br1 flies to methoprene is not significantly different from wild-type flies.

1% of hemizygous males have a malformed leg phenotype.

Hemizygous males and homozygous females maintained at 21oC have malformed legs at a low frequency (0.4%).

The br1/brnpr-6 and br1/brA47 mothers produce eggs that have reduced dorsal appendages. br1/br5 and br1/br6 females produce eggs that have normal dorsal appendages. br1/brrbp-1 mothers produce eggs that have reduced dorsal appendages, similar to the phenotype seen in br1/brA47 mothers.

Female progeny brA47/br1 survive until adulthood and produce eggs with reduced dorsal appendages. Normal embryos develop that successfully hatch into larvae. Female progeny brnpr-6/br1 survive until adulthood and produce eggs with reduced dorsal appendages.

Viable allele.

Heterozygotes with brnpr-7 display small maxillary palps that are virtually devoid of mechanosensory bristles. Rostral membrane is lost so the proboscis is barely visible.

Failure of salivary gland degeneration. Reduction in dorso-ventral class of indirect flight muscles. Some show proventriculus abnormality: foregut-midgut junction less proventriculus-like in appearance.

Homozygote br1 wings are shorter and wider than wild type. The phenotype of br1 homozygotes is intensified when placed in trans with brnpr-3 resulting in the mlf syndrome. zip interacts with br1 hemizygous males.

41% penetrance of abnormal SEG-TG separation phenotype, 55% of individuals show an abnormal optic lobe position and 35% a brain fusion failure.

Heterozygotes with Df(1)RA19 are partially viable at 29oC, survivors have either short or faded wings.

Heterozygotes with Df(1)br25 have normal viability and br wings.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

br1 has visible | dominant phenotype, enhanceable by Rho1[+]/Rho1k02107b

br1 has visible | dominant phenotype, enhanceable by zip[+]/zipEbr

br1 has visible | dominant phenotype, enhanceable by Rho172O/Rho1[+]

br1 has visible phenotype, enhanceable by Df(3L)Scf-R6/+

br1 has visible phenotype, enhanceable by Df(3L)Ten-m-AL29/+

br1 has visible phenotype, enhanceable by +/Df(3L)XS2182

br1 has visible phenotype, enhanceable by Df(3L)XS533/+

br1 has visible phenotype, enhanceable by Df(3L)XS543/+

br1 has visible phenotype, enhanceable by Df(3L)XS572/+

br1 has visible phenotype, enhanceable by +/Df(3L)brm11

br1 has visible phenotype, enhanceable by Df(3L)fz-M21/+

br1 has visible phenotype, enhanceable by Df(3L)kto2/+

br1 has visible phenotype, enhanceable by Df(3L)lxd6/+

br1 has visible phenotype, enhanceable by Df(3R)3450/+

br1 has visible phenotype, enhanceable by Df(3R)D6/+

br1 has visible phenotype, enhanceable by Df(3R)D7/+

br1 has visible phenotype, enhanceable by Df(3R)DG2/+

br1 has visible phenotype, enhanceable by +/Df(3R)Dl-BX12

br1 has visible phenotype, enhanceable by Df(3R)H-B79/+

br1 has visible phenotype, enhanceable by +/Df(3R)L127

br1 has visible phenotype, enhanceable by Df(3R)M-Kx1/+

br1 has visible phenotype, enhanceable by Df(3R)ME15/+

br1 has visible phenotype, enhanceable by Df(3R)RD31/+

br1 has visible phenotype, enhanceable by Df(3R)ea/+

br1 has visible phenotype, enhanceable by Df(3R)mbc-30/+

br1 has visible phenotype, enhanceable by Df(3R)mbc-R1/+

br1 has visible phenotype, enhanceable by Df(3R)p25/Df(3R)P2

br1 has visible phenotype, enhanceable by Df(3R)p712/+

br1 has visible phenotype, enhanceable by E(br)121Ebr121/E(br)121[+]

br1 has visible phenotype, enhanceable by E(br)155[+]/Mcr1

br1 has visible phenotype, enhanceable by E(br)160[+]/E(br)160Ebr160

br1 has visible phenotype, enhanceable by E(br)165[+]/Sec61αEbr165

br1 has visible phenotype, enhanceable by E(br)187Ebr187/E(br)187[+]

br1 has visible phenotype, enhanceable by Rho1[+]/Rho1k02107b

br1 has visible phenotype, enhanceable by E(br)24[+]/E(br)24Ebr24

br1 has visible phenotype, enhanceable by E(br)333[+]/E(br)333Ebr333

br1 has visible phenotype, enhanceable by E(br)420[+]/E(br)420Ebr420

br1 has visible phenotype, enhanceable by E(br)444[+]/E(br)444Ebr444

br1 has visible phenotype, enhanceable by E(br)65Ebr65/E(br)65[+]

br1 has visible phenotype, enhanceable by E(br)72Ebr72/E(br)72[+]

br1 has visible phenotype, enhanceable by In(2LR)DTD116LDTD24R/+

br1 has visible phenotype, enhanceable by In(2LR)DTD16LDTD42R/+

br1 has visible phenotype, enhanceable by Rho1E3.10/Rho1[+]

br1 has visible phenotype, enhanceable by Rho1Ebr233/Rho1[+]

br1 has visible phenotype, enhanceable by Rho1[+]/Rho1Ebr246

br1 has visible phenotype, enhanceable by Rho1J3.8/Rho1[+]

br1 has visible phenotype, enhanceable by Sb[+]/SbEbr20

br1 has visible phenotype, enhanceable by Sb[+]/SbEbr228

br1 has visible phenotype, enhanceable by Sb[+]/SbEbr448

br1 has visible phenotype, enhanceable by Sb[+]/SbEbr48

br1 has visible phenotype, enhanceable by Sb[+]/SbEbr536

br1 has visible phenotype, enhanceable by SbEbr623/Sb[+]

br1 has visible phenotype, enhanceable by Tm1[+]/Tm102299

br1 has visible phenotype, enhanceable by Tm1[+]/Tm1eg9

br1 has visible phenotype, enhanceable by bs[+]/bsEbr292

br1 has visible phenotype, enhanceable | cold sensitive by bs03267/bs[+]

br1 has visible phenotype, enhanceable | cold sensitive by bs[+]/bsk07909

br1 has visible phenotype, enhanceable by Df(2L)ast2/+

br1 has visible phenotype, enhanceable by Df(2L)N22-14/+

br1 has visible phenotype, enhanceable by Df(2L)TW3/+

br1 has visible phenotype, enhanceable by Df(2L)TW50/+

br1 has visible phenotype, enhanceable by Df(2L)VA12/+

br1 has visible phenotype, enhanceable by Df(2L)VA18/+

br1 has visible phenotype, enhanceable by Df(2L)cl-h3/+

br1 has visible phenotype, enhanceable by Df(2L)pr-A14/+

br1 has visible phenotype, enhanceable by Df(2L)pr-A16/+

br1 has visible phenotype, enhanceable by Df(2R)CX1/+

br1 has visible phenotype, enhanceable by Df(2R)H3E1/+

br1 has visible phenotype, enhanceable by Df(2R)Jp1/+

br1 has visible phenotype, enhanceable by +/Df(2R)Jp4

br1 has visible phenotype, enhanceable by Df(2R)Jp5/+

br1 has visible phenotype, enhanceable by Df(2R)Jp7/+

br1 has visible phenotype, enhanceable by Df(2R)Jp8/+

br1 has visible phenotype, enhanceable by Df(2R)Kr10/+

br1 has visible phenotype, enhanceable by +/Df(2R)M41A4

br1 has visible phenotype, enhanceable by Df(2R)Np3/+

br1 has visible phenotype, enhanceable by Df(2R)Np4/+

br1 has visible phenotype, enhanceable by Df(2R)Np5/+

br1 has visible phenotype, enhanceable by Df(2R)P34/+

br1 has visible phenotype, enhanceable by Df(2R)Pcl11B/+

br1 has visible phenotype, enhanceable by Df(2R)Pcl7B/+

br1 has visible phenotype, enhanceable by +/Df(2R)Px1

br1 has visible phenotype, enhanceable by Df(2R)Px2/+

br1 has visible phenotype, enhanceable by Df(2R)RM2-1/+

br1 has visible phenotype, enhanceable by Df(2R)ST1/+

br1 has visible phenotype, enhanceable by Df(2R)X58-12/+

br1 has visible phenotype, enhanceable by Df(2R)X58-8/+

br1 has visible phenotype, enhanceable by Df(2R)vg-C/+

br1 has visible phenotype, enhanceable by Df(3L)66C-G28/+

br1 has visible phenotype, enhanceable by Df(3L)81k19/+

br1 has visible phenotype, enhanceable by +/Df(3L)Brd6

br1 has visible phenotype, enhanceable by Df(3L)GN24/+

br1 has visible phenotype, enhanceable by Df(3L)HR119/+

br1 has visible phenotype, enhanceable by Df(3L)HR218/+

br1 has visible phenotype, enhanceable by Df(3L)R-G7/+

NOT Enhanced by
Statement
Reference

br1 has visible | dominant phenotype, non-enhanceable by Rac1J11/Rac1[+]

br1 has visible | dominant phenotype, non-enhanceable by Rac2314/Rac2[+]

br1 has visible phenotype, non-enhanceable by Tm1er4/Tm1[+]

br1 has visible phenotype, non-enhanceable by Tm23/Tm2[+]

br1 has visible phenotype, non-enhanceable by bs[+]/bsba

NOT suppressed by
Statement
Reference

br1 has visible phenotype, non-suppressible by bs[+]/bsba

Enhancer of
Statement
Reference

br1 is an enhancer of visible phenotype of LIMK1D522A.UAS, Scer\GAL4hs.PB

NOT Enhancer of
Statement
Reference

br1 is a non-enhancer of visible phenotype of Met27

br1 is a non-enhancer of visible phenotype of MetW3

NOT Suppressor of
Statement
Reference

br1/br1 is a non-suppressor of chemical sensitive phenotype of Met3

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

br1 has ovary phenotype, enhanceable by Met27/Met27

br1 has ovary phenotype, enhanceable by Met128/Met128

br1 has ovary phenotype, enhanceable by Met253/Met253

br1 has ovary phenotype, enhanceable by Met3/Met3

br1 has ovary phenotype, enhanceable by MetA3/MetA3

br1 has ovary phenotype, enhanceable by MetD29/MetD29

br1 has ovary phenotype, enhanceable by MetW3/MetW3

br1 has leg phenotype, enhanceable by LIMK1D522A.UAS/Scer\GAL4hs.PB

br1 has leg phenotype, enhanceable by Rho1[+]/Rho1k02107b

br1 has leg phenotype, enhanceable by zip[+]/zipEbr

br1 has leg phenotype, enhanceable by Rho172O/Rho1[+]

br1 has leg phenotype, enhanceable by Df(3L)Scf-R6/+

br1 has leg phenotype, enhanceable by Df(3L)Ten-m-AL29/+

br1 has leg phenotype, enhanceable by +/Df(3L)XS2182

br1 has leg phenotype, enhanceable by Df(3L)XS533/+

br1 has leg phenotype, enhanceable by Df(3L)XS543/+

br1 has leg phenotype, enhanceable by Df(3L)XS572/+

br1 has leg phenotype, enhanceable by +/Df(3L)brm11

br1 has leg phenotype, enhanceable by Df(3L)fz-M21/+

br1 has leg phenotype, enhanceable by Df(3L)kto2/+

br1 has leg phenotype, enhanceable by Df(3L)lxd6/+

br1 has leg phenotype, enhanceable by Df(3R)3450/+

br1 has leg phenotype, enhanceable by Df(3R)D6/+

br1 has leg phenotype, enhanceable by Df(3R)D7/+

br1 has leg phenotype, enhanceable by Df(3R)DG2/+

br1 has leg phenotype, enhanceable by +/Df(3R)Dl-BX12

br1 has leg phenotype, enhanceable by Df(3R)H-B79/+

br1 has leg phenotype, enhanceable by +/Df(3R)L127

br1 has leg phenotype, enhanceable by Df(3R)M-Kx1/+

br1 has leg phenotype, enhanceable by Df(3R)ME15/+

br1 has leg phenotype, enhanceable by Df(3R)RD31/+

br1 has leg phenotype, enhanceable by Df(3R)ea/+

br1 has leg phenotype, enhanceable by Df(3R)mbc-30/+

br1 has leg phenotype, enhanceable by Df(3R)mbc-R1/+

br1 has leg phenotype, enhanceable by Df(3R)p25/Df(3R)P2

br1 has leg phenotype, enhanceable by Df(3R)p712/+

br1 has leg phenotype, enhanceable by E(br)121Ebr121/E(br)121[+]

br1 has leg phenotype, enhanceable by E(br)155[+]/Mcr1

br1 has leg phenotype, enhanceable by E(br)160[+]/E(br)160Ebr160

br1 has leg phenotype, enhanceable by E(br)165[+]/Sec61αEbr165

br1 has leg phenotype, enhanceable by E(br)187Ebr187/E(br)187[+]

br1 has leg phenotype, enhanceable by E(br)24[+]/E(br)24Ebr24

br1 has leg phenotype, enhanceable by E(br)333[+]/E(br)333Ebr333

br1 has leg phenotype, enhanceable by E(br)420[+]/E(br)420Ebr420

br1 has leg phenotype, enhanceable by E(br)444[+]/E(br)444Ebr444

br1 has leg phenotype, enhanceable by E(br)65Ebr65/E(br)65[+]

br1 has leg phenotype, enhanceable by E(br)72Ebr72/E(br)72[+]

br1 has leg phenotype, enhanceable by In(2LR)DTD116LDTD24R/+

br1 has leg phenotype, enhanceable by In(2LR)DTD16LDTD42R/+

br1 has leg phenotype, enhanceable by Rho1E3.10/Rho1[+]

br1 has leg phenotype, enhanceable by Rho1Ebr233/Rho1[+]

br1 has leg phenotype, enhanceable by Rho1[+]/Rho1Ebr246

br1 has leg phenotype, enhanceable by Rho1J3.8/Rho1[+]

br1 has leg phenotype, enhanceable by Sb[+]/SbEbr20

br1 has leg phenotype, enhanceable by Sb[+]/SbEbr228

br1 has leg phenotype, enhanceable by Sb[+]/SbEbr448

br1 has leg phenotype, enhanceable by Sb[+]/SbEbr48

br1 has leg phenotype, enhanceable by Sb[+]/SbEbr536

br1 has leg phenotype, enhanceable by SbEbr623/Sb[+]

br1 has leg phenotype, enhanceable by Tm1[+]/Tm102299

br1 has leg phenotype, enhanceable by Tm1[+]/Tm1eg9

br1 has leg phenotype, enhanceable by bs[+]/bsEbr292

br1 has leg phenotype, enhanceable | cold sensitive by bs03267/bs[+]

br1 has leg phenotype, enhanceable | cold sensitive by bs[+]/bsk07909

br1 has leg phenotype, enhanceable by Df(2L)ast2/+

br1 has leg phenotype, enhanceable by Df(2L)N22-14/+

br1 has leg phenotype, enhanceable by Df(2L)TW3/+

br1 has leg phenotype, enhanceable by Df(2L)TW50/+

br1 has leg phenotype, enhanceable by Df(2L)VA12/+

br1 has leg phenotype, enhanceable by Df(2L)VA18/+

br1 has leg phenotype, enhanceable by Df(2L)cl-h3/+

br1 has leg phenotype, enhanceable by Df(2L)pr-A14/+

br1 has leg phenotype, enhanceable by Df(2L)pr-A16/+

br1 has leg phenotype, enhanceable by Df(2R)CX1/+

br1 has leg phenotype, enhanceable by Df(2R)H3E1/+

br1 has leg phenotype, enhanceable by Df(2R)Jp1/+

br1 has leg phenotype, enhanceable by +/Df(2R)Jp4

br1 has leg phenotype, enhanceable by Df(2R)Jp5/+

br1 has leg phenotype, enhanceable by Df(2R)Jp7/+

br1 has leg phenotype, enhanceable by Df(2R)Jp8/+

br1 has leg phenotype, enhanceable by Df(2R)Kr10/+

br1 has leg phenotype, enhanceable by +/Df(2R)M41A4

br1 has leg phenotype, enhanceable by Df(2R)Np3/+

br1 has leg phenotype, enhanceable by Df(2R)Np4/+

br1 has leg phenotype, enhanceable by Df(2R)Np5/+

br1 has leg phenotype, enhanceable by Df(2R)P34/+

br1 has leg phenotype, enhanceable by Df(2R)Pcl11B/+

br1 has leg phenotype, enhanceable by Df(2R)Pcl7B/+

br1 has leg phenotype, enhanceable by +/Df(2R)Px1

br1 has leg phenotype, enhanceable by Df(2R)Px2/+

br1 has leg phenotype, enhanceable by Df(2R)RM2-1/+

br1 has leg phenotype, enhanceable by Df(2R)ST1/+

br1 has leg phenotype, enhanceable by Df(2R)X58-12/+

br1 has leg phenotype, enhanceable by Df(2R)X58-8/+

br1 has leg phenotype, enhanceable by Df(2R)vg-C/+

br1 has leg phenotype, enhanceable by Df(3L)66C-G28/+

br1 has leg phenotype, enhanceable by Df(3L)81k19/+

br1 has leg phenotype, enhanceable by +/Df(3L)Brd6

br1 has leg phenotype, enhanceable by Df(3L)GN24/+

br1 has leg phenotype, enhanceable by Df(3L)HR119/+

br1 has leg phenotype, enhanceable by Df(3L)HR218/+

br1 has leg phenotype, enhanceable by Df(3L)R-G7/+

NOT Enhanced by
Statement
Reference

br1 has ovary phenotype, non-enhanceable by MetE1/MetE1

br1 has leg phenotype, non-enhanceable by Rac1J11/Rac1[+]

br1 has leg phenotype, non-enhanceable by Rac2314/Rac2[+]

br1 has leg phenotype, non-enhanceable by Tm1er4/Tm1[+]

br1 has leg phenotype, non-enhanceable by Tm23/Tm2[+]

br1 has leg phenotype, non-enhanceable by bs[+]/bsba

NOT suppressed by
Statement
Reference

br1 has leg phenotype, non-suppressible by bs[+]/bsba

br1 has phenotype, non-suppressible by su(Hw)2

Enhancer of
Statement
Reference

br1/br1 is an enhancer of ovary phenotype of Met27

br1 is an enhancer of leg phenotype of LIMK1D522A.UAS, Scer\GAL4hs.PB

NOT Enhancer of
Statement
Reference

br1 is a non-enhancer of eye phenotype of Met27

br1 is a non-enhancer of eye phenotype of MetW3

Other
Statement
Reference

Rho1E3.10/Rho1[+], br1 has leg | cold sensitive phenotype

Rho1J3.8/Rho1[+], br1 has leg | cold sensitive phenotype

Rho1E3.10, br1 has leg | cold sensitive phenotype

Rho1J3.8, br1 has leg | cold sensitive phenotype

Additional Comments
Genetic Interactions
Statement
Reference

br1/br1, Rst(1)JH27/Rst(1)JH27 mutants are lethal in both pupal and especially pharate adult stages, but small numbers of escaper adults eclose. When these mutants express the Rst(1)JH+tSt-H.hs transgene, they survive to adulthood. 54% of br5/br1, Rst(1)JH27/+ mutants survive to adulthood but br5/br1, Rst(1)JH27/Rst(1)JH27 mutants are lethal in prepupal/early pupal development. br1, Rst(1)JH3/Y, br1, Rst(1)JHE1/Y and br1, Rst(1)JHD29/Y hemizygotes show good levels of survival. br1, Rst(1)JH3 flies show the same sensitivity to methoprene as br1 single mutant flies. br1, Rst(1)JH27 female escapers show strong reductions in oogenesis. The following double mutant escapers show significantly reduced levels of oogenesis compared to br1 single mutants: br1, Rst(1)JHA3; br1, Rst(1)JH128; br1, Rst(1)JHW3; br1, Rst(1)JHD29; br1, Rst(1)JH3 and br1, Rst(1)JH253.

The expressivity of the defective eye phenotype seen in MetW3 and Met27 flies is not increased by br1.

The frequency of the malformed leg phenotype seen in br1/Y males (1%) is increased if the flies are also heterozygous for Rho172O (12%), Rho1k02107b (55%) or zipEbr (56%). The frequency of the malformed leg phenotype seen in br1/Y males (1%) is not increased if the flies are also heterozygous for Rac1J11/+ (0%) or Rac2314/+ (2%). Expression of LIMK1D522A.Scer\UAS under the control of Scer\GAL4hs.PB enhances the frequency of the malformed leg phenotype seen in br1/Y males from 1% to 36%.

br1 fails to show a significant genetic interaction (assayed in terms of a malformed leg phenotype) with RhoGEF21.1, RhoGEF24.1, RhoGEF204291, RhoGEF211-3, E(zip)12-512-5, Rho112-6, E(zip)18-518-5, E(zip)31-631-6 or zip33-1.

At 18oC, 73% of br1/Y ; bs03267/+ animals have malformed legs, at 21oC, the frequency of malformed legs is 15%. At 18oC, 30% of br1/Y ; bsk07909/+ animals have malformed legs, at 21oC, the frequency of malformed legs is 9%.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially complements
Fails to complement
Comments

br1/brnpr-6 show reduced viability.

Images (1)
Stocks (8)
Notes on Origin
Discoverer

Bridges, 26th Sep. 1915.

Comments
Comments

Deficient in 'rbp' function.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (31)