FlyBase Allele Report: Dmel\brat[11]

brat^DG19310/brat¹¹ mutant clones originating from either a single ase+ immature intermediate neural progenitor (INP) or INP contain a similar number of neuroblasts (reverted clones) as controls.

(Janssens et al., 2014)

brat¹¹/brat^2L-192-9 larvae show an increase in total bouton number and in number of satellite boutons at the neuromuscular junction compared to wild type. Ultrastructurally, the presynaptic mitochondria and postsynaptic subsynaptic reticulum appear largely normal in the mutant boutons. However, vesicle density within the bouton is moderately, but significantly, reduced and a subpopulation of vesicles are larger than in wild type. There are fewer synaptic vesicles within a 200nm radius of the T-bar than normal, and the mean synaptic vesicle diameter within the active zone is significantly increased. There is a significant increase in the number of presynaptic membrane ruffles within the active zone and the mean length of the postsynaptic density is increased.

The mean EJP amplitude and mEJP frequency is not significantly different from wild type at the neuromuscular junction of brat¹¹/brat^2L-192-9 larvae. However, mean mEJP amplitude is increased compared to wild type and quantal content is significantly reduced.

The neuromuscular junctions of brat¹¹/brat^2L-192-9 larvae show reduced uptake of FM1-43 dye compared to wild type, indicating a defect in endocytosis.

(Shi et al., 2013)

brat¹¹/brat^DG19310 larval brains contain supernumerary type II neuroblasts.

brat¹¹/brat^k06028 larval brains contain supernumerary type II neuroblasts.

(Xiao et al., 2012)

brat¹¹ germ line clones dispay an increased growth phenotype, with larger cells than wild-type. There is an increase in the number of germline stem cells in these mutants.

(Harris et al., 2011)

In late third instar brat¹¹ mutant larvae, brain hemispheres are markedly enlarged and characterized by cellular overgrowth whereas ventral ganglia appear normal. The central brain is characterized by dense cellular masses of numerous small and pleiomorphic cells in addition to a limited number of large cells. At earlier larval stages, brain hemispheres, brat¹¹ mutants brain hemispheres are the same overall size as wild-type larvae.

brat¹¹ clones in the central brain of third instar larvae populate large areas of the brain hemispheres and are up to ten times larger than wild-type central brain clones: over 80% of the mutant clones comprise 200-1000 cells, while wild-type clones comprise >100 cells. In the early larval instar, brat¹¹ clones are clearly distinguishable and separated from one another, but by the late third instar almost all of the central brain appears to be covered by an indistinguishable clonal cell mass. Cells in brat¹¹ clones lack axonal processes. In the ventral ganglia, brat¹¹ clones are recovered at a similar frequency to wild-type clones.

brat¹¹ clones induced in first instar larvae appear dramatically enlarged in size and cell number in the adult brain and appear to be mitotically active (according to phosphorylated His3 staining).

(Bello et al., 2006)

In brat¹¹ homozygous mutant larvae there is a dramatic increase in neuroblast number, over 500 by 96 hours after larval hatching and an estimated several thousand by 120 hours after larval hatching. This corresponds to a reduction in elav staining, indicating ectopic neuroblast generation at the expense of neurons.

brat¹¹ neuroblasts generate GMC-sized progeny that are cell cycle delayed and continue to express neuroblast markers; some of these 'GMCs' differentiate into neurons, but many appear to develop into proliferative neuroblasts.

(Lee et al., 2006)

brat¹¹ homozygous somatic clones in third instar larvae are consistently larger than wild-type. the cells themselves are larger than individual wild-type cells. Mutant cells also have nucleoli that are 18 to 33% larger than wild-type cells, mutant dells contain 1.6 times more rRNA than control cells.

(Frank et al., 2002)

The median survival of adult hosts transplanted with brat¹¹/brat¹⁴ brain fragments is reduced compared to adult hosts transplanted with wild-type brain fragments. Cells from transplanted brat¹¹/brat¹⁴ brain fragments form at least one secondary tumour in the wild-type host in 84% of cases. Imaginal discs from brat¹¹/brat¹⁴ larvae form secondary tumours in 53% of hosts.

(Woodhouse et al., 1998)

Hemizygous larval brain tissue transplanted into the abdomens of adult female hosts shows unrestrained and invasive growth.

(Wright, 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Usp5^leon-2/Usp5^leon-1

(Komori et al., 2025)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Usp5^JF02163/Scer\GAL4^wor.PA

(Komori et al., 2025)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Usp5^leon-1/Usp5^leon-1

(Komori et al., 2025)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Scer\GAL4^wor.PA/Patr-1^HMS01144

(Komori et al., 2025)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by DCP2^HMS00115/Scer\GAL4^wor.PA

(Komori et al., 2025)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Scer\GAL4^wor.PA/tral^HM05028

(Komori et al., 2025)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Scer\GAL4^wor.PA/pcm^HMS01169

(Komori et al., 2025)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Scer\GAL4^wor.PA/Edc3^HMS00392

(Komori et al., 2025)

brat^DG19310/brat¹¹ has increased cell number phenotype, enhanceable by fru^AJ96u3

(Rajan et al., 2023)

brat^DG19310/brat¹¹ has increased cell number phenotype, enhanceable by fru^AJ96u3/fru^ΔC

(Rajan et al., 2023)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(3R)BSC56/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Tis11[+]/Tis11^IE35

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(1)BSC726/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(1)BSC623/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Not1^LL08100/Not1[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Pop2^MB11505/Pop2[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by PAN2^f00130/PAN2[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by me31B^k06607/me31B[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell growth rate | larval stage phenotype, enhanceable by Tis11^{H198Q.UAS.Tag:FLAG}/Tis11[+]/Scer\GAL4^wor.PA/Tis11^IE35/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell growth rate | larval stage phenotype, enhanceable by Tis11[+]/Scer\GAL4^wor.PA/Tis11^{ΔNot1.UAS.Tag:FLAG}/Tis11^IE35/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell growth rate | larval stage phenotype, enhanceable by Scer\GAL4^wor.PA/Cul1^HM05197/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by numb^NP2301/numb¹⁵

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by insb^exA45

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(2L)ED94/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(2L)ED105/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(2L)BSC688/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(1)BSC625/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(2R)BSC355/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by +/Df(2L)BSC292

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by +/Df(3L)brm11

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(3L)BSC574/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by +/Df(3R)L127

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(3R)Exel7327/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by +/Df(2R)Exel7094

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by +/Df(2L)ED690

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by +/Df(2R)BSC161

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(2R)ED1791/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(2R)BSC408/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(3L)ED4288/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by +/Df(3R)Exel9012

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(3R)DG2/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(3R)crb-F89-4/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, enhanceable by erm[+]/erm¹

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, enhanceable by osa[+]/osa³⁰⁸

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, enhanceable by brm[+]/brm²

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, enhanceable by mor[+]/mor¹

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, enhanceable by Scer\GAL4^GMR9D11/brm^{K804R.UAS.Tag:HA}

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, enhanceable by Scer\GAL4^wor.PA/brm^{K804R.UAS.Tag:HA}

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, enhanceable by klu^UAS.Tag:HA/Scer\GAL4^GMR9D11

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, enhanceable by dpn^UAS.cWa/Scer\GAL4^GMR9D11

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy | larval stage phenotype, enhanceable by Apc2^g10/Apc2[+]

(Komori et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy | larval stage phenotype, enhanceable by CkIalpha[+]/CkIα^8B12

(Komori et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy | larval stage phenotype, enhanceable by sgg[+]/sgg^8E22

(Komori et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy | larval stage phenotype, enhanceable by Axn[+]/Axn^S044230

(Komori et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy | larval stage phenotype, enhanceable by Scer\GAL4^wor.PA/arm^{S10.UAS.Tag:MYC}

(Komori et al., 2014)

NOT Enhanced by

Statement

Reference

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, non-enhanceable by Uuuu\Ub^{AA.UAS.Tag:HA}/Scer\GAL4^wor.PA

(Komori et al., 2025)

brat^DG19310/brat¹¹ has increased cell growth rate | larval stage phenotype, non-enhanceable by Tis11[+]/Scer\GAL4^wor.PA/Tis11^{UAS.cKa.Tag:FLAG}/Tis11^IE35/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, non-enhanceable by Scer\GAL4^GMR9D11/brm^{K804R.UAS.Tag:HA}

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, non-enhanceable by klu^UAS.Tag:HA/Scer\GAL4^GMR9D11

(Janssens et al., 2014)

Suppressed by

Statement

Reference

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2025, Komori et al., 2018)

Usp5^leon-1, brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, suppressible by Scer\GAL4^GMR9D11/Usp5^UAS.Tag:FLAG

(Komori et al., 2025)

brat¹¹/Df(2L)Exel8040 has decreased cell number | somatic clone phenotype, suppressible | partially by fru^{C-ZF.ERD.UAS.Tag:MYC}/Scer\GAL4^Act5C.PP

(Rajan et al., 2023)

brat¹¹/Df(2L)Exel8040 has decreased cell number | somatic clone phenotype, suppressible | partially by fru^{C.UAS.Tag:MYC}/Scer\GAL4^Act5C.PP

(Rajan et al., 2023)

brat¹¹/Df(2L)Exel8040 has increased cell number | larval stage phenotype, suppressible | partially by Scer\GAL4^wor.PA/Scer\GAL80^ase.PN/insb^UAS.Tag:MYC

(Rives-Quinto et al., 2020)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, suppressible by Df(1)ED6565/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, suppressible by Df(3R)3450/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, suppressible by +/Df(3L)BSC377

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, suppressible by Df(3R)Tl-P/+

(Komori et al., 2018)

Df(2R)ED1791/+, brat^DG19310/brat¹¹ has increased cell growth rate | larval stage phenotype, suppressible | partially by Scer\GAL4^wor.PA/PAN2^UAS.Tag:V5/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹, insb^exA45 has increased cell number | larval stage phenotype, suppressible by insb^cKa.GFP

(Komori et al., 2018)

Tis11^IE35, brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2018)

brat^DG19310/brat¹¹, insb^exA45 has increased cell number | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2018)

brat^DG19310/brat¹¹, erm[+]/erm¹ has abnormal neuroanatomy | somatic clone phenotype, suppressible by Scer\GAL4^GMR9D11/erm^UAS.Tag:HA

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, suppressible by Scer\GAL4^GMR9D11/erm^UAS.Tag:HA

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, suppressible by E(spl)mγ-HLH^UAS.cLa/Scer\GAL4^GMR9D11

(Janssens et al., 2014)

Apc2^g10/Apc2[+], brat^DG19310/brat¹¹ has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by arm⁸/arm[+]

(Komori et al., 2014)

brat^2L-192-9/brat¹¹ has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by Mad¹²/Mad[+]

(Shi et al., 2013)

brat^2L-192-9/brat¹¹ has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by Df(2L)BSC162/+

(Shi et al., 2013)

brat^DG19310/brat¹¹ has abnormal neuroanatomy | larval stage phenotype, suppressible by klu[+]/klu^unspecified

(Xiao et al., 2012)

brat^k06028/brat¹¹ has abnormal neuroanatomy | larval stage phenotype, suppressible | somatic clone by klu^unspecified/klu^unspecified

(Xiao et al., 2012)

brat¹¹ has abnormal neuroanatomy | somatic clone phenotype, suppressible by pros^UAS.cMa/Scer\GAL4^αTub84B.PL

(Bello et al., 2006)

brat¹¹ has increased cell number | somatic clone | larval stage phenotype, suppressible by pros^UAS.cMa/Scer\GAL4^αTub84B.PL

(Bello et al., 2006)

NOT suppressed by

Statement

Reference

Df(2R)ED1791/+, brat^DG19310/brat¹¹ has increased cell growth rate | larval stage phenotype, non-suppressible by PAN2^{D1039N.E1041Q.UAS.Tag:V5}/Scer\GAL4^wor.PA/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, non-suppressible by Scer\GAL4^GMR9D11/erm^UAS.Tag:HA

(Janssens et al., 2014)

brat^2L-192-9/brat¹¹ has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by wit^A12/wit[+]

(Shi et al., 2013)

brat^2L-192-9/brat¹¹ has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by tkv⁷/tkv[+]

(Shi et al., 2013)

Enhancer of

Statement

Reference

brat^DG19310/brat¹¹ is an enhancer of increased cell growth rate | larval stage phenotype of Cul1^HM05197, Scer\GAL4^wor.PA, Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ is an enhancer of increased cell number | larval stage phenotype of numb^NP2301/numb¹⁵

(Komori et al., 2018)

Suppressor of

Statement

Reference

brat¹¹ is a suppressor of increased occurrence of cell division | embryonic stage phenotype of Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG, sisRNA:2^{UAS.Tag:MYC,DsRed(Unk)}

(Osman and Pek, 2021)

brat¹¹ is a suppressor of increased cell number | embryonic stage phenotype of Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG, sisRNA:2^{UAS.Tag:MYC,DsRed(Unk)}

(Osman and Pek, 2021)

Other

Statement

Reference

brat^DG19310/brat¹¹, erm[+]/erm¹ has abnormal neuroanatomy | somatic clone phenotype

(Janssens et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Usp5^leon-2/Usp5^leon-1

(Komori et al., 2025)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Usp5^JF02163/Scer\GAL4^wor.PA

(Komori et al., 2025)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Usp5^leon-1/Usp5^leon-1

(Komori et al., 2025)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Scer\GAL4^wor.PA/Patr-1^HMS01144

(Komori et al., 2025)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by DCP2^HMS00115/Scer\GAL4^wor.PA

(Komori et al., 2025)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Scer\GAL4^wor.PA/tral^HM05028

(Komori et al., 2025)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Scer\GAL4^wor.PA/pcm^HMS01169

(Komori et al., 2025)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Scer\GAL4^wor.PA/Edc3^HMS00392

(Komori et al., 2025)

brat^DG19310/brat¹¹ has neuroblast | increased number phenotype, enhanceable by fru^AJ96u3

(Rajan et al., 2023)

brat^DG19310/brat¹¹ has neuroblast | increased number phenotype, enhanceable by fru^AJ96u3/fru^ΔC

(Rajan et al., 2023)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(3R)BSC56/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Tis11[+]/Tis11^IE35

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Tis11[+]/Tis11^IE35

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(1)BSC726/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(1)BSC726/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(1)BSC623/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(1)BSC623/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Not1^LL08100/Not1[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Not1^LL08100/Not1[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Pop2^MB11505/Pop2[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Pop2^MB11505/Pop2[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by PAN2^f00130/PAN2[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by PAN2^f00130/PAN2[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by me31B^k06607/me31B[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by me31B^k06607/me31B[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Tis11^{H198Q.UAS.Tag:FLAG}/Tis11[+]/Scer\GAL4^wor.PA/Tis11^IE35/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, enhanceable by Tis11^{H198Q.UAS.Tag:FLAG}/Tis11[+]/Scer\GAL4^wor.PA/Tis11^IE35/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Tis11[+]/Scer\GAL4^wor.PA/Tis11^{ΔNot1.UAS.Tag:FLAG}/Tis11^IE35/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, enhanceable by Tis11[+]/Scer\GAL4^wor.PA/Tis11^{ΔNot1.UAS.Tag:FLAG}/Tis11^IE35/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Scer\GAL4^wor.PA/Cul1^HM05197/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, enhanceable by Scer\GAL4^wor.PA/Cul1^HM05197/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by numb^NP2301/numb¹⁵

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by numb^NP2301/numb¹⁵

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by insb^exA45

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, enhanceable by insb^exA45

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by +/Df(3L)BSC377

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by +/Df(3L)BSC377

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(2L)ED94/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(2L)ED94/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(2L)ED105/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(2L)ED105/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(2L)BSC688/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(2L)BSC688/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(1)BSC625/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(1)BSC625/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(2R)BSC355/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(2R)BSC355/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by +/Df(2L)BSC292

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by +/Df(2L)BSC292

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by +/Df(3L)brm11

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by +/Df(3L)brm11

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(3L)BSC574/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(3L)BSC574/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by +/Df(3R)L127

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by +/Df(3R)L127

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(3R)Exel7327/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(3R)Exel7327/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by +/Df(2R)Exel7094

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by +/Df(2R)Exel7094

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by +/Df(2L)ED690

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by +/Df(2L)ED690

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by +/Df(2R)BSC161

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by +/Df(2R)BSC161

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(2R)ED1791/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(2R)ED1791/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(2R)BSC408/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(2R)BSC408/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(3L)ED4288/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(3L)ED4288/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by +/Df(3R)Exel9012

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by +/Df(3R)Exel9012

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(3R)DG2/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(3R)DG2/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(3R)crb-F89-4/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(3R)crb-F89-4/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(3R)BSC56/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by erm[+]/erm¹

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by brm[+]/brm²

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by mor[+]/mor¹

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Scer\GAL4^GMR9D11/brm^{K804R.UAS.Tag:HA}

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Scer\GAL4^wor.PA/brm^{K804R.UAS.Tag:HA}

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by klu^UAS.Tag:HA/Scer\GAL4^GMR9D11

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by dpn^UAS.cWa/Scer\GAL4^GMR9D11

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by E(spl)mγ-HLH^UAS.cLa/Scer\GAL4^GMR9D11

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by osa[+]/osa³⁰⁸

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Apc2^g10/Apc2[+]

(Komori et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by CkIalpha[+]/CkIα^8B12

(Komori et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by sgg[+]/sgg^8E22

(Komori et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Axn[+]/Axn^S044230

(Komori et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Scer\GAL4^wor.PA/arm^{S10.UAS.Tag:MYC}

(Komori et al., 2014)

NOT Enhanced by

Statement

Reference

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, non-enhanceable by Uuuu\Ub^{AA.UAS.Tag:HA}/Scer\GAL4^wor.PA

(Komori et al., 2025)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, non-enhanceable by Tis11[+]/Scer\GAL4^wor.PA/Tis11^{UAS.cKa.Tag:FLAG}/Tis11^IE35/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, non-enhanceable by Tis11[+]/Scer\GAL4^wor.PA/Tis11^{UAS.cKa.Tag:FLAG}/Tis11^IE35/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, non-enhanceable by Scer\GAL4^GMR9D11/brm^{K804R.UAS.Tag:HA}

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, non-enhanceable by klu^UAS.Tag:HA/Scer\GAL4^GMR9D11

(Janssens et al., 2014)

Suppressed by

Statement

Reference

Usp5^leon-1, brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, suppressible by Scer\GAL4^GMR9D11/Usp5^UAS.Tag:FLAG

(Komori et al., 2025)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2025)

brat¹¹/Df(2L)Exel8040 has ganglion mother cell | somatic clone | decreased number phenotype, suppressible | partially by fru^{C.UAS.Tag:MYC}/Scer\GAL4^Act5C.PP

(Rajan et al., 2023)

brat¹¹/Df(2L)Exel8040 has intermediate neuronal progenitor | somatic clone | decreased number phenotype, suppressible | partially by fru^{C.UAS.Tag:MYC}/Scer\GAL4^Act5C.PP

(Rajan et al., 2023)

brat¹¹/Df(2L)Exel8040 has ganglion mother cell | somatic clone | decreased number phenotype, suppressible | partially by fru^{C-ZF.ERD.UAS.Tag:MYC}/Scer\GAL4^Act5C.PP

(Rajan et al., 2023)

brat¹¹/Df(2L)Exel8040 has type II neuroblast | increased number | larval stage phenotype, suppressible | partially by Scer\GAL4^wor.PA/Scer\GAL80^ase.PN/insb^UAS.Tag:MYC

(Rives-Quinto et al., 2020)

brat¹¹/Df(2L)Exel8040 has larval brain | larval stage phenotype, suppressible | partially by Scer\GAL4^wor.PA/Scer\GAL80^ase.PN/insb^UAS.Tag:MYC

(Rives-Quinto et al., 2020)

brat^DG19310/brat¹¹, insb^exA45 has type II neuroblast | increased number | larval stage phenotype, suppressible by insb^cKa.GFP

(Komori et al., 2018)

brat^DG19310/brat¹¹, insb^exA45 has embryonic/larval optic lobe | larval stage phenotype, suppressible by insb^cKa.GFP

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, suppressible by Df(3R)3450/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, suppressible by Df(3R)Tl-P/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, suppressible by Df(1)ED6565/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, suppressible by +/Df(3L)BSC377

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, suppressible by Df(1)ED6565/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, suppressible by Df(3R)3450/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, suppressible by Df(3R)Tl-P/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, suppressible by +/Df(3L)BSC377

(Komori et al., 2018)

Df(2R)ED1791/+, brat^DG19310/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, suppressible | partially by Scer\GAL4^wor.PA/PAN2^UAS.Tag:V5/Scer\GAL80^ase.PU

(Komori et al., 2018)

Df(2R)ED1791/+, brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, suppressible | partially by Scer\GAL4^wor.PA/PAN2^UAS.Tag:V5/Scer\GAL80^ase.PU

(Komori et al., 2018)

Tis11^IE35, brat^DG19310/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2018)

Tis11^IE35, brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2018)

brat^DG19310/brat¹¹, insb^exA45 has type II neuroblast | increased number | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2018)

brat^DG19310/brat¹¹, insb^exA45 has embryonic/larval optic lobe | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2018)

brat^DG19310/brat¹¹, erm[+]/erm¹ has type II neuroblast | somatic clone phenotype, suppressible by Scer\GAL4^GMR9D11/erm^UAS.Tag:HA

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, suppressible by Scer\GAL4^GMR9D11/erm^UAS.Tag:HA

(Janssens et al., 2014)

Apc2^g10/Apc2[+], brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, suppressible | partially by arm⁸/arm[+]

(Komori et al., 2014)

brat^2L-192-9/brat¹¹ has NMJ bouton | increased number | third instar larval stage phenotype, suppressible by Mad¹²/Mad[+]

(Shi et al., 2013)

brat^2L-192-9/brat¹¹ has NMJ bouton | increased number | third instar larval stage phenotype, suppressible by Df(2L)BSC162/+

(Shi et al., 2013)

brat^k06028/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, suppressible | somatic clone by klu^unspecified/klu^unspecified

(Xiao et al., 2012)

brat^DG19310/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, suppressible by klu[+]/klu^unspecified

(Xiao et al., 2012)

brat¹¹ has larval brain | somatic clone phenotype, suppressible by pros^UAS.cMa/Scer\GAL4^αTub84B.PL

(Bello et al., 2006)

NOT suppressed by

Statement

Reference

Df(2R)ED1791/+, brat^DG19310/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, non-suppressible by PAN2^{D1039N.E1041Q.UAS.Tag:V5}/Scer\GAL4^wor.PA/Scer\GAL80^ase.PU

(Komori et al., 2018)

Df(2R)ED1791/+, brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, non-suppressible by PAN2^{D1039N.E1041Q.UAS.Tag:V5}/Scer\GAL4^wor.PA/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, non-suppressible by Scer\GAL4^GMR9D11/erm^UAS.Tag:HA

(Janssens et al., 2014)

brat^2L-192-9/brat¹¹ has NMJ bouton | increased number | third instar larval stage phenotype, non-suppressible by wit^A12/wit[+]

(Shi et al., 2013)

brat^2L-192-9/brat¹¹ has NMJ bouton | increased number | third instar larval stage phenotype, non-suppressible by tkv⁷/tkv[+]

(Shi et al., 2013)

Enhancer of

Statement

Reference

brat^DG19310/brat¹¹ is an enhancer of embryonic/larval optic lobe | larval stage phenotype of Cul1^HM05197, Scer\GAL4^wor.PA, Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ is an enhancer of type II neuroblast | larval stage | increased number phenotype of Cul1^HM05197, Scer\GAL4^wor.PA, Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ is an enhancer of type II neuroblast | larval stage | increased number phenotype of numb^NP2301/numb¹⁵

(Komori et al., 2018)

brat^DG19310/brat¹¹ is an enhancer of embryonic/larval optic lobe | larval stage | increased number phenotype of numb^NP2301/numb¹⁵

(Komori et al., 2018)

Suppressor of

Statement

Reference

brat¹¹ is a suppressor of primordial germ cell | embryonic stage phenotype of Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG, sisRNA:2^{UAS.Tag:MYC,DsRed(Unk)}

(Osman and Pek, 2021)

Other

Statement

Reference

brat^DG19310/brat¹¹, erm[+]/erm¹ has type II neuroblast | increased number | somatic clone phenotype

(Janssens et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of erm¹ enhances the supernumerary type II neuroblast phenotype seen in brat^DG19310/brat¹¹ mutants.

In contrast to brat^DG19310/brat¹¹ clones alone, clones originating from either a single ase+ immature Intermediate Neural Progenitor (INP) or INP that are also heterozygous for erm¹ contain an increased number of neuroblasts 'reverted clones'. This phenotype is reversed upon expression of erm^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR9D11. This rescue is seen using an insertion line of the driver that expressed in ase[-] INPs (P{GMR9D11-GAL4}2) and one that expresses in ase[+] INPs (P{GMR9D11-GAL4}attP2).

Expression of erm^{Scer\UAS.T:Ivir\HA1} under the control of an insertion of Scer\GAL4^GMR9D11 that expresses in ase[-] immature Intermediate Neural Progenitors (INPs) (P{GMR9D11-GAL4}2) suppresses the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ mutant larval brains. Expression of erm^{Scer\UAS.T:Ivir\HA1} using a line that expresses in ase[+] INPs (P{GMR9D11-GAL4}attP2) does not suppress the phenotype.

Expression of klu^{Scer\UAS.T:Ivir\HA1} under the control of an insertion of Scer\GAL4^GMR9D11 that expresses in ase[-] immature Intermediate Neural Progenitors (INPs) (P{GMR9D11-GAL4}2) enhances the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ mutant larval brains. No enhancement is seen when klu^{Scer\UAS.T:Ivir\HA1} is expressed using an insertion of Scer\GAL4^GMR9D11 that expresses in ase[+] INPs (P{GMR9D11-GAL4}attP2).

Expression of dpn^Scer\UAS.cWa under the control of an insertion of Scer\GAL4^GMR9D11 that expresses in ase[-] immature Intermediate Neural Progenitors (INPs) (P{GMR9D11-GAL4}2) enhances the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ mutant larval brains. A milder enhancement is seen when dpn^Scer\UAS.cWa is expressed using an insertion of Scer\GAL4^GMR9D11 that expresses in ase[+] INPs (P{GMR9D11-GAL4}attP2).

Expression of E(spl)mγ-HLH^Scer\UAS.cLa under the control of an insertion of Scer\GAL4^GMR9D11 that expresses in ase[-] immature Intermediate Neural Progenitors (INPs) (P{GMR9D11-GAL4}2) strongly enhances the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ mutant larval brains. A milder enhancement is seen when E(spl)mγ-HLH^Scer\UAS.cLa is expressed using an insertion of Scer\GAL4^GMR9D11 that expresses in ase[+] INPs (P{GMR9D11-GAL4}attP2).

One copy of osa³⁰⁸ enhances the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ mutants.

One copy of brm² enhances the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ mutants.

One copy of mor¹ enhances the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ mutants.

Expression of brm^{K804R.Scer\UAS.T:Ivir\HA1} under the control of an insertion of Scer\GAL4^GMR9D11 that expresses in ase[-] immature Intermediate Neural Progenitors (INPs) (P{GMR9D11-GAL4}2) enhances the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ mutant larval brains. Expression of brm^{K804R.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^wor.PA also enhances the phenotype. No enhancement is seen when brm^{K804R.Scer\UAS.T:Ivir\HA1} is expressed using an insertion of Scer\GAL4^GMR9D11 that expresses in ase[+] INPs (P{GMR9D11-GAL4}attP2).

(Janssens et al., 2014)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} in type II neuroblasts or ase- immature intermediate neural progenitors (INPs) enhances the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ larval brains, whereas expression in ase+ immature INPs does not (different insertions of Scer\GAL4^GMR9D11 are used to drive expression in each case).

Expression of pan^ΔN.Scer\UAS in type II neuroblasts or ase- immature intermediate neural progenitors (INPs) suppresses the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ larval brains, whereas expression in ase+ immature INPs does not (different insertions of Scer\GAL4^GMR9D11 are used to drive expression in each case).

(Komori et al., 2014)

The neuromuscular junction overgrowth phenotype (increased total number of boutons and increased number of satellite boutons) of brat¹¹/brat^2L-192-9 larvae is not suppressed by either wit^A12/+ or tkv⁷/+.

The neuromuscular junction overgrowth phenotype (increased total number of boutons and increased number of satellite boutons) of brat¹¹/brat^2L-192-9 larvae is significantly suppressed by Mad¹²/+ and by Df(2L)BSC162/+.

The reduced uptake of FM1-43 dye seen at the neuromuscular junction in brat¹¹/brat^2L-192-9 larvae is significantly suppressed by Mad¹²/+ and by Df(2L)BSC162/+.

(Shi et al., 2013)

klu^unspecified/+ strongly suppresses the formation of supernumerary type II neuroblasts which is seen in brat¹¹/brat^DG19310 larval brains.

The formation of supernumerary type II neuroblasts is suppressed in homozygous klu^unspecified type II neuroblast clones in brat¹¹/brat^k06028 larval brains.

(Xiao et al., 2012)

Expression of pros^Scer\UAS.cMa, under the control of Scer\GAL4^αTub84B.PL, in brat¹¹ mutant larval clones significantly suppresses the overproliferation phenotype in these clones in the central larval brain. Over 90% of Scer\GAL4^αTub84B.PL>pros^Scer\UAS.cMa, brat¹¹ clones in the central brain have <100 cells, while over 80% of brat¹¹ clones have 200-1000 cells.

(Bello et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

brat¹¹/Df(2L)Exel8040 is rescued by brat^UAS.Tag:MYC/Scer\GAL4^wor.PA

(Komori et al., 2014)

brat¹¹/Df(2L)Exel8040 is rescued by Scer\GAL4^wor.PA/brat^{ΔB-box-1.UAS.Tag:MYC}

(Komori et al., 2014)

brat¹¹/Df(2L)Exel8040 is rescued by Scer\GAL4^wor.PA/brat^{ΔB-box-2.UAS.Tag:MYC}

(Komori et al., 2014)

brat¹¹/Df(2L)Exel8040 is rescued by Scer\GAL4^wor.PA/brat^{ΔC-coil.UAS.Tag:MYC}

(Komori et al., 2014)

brat¹¹/Df(2L)Exel8040 is rescued by Scer\GAL4^wor.PA/brat^{ΔNHL.UAS.Tag:MYC}

(Komori et al., 2014)

Partially rescued by

brat^2L-192-9/brat¹¹ is partially rescued by Scer\GAL4^RapGAP1-OK6/brat^UAS.Tag:FLAG

(Shi et al., 2013)

brat^2L-192-9/brat¹¹ is partially rescued by Scer\GAL4^elav.PU/brat^UAS.Tag:FLAG

(Shi et al., 2013)

Not rescued by

brat¹¹/Df(2L)Exel8040 is not rescued by brat^{ΔB-boxes.UAS.Tag:MYC}/Scer\GAL4^wor.PA

(Komori et al., 2014)

brat^2L-192-9/brat¹¹ is not rescued by brat^UAS.Tag:FLAG/Scer\GAL4^Mhc.PW

(Shi et al., 2013)

Comments

Expression of either brat^{Scer\UAS.T:Hsap\MYC}, brat^{ΔB-box-1.Scer\UAS.T:Hsap\MYC}, brat^{ΔB-box-2.Scer\UAS.T:Hsap\MYC}, brat^{ΔC-coil.Scer\UAS.T:Hsap\MYC} or brat^{ΔNHL.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^wor.PA suppresses the supernumerary type II neuroblast phenotype seen in brat¹¹/Df(2L)Exel8040 larval brains.

Expression of brat^{ΔB-boxes.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^wor.PA fails to suppress the supernumerary type II neuroblast phenotype seen in brat¹¹/Df(2L)Exel8040 larval brains.

(Komori et al., 2014)

Expression of brat^{Scer\UAS.T:Zzzz\FLAG} under the control of either Scer\GAL4^elav.PU or Scer\GAL4^RapGAP1-OK6 at 18[o]C partially rescues the increase in number of satellite boutons at the neuromuscular junction (NMJ) seen in brat¹¹/brat^2L-192-9 larvae. Expression under the control of Scer\GAL4^Mhc.PW at 18[o]C does not rescue the NMJ phenotype.

Expression of brat^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^elav.PU at 18[o]C partially rescues the endocytotic defects seen at the NMJ of brat¹¹/brat^2L-192-9 larvae.

(Shi et al., 2013)

Expression of brat^Scer\UAS.cSa under the control of Scer\GAL4^αTub84B.PL in brat¹¹ mutant clones partially rescues the overproliferation phenotype in the central larval brain.

(Bello et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

97265

brat¹¹; P{UAS-btau::GFP.T:Myc}2/CyO, P{en1}wg^en11; P{UASp-brat.H}3

97267

brat¹¹; P{UAS-btau::GFP.T:Myc}2/CyO, P{en1}wg^en11; P{UASp-brat.R837D}3

Notes on Origin

Discoverer

Wright.

External Crossreferences and Linkouts ( 3 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AF195870

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAF13926

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q8MQJ9

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

l(2)347

l(2)37Cf¹¹

(Gateff and Mechler, 1989)

Name Synonyms

Secondary FlyBase IDs

References (30)

Report Sections

Open Close