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General Information
Symbol
Dmel\brm2
Species
D. melanogaster
Name
FlyBase ID
FBal0001296
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
brm2 heterozygotes do not show an ectopic scutellar bristle phenotype, as compared to controls.
The formation of ectopic wing veins observed in adult flies expressing Marcal1Scer\UAS.cBa under the control of Scer\GAL4tub.PU is ameliorated by combination with a single copy of brm2.
brm2 mutant intestinal stem cell clones in 3-day old flies contain fewer cells than controls (1-2 cells, compared to an average of 5), and are composed of all small nuclear cells rather than a mixture of large and small nuclear cells. The same is seen at 8 days, suggesting that enteroblast differentiation is affected.
brm2/+ enhances the position effect variegation at the w locus which is seen in In(1)wm4 flies. 4% of heterozygous adult males show transformation of A6 to A5.
Heterozygotes have normal wings.
PBac{GH146-GAL4.B}-marked anterodorsal single cell clones in brm2 mutants display mistargeting to non-stereotyped glomeruli throughout the antennal lobe. PBac{GH146-GAL4.B}-marked neuroblast clones in brm2 mutants display phenotypes where dendrites make small, meandering projections throughout the antennal lobe and exhibit perturbed cell morphology.
Female germline clones homozygous for brm2 arrest their development early in oogenesis.
brm2/+ mutant adults display a low penetrant (1.4%) "held-out" wing phenotype.
S-phase in secondary precursor cells in the bristle lineage is prolonged by around 30 minutes in brm2 animals.
3.5% of heterozygotes have ectopic or duplicated macrochaetae.
7% of heterozygotes show loss of humeral bristles.
brm2/+ enhances the telomeric position effect (TPE) of P{hsp26-pt-T}39C-5, P{hsp26-pt-T}39C-27, P{hsp26-pt-T}39C-31 and P{wA}4-4.
2% of heterozygous flies have a held-out wings phenotype.
2% of heterozygotes have a held-out wing phenotype.
Heterozygotes have normal lymph glands, but the concentration of circulating hemocytes is reduced compared to controls.
Transformation of abdominal segment A6 to A5.
Shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w+mW.hs allele at the telomeres of the second and third chromosomes.
The size and frequency of homozygous clones in the head and thoracic segments are significantly reduced compared to controls. The size and frequency of homozygous and control clones in the abdomen are similar. The mechanosensory bristles of homozygous clones in the head, thoracic and abdominal segments are either duplicated, stunted or fused.
No effect on the eye pigment phenotype of wT81.
Pairing sensitive repression is unchanged in iab-7 PRE lines that carry brm2.
Mutation changes the level of w expression in ph-plac+3 flies; eye colour is lighter.
Majority of lethality is observed during embryogenesis. There are no major abnormalities in formation or identity of the trunk segments. Formation of larval head structures is abnormal but the nature of the defects is undetermined.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
brm2 has visible | dominant phenotype, enhanceable by pont[+]/pont5.1
brm2 has visible | dominant phenotype, enhanceable by vn[+]/vn643
brm2 has visible | dominant phenotype, enhanceable by Df(3L)ZN47/+
brm2 has visible | dominant phenotype, enhanceable by Dl2371/Dl[+]
brm2 has visible | dominant phenotype, enhanceable by Dl266/Dl[+]
brm2 has visible | dominant phenotype, enhanceable by Dl9P/Dl[+]
brm2 has visible | dominant phenotype, enhanceable by mor[+]/mor4
brm2 has visible | dominant phenotype, enhanceable by Bap60[+]/Bap601
brm2, trx[+]/trxE2 has visible | dominant phenotype, enhanceable by Bap60[+]/Bap601
brm2 has visible | dominant phenotype, enhanceable by osa1
brm2 has visible | dominant phenotype, enhanceable by tara20
brm2 has visible | dominant phenotype, enhanceable by tnaS058302/tara20
brm2 has visible | dominant phenotype, enhanceable by tara2
brm2 has visible | dominant phenotype, enhanceable by tnaS058302/tara2
brm2 has visible | dominant phenotype, enhanceable by tna1
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by JIL-1[+]/JIL-1z2
brm[+]/brm2, taraL4 has visible | dominant phenotype, enhanceable by trx[+]/trxE2
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by Asx[+]/Asx13
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by Asx3/Asx[+]
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by E(z)[+]/E(z)5
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by Psc[+]/Psc1
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by Sce[+]/SceD1
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by Su(z)21/Su(z)2[+]
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by Su(z)2Arp1/Su(z)2[+]
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by Su(z)4[+]/Su(z)41
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by Su(z)6[+]/Su(z)61
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by Su(z)7[+]/Su(z)71
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by Trl[+]/TrlR85
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by lidk06801/lid[+]
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by sxc[+]/sxc1
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by E(Pc)[+]/E(Pc)1
brm2, trx[+]/trxE2 has visible | dominant | homeotic phenotype, enhanceable by lawcp1/lawc[+]
brm2, trx[+]/trxE2 has visible | dominant | homeotic phenotype, enhanceable by lawc[+]/lawcEF520
brm2, trx[+]/trxE2 has visible | dominant | homeotic phenotype, enhanceable by Df(1)RA2/+
brm2, lawcp1 has visible | homeotic phenotype, enhanceable by trxE2
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by lawcp1/lawc[+]
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by lawc[+]/lawcEF520
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by Df(1)RA2/+
brm2, trx[+]/trxE2 has visible | dominant | homeotic phenotype, enhanceable by mod(mdg4)T16/mod(mdg4)[+]
brm2, trx[+]/trxE2 has visible | dominant | homeotic phenotype, enhanceable by mod(mdg4)[+]/mod(mdg4)ul
brm2, trx[+]/trxE2 has visible | dominant | homeotic phenotype, enhanceable by mod(mdg4)[+]/mod(mdg4)T6
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by mod(mdg4)T16/mod(mdg4)[+]
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by mod(mdg4)[+]/mod(mdg4)ul
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, enhanceable by mod(mdg4)[+]/mod(mdg4)T6
NOT Enhanced by
Statement
Reference
brm2 has visible | dominant phenotype, non-enhanceable by rept35/rept[+]/pont[+]/pont5.1
brm2 has visible | dominant phenotype, non-enhanceable by tnaS058302
brm2 has visible | homeotic phenotype, non-enhanceable by lawcp1
brm2 has visible | dominant | homeotic phenotype, non-enhanceable by lawcp1
brm2 has visible | dominant | homeotic phenotype, non-enhanceable by lawcEF520
brm2 has visible | dominant | homeotic phenotype, non-enhanceable by lawc+10
brm2 has visible | dominant | homeotic phenotype, non-enhanceable by Df(1)RA2
Suppressed by
Statement
Reference
brm[+]/brm2, trxE2 has homeotic | dominant phenotype, suppressible by CG9007[+]/upSETe00365
brm[+]/brm2, trxE2 has homeotic | dominant phenotype, suppressible by upSETMB08950/CG9007[+]
brm2, pont[+]/pont5.1 has visible | dominant phenotype, suppressible by pontUAS.cDa/Scer\GAL4arm.PS
brm2 has visible | dominant phenotype, suppressible by rept35/rept[+]
brm2, rept35/rept[+] has visible | dominant phenotype, suppressible by reptUAS.cDa/Scer\GAL4arm.PS
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, suppressible by dom14/dom[+]
brm2, trx[+]/trxE2 has visible | dominant | homeotic phenotype, suppressible by dom14/dom[+]
brm2 has visible | homeotic phenotype, suppressible by dom14/dom[+]
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, suppressible by M(2)21AB[+]/Sam-S1
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, suppressible by Pc3/Pc[+]
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, suppressible by Pcl7/Pcl[+]
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, suppressible by esc10/esc[+]
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, suppressible by esc21/esc[+]
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, suppressible by esc9/esc[+]
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, suppressible by mxc[+]/mxc1
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, suppressible by mxc[+]/mxcM1
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, suppressible by ph-d[+]/ph-d503
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, suppressible by phob/pho[+]
brm[+]/brm2, trxE2 has visible | dominant | homeotic phenotype, suppressible by sxc[+]/sxc4
Enhancer of
Statement
Reference
brm[+]/brm2 is an enhancer of neuroanatomy defective phenotype of bratDG19310/brat11
brm[+]/brm2 is an enhancer of neuroanatomy defective phenotype of numbNP2301
brm2 is an enhancer of visible phenotype of sd1
brm[+]/brm2 is an enhancer of visible | dominant phenotype of gcmPyx
osa2, osa[+], brm[+], brm2 is an enhancer of visible | dominant phenotype of gcmPyx
brm[+]/brm2 is an enhancer of visible phenotype of Df(2L)3G/γTub23CA14-9
brm[+]/brm2 is an enhancer of eye color defective phenotype of wPRECycA
brm[+]/brm2 is an enhancer of visible | dominant phenotype of mor4
brm[+]/brm2 is an enhancer of visible | dominant phenotype of Dl9P
brm[+]/brm2 is an enhancer of visible | dominant phenotype of Dl266
brm[+]/brm2 is an enhancer of visible | dominant phenotype of Dl2371
brm[+]/brm2 is an enhancer of visible phenotype of ct53d
brm2 is an enhancer of visible | dominant phenotype of osa1
brm2 is an enhancer of visible | dominant phenotype of tna1
trx[+], trxE2, brm[+], brm2 is an enhancer of visible | homeotic phenotype of lawcp1
NOT Enhancer of
Statement
Reference
brm[+]/brm2 is a non-enhancer of visible phenotype of E2f1UAS.cNa, Scer\GAL4Act88F.PD
brm[+]/brm2 is a non-enhancer of visible phenotype of DpUAS.cDa, E2f1UAS.cNa, Scer\GAL4GMR.PU
brm[+]/brm2 is a non-enhancer of visible phenotype of ctK
brm[+]/brm2 is a non-enhancer of visible | homeotic phenotype of Dsp11
Suppressor of
Statement
Reference
brm[+]/brm2 is a suppressor of visible | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU
brm[+]/brm2 is a suppressor of visible phenotype of E2f1dsRNA.UAS.cJa, Scer\GAL4GMR.PU
brm[+]/brm2 is a suppressor | partially of visible phenotype of E2f1dsRNA.UAS.cJa, Scer\GAL4ptc-559.1
brm[+]/brm2 is a suppressor of visible | dominant phenotype of Snr1E1
brm[+]/brm2 is a suppressor of visible | dominant phenotype of EgfrE3
brm2 is a suppressor | partially of visible | dominant phenotype of HDAC3B, Snr1E1/Snr1[+]
brm2 is a suppressor | partially of visible | dominant phenotype of HDAC104556, Snr1R3/Snr1[+]
brm2 is a suppressor | partially of visible | dominant phenotype of HDAC104556, Snr1E1/Snr1[+]
brm2 is a suppressor of lethal phenotype of Ras85DV12.sev, sevS11.Tag:MYC
NOT Suppressor of
Statement
Reference
brm[+]/brm2 is a non-suppressor of visible phenotype of E2f1UAS.cNa, Scer\GAL4Act88F.PD
brm[+]/brm2 is a non-suppressor of visible phenotype of DpUAS.cDa, E2f1UAS.cNa, Scer\GAL4GMR.PU
brm[+]/brm2 is a non-suppressor of visible phenotype of ctK
brm2 is a non-suppressor of visible phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS
Other
Statement
Reference
RelE20, brm[+]/brm2 has short lived | conditional phenotype
Su(var)3-3[+]/Su(var)3-3ΔN, brm2 has visible | dominant phenotype
γTub23CPl-2, brm[+]/brm2, osa1/osa[+] has visible | dominant phenotype
brm[+]/brm2, vnC221 has visible phenotype
brm[+]/brm2, vn643 has visible phenotype
brm[+]/brm2, mor4 has visible phenotype
Egfrf2, brm[+]/brm2 has visible phenotype
Dl266, brm[+]/brm2 has visible phenotype
Dl2371, brm[+]/brm2 has visible phenotype
brm[+]/brm2, tara1, trx[+]/trxE2 has visible | dominant phenotype
brm2, tara1/tara[+] has visible | dominant phenotype
brm2, tara1/tara[+], trx[+]/trxE2 has visible | dominant phenotype
brm2, taraL4/tara[+], trx[+]/trxE2 has visible | dominant phenotype
brm2, taraL4/tara[+] has visible | dominant phenotype
brm[+]/brm2, tara1/tara[+], trxE2 has visible | dominant phenotype
brm[+]/brm2, taraL4/tara[+], trxE2 has visible | dominant phenotype
Phenotype Manifest In
Enhanced by
Statement
Reference
brm2 has wing phenotype, enhanceable by pont[+]/pont5.1
brm2 has phenotype, enhanceable by +/Df(3L)vtd14
brm2 has macrochaeta phenotype, enhanceable by Df(3L)ZN47/+
brm2 has macrochaeta phenotype, enhanceable by Dl2371/Dl[+]
brm2 has macrochaeta phenotype, enhanceable by Dl266/Dl[+]
brm2 has macrochaeta phenotype, enhanceable by Dl9P/Dl[+]
brm2 has macrochaeta phenotype, enhanceable by mor[+]/mor4
brm2 has macrochaeta phenotype, enhanceable by vn[+]/vn643
brm2 has humeral bristle phenotype, enhanceable by Bap60[+]/Bap601
brm2, trx[+]/trxE2 has humeral bristle phenotype, enhanceable by Bap60[+]/Bap601
brm2 has wing phenotype, enhanceable by osa1
brm2 has wing phenotype, enhanceable by tnaS058302/tara03881
brm2 has wing phenotype, enhanceable by tara20
brm2 has wing phenotype, enhanceable by tnaS058302/tara20
brm2 has wing phenotype, enhanceable by tara2
brm2 has wing phenotype, enhanceable by tnaS058302/tara2
brm2 has wing phenotype, enhanceable by tna1
brm[+]/brm2, trxE2 has adult abdominal segment 5 | ectopic | male phenotype, enhanceable by JIL-1[+]/JIL-1z2
brm[+]/brm2, trxE2 has adult abdominal segment 6 | male phenotype, enhanceable by JIL-1[+]/JIL-1z2
brm[+]/brm2, taraL4 has wing phenotype, enhanceable by trx[+]/trxE2
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, enhanceable by Asx[+]/Asx13
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, enhanceable by Asx3/Asx[+]
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, enhanceable by E(Pc)[+]/E(Pc)1
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, enhanceable by E(z)[+]/E(z)5
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, enhanceable by Psc[+]/Psc1
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, enhanceable by Sce[+]/SceD1
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, enhanceable by Su(z)21/Su(z)2[+]
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, enhanceable by Su(z)2Arp1/Su(z)2[+]
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, enhanceable by Su(z)4[+]/Su(z)41
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, enhanceable by Su(z)6[+]/Su(z)61
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, enhanceable by Su(z)7[+]/Su(z)71
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, enhanceable by Trl[+]/TrlR85
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, enhanceable by lidk06801/lid[+]
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, enhanceable by sxc[+]/sxc1
brm2, trxB11/trx[+] has haltere phenotype, enhanceable by lawcp1/lawc[+]
brm2, trxB11/trx[+] has metathoracic leg phenotype, enhanceable by lawcp1/lawc[+]
brm[+]/brm2, trxE2 has haltere phenotype, enhanceable by lawcp1/lawc[+]
brm[+]/brm2, trxE2 has metathoracic leg phenotype, enhanceable by lawcp1/lawc[+]
brm2, lawcp1 has arista phenotype, enhanceable by trxE2
NOT Enhanced by
Statement
Reference
brm2 has wing phenotype, non-enhanceable by rept35/rept[+]/pont[+]/pont5.1
brm2 has wing phenotype, non-enhanceable by tnaS058302
Suppressed by
Statement
Reference
brm[+]/brm2, trxE2 has metathoracic leg phenotype, suppressible by CG9007[+]/upSETe00365
brm[+]/brm2, trxE2 has metathoracic leg phenotype, suppressible by upSETMB08950/CG9007[+]
brm2, pont[+]/pont5.1 has wing phenotype, suppressible by pontUAS.cDa/Scer\GAL4arm.PS
brm2 has wing phenotype, suppressible by rept35/rept[+]
brm2, rept35/rept[+] has wing phenotype, suppressible by reptUAS.cDa/Scer\GAL4arm.PS
brm2, rhove-1 has wing vein L5 phenotype, suppressible by Snr1E1
brm[+]/brm2, trxE2 has abdominal segment 6 phenotype, suppressible by dom14/dom[+]
brm2 has abdominal segment 6 phenotype, suppressible by dom14/dom[+]
brm2, trx[+]/trxE2 has abdominal segment 6 phenotype, suppressible by dom14/dom[+]
brm2, trx[+]/trxE2 has haltere phenotype, suppressible by dom14/dom[+]
brm[+]/brm2, trxE2 has haltere phenotype, suppressible by dom14/dom[+]
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, suppressible by M(2)21AB[+]/Sam-S1
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, suppressible by Pc3/Pc[+]
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, suppressible by Pcl7/Pcl[+]
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, suppressible by esc10/esc[+]
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, suppressible by esc21/esc[+]
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, suppressible by esc9/esc[+]
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, suppressible by mxc[+]/mxc1
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, suppressible by mxc[+]/mxcM1
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, suppressible by ph-d[+]/ph-d503
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, suppressible by phob/pho[+]
brm[+]/brm2, trxE2 has adult metathoracic segment phenotype, suppressible by sxc[+]/sxc4
Enhancer of
Statement
Reference
brm[+]/brm2 is an enhancer of type II neuroblast | supernumerary phenotype of numbNP2301
brm2 is an enhancer of wing phenotype of sd1
brm[+]/brm2 is an enhancer of chaeta | supernumerary phenotype of gcmPyx
osa2, osa[+], brm[+], brm2 is an enhancer of chaeta | supernumerary phenotype of gcmPyx
brm[+]/brm2 is an enhancer of leg phenotype of e(y)34
brm[+]/brm2 is an enhancer of wing phenotype of Df(2L)3G/γTub23CA14-9
brm[+]/brm2 is an enhancer of pigment cell phenotype of wPRECycA
brm[+]/brm2 is an enhancer of humeral bristle phenotype of vnC221
brm[+]/brm2 is an enhancer of macrochaeta phenotype of mor4
brm[+]/brm2 is an enhancer of macrochaeta phenotype of Dl9P
brm[+]/brm2 is an enhancer of macrochaeta phenotype of Dl266
brm[+]/brm2 is an enhancer of ommatidium phenotype of Dl266
brm[+]/brm2 is an enhancer of macrochaeta phenotype of Dl2371
brm[+]/brm2 is an enhancer of ommatidium phenotype of Dl2371
brm[+]/brm2 is an enhancer of wing phenotype of ct53d
brm2 is an enhancer of wing vein L5 phenotype of rhove-1
brm2 is an enhancer of wing phenotype of osa1
brm2 is an enhancer of wing phenotype of tna1
brm2 is an enhancer of thorax phenotype of ChiE
brm[+]/brm2 is an enhancer of adult abdomen | somatic clone phenotype of Snr1R3
brm[+]/brm2 is an enhancer of adult abdominal segment 4 | ectopic phenotype of E(z)Trm
brm[+]/brm2 is an enhancer of adult abdominal segment 5 phenotype of E(z)Trm
brm[+]/brm2 is an enhancer of adult mesothoracic segment | ectopic phenotype of E(z)Trm
brm[+]/brm2 is an enhancer of adult metathoracic segment phenotype of E(z)Trm
brm[+]/brm2 is an enhancer of adult prothoracic segment phenotype of E(z)Trm
brm[+]/brm2 is an enhancer of wing margin phenotype of Scer\GAL4en-e16E, shgUAS.cSa
brm[+]/brm2 is an enhancer of eye phenotype of Scer\GAL4ey.PH, osaUAS.cCa
trx[+], trxE2, brm[+], brm2 is an enhancer of arista phenotype of lawcp1
trx[+], trxE2, brm[+], brm2 is an enhancer of phenotype of mod(mdg4)ul
NOT Enhancer of
Statement
Reference
brm[+]/brm2 is a non-enhancer of wing phenotype of E2f1UAS.cNa, Scer\GAL4Act88F.PD
brm[+]/brm2 is a non-enhancer of eye phenotype of DpUAS.cDa, E2f1UAS.cNa, Scer\GAL4GMR.PU
brm[+]/brm2 is a non-enhancer of phenotype of ct6
brm[+]/brm2 is a non-enhancer of triple row phenotype of ctK
brm[+]/brm2 is a non-enhancer of phenotype of ct2s
brm[+]/brm2 is a non-enhancer of wing vein | ectopic phenotype of net1
brm[+]/brm2 is a non-enhancer of haltere phenotype of Dsp11
brm[+]/brm2 is a non-enhancer of wing | ectopic phenotype of Dsp11
brm2 is a non-enhancer of eye phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS
Suppressor of
Statement
Reference
brm[+]/brm2 is a suppressor of eye phenotype of E2f1dsRNA.UAS.cJa, Scer\GAL4GMR.PU
brm[+]/brm2 is a suppressor of wing vein | ectopic phenotype of Snr1E1
brm[+]/brm2 is a suppressor of eye phenotype of EgfrE3
brm2 is a suppressor | partially of wing vein | ectopic phenotype of bs2
brm2 is a suppressor of wing vein | ectopic phenotype of Snr1E1
brm2 is a suppressor | partially of wing vein | ectopic phenotype of bs03267
brm2 is a suppressor | partially of wing vein | ectopic phenotype of HDAC3B, Snr1R3/Snr1[+]
brm2 is a suppressor | partially of wing phenotype of HDAC3B, Snr1R3/Snr1[+]
brm2 is a suppressor | partially of wing vein | ectopic phenotype of HDAC104556, Snr1R3/Snr1[+]
brm2 is a suppressor | partially of wing vein | ectopic phenotype of HDAC104556, Snr1E1/Snr1[+]
brm2 is a suppressor | partially of wing phenotype of HDAC104556, Snr1R3/Snr1[+]
brm2 is a suppressor | partially of wing phenotype of HDAC104556, Snr1E1/Snr1[+]
brm2 is a suppressor of dorsocentral bristle phenotype of ChiE
brm2 is a suppressor of eye phenotype of CycEJP
brm2 is a suppressor of wing vein L5 phenotype of CycEJP
brm2 is a suppressor of wing phenotype of CycEJP
brm[+]/brm2 is a suppressor of eye phenotype of Scer\GAL4ey.PH, asf1UAS.cMa
brm[+]/brm2 is a suppressor | partially of eye phenotype of armS56F.GMR
brm[+]/brm2 is a suppressor of eye phenotype of DrefUAS.cSa, Scer\GAL4GMR.PS
brm2 is a suppressor of sex comb | ectopic phenotype of Asxunspecified, Pcl[-]/+, Psc[-]
brm2 is a suppressor of sex comb | ectopic phenotype of Asx[-], Pcl[-]/+, Pscunspecified
brm2 is a suppressor of phenotype of Pcunspecified
brm2 is a suppressor of sex comb | ectopic phenotype of Asx[-], Pclunspecified, Psc[-]
brm2 is a suppressor of phenotype of Pc4
NOT Suppressor of
Statement
Reference
brm[+]/brm2 is a non-suppressor of wing phenotype of E2f1UAS.cNa, Scer\GAL4Act88F.PD
brm[+]/brm2 is a non-suppressor of eye phenotype of DpUAS.cDa, E2f1UAS.cNa, Scer\GAL4GMR.PU
brm[+]/brm2 is a non-suppressor of phenotype of ct2s
brm[+]/brm2 is a non-suppressor of phenotype of ct6
brm[+]/brm2 is a non-suppressor of triple row phenotype of ctK
brm[+]/brm2 is a non-suppressor of wing vein | ectopic phenotype of net1
brm[+]/brm2 is a non-suppressor of lamellocyte phenotype of hopTum
brm[+]/brm2 is a non-suppressor of lamellocyte phenotype of Tl10b
brm[+]/brm2 is a non-suppressor of embryonic/larval hemocyte phenotype of Tl10b
brm[+]/brm2 is a non-suppressor of plasmatocyte phenotype of Tl10b
brm[+]/brm2 is a non-suppressor of podocyte phenotype of Tl10b
brm2 is a non-suppressor of eye phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS
trxE2/brm2 is a non-suppressor of wing phenotype of Scer\GAL4OK386, nejUAS.cMa
Other
Statement
Reference
Su(var)3-3[+]/Su(var)3-3ΔN, brm2 has wing vein | ectopic phenotype
γTub23CPl-2, brm[+]/brm2, osa1/osa[+] has wing phenotype
brm2, vn[+]/vn643 has wing phenotype
brm2, vn[+]/vnC221 has wing phenotype
KrIf-1, brm[+]/brm2 has eye phenotype
brm[+]/brm2, tara1, trx[+]/trxE2 has wing phenotype
brm2, tara1/tara[+] has wing phenotype
brm2, tara1/tara[+], trx[+]/trxE2 has wing phenotype
brm2, taraL4/tara[+] has wing phenotype
brm2, taraL4/tara[+], trx[+]/trxE2 has wing phenotype
brm2, trx[+]/trxE2 has wing phenotype
brm[+]/brm2, tara1/tara[+], trxE2 has wing phenotype
brm[+]/brm2, taraL4/tara[+], trxE2 has wing phenotype
SceD1, brm[+]/brm2, trx[+]/trx2 has metathoracic leg phenotype
Snr1R3/Snr1[+], brm2 has humerus phenotype
ash11, brm[+]/brm2 has haltere phenotype
ash128, brm[+]/brm2 has haltere phenotype
ash16, brm[+]/brm2 has haltere phenotype
ash1[+]/ash11, brm2 has haltere phenotype
ash1[+]/ash11, brm2 has scutellum phenotype
ash1[+]/ash16, brm2 has haltere phenotype
ash1[+]/ash16, brm2 has scutellum phenotype
ash128/ash1[+], brm2 has haltere phenotype
Additional Comments
Genetic Interactions
Statement
Reference
sxcH537A/+, brm2/+ individuals and sxcH537A/sxcH537A, brm2/+ individuals show a minor ectopic scutellar bristle phenotype, as compared to controls.
Flies heterozygous for both RelE20 and brm2 show a significant decrease in survival following Erwinia carotovora Ecc15 infection.
One copy of brm2 enhances the supernumerary neuroblast phenotype seen in bratDG19310/brat11 mutants. One copy of brm2 enhances the supernumerary neuroblast phenotype seen in numbNP2301 mutant larval brains.
One copy of brm2 enhances the scalloped wing phenotype seen in sd1 mutant males. brm2 completely suppresses the significant increase in cell numbers seen in intestinal stem cell clones overexpressing of ykiScer\UAS.cZa under the control of Scer\GAL4esg-NP5130.
12% of TrlR85/brm2 double heterozygous adult males show transformation of A6 to A5.
56% of brm2 trxE2 double heterozygotes have an apical bristle on the third leg (usually found on the second leg). Heterozygosity for either upSETe00365 or upSETMB08950 reduces the penetrance of this phenotype to 9% or 4% respectively.
Su(var)3-3ΔN brm2 double heterozygotes can have ectopic wing vein material distal to the posterior crossvein.
brm2/+ significantly suppresses the notched wing phenotype resulting from the expression of phlScer\UAS.F179 via Scer\GAL4bbg-C96. The small rough eye phenotype of EgfrE3/+ is suppressed by brm2/+.
The ectopic wing vein phenotype observed in homozygous bs2 mutant wings is suppressed in animals doubly heterozygous for osa308 and brm2. net1, px72 double mutants develop ectopic wing veins in the L2/L3 and L4/L5 intervein regions. This phenotype is suppressed in flies double heterozygous for osa308 and brm2.
brm2 acts as strong dominant enhancer of the penetrance of the e(y)34/Y bent-leg phenotype in male flies.
The low-penetrance "held-out" wing phenotype of brm2/+ adults is enhanced in a pont5.1/+ background. Held-out wings are observed in 15% of double-heterozygous animals compared to 1.4% in brm2/+ mutants. Co-expression of pontScer\UAS.cDa under the control of Scer\GAL4arm.PS in brm2/pont5.1 animals reduces the penetrance of the wing phenotype to 1.7%. The low-penetrance "held-out" wing phenotype of brm2/+ adults is suppressed in a rept35/+ background. Held-out wings are observed in 0.6% of double-heterozygous animals compared to 1.4% in brm2/+ mutants. Co-expression of reptScer\UAS.cDa under the control of Scer\GAL4arm.PS in brm2/rept35 animals completely rescues the wing phenotype. Triple-heterozygous brm2, pont5.1, and rept35 mutant adults have a "held-out" wing phenotype at a low penetrance (2.1%), quite similar to the penetrance observed in brm2/+ animals. The wings of brm2/+ animals expressing pontD302N.Scer\UAS under the control of Scer\GAL4arm.PS display a "held-out" phenotype in 35.5% of animals, much enhanced compared to brm2/+.
γTub23CPl-2 results in a held-out wing phenotype in double heterozygous combination with brm2 (76% penetrance). γTub23CPl-2/+ ; brm2/osa1 triple heterozygous flies show poor survival and have twisted and blistered wings. The reduced viability of γTub23CA14-9/γTub23CA6-2, γTub23CA14-9/γTub23CA15-2 and γTub23CA14-9/Df(2L)3G flies is not further reduced by brm2/+.
Df(2R)ED3921; brm2/+ flies show an enhancement of the loss of vein L5 seen in Df(2R)ED3921 single mutants and a new held out wing phenotype not observed in either single mutant.
The penetrance of the loss of humeral bristle phenotype seen in brm2/+ flies is increased by Bap601/+ from 7% to 14%. 5% of brm2 trxE2 double heterozygotes show loss of humeral bristles. The penetrance of this phenotype is increased to 15% by Bap601/+.
Pc4/brm2 animals have an incomplete L3 wing vein (15%). brm2 enhances the loss of wing vein L5 seen in rhove-1 homozygotes. Snr1E1 suppresses the shortened L5 wing vein that results from the interaction between rhove-1 and brm2.
Rpd304556/brm2 double heterozygotes have a normal wing phenotype. The ectopic wing vein phenotype seen in Rpd304556/Snr1R3, Rpd304556/Snr1E1 and Hdac3N/Snr1E1 double heterozygotes at 29oC is partially suppressed by brm2/+.
100% of brm2/tna1 flies have a held-out wings phenotype. brm2/tnaS058302 flies do not have a held-out wings phenotype. 23% of brm2/tara2 flies have a held-out wings phenotype. 8% of brm2/tara20 flies have a held-out wings phenotype. 60% of brm2/tnaS058302 tara2 flies have a held-out wings phenotype. 75% of brm2/tnaS058302 tara20 flies have a held-out wings phenotype. Less than 1% of brm2/tara03881 flies have a held-out wings phenotype. 30% of brm2/tnaS058302 tara03881 flies have a held-out wings phenotype. 100% of brm2/osa1 flies have a held-out wings phenotype.
5+/-1% of KrIf-1/+ flies born to brm2/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers.
brm2 trxE2 double heterozygous males show a low frequency of A6 to A5 transformation; the frequency is 9% if brm2 trxE2 is maternally derived and 17% if brm2 trxE2 is paternally derived. The frequency of A6 to A5 transformation seen in brm2 trxE2 double heterozygous males is increased if they also carry JIL-1z2; the frequency is 65% if JIL-1z2 is maternally derived and brm2 trxE2 is paternally derived and is 75% in the reciprocal cross.
Homozygous Snr1R3 clones induced in a brm2/+ background are less frequently observed and are smaller in size compared to both brm+ and control clones induced at similar stages, suggesting an additive effect between brm and Snr1. The presence of brm2/+ enhances the Snr1R3 clone phenotype in the abdomen.
Suppresses the CycEJP rough eye phenotype.
12% of brm2 taraL4 double heterozygotes have a held-out wing phenotype. 10% of brm2 tara1 double heterozygotes have a held-out wing phenotype. 5% of trxE2 brm2 double heterozygotes have a held-out wing phenotype. 45% of trxE2 brm2 taraL4 triple heterozygotes have a held-out wing phenotype. 38% of trxE2 brm2 tara1 triple heterozygotes have a held-out wing phenotype.
brm2/+ suppresses the rough eye phenotype due to Scer\GAL4ey.PH; asf1Scer\UAS.cMa.
The increased concentration of circulating hemocytes seen in mxcG43 larvae is suppressed by brm2/+. The increased concentration of circulating hemocytes seen in hopTum larvae is significantly reduced by brm2/+, although lamellocyte ratios remain unchanged in the double mutants.
brm2/+ does not significantly enhance the frequency of transformation of halteres into wings seen in Dsp11/Y flies.
A brm2/+, background significantly suppresses the rough eye phenotype found in flies expressing DrefScer\UAS.cSa under the control of Scer\GAL4GMR.PS.
The abdominal segment A6 to A5 transformation and the haltere to wing transformation of brm2/+, trxE2/+ is dominantly suppressed by dom14.
SceD1/+ ; brm2/+ flies can show minimal transformation of the third leg to second leg; the third leg can have an apical bristle but does not have sternopleural bristles (both characteristics of the wild-type second leg). SceD1/+ ; brm2 trx2/+ triple heterozygotes show transformations of third leg to second leg, having both apical and preapical bristles on the distal tibia of the third leg (which are characteristic of the wild-type second leg). The third leg may also have sternopleural bristles (characteristics of the wild-type second leg). Double heterozygotes with Df(2L)Mdh, Df(2R)or-BR6, Df(3L)Ar14-8, Df(2L)cl-h3, Df(2R)Pu-D17, lidk06801, E(Pc)1, Su(z)21, Psc1, TrlR85, Su(z)71, Su(z)61, AsxXF23, Asx3 or Asx13 show T3 to T2 transformations. 35.3% of trxE2 brm2 double heterozygotes show T3 to T2 transformations. The penetrance of this phenotype is enhanced by one copy of lidk06801, sxc1, SceD1, E(z)5, TrlR85, Su(z)41, Su(z)71, Su(z)61, E(Pc)1, Su(z)21, Su(z)2Arp1, Psc1, Asx3 or Asx13 and suppressed by one copy of Pc3, ph-d503, Pcl7, phob, mxcM1, mxc1, esc9, esc10, esc21, sxc4 or M(2)21AB1.
Mutant heterozygotes show a strong enhancement of the eye phenotype seen in P{UAS-lacZ.Abd-B.5F24}, leading to lighter eyes.
The addition of brm2 enhances the variable eye size phenotype seen in osaScer\UAS.cCa/Scer\GAL4ey.PH flies.
brm2 osa2 double heterozygotes have held-out wings in 97% of cases, a phenotype which is rarely seen in either single heterozygote. brm2 osa11 double heterozygotes have held-out wings in 35% of cases, a phenotype which is rarely seen in either single heterozygote. brm2 osa12 double heterozygotes have held-out wings. brm2 osa1 double heterozygotes have held-out wings. This phenotype is partially suppressed if the flies are also carrying brm+t14.4. brm2 shows little if any interaction in double heterozygous combination with Trl62, Trl3, Snr101319, skd2, skd3, btldev1, btldev2, Vha5516, kto3, kis1 or kis2; less than 3% of flies have held-out wings. brm2 shows some interaction in double heterozygous combination with mor1 or mor2; slightly more than 20% of flies have held-out wings. brm2 trxE2 and brm2 ash16 double heterozygotes show partial transformation of the 5th abdominal segment to fourth abdominal segment, but do not hold out their wings at any significantly higher frequency than that seen in brm2/+ single heterozygotes.
The frequency of homeotic transformations in heterozygotes is not enhanced by lawcp1, lawcEF520, lawc+10 or Df(1)RA2. The frequency and severity of homeotic transformations (such as haltere to wing or third leg to second leg transformations) in brm2 trxE2 double heterozygotes is dominantly enhanced by lawcp1. The enhancement is stronger in a lawcp1 maternal background. The arista to leg transformation characteristic of lawcp1 is also enhanced in these flies. The frequency of homeotic transformations in brm2 trxE2 double heterozygotes is dominantly enhanced by lawcEF520 or Df(1)RA2. lawcp1/lawcEF520 females are viable. However, in combination with brm2, lawcp1/lawcEF520 results in lethality. lawcp1/Df(1)RA2 females are viable. However, in combination with brm2, lawcp1/Df(1)RA2 results in lethality.
10.0% of trxE2 brm2 double heterozygous adults show a homeotic phenotype. This is increased to 56.5% if the flies are also heterozygous for mod(mdg4)T16, 24.9% if the flies are also heterozygous for mod(mdg4)ul and 35.7% if the flies are also heterozygous for mod(mdg4)T6. The combination brm2 trxE2 dominantly enhances the effect of mod(mdg4)ul on the y2 phenotype.
The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by brm2.
Double heterozygotes with ash1 mutations exhibit transformation of third leg to second leg identity and haltere to wing transformation.
Completely suppresses the extra sex comb phenotype of Psc-,Asx-,Pcl-/+ males.
Snr1R3/brm2 transheterozygous adults display prothoracic defects, including loss of the humerus.
Heterozygotes of ash11, ash16, and ash128 with brm2 have homeotic transformations of the third to the second leg. The expressivity of the transformed leg is variable, some have only a second leg apical bristle while others have a second leg preapical bristle as well. There is a lower penetrance of third leg transformations among flies heterozygous for ash11, ash16, and ash128 with brm5. Degree of penetrance corresponds to the severity of the ash1 allele (ash11 < ash16 < ash128). There is a lower penetrance of partial homeotic transformation of the haltere to the wing, or dorsal metathoracic cuticle to mesothoracic cuticle, and an even lower penetrance of first leg to second leg transformations.
Suppresses all Pc leg transformations and Pcl second and third leg to first leg transformations. trxE2, brm2 double heterozygotes frequently display homeotic transformations: fifth abdominal segment is transformed to a more anterior identity and haltere to wing.
Suppresses the extra sex comb phenotype of Pc4, Ts(YLt;2Lt)L124. Causes between 50% and 100% suppression of the Pc4/+ extra sex combs phenotype.
Xenogenetic Interactions
Statement
Reference
The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1Scer\UAS.cBa under the control of Scer\GAL4Bx-MS1096 is ameliorated by combination with a single copy of brm2.
Complementation and Rescue Data
Comments
The mechanosensory bristle phenotypes are rescued if the clones are carrying brm+t14.4. Homozygous and hemizygous lethality is rescued by brm+t14.4. Hemizygous lethality is rescued by brmΔ1446-1517. brm2/Df(3L)th102 animals carrying two copies of brmK804R.T:Ivir\HA1 do not survive to adulthood.
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Mutant
Wild-type
Stocks (4)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (100)