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General Information
Symbol
Dmel\bs2
Species
D. melanogaster
Name
FlyBase ID
FBal0001305
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Heterozygous bs2 mutant flies show a significant loss of visual orientation memory.

    Transheterozygous bs2/bs1348 mutant flies show a significant loss of visual orientation memory.

    Homozygous flies have ectopic wing vein tissue.

    bs2 and bs2/In(2LR)Px4 mutants do not increase sleep after social enrichment.

    Circadian rhythms are intact in bs2 mutants.

    Homozygous bs2 mutant wings show ectopic wing vein tissue in the distal regions of the L3, L4 and most L5 veins.

    Wings from bs2 heterozygotes are normal.

    Homozygotes have extra wing veins.

    bs03267/bs2 is a viable combination that displays almost entirely wing vein tissue in the wing.

    Extra vein mutation.

    More extreme allele than bs1. RK2.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhanced by
    Statement
    Reference

    bs2 has visible phenotype, enhanceable by Bap170hfl1/Bap170[+]

    Enhancer of
    Statement
    Reference

    bs[+]/bs2 is an enhancer of visible phenotype of if3

    Suppressor of
    Statement
    Reference

    bs[+]/bs2 is a suppressor of visible phenotype of LIMK1UAS.cCa, Scer\GAL4en-e16E

    bs2 is a suppressor | partially of visible phenotype of cswlf

    bs03267/bs2 is a suppressor of visible phenotype of rho9/rhove-1, vnM2/vn1

    Phenotype Manifest In
    Enhanced by
    Statement
    Reference

    bs2 has wing vein | ectopic phenotype, enhanceable by Bap170hfl1/Bap170[+]

    Suppressed by
    Statement
    Reference

    bs2 has wing vein | ectopic phenotype, suppressible | partially by brm2

    NOT suppressed by
    Statement
    Reference

    bs2 has phenotype, non-suppressible by su(Hw)2

    Enhancer of
    Statement
    Reference

    bs[+]/bs2 is an enhancer of wing vein | ectopic phenotype of Snr1E1

    bs2 is an enhancer of wing vein | ectopic phenotype of rhohs.PSt

    bs[+]/bs2 is an enhancer of wing phenotype of if3

    Suppressor of
    Statement
    Reference

    bs[+]/bs2 is a suppressor of wing phenotype of LIMK1UAS.cCa, Scer\GAL4en-e16E

    bs2 is a suppressor | partially of wing vein phenotype of cswlf

    bs03267/bs2 is a suppressor of wing vein phenotype of rho9/rhove-1, vnM2/vn1

    bs2 is a suppressor of wing vein phenotype of rhove-1

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Bap170hfl1/+ enhances the ectopic wing vein phenotype of bs2 homozygotes.

    The ectopic wing vein phenotype observed in homozygous bs2 mutant wings is suppressed in animals doubly heterozygous for osa308 and brm2.

    Overexpression of osaC819 by Scer\GAL4MD-638 enhances the ectopic veins observed in bs2 mutant animals.

    bs2/+ suppresses the mutant wing phenotype caused by expression of LIMK1Scer\UAS.cCa under the control of Scer\GAL4en-e16E (the % of wings with normal morphology at 18oC is increased from 9% to 81%).

    The bs2 extra wing vein phenotype is enhanced by emc1/emc11. emc1 clones in bs2 wings differentiate as vein everywhere in the wing blade covering intervein regions as vein.

    bs03267/bs2; rho9, vnM2/rhove-1, vn1 triple mutants show an almost wild type wing vein pattern.

    Enhancement of rhohs.PSt ectopic vein phenotype and suppression of the rhove-1 loss of vein phenotype.

    Enhances the wing blister phenotype of if3 flies.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments

    Expression of bsScer\UAS.cHa in ring neurons under the control of any of Scer\GAL4c105 (R1), Scer\GAL4EB1 (R2) or Scer\GAL4Aph-4-c232 (R3/R4d) rescues the visual orientation memory defects seen in heterozygous bs2 mutants. Expressing bsScer\UAS.cHa under the control of Scer\GAL4ftz.ng (R4) in bs2 mutant flies leads to general locomotor and orientation defects so these flies could not be tested for visual orientation memory phenotype defects.

    Images (1)
    Stocks (2)
    Notes on Origin
    Discoverer

    Bridges, 24 Nov. 1925.

    Comments
    Comments

    bs2/Df(2R)Px1 easily separable from +/Df(2R)Px1, especially at or below 19oC.

    Wing phenotype caused by same mechanism as that of px.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    References (16)