Allele Dmel\bss²

General Information
Symbol	Dmel\bss²	Species	D. melanogaster
Name		FlyBase ID	FBal0001326
Feature type	allele	Associated gene	Dmel\bss

Allele class
Mutagen
Recent Updates
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	bang sensitive \| semidominant (Ganetzky and Wu, 1982) behavior defective \| semidominant (Kulkarni et al., 1988) paralytic \| semidominant (Ganetzky and Wu, 1982)
Phenotype Manifest In

Detailed Description
	Statement Reference Electroconvulsive stimulation delivered to the brain of bss¹ flies reproducibly induces the bang-sensitive repertoire of seizure behaviour; such electroconvulsive seizures can actually be induced in wild-type flies but this requires more extreme stimulus intensities than for bss² flies. The failure and recovery of the giant fibre (GF) pathway can be detected by recording the dorsal longitudinal muscle (DLM) physiological response. Following 1 Hz brain stimulation, bss² mutants have a significantly longer period of DLM response failure, and have an increased sensitivity for induction of this response failure, compared to wild type. Additionally, the maximal initial discharge induction is shifted toward lower stimulus intensities in the mutant flies. (Lee and Wu, 2002) Bang sensitive paralytic mutant. (Ganetzky and Wu, 1982)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Phenotype suppressed by mle^nap-ts1, even at permissive temperatures. (Ganetzky and Wu, 1982)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	bss² bss^PC75 (Kulkarni et al., 1988, )
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Lee and Wu, 2002, J. Neurosci. 22(24): 11065--11079 Electroconvulsive seizure behavior in Drosophila: analysis of the physiological repertoire underlying a stereotyped action pattern in bang-sensitive mutants. [FBrf0155894] Kulkarni et al., 1988, Genetics 118: 267--285 The dissonance mutant of courtship song in Drosophila melanogaster: Isolation, behavior and cytogenetics. [FBrf0048204] Ganetzky and Wu, 1982, Genetics 100(4): 597--614 Indirect suppression involving behavioral mutants with altered nerve excitability in Drosophila melanogaster. [FBrf0038065]

Allele Dmel\bss2

Allele Dmel\bss²