Open Close
General Information
Symbol
Dmel\bw1
Species
D. melanogaster
Name
FlyBase ID
FBal0001342
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
bw
Allele class
Mutagen
Nature of the Allele
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

21-days old bw1 mutant adults raised at 29[o]C do not show significantly changes in PPL1 neurons, as compared to age-matched controls.

Sound-evoked compound action potentials in the antennal nerve are not significantly different from wild type in mutant flies. However, nonlinear mechanical amplification is significantly increased compared to wild type.

Mutant flies have significantly fewer synaptic vesicles in the terminals of the photoreceptor cells R1-R6 in the lamina. However, in contrast to the absolute numbers of synaptic vesicles, the profile density is not significantly different from wild type.

Male heterozygous and homozygous bw1 flies have an increased resistance to the anesthetic enflurane compared to wild-type controls, as judged by climbing ability. This effect is true whether enflurane resistance is measured in regular light or red light. bw1 male flies show no increased resistance to the anesthetic halothane compared to wild-type flies when climbing ability is measured in regular light. However, bw1 mutants show increased sensitivity to this anesthetic when climbing ability is measured in red light.

Affects the formation of drosopterins and reduces level of ommochrome in the eye.

Red pigments lacking. Xanthommatin mostly replaced by dihydroxanthommatin. Pigment granules present but somewhat smaller than in wild type.

Malpighian tubule colour: pale yellow. Testes colour: colourless.

Eye colour: brown. Eye colour: light brownish wine on emergence, darkening to garnet. Eye colour: white, with cn1. Eye colour: white, with st1. Eye colour: white, with v1.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement
Reference

bw1 has chemical resistant | dominant | male phenotype, non-enhanceable by st1

NOT suppressed by
Statement
Reference

bw1 has chemical resistant | dominant | male phenotype, non-suppressible by st1

Enhancer of
Statement
Reference
Other
Statement
Reference
Phenotype Manifest In
NOT suppressed by
Statement
Reference

bw1 has phenotype, non-suppressible by su(Hw)2

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The glycerol hypersensitivity of flies expressing GykdsRNA.Scer\UAS under the control of Scer\GAL4c564 (seen as a reduction in survival on a glycerol only food source) is enhanced if the flies are also heterozygous for bw1.

The increased resistance of bw1 homozygous males to enflurane is not enhanced or suppressed by st1/st1. bw1/+, st1/+ males from bw1, st1 homozygous mothers show increased resistance to halothane when tested under red light and a slight increase in this resistance when tested under white light. A maternal effect is necessary for this phenotype as it is not seen in bw1/+, st1/+ males from bw1, st1 homozygous fathers.

Eye colour: off-white, with In(2LR)Nella.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (2)
Stocks (2,271)
Notes on Origin
Discoverer
Comments
Comments

Marker mutation present in the strain used in the genome sequencing project.

Eye color autonomous when transplanted into wild-type host.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (35)