Allele Dmel\bw^D

General Information
Symbol	Dmel\bw^D	Species	D. melanogaster
Name		FlyBase ID	FBal0001375
Feature type	allele	Associated gene	Dmel\bw
Also Known As	bwD, brown^Dominant

Allele class	amorphic allele - genetic evidence
Mutagen	spontaneous
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Talbert et al., 1994, Henikoff et al., 1995)
Mutagen	spontaneous
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AF047460

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion of sequences, interrupting Gly 577 of the open reading frame. (Platero et al., 1998) Insertion of a large block (greater than 1 megabase) of heterochromatin containing AAGAG satellite into the coding region of bw. (Csink and Henikoff, 1996) Insertion of a block of heterochromatin into the bw locus. (Dernburg et al., 1996) bw gene is interrupted by sequences that lack tested restriction sites and are likely to be simple sequence repeats characteristic of heterochromatin. (Talbert et al., 1994)
Caused by aberration	Dp(?;2)bw^D (Platero et al., 1998, Henikoff and Comai, 1998, Delattre et al., 2000, Kosak and Groudine, 2004, Csink et al., 2002, Sage and Csink, 2003, Talbert et al., 1994, Henikoff et al., 1995, Dernburg et al., 1996, Belyaeva et al., 1997)
Carried on aberration	Byron (Henikoff et al., 1995) Dp(2;2)bw-DX7.bw^D (Sass and Henikoff, 1999)
Cytology
Phenotypic Data
Phenotypic Class
	enhancer of variegation, with lawc^p1 (Zorin et al., 1999) eye color defective (Dernburg et al., 1996, Talbert et al., 1994) eye color defective \| dominant (Schneiderman et al., 2010) fertile viable visible \| dominant (Talbert et al., 1994)
Phenotype Manifest In
	eye (Schneiderman et al., 2010) pigment cell (Dernburg et al., 1996, Talbert et al., 1994) wing
Detailed Description
	Statement Reference Only about 5% of the eye cells are pigmented in bw[D]/+ heterozygous flies. (Schneiderman et al., 2010) When the polyamide P31 is fed to bw^D flies a developmental delay (not seen in wild-type) is observed. This is seen in both heterozygotes and homozygotes, though is more marked in homozygotes. These flies also exhibit a transformation of abdominal segment A6 to A5 and slight roughening of the eye. The addition of P31 enhances the A6 to A5 phenotypes seen in bw^D, Ubx¹ flies and reduces their viability. (Janssen et al., 2000) When bw^D males are mated with females that have already been mated, bw^D males are weaker sperm displacers than wild-type males. (Civetta, 1999) Enhances transinactivation of bw caused by Tp(2;2)bw-DX7. (Sass and Henikoff, 1999) Heterozygotes have eyes that are white with a quite uniform scattering of individual reddish spots within ommatidia. (Talbert et al., 1994) Antagonizes the expression of as many as three normal copies of bw in trans. bw^D/+ shows nearly a 100-fold reduction in pteridine levels. bw^D/bw^V1 > bw^D/+ > bw^D/bw^D in severity of effect. (Henikoff and Dreesen, 1989) Variegation suppressed by extra Y chromosomes. (Brosseau, 1959) Malpighian tubule colour: bright yellow. (Brehme and Demerec, 1942) dominant position-effect variegation for bw Eye colour: purple to brown; varies with age. Shows slight variegation in combination with st (FBrf0010216). Wings pebbled.
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference bw^+t8.4, bw^D has eye color defective phenotype, enhanceable by Mod(Prat:bw)2-5^2-5 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, enhanceable by Mod(Prat:bw)2-5^2-5/Mod(Prat:bw)2-5[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, enhanceable by Mod(Prat:bw)3-1[+]/Mod(Prat:bw)3-1^3-1 (Malmanche and Clark, 2003) bw^D has eye color defective \| dominant phenotype, enhanceable by blanks^LA4.4/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, enhanceable by CG8036^LA3.2/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, enhanceable by Chd1^EP/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, enhanceable by Ino80^d10097/Scer\GAL4^ey.PH (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, enhanceable by Ino80^d10097/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, enhanceable by psq^LA11A/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, enhanceable by Pur-α^LA77A/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, enhanceable by Samuel^LAE154/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, enhanceable by Scer\GAL4^GMR.PF/jim^LA3.1 (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, enhanceable by Ubp64E^LA5.3/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, enhanceable by vig2^LA4.5/Scer\GAL4^GMR.PF (Schneiderman et al., 2010)
NOT Enhanced by
Statement Reference Acf1^EY08629, Scer\GAL4^GMR.PF, bw^D has eye color defective \| dominant phenotype, non-enhanceable by Hsap\CDKN1A^GMR.PH (Schneiderman et al., 2010) bw^+t8.4, bw^D has eye color defective phenotype, non-enhanceable by Mod(Prat:bw)1-2^1-2 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-enhanceable by Mod(Prat:bw)2-3^2-3 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-enhanceable by Mod(Prat:bw)2-4^2-4 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-enhanceable by Mod(Prat:bw)3-1^3-1 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-enhanceable by Mod(Prat:bw)3-2^3-2 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-enhanceable by Mod(Prat:bw)3-5^3-5 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-enhanceable by Mod(Prat:bw)3-6^3-6 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-enhanceable by Mod(Prat:bw)3-8^3-8 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-enhanceable by Mod(Prat:bw)3-9^3-9 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-enhanceable by Mod(Prat:bw)3-10^3-10 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-enhanceable by Mod(Prat:bw)3-12^3-12 (Malmanche and Clark, 2003)
Suppressed by
Statement Reference bw^+t8.4, bw^D has eye color defective phenotype, suppressible \| partially by Mod(Prat:bw)1-3^1-3 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, suppressible \| partially by Mod(Prat:bw)3-3^3-3 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, suppressible by Mod(Prat:bw)1-1^1-1 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, suppressible by Mod(Prat:bw)1-4^1-4 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, suppressible by Mod(Prat:bw)1-5^1-5 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, suppressible by Mod(Prat:bw)2-1^2-1 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, suppressible by Mod(Prat:bw)2-1^2-2 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, suppressible by Mod(Prat:bw)3-4^3-4 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, suppressible by Mod(Prat:bw)3-7^3-7 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, suppressible by Mod(Prat:bw)3-11^3-11 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, suppressible by Mod(Prat:bw)Y-1^Y-1 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible \| partially by Mod(Prat:bw)2-3[+]/Mod(Prat:bw)2-3^2-3 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible \| partially by Mod(Prat:bw)3-2[+]/Mod(Prat:bw)3-2^3-2 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible \| partially by Mod(Prat:bw)3-3[+]/Mod(Prat:bw)3-3^3-3 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible \| partially by Mod(Prat:bw)3-4[+]/Mod(Prat:bw)3-4^3-4 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible \| partially by Mod(Prat:bw)3-6^3-6/Mod(Prat:bw)3-6[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible \| partially by Mod(Prat:bw)3-9[+]/Mod(Prat:bw)3-9^3-9 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible \| partially by Mod(Prat:bw)3-10[+]/Mod(Prat:bw)3-10^3-10 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible \| partially by Mod(Prat:bw)3-12^3-12/Mod(Prat:bw)3-12[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible by Mod(Prat:bw)1-1[+]/Mod(Prat:bw)1-1^1-1 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible by Mod(Prat:bw)1-2^1-2/Mod(Prat:bw)1-2[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible by Mod(Prat:bw)1-3^1-3/Mod(Prat:bw)1-3[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible by Mod(Prat:bw)1-4^1-4/Mod(Prat:bw)1-4[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible by Mod(Prat:bw)1-5[+]/Mod(Prat:bw)1-5^1-5 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible by Mod(Prat:bw)2-1[+]/Mod(Prat:bw)2-1^2-1 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible by Mod(Prat:bw)2-1[+]/Mod(Prat:bw)2-1^2-2 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible by Mod(Prat:bw)2-4^2-4/Mod(Prat:bw)2-4[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible by Mod(Prat:bw)3-5^3-5/Mod(Prat:bw)3-5[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible by Mod(Prat:bw)3-7[+]/Mod(Prat:bw)3-7^3-7 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible by Mod(Prat:bw)3-8^3-8/Mod(Prat:bw)3-8[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible by Mod(Prat:bw)3-11^3-11/Mod(Prat:bw)3-11[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has eye color defective phenotype, suppressible by Mod(Prat:bw)Y-1[+]/Mod(Prat:bw)Y-1^Y-1 (Malmanche and Clark, 2003) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by Acf1^EY08629/Scer\GAL4^ey.PH (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by asf1^LA00872/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by ban^LA2.5/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by ban^LAS55/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by crol^d03228/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by crol^LAJJ2A/Scer\GAL4^ey.PH (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by crol^LAJJ2A/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by Etl1^EP701/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by His3.3B^d04051/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by HmgZ^EY23248/Scer\GAL4^ey.PH (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by HmgZ^EY23248/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by Hr39^LA1.4/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by Ime4^LA1.3/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by Kdm4B^EY10737 (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by kis^EY12846/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by kis^LA4.3/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by l(3)neo38^LAS146/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by LAS110^LAS110/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by Prp3^LA2.4/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by Rm62^EY06795/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by Scer\GAL4^GMR.PF/CG5794^LA3.4 (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by Scer\GAL4^GMR.PF/DLP^EY09290 (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by Scer\GAL4^GMR.PF/HmgD^EY03609 (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by Scer\GAL4^GMR.PF/Hpr1^EY04120 (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by Scer\GAL4^GMR.PF/LA2.1^LA2.1 (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by Scer\GAL4^GMR.PF/LS2^LA1.6 (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by Smc5^EY03252/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by vig2^LA4.5/Scer\GAL4^ey.PH (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by XNP^EP635/Scer\GAL4^ey.PH (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible \| partially by XNP^EP635/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible by Acf1^EY08629/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible by CG13895^EP14C/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible by Dek^EP13/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible by Kdm4B^EY10737/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible by pita^LA4.1/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible by sle^EPDJ1/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye color defective \| dominant phenotype, suppressible by tai^EP27/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) Scer\GAL4^GMR.PF, ban^unspecified, bw^D has eye color defective \| dominant phenotype, suppressible by Hsap\CDKN1A^GMR.PH (Schneiderman et al., 2010) Scer\GAL4^GMR.PF, bw^D, crol^unspecified has eye color defective \| dominant phenotype, suppressible by Hsap\CDKN1A^GMR.PH (Schneiderman et al., 2010)
NOT suppressed by
Statement Reference Acf1^EY08629, Scer\GAL4^GMR.PF, bw^D has eye color defective \| dominant phenotype, non-suppressible by Hsap\CDKN1A^GMR.PH (Schneiderman et al., 2010) bw^+t8.4, bw^D has eye color defective phenotype, non-suppressible by Mod(Prat:bw)1-2^1-2 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-suppressible by Mod(Prat:bw)2-3^2-3 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-suppressible by Mod(Prat:bw)2-4^2-4 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-suppressible by Mod(Prat:bw)3-1^3-1 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-suppressible by Mod(Prat:bw)3-2^3-2 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-suppressible by Mod(Prat:bw)3-5^3-5 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-suppressible by Mod(Prat:bw)3-6^3-6 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-suppressible by Mod(Prat:bw)3-8^3-8 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-suppressible by Mod(Prat:bw)3-9^3-9 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-suppressible by Mod(Prat:bw)3-10^3-10 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has eye color defective phenotype, non-suppressible by Mod(Prat:bw)3-12^3-12 (Malmanche and Clark, 2003) bw^D has eye color defective phenotype, non-suppressible by Df(2R)M41A10 (Sage and Csink, 2003)
Other
Statement Reference CycB[+]/CycB², Scer\GAL4^unspecified, bw^D, crol^unspecified has eye color defective \| dominant phenotype (Schneiderman et al., 2010)
Phenotype Manifest In
Enhanced by
Statement Reference bw^+t8.4, bw^D has pigment cell phenotype, enhanceable by Mod(Prat:bw)2-5^2-5 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, enhanceable by Mod(Prat:bw)2-5^2-5/Mod(Prat:bw)2-5[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, enhanceable by Mod(Prat:bw)3-1[+]/Mod(Prat:bw)3-1^3-1 (Malmanche and Clark, 2003) bw^D has eye phenotype, enhanceable by blanks^LA4.4/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, enhanceable by CG8036^LA3.2/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, enhanceable by Chd1^EP/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, enhanceable by Ino80^d10097/Scer\GAL4^ey.PH (Schneiderman et al., 2010) bw^D has eye phenotype, enhanceable by Ino80^d10097/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, enhanceable by Scer\GAL4^GMR.PF/jim^LA3.1 (Schneiderman et al., 2010) bw^D has eye phenotype, enhanceable by Ubp64E^LA5.3/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, enhanceable by vig2^LA4.5/Scer\GAL4^GMR.PF (Schneiderman et al., 2010)
NOT Enhanced by
Statement Reference Acf1^EY08629, Scer\GAL4^GMR.PF, bw^D has eye phenotype, non-enhanceable by Hsap\CDKN1A^GMR.PH (Schneiderman et al., 2010) bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)1-2^1-2 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)2-3^2-3 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)2-4^2-4 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)3-1^3-1 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)3-2^3-2 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)3-5^3-5 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)3-6^3-6 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)3-8^3-8 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)3-9^3-9 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)3-10^3-10 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)3-12^3-12 (Malmanche and Clark, 2003)
Suppressed by
Statement Reference bw^+t8.4, bw^D has pigment cell phenotype, suppressible \| partially by Mod(Prat:bw)1-3^1-3 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, suppressible \| partially by Mod(Prat:bw)3-3^3-3 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, suppressible by Mod(Prat:bw)1-1^1-1 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, suppressible by Mod(Prat:bw)1-4^1-4 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, suppressible by Mod(Prat:bw)1-5^1-5 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, suppressible by Mod(Prat:bw)2-1^2-1 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, suppressible by Mod(Prat:bw)2-1^2-2 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, suppressible by Mod(Prat:bw)3-4^3-4 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, suppressible by Mod(Prat:bw)3-7^3-7 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, suppressible by Mod(Prat:bw)3-11^3-11 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, suppressible by Mod(Prat:bw)Y-1^Y-1 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible \| partially by Mod(Prat:bw)2-3[+]/Mod(Prat:bw)2-3^2-3 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible \| partially by Mod(Prat:bw)3-2[+]/Mod(Prat:bw)3-2^3-2 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible \| partially by Mod(Prat:bw)3-3[+]/Mod(Prat:bw)3-3^3-3 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible \| partially by Mod(Prat:bw)3-4[+]/Mod(Prat:bw)3-4^3-4 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible \| partially by Mod(Prat:bw)3-6^3-6/Mod(Prat:bw)3-6[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible \| partially by Mod(Prat:bw)3-9[+]/Mod(Prat:bw)3-9^3-9 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible \| partially by Mod(Prat:bw)3-10[+]/Mod(Prat:bw)3-10^3-10 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible \| partially by Mod(Prat:bw)3-12^3-12/Mod(Prat:bw)3-12[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)1-1[+]/Mod(Prat:bw)1-1^1-1 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)1-2^1-2/Mod(Prat:bw)1-2[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)1-3^1-3/Mod(Prat:bw)1-3[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)1-4^1-4/Mod(Prat:bw)1-4[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)1-5[+]/Mod(Prat:bw)1-5^1-5 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)2-1[+]/Mod(Prat:bw)2-1^2-1 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)2-1[+]/Mod(Prat:bw)2-1^2-2 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)2-4^2-4/Mod(Prat:bw)2-4[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)3-5^3-5/Mod(Prat:bw)3-5[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)3-7[+]/Mod(Prat:bw)3-7^3-7 (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)3-8^3-8/Mod(Prat:bw)3-8[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)3-11^3-11/Mod(Prat:bw)3-11[+] (Malmanche and Clark, 2003) bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)Y-1[+]/Mod(Prat:bw)Y-1^Y-1 (Malmanche and Clark, 2003) bw^D has eye phenotype, suppressible \| partially by Acf1^EY08629/Scer\GAL4^ey.PH (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by asf1^LA00872/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by crol^LAJJ2A/Scer\GAL4^ey.PH (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by Etl1^EP701/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by His3.3B^d04051/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by HmgZ^EY23248/Scer\GAL4^ey.PH (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by HmgZ^EY23248/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by Hr39^LA1.4/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by Ime4^LA1.3/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by Kdm4B^EY10737 (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by kis^EY12846/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by kis^LA4.3/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by l(3)neo38^LAS146/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by LAS110^LAS110/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by Prp3^LA2.4/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by Rm62^EY06795/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by Scer\GAL4^GMR.PF/CG5794^LA3.4 (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by Scer\GAL4^GMR.PF/DLP^EY09290 (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by Scer\GAL4^GMR.PF/HmgD^EY03609 (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by Scer\GAL4^GMR.PF/Hpr1^EY04120 (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by Scer\GAL4^GMR.PF/LS2^LA1.6 (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by Smc5^EY03252/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by vig2^LA4.5/Scer\GAL4^ey.PH (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by XNP^EP635/Scer\GAL4^ey.PH (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible \| partially by XNP^EP635/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible by Acf1^EY08629/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible by CG13895^EP14C/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible by Dek^EP13/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible by Kdm4B^EY10737/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible by pita^LA4.1/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible by sle^EPDJ1/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) bw^D has eye phenotype, suppressible by tai^EP27/Scer\GAL4^GMR.PF (Schneiderman et al., 2010) Scer\GAL4^GMR.PF, ban^unspecified, bw^D has eye phenotype, suppressible by Hsap\CDKN1A^GMR.PH (Schneiderman et al., 2010) Scer\GAL4^GMR.PF, bw^D, crol^unspecified has eye phenotype, suppressible by Hsap\CDKN1A^GMR.PH (Schneiderman et al., 2010)
NOT suppressed by
Statement Reference Acf1^EY08629, Scer\GAL4^GMR.PF, bw^D has eye phenotype, non-suppressible by Hsap\CDKN1A^GMR.PH (Schneiderman et al., 2010) bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)1-2^1-2 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)2-3^2-3 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)2-4^2-4 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)3-1^3-1 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)3-2^3-2 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)3-5^3-5 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)3-6^3-6 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)3-8^3-8 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)3-9^3-9 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)3-10^3-10 (Malmanche and Clark, 2003) bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)3-12^3-12 (Malmanche and Clark, 2003) bw^D has pigment cell phenotype, non-suppressible by Df(2R)M41A10 (Sage and Csink, 2003)
Other
Statement Reference CG8036^LA3.2, Scer\GAL4^unspecified, bw^D, crol^unspecified has eye phenotype (Schneiderman et al., 2010) CycB[+]/CycB², Scer\GAL4^unspecified, bw^D, crol^unspecified has eye phenotype (Schneiderman et al., 2010) Hr39^LA1.4, Scer\GAL4^ey.PH, bw^D has eye phenotype (Schneiderman et al., 2010) LA2.1^LA2.1, Scer\GAL4^GMR.PF, bw^D has eye phenotype (Schneiderman et al., 2010) Pur-α^LA77A, Scer\GAL4^GMR.PF, bw^D has eye phenotype (Schneiderman et al., 2010) Samuel^LAE154, Scer\GAL4^GMR.PF, bw^D has eye phenotype (Schneiderman et al., 2010) Scer\GAL4^ey.PH, bw^D, psq^LA11A has eye phenotype (Schneiderman et al., 2010) Scer\GAL4^ey.PH, bw^D, tai^EP27 has eye phenotype (Schneiderman et al., 2010) Scer\GAL4^GMR.PF, ban^LA2.5, bw^D has eye phenotype (Schneiderman et al., 2010) Scer\GAL4^GMR.PF, ban^LAS55, bw^D has eye phenotype (Schneiderman et al., 2010) Scer\GAL4^GMR.PF, bw^D, crol^d03228 has eye phenotype (Schneiderman et al., 2010) Scer\GAL4^GMR.PF, bw^D, crol^LAJJ2A has eye phenotype (Schneiderman et al., 2010) Scer\GAL4^GMR.PF, bw^D, psq^LA11A has eye phenotype (Schneiderman et al., 2010) Scer\GAL4^unspecified, bw^D, crol^unspecified, jim^LA3.1 has eye phenotype (Schneiderman et al., 2010) Scer\GAL4^unspecified, Ubp64E^LA5.3, bw^D, crol^unspecified has eye phenotype (Schneiderman et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference CycB[2] dominantly reduces the area of sectors of increased pigmentation in a bw[D]/+ genetic background resulting from the over-expression of crol[unspecified] driven by Scer\GAL4[unspecified]. Mis-expression of Kdm4B[EY10737] driven by Scer\GAL4[GMR.PF] restores eye pigmentation in bw[D]/+ heterozygotes. Kdm4B[EY10737] partially restores eye pigmentation in bw[D]/+ heterozygotes. Flies expressing Scer\GAL4[ey.PH]-driven crol[LAJJ2A] display sectors of increased pigmentation in a speckled background. Flies expressing Scer\GAL4[ey.PH]-driven crol[d03228] in a bw[D]/+ genetic background display sectors of increased pigmentation in a speckled background. Flies expressing Scer\GAL4[ey.PH]-driven tai[EP27] in a bw[D]/+ genetic background display rough eyes. Flies expressing Scer\GAL4[ey.PH]-driven Hr39[LA1.4] in a bw[D]/+ genetic background display rough eyes. Flies expressing Scer\GAL4[ey.PH]-driven in a bw[D]/+ genetic background psq[LA11A] have small eyes. Mis-expression of Acf1[EY08629] driven by Scer\GAL4[ey.PH] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of XNP[EP635] driven by Scer\GAL4[ey.PH] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of HmgZ[EY23248] driven by Scer\GAL4[ey.PH] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of vig2[LA4.5] driven by Scer\GAL4[ey.PH] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of Ino80[d10097] driven by Scer\GAL4[ey.PH] results in decreased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of Dek[EP13] driven by Scer\GAL4[GMR.PF] restores eye pigmentation in bw[D]/+ heterozygotes. Mis-expression of tai[EP27] driven by Scer\GAL4[GMR.PF] restores eye pigmentation in bw[D]/+ heterozygotes. Mis-expression of sle[EPDJ1] driven by Scer\GAL4[GMR.PF] restores eye pigmentation in bw[D]/+ heterozygotes. Mis-expression of pita[LA4.1] driven by Scer\GAL4[GMR.PF] restores eye pigmentation in bw[D]/+ heterozygotes. Mis-expression of CG13895[EP14C] driven by Scer\GAL4[GMR.PF] restores eye pigmentation in bw[D]/+ heterozygotes. Mis-expression of Acf1[EY08629] driven by Scer\GAL4[GMR.PF] restores eye pigmentation in bw[D]/+ heterozygotes. Mis-expression of XNP[EP635] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of CG5794[LA3.4] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of HmgD[EY03609] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of HmgZ[EY23248] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of His3.3B[d04051] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of asf1[LA00872] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of Smc5[EY03252] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of Rm62[EY06795] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of CG3162[LA1.6] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of ban[LA2.5] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Flies expressing Scer\GAL4[GMR.PF]-driven ban[LA2.5] in a bw[D]/+ genetic background display rough eyes. Mis-expression of ban[LAS55] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Flies expressing Scer\GAL4[GMR.PF]-driven ban[LAS55] in a bw[D]/+ genetic background display rough eyes. Mis-expression of Hpr1[EY04120] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of DLP[EY09290] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of crol[LAJJ2A] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Flies expressing Scer\GAL4[GMR.PF]-driven crol[LAJJ2A] in a bw[D]/+ genetic background display rough eyes. Mis-expression of Mta70[LA1.3] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of LAS110[LAS110] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of CG7757[LA2.4] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of l(3)neo38[LAS146] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of kis[LA4.3] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of kis[EY12846] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of Etl1[EP701] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of Hr39[LA1.4] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of LA2.1[LA2.1] driven by Scer\GAL4[GMR.PF] results in increased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Flies expressing Scer\GAL4[GMR.PF]-driven LA2.1[LA2.1] in a bw[D]/+ genetic background display rough eyes. Mis-expression of psq[LA11A] driven by Scer\GAL4[GMR.PF] results in decreased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Flies expressing Scer\GAL4[GMR.PF]-driven psq[LA11A] in a bw[D]/+ genetic background display rough eyes. Mis-expression of Samuel[LAE154] driven by Scer\GAL4[GMR.PF] results in decreased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Flies expressing Scer\GAL4[GMR.PF]-driven Samuel[LAE154] in a bw[D]/+ genetic background display rough eyes. Mis-expression of Ubp64E[LA5.3] driven by Scer\GAL4[GMR.PF] results in decreased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of jim[LA3.1] driven by Scer\GAL4[GMR.PF] results in decreased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of CG8036[LA3.2] driven by Scer\GAL4[GMR.PF] results in decreased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of CG10630[LA4.4] driven by Scer\GAL4[GMR.PF] results in decreased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of vig2[LA4.5] driven by Scer\GAL4[GMR.PF] results in decreased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of Pur-α[LA77A] driven by Scer\GAL4[GMR.PF] results in decreased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Flies expressing Scer\GAL4[GMR.PF]-driven Pur-α[LA77A] in a bw[D]/+ genetic background display rough eyes. Mis-expression of Ino80[d10097] driven by Scer\GAL4[GMR.PF] results in decreased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Mis-expression of Chd1[EP] driven by Scer\GAL4[GMR.PF] results in decreased eye pigmentation in bw[D]/+ heterozygotes compared with that in the parental bw[D]/+ line. Contemporaneous expression of jim[LA3.1] with crol[unspecified] driven by Scer\GAL4[unspecified] reduces the size and frequency of sectors of increased pigmentation in a bw[D]/+ genetic background, but the background speckled variegation remains unchanged. Contemporaneous expression of CG8036[LA3.2] with crol[unspecified] driven by Scer\GAL4[unspecified] reduces the size and frequency of sectors of increased pigmentation in a bw[D]/+ genetic background, but the background speckled variegation remains unchanged. Contemporaneous expression of CG10630[LA4.4] with crol[unspecified] driven by Scer\GAL4[unspecified] reduces the size and frequency of sectors of increased pigmentation in a bw[D]/+ genetic background, but the background speckled variegation remains unchanged. Contemporaneous expression of Ubp64E[LA5.3] with crol[unspecified] driven by Scer\GAL4[unspecified] increases the size or frequency of sectors of increased pigmentation in a bw[D]/+ genetic background, but the background speckled variegation remains unchanged. (Schneiderman et al., 2010) Df(2R)M41A10 does not suppress the bw^D/+ phenotype. Transinactivation of bw in interspecific bw^D heterozygotes (in which D.melanogaster bw^D has been introgressed into the D.simulans background and backcrossed to D.simulans for six generations) is moderately suppressed compared to D.melanogaster bw^D heterozygotes. (Sage and Csink, 2003) The w^+mC gene in the P{lacW} transposon shows trans-inactivation in the presence of Dp(?;2)bw^D in the P{lacW}chrw^k06908, P{lacW}Dcp-1^k05606, P{lacW}l(2)s4830^s4830 and P{lacW}apt^k15608 insertions. The P{lacW}l(2)k09913^k09913, P{lacW}l(2)k07136^k07136 and P{lacW}apt^k11531 insertions do not show trans-inactivation of the w^+mC gene in the presence of Dp(?;2)bw^D. The P{lacW}apt^k15608 insertion does not show cis-inactivation of the w^+mC gene in the presence of Dp(?;2)bw^D. The w^+mW.hs gene in the P{hsp26-pt-T} transposon shows a partial salt and pepper trans-inactivation in the posterior section of the eye in the P{hsp26-pt-T}chrw^ab28 insertion in the presence of Dp(?;2)bw^D. The w^+mW.hs gene in the P{hsp26-pt-T} transposon does not show trans-inactivation or cis-inactivation in the P{hsp26-pt-T}Dcp-1^mgb48 insertion in the presence of Dp(?;2)bw^D. (Csink et al., 2002)
Xenogenetic Interactions
Statement Reference The increased eye pigmentation in bw[D]/+ heterozygotes resulting from the mis-expression of Acf1[EY08629] driven by Scer\GAL4[GMR.PF] is not affected by Hsap\CDKN1A[GMR.PH]. The increased eye pigmentation in bw[D]/+ heterozygotes resulting from the mis-expression of ban[unspecified] driven by Scer\GAL4[GMR.PF] is suppressed by Hsap\CDKN1A[GMR.PH]. The increased eye pigmentation in bw[D]/+ heterozygotes resulting from the mis-expression of crol[unspecified] driven by Scer\GAL4[GMR.PF] is suppressed by Hsap\CDKN1A[GMR.PH]. (Schneiderman et al., 2010)
Complementation & Rescue Data
Comments
Stocks ( 64 )
Bloomington	6144 Df(2R)NCX8, Dp(?;2)bw^D, bw^D/CyO 8873 Df(2R)pwn5, Dp(?;2)bw^D, bw^D/CyO 8880 Df(2R)EW60, Dp(?;2)bw^D, bw^D/CyO 6145 Df(2R)NCX10, Dp(?;2)bw^D, bw^D/CyO 8874 Dp(?;2)bw^D, so³ bw^D/CyO 4126 Dp(?;2)bw^D, dpa¹ bw^D/CyO 4127 Dp(?;2)bw^D, U2A¹ bw^D/CyO 8877 Dp(?;2)bw^D, pwn⁴ bw^D/CyO 9151 Dp(?;2)bw^D, nec² bw^D/CyO
Kyoto	101339 bw^D 101551 pk^pk-sple-6 bw^D / SM5 108645 Df(2R)NCX10, Dp(?;2)bw^D, bw^D/CyO
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Notes on Origin
Discoverer	T. Hinton, 1940.

Comments
	Using the FISH technique is can be shown that bw^D insertion does not affect the pairing or vertical placement of the bw locus, but the insertion of heterochromatin appears to target to bw locus to the nuclear envelope. bw^D associates with centromeric satellite sequences in diploid larval tissues. Insertion of satellite DNA at one bw locus causes both gene copies to associate with heterochromatin. The effect of the insertion is a specific association of the bw gene with other heterochromatin on chromosome 2. (Dernburg et al., 1996) Whereas this alleles has previously been reported to be revertable (FBrf0007893), recent efforts have shown it to be non-revertable (K. Loughney, unpublished data). (Talbert et al., 1994) Since 1950 some and perhaps all lines of bw^D have undergone a secondary event that removed a portion of the coding region of the brown gene, generating a null allele. (Henikoff and Dreesen, 1989)
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Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	brown^Dominant (Eissenberg and Elgin, 2000, Aasland, 2000) bw(D) (Chandler and Stam, 2004) bw^D (Nisha and Csink, 2007, Zuckerkandl and Cavalli, 2007, Schneiderman et al., 2010) bwD (Malmanche and Clark, 2001, Delattre et al., 1999)
Name Synonym	brown(Dominant) brown^Dominant (Schneiderman et al., 2010)
Secondary FlyBase IDs

References ( 76 )

Generate a list of	All references relating to this allele ( 76 )

List References by type	Research paper ( 32 ) Review ( 29 ) Abstract ( 14 ) Stock list ( 1 )
Recent research papers (0)
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Allele Dmel\bwD

Allele Dmel\bw^D