Allele Dmel\bw^V1

General Information
Symbol	Dmel\bw^V1	Species	D. melanogaster
Name	Variegated	FlyBase ID	FBal0001401
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\bw

Allele class
Mutagen	X ray
Nature of the Allele
Allele class
Mutagen	X ray
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Sharply reduced levels of transcript from both the bw⁺ allele in cis with the rearrangement and the bw allele on the homologous second chromosome. (Henikoff and Dreesen, 1989)
Assay mode
Caused by aberration	In(2LR)bw^V1
Cytology
Phenotypic Data
Phenotypic Class
	visible (Kadel, 1959) eye color defective \| dominant
Phenotype Manifest In
	pigment cell
Detailed Description
	Statement Reference Malpighian tubule colour: wild-type. Eye colour: brown; mottled with darker spots that deepen in red color with age. Eye colour: pale orange; dark orange spots, with st¹. Eye colour: pale orange; dark orange spots, with v¹. RK1A. bw^V1 is recessive in D.melanogaster/D.simulans hybrids. (Goldschmidt, 1999)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference bw^V1 has visible phenotype, suppressible by Dp(2;2)Su(Pm) (Kadel, 1959)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference Dp(2;2)Su(Pm) suppresses the bw phenotype in bw^V1, leaving only the variegation; Dp(2;2)Su(Pm)/bw^V1 flies have variegated red eyes. (Kadel, 1959)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 37 )
Bloomington	1580 In(2LR)bw^V1, ds^33k bw^V1/SM5 390 S²/In(2LR)bw^V1, ds^33k bw^V1 4525 Ruf¹/In(2LR)bw^V1, ds^33k bw^V1 224 Df(2R)cn87e/In(2LR)bw^V1, ds^33k b¹ bw^V1 351 mr¹ bs²/In(2LR)bw^V1, ds^33k bw^V1 3170 In(2LR)bw^V1, ds^33k l(2)DTS18WF¹ bw^V1/CyO
Kyoto	106399 In(2LR)bw^V1, ds^33k bw^V1/SM5 101344 cn¹ bw¹ bgcn^Q52 / bw^V1 105885 S²/In(2LR)bw^V1, ds^33k bw^V1 105798 Df(2R)cn87e/In(2LR)bw^V1, ds^33k b¹ bw^V1 101501 In(2L)Cy, Cy¹ / In(2LR)bw^V1, ds^33k bw^V1 105865 mr¹ bs²/In(2LR)bw^V1, ds^33k bw^V1
	More stocks available...
Notes on Origin
Discoverer	Muller, 1929.

Comments
	Extra Y chromosome, as with other variegated browns, suppresses brown color, giving red eye sparsely speckled or splotched with darker spots. Amount of wild-type eye color also responds to fourth-chromosome constitution; 4/C(4) > C(4) = 4/4 > 4/0, with the first approaching wild type and the latter nearly bw (Lindsley and Rokop). Generally lethal homozygous and in combination with other brown-Variegateds. Heterozygotes fully viable and fertile.
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	bw^V1 bw^V (Henikoff, 1992, Spradling and Karpen, 1990) Pm (Goldschmidt, 1999, )
Name Synonym	Plum (Kadel, 1959, Morgan, 1947, ) Variegated
Secondary FlyBase IDs

References ( 16 )
Research paper	Dreesen et al., 1991, Genes Dev. 5: 331--340 A pairing-sensitive element that mediates trans-inactivation is associated with the Drosophila brown gene. [FBrf0054058] Henikoff and Dreesen, 1989, Proc. Natl. Acad. Sci. USA 86: 6704--6708 Trans-inactivation of the Drosophila brown gene: evidence for transcriptional repression and somatic pairing dependence. [FBrf0050859] Holm and Chovnick, 1975, Genetics 81: 293--311 Compound autosomes in Drosophila melanogaster: The meiotic behavior of compound thirds. [FBrf0027491] Valentin, 1972, Hereditas 72: 243--254 Interchromosomal effects of autosomal inversions in Drosophila melanogaster. [FBrf0024058] Kadel, 1959, D. I. S. 33: 95 [New mutants report.] [FBrf0063557] Morgan, 1947, Genetics 32: 200--219 A variable phenotype associated with the fourth chromosome of Drosophila melanogaster and affected by heterochromatin. [FBrf0006848] Bridges, 1937, Cytologia Fujii Jubil. Vol.: 745--755 Correspondences between linkage maps and salivary chromosome structure as illustrated in the tip of chromosome 2R of Drosophila melanogaster. [FBrf0003816] Glass, 1934, Am. Nat. 68: 107--114 A study of dominant mosaic eye-color mutants in Drosophila melanogaster. [FBrf0002679] Glass, 1933, J. Genet. 28: 69--112 A study of dominant mosaic eye-colour mutants in Drosophila melanogaster. [FBrf0002572] Muller, 1930, J. Genet. 22(3): 299--334 Types of visible variations induced by X-rays in Drosophila. [FBrf0001992]
Review	Henikoff, 1992, Curr. Opin. Genet. Dev. 2(6): 907--912 Position effect and related phenomena. [FBrf0055661] Spradling and Karpen, 1990, Genetics 126: 779--784 Sixty years of mystery. [FBrf0051975]
Teaching note	Goldschmidt, 1999, D. I. S. 82: 129 Phenocopy and species hybrid in class work. [FBrf0111885]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905] Bridges and Brehme, 1944, Publs Carnegie Instn 552: vii + 257pp The mutants of Drosophila melanogaster. [FBrf0006100]
Stock list	The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Russia, 1997, D. I. S. 80: 109--130 Stock list. [FBrf0098381]

Allele Dmel\bwV1

Allele Dmel\bw^V1