A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\Bx1

General Information
SymbolDmel\Bx1SpeciesD. melanogaster
NameFlyBase IDFBal0001431
Feature typealleleAssociated geneDmel\Bx
Allele classhypermorphic allele - genetic evidence
Mutagenspontaneous
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Description
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FB2013_03
FB2013_02
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hide Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
The roo{}Bx1 insertion is within the 3' untranslated region of Bx.
Insertion of approximately 8kb into the 3' UTR.
Insertion within the 3' untranslated region. Insert stated as cause: undefined.
Insertion of a roo element.
8.5 kb (roo)
 
Caused by insertion
Cytology
hide Phenotypic Data
hide Phenotypic Class
 
hide Phenotype Manifest In
hide Detailed Description
Statement
Reference
Mutant flies show increased resistance to ethanol sedation compared to control flies.
Heterozygotes show loss of the posterior wing margin. Homozygotes show loss of both anterior and posterior wing margin. Wing discs in heterozygous larvae show ectopic apoptosis.
Heterozygotes show scalloping of the wing margin.
Mutant animals exhibit an decreased sensitivity to cocaine.
Homozygotes have a scalloped wing phenotype.
Heterozygotes show mild scalloping of the wing in the posterior compartment.
Homozygous flies show severe scalloping of the wing margin and transformation of dorsal to ventral fate in the alula at the posterior margin of the wing. Heterozygous flies show mild notching of the wing.
Male and homozygous female with Beaded-like wings; long, narrow and excised along both margins; fully viable. Heterozygous female less extreme and overlaps wild type. Some venation abnormality.
 
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Linkouts
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hide Phenotypic Class
hideEnhanced by
Statement
Reference
Bx1 has visible | dominant phenotype, enhanceable by ap[+]/apUGO35
Bx1 has visible | dominant phenotype, enhanceable by apUGO35
Bx1 has visible | dominant phenotype, enhanceable by brmT362/brm[+]
Bx1 has visible | dominant phenotype, enhanceable by caps65.2/caps[+]
Bx1 has visible | dominant phenotype, enhanceable by CG11399EY11352/CG11399[+]
Bx1 has visible | dominant phenotype, enhanceable by Chie5.5
Bx1 has visible | dominant phenotype, enhanceable by cic[+]/cicD49
Bx1 has visible | dominant phenotype, enhanceable by Df(2L)C144/+
Bx1 has visible | dominant phenotype, enhanceable by Df(2L)spd/+
Bx1 has visible | dominant phenotype, enhanceable by Df(2R)Jp1/+
Bx1 has visible | dominant phenotype, enhanceable by Df(3L)29A6/+
Bx1 has visible | dominant phenotype, enhanceable by Df(3L)Cat/+
Bx1 has visible | dominant phenotype, enhanceable by Df(3L)HR232/+
Bx1 has visible | dominant phenotype, enhanceable by Df(3L)HR370/+
Bx1 has visible | dominant phenotype, enhanceable by Df(3L)XS572/+
Bx1 has visible | dominant phenotype, enhanceable by Df(3R)3450/+
Bx1 has visible | dominant phenotype, enhanceable by Df(3R)Antp17/+
Bx1 has visible | dominant phenotype, enhanceable by Df(3R)by10/+
Bx1 has visible | dominant phenotype, enhanceable by Df(3R)Cha7/+
Bx1 has visible | dominant phenotype, enhanceable by Df(3R)M-Kx1/+
Bx1 has visible | dominant phenotype, enhanceable by Df(3R)p40/+
Bx1 has visible | dominant phenotype, enhanceable by Df(3R)p712/+
Bx1 has visible | dominant phenotype, enhanceable by Df(3R)Tpl10/+
Bx1 has visible | dominant phenotype, enhanceable by fng[+]/fng80
Bx1 has visible | dominant phenotype, enhanceable by fng80
Bx1 has visible | dominant phenotype, enhanceable by l(3)0470804708/l(3)04708[+]
Bx1 has visible | dominant phenotype, enhanceable by lilli00632/lilli[+]
Bx1 has visible | dominant phenotype, enhanceable by Mpcp00564/Mpcp[+]
Bx1 has visible | dominant phenotype, enhanceable by nufKG02305/nuf[+]
Bx1 has visible | dominant phenotype, enhanceable by osa[+]/osa308
Bx1 has visible | dominant phenotype, enhanceable by sbb[+]/sbb6
Bx1 has visible | dominant phenotype, enhanceable by Ser[+]/SerRX82
Bx1 has visible | dominant phenotype, enhanceable by shn1/shn[+]
Bx1 has visible | dominant phenotype, enhanceable by shn04738/shn[+]
Bx1 has visible | dominant phenotype, enhanceable by Su(Tpl)[+]/Su(Tpl)17
Bx1 has visible | dominant phenotype, enhanceable by Su(Tpl)[+]/Su(Tpl)S-192
Bx1 has visible | dominant phenotype, enhanceable by tara1/tara[+]
Bx1 has visible | dominant phenotype, enhanceable by tara03881/tara[+]
Bx1 has visible | dominant phenotype, enhanceable by trn28.4/trn[+]
Bx1 has visible phenotype, enhanceable by +/Df(1)ct-J4
Bx1 has visible phenotype, enhanceable by +/Df(2R)M41A4
Bx1 has visible phenotype, enhanceable by +/Df(3L)brm11
Bx1 has visible phenotype, enhanceable by +/Df(3R)D605
Bx1 has visible phenotype, enhanceable by ap[+]/apmd544
Bx1 has visible phenotype, enhanceable by caps05121/caps[+]
Bx1 has visible phenotype, enhanceable by Df(1)C246/+
Bx1 has visible phenotype, enhanceable by Df(1)N19/+
Bx1 has visible phenotype, enhanceable by Df(2L)al/+
Bx1 has visible phenotype, enhanceable by Df(2R)CX1/+
Bx1 has visible phenotype, enhanceable by Df(2R)E3363/+
Bx1 has visible phenotype, enhanceable by Df(2R)nap1/+
Bx1 has visible phenotype, enhanceable by Df(2R)Np5/+
Bx1 has visible phenotype, enhanceable by Df(2R)or-BR6/+
Bx1 has visible phenotype, enhanceable by Df(2R)vg-C/+
Bx1 has visible phenotype, enhanceable by Df(2R)X58-12/+
Bx1 has visible phenotype, enhanceable by Df(3L)AC1/+
Bx1 has visible phenotype, enhanceable by Df(3R)DG2/+
Bx1 has visible phenotype, enhanceable by Df(3R)M-Kx1/+
Bx1 has visible phenotype, enhanceable by In(3LR)C190LUbx42TR/+
Bx1 has visible phenotype, enhanceable by trn28.4/trn[+]
Bx1 has visible phenotype, enhanceable by trnΔ2.9/caps65.2
hideNOT Enhanced by
Statement
Reference
Bx1 has visible | dominant phenotype, non-enhanceable by cbt[+]/cbtEP2237E28
Bx1 has visible | dominant phenotype, non-enhanceable by mir-14[+]/mir-14Δ1
Bx1 has visible | dominant phenotype, non-enhanceable by pnt[+]/pntΔ88
hideSuppressed by
Statement
Reference
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by cbtEP2-408/Scer\GAL4ap-md544
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by cicEP3-1005/Scer\GAL4ap-md544
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by drprEP2-867
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by lilliEP2-27/Scer\GAL4ap-md544
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by nmdEP2-446
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by osaEP3-1591/Scer\GAL4ap-md544
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by pntEP3-853/Scer\GAL4ap-md544
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by pntEP3-1859/Scer\GAL4ap-md544
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by sbbEP2-473/Scer\GAL4ap-md544
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/apEP2-1583
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/chmEP2-1069
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/fngEP3-511
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/fngEP3-581
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/MpcpEP3-488
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/nufEP3-1715
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/osaEP3-473
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/osaEP3-619
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/osaEP3-900
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/osaEP3-1386
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/pntEP3-1638
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/shnEP2-1279
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by shnEP2-1743/Scer\GAL4ap-md544
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by skdEP3-532
Bx1, ap[+]/apmd544 has visible phenotype, suppressible by SlhEP2-18/Scer\GAL4ap-md544
Bx1 has visible | dominant phenotype, suppressible by drpr[+]/drprΔ19
Bx1 has visible | dominant phenotype, suppressible by drprEP522/drpr[+]
Bx1 has visible | dominant phenotype, suppressible by drprΔ5/drpr[+]
Bx1 has visible | dominant phenotype, suppressible by H[+]/HE31
Bx1 has visible | dominant phenotype, suppressible by NAx-M1/N[+]
Bx1 has visible | dominant phenotype, suppressible by nmdry4/nmd[+]
Bx1 has visible | dominant phenotype, suppressible by skd[+]/skdrK760
Bx1 has visible | dominant phenotype, suppressible by skdEP3375/skd[+]
Bx1 has visible | dominant phenotype, suppressible by skdL7062/skd[+]
hideNOT suppressed by
Statement
Reference
Bx1 has visible | dominant phenotype, non-suppressible by cbt[+]/cbtEP2237E28
Bx1 has visible | dominant phenotype, non-suppressible by mir-14[+]/mir-14Δ1
Bx1 has visible | dominant phenotype, non-suppressible by pnt[+]/pntΔ88
hideOther
Statement
Reference
hide Phenotype Manifest In
hideEnhanced by
Statement
Reference
Bx1 has wing margin phenotype, enhanceable by ap[+]/apmd544
Bx1 has wing margin phenotype, enhanceable by ap[+]/apUGO35
Bx1 has wing margin phenotype, enhanceable by brmT362/brm[+]
Bx1 has wing margin phenotype, enhanceable by caps65.2/caps[+]
Bx1 has wing margin phenotype, enhanceable by CG11399EY11352/CG11399[+]
Bx1 has wing margin phenotype, enhanceable by cic[+]/cicD49
Bx1 has wing margin phenotype, enhanceable by Df(2L)C144/+
Bx1 has wing margin phenotype, enhanceable by Df(2L)spd/+
Bx1 has wing margin phenotype, enhanceable by Df(2R)Jp1/+
Bx1 has wing margin phenotype, enhanceable by Df(3L)29A6/+
Bx1 has wing margin phenotype, enhanceable by Df(3L)Cat/+
Bx1 has wing margin phenotype, enhanceable by Df(3L)HR232/+
Bx1 has wing margin phenotype, enhanceable by Df(3L)HR370/+
Bx1 has wing margin phenotype, enhanceable by Df(3L)XS572/+
Bx1 has wing margin phenotype, enhanceable by Df(3R)3450/+
Bx1 has wing margin phenotype, enhanceable by Df(3R)Antp17/+
Bx1 has wing margin phenotype, enhanceable by Df(3R)by10/+
Bx1 has wing margin phenotype, enhanceable by Df(3R)Cha7/+
Bx1 has wing margin phenotype, enhanceable by Df(3R)M-Kx1/+
Bx1 has wing margin phenotype, enhanceable by Df(3R)p40/+
Bx1 has wing margin phenotype, enhanceable by Df(3R)p712/+
Bx1 has wing margin phenotype, enhanceable by Df(3R)Tpl10/+
Bx1 has wing margin phenotype, enhanceable by fng[+]/fng80
Bx1 has wing margin phenotype, enhanceable by l(3)0470804708/l(3)04708[+]
Bx1 has wing margin phenotype, enhanceable by lilli00632/lilli[+]
Bx1 has wing margin phenotype, enhanceable by Mpcp00564/Mpcp[+]
Bx1 has wing margin phenotype, enhanceable by nufKG02305/nuf[+]
Bx1 has wing margin phenotype, enhanceable by osa[+]/osa308
Bx1 has wing margin phenotype, enhanceable by sbb[+]/sbb6
Bx1 has wing margin phenotype, enhanceable by Ser[+]/SerRX82
Bx1 has wing margin phenotype, enhanceable by shn1/shn[+]
Bx1 has wing margin phenotype, enhanceable by shn04738/shn[+]
Bx1 has wing margin phenotype, enhanceable by Su(Tpl)[+]/Su(Tpl)17
Bx1 has wing margin phenotype, enhanceable by Su(Tpl)[+]/Su(Tpl)S-192
Bx1 has wing margin phenotype, enhanceable by tara1/tara[+]
Bx1 has wing margin phenotype, enhanceable by tara03881/tara[+]
Bx1 has wing margin phenotype, enhanceable by trn28.4/trn[+]
Bx1 has wing phenotype, enhanceable by +/Df(1)ct-J4
Bx1 has wing phenotype, enhanceable by +/Df(2R)M41A4
Bx1 has wing phenotype, enhanceable by +/Df(3L)brm11
Bx1 has wing phenotype, enhanceable by +/Df(3R)D605
Bx1 has wing phenotype, enhanceable by apUGO35
Bx1 has wing phenotype, enhanceable by caps05121/caps[+]
Bx1 has wing phenotype, enhanceable by Chie5.5
Bx1 has wing phenotype, enhanceable by Df(1)C246/+
Bx1 has wing phenotype, enhanceable by Df(1)N19/+
Bx1 has wing phenotype, enhanceable by Df(2L)al/+
Bx1 has wing phenotype, enhanceable by Df(2R)CX1/+
Bx1 has wing phenotype, enhanceable by Df(2R)E3363/+
Bx1 has wing phenotype, enhanceable by Df(2R)nap1/+
Bx1 has wing phenotype, enhanceable by Df(2R)Np5/+
Bx1 has wing phenotype, enhanceable by Df(2R)or-BR6/+
Bx1 has wing phenotype, enhanceable by Df(2R)vg-C/+
Bx1 has wing phenotype, enhanceable by Df(2R)X58-12/+
Bx1 has wing phenotype, enhanceable by Df(3L)AC1/+
Bx1 has wing phenotype, enhanceable by Df(3R)DG2/+
Bx1 has wing phenotype, enhanceable by Df(3R)M-Kx1/+
Bx1 has wing phenotype, enhanceable by fng80
Bx1 has wing phenotype, enhanceable by In(3LR)C190LUbx42TR/+
Bx1 has wing phenotype, enhanceable by trn28.4/trn[+]
Bx1 has wing phenotype, enhanceable by trnΔ2.9/caps65.2
hideNOT Enhanced by
Statement
Reference
Bx1 has wing margin phenotype, non-enhanceable by cbt[+]/cbtEP2237E28
Bx1 has wing margin phenotype, non-enhanceable by mir-14[+]/mir-14Δ1
Bx1 has wing margin phenotype, non-enhanceable by pnt[+]/pntΔ88
hideSuppressed by
Statement
Reference
Bx1, ap[+]/apmd544 has wing margin phenotype, suppressible by drprEP2-867
Bx1, ap[+]/apmd544 has wing margin phenotype, suppressible by nmdEP2-446
Bx1, ap[+]/apmd544 has wing margin phenotype, suppressible by skdEP3-532
Bx1 has wing margin phenotype, suppressible by drpr[+]/drprΔ19
Bx1 has wing margin phenotype, suppressible by drprEP522/drpr[+]
Bx1 has wing margin phenotype, suppressible by drprΔ5/drpr[+]
Bx1 has wing margin phenotype, suppressible by H[+]/HE31
Bx1 has wing margin phenotype, suppressible by NAx-M1/N[+]
Bx1 has wing margin phenotype, suppressible by nmdry4/nmd[+]
Bx1 has wing margin phenotype, suppressible by skd[+]/skdrK760
Bx1 has wing margin phenotype, suppressible by skdEP3375/skd[+]
Bx1 has wing margin phenotype, suppressible by skdL7062/skd[+]
hideNOT suppressed by
Statement
Reference
Bx1 has wing margin phenotype, non-suppressible by cbt[+]/cbtEP2237E28
Bx1 has wing margin phenotype, non-suppressible by mir-14[+]/mir-14Δ1
Bx1 has wing margin phenotype, non-suppressible by pnt[+]/pntΔ88
hideOther
Statement
Reference
hide Additional Comments
hide Genetic Interactions
Statement
Reference
Bx[1]/Y ; ap[md544]/+ males have a strong wing scalloping phenotype.
apmd544/+ enhances the severity of the Bx1 wing scalloping phenotype. The Bx1 scalloped wing phenotype is completely suppressed by expression of apScer\UAS.cMa under the control of Scer\GAL4ap-md544. The Bx1 scalloped wing phenotype is suppressed by expression of fngScer\UAS.cKa or SerScer\UAS.cSa under the control of Scer\GAL4ap-md544. The severity of the Bx1/+ wing scalloping phenotype is enhanced by one copy of apUGO35, fng80, SerRX82, osa308 or brmT362. The Bx1 scalloped wing phenotype is completely suppressed by expression of osaScer\UAS.cCa, osaEP3-900, osaEP3-1591, osaEP3-619, osaEP3-941, osaEP3-473, osaEP3-1074 or osaEP3-1386 under the control of Scer\GAL4ap-md544.
The wing phenotype of Bx1 heterozygotes is dominantly enhanced by apUGO35, fng80 or Chie5.5. The wing phenotype of heterozygotes is completely suppressed by apScer\UAS.cMa expressed under the control of Scer\GAL4ap-md544. The wing scalloping phenotype of heterozygotes is fully rescued by fngScer\UAS.cKa expressed under the control of Scer\GAL4ap-md544, but the transformation phenotype of the alula is not.
hide Xenogenetic Interactions
Statement
Reference
hide Complementation & Rescue Data
Comments
hide Stocks ( 5 )
Bloomington
15
Kyoto
105676
hide Notes on Origin
Discoverer
Bridges, 3rd Jan. 1923.
hide Comments
Alleles fall into an allelic series based on cocaine resistance phenotype. BxJ > Bx1 = Bx2 = Bx3.
No interaction with Doa alleles is observed.
hide External Crossreferences & Linkouts
Other Crossreferences
Linkouts
hide Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym
Name Synonym
Secondary FlyBase IDs
hide References ( 18 )
Research paper
Lasek et al., 2011, Alcoholism, Clin. Exp. Res. 35(9): 1600--1606
Lmo Genes Regulate Behavioral Responses to Ethanol in Drosophila melanogaster and the Mouse. [FBrf0215015]
Bejarano et al., 2010, Dev. Biol. 338(1): 63--73
miR-9a prevents apoptosis during wing development by repressing Drosophila LIM-only. [FBrf0209786]
Bejarano et al., 2008, Genetics 178(1): 307--323
A gain-of-function suppressor screen for genes involved in dorsal-ventral boundary formation in the Drosophila wing. [FBrf0202749]
Milan et al., 2004, Mech. Dev. 121(5): 491--497
Osa modulates the expression of Apterous target genes in the Drosophila wing. [FBrf0179340]
Tsai et al., 2004, PLoS Biol. 2(12): e408
Lmo Mutants Reveal a Novel Role for Circadian Pacemaker Neurons in Cocaine-Induced Behaviors. [FBrf0180477]
Delanoue et al., 2002, Genes Cells 7(12): 1255--1266
Interaction between apterous and early expression of vestigial in formation of the dorso-ventral compartments in the Drosophila wing disc. [FBrf0155789]
Milan et al., 2001, Cell 106(6): 785--794
The LRR proteins Capricious and Tartan mediate cell interactions during DV boundary formation in the Drosophila wing. [FBrf0139604]
Milan et al., 1998, Genes Dev. 12(18): 2912--2920
Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function. [FBrf0104769]
Shoresh et al., 1998, Genetics 150(1): 283--299
Overexpression beadex mutations and loss-of-function heldup-a mutations in Drosophila affect the 3' regulatory and coding components, respectively, of the dlmo gene. [FBrf0104513]
Zeng et al., 1998, Proc. Natl. Acad. Sci. U.S.A. 95(18): 10637--10642
The Drosophila LIM-only gene, dLMO, is mutated in beadex alleles and might represent an evolutionarily conserved function in appendage development. [FBrf0104534]
Rabinow et al., 1993, Genetics 134(4): 1175--1185
Mutations at the darkener of apricot locus modulate transcript levels of copia and copia-induced mutations in Drosophila melanogaster. [FBrf0058584]
Mattox and Davidson, 1984, Mol. Cell. Biol. 4: 1343--1353
Isolation and characterization of the Beadex locus of Drosophila melanogaster: a putative cis-acting negative regulatory element for the heldup-a gene. [FBrf0041457]
Green, 1953, Genetics 38: 91--105
The Beadex locus in Drosophila melanogaster: on the nature of the mutants Bxr and Bxl. [FBrf0009023]
Waddington, 1940, J. Genet. 41: 75--139
The genetic control of wing development in Drosophila. [FBrf0005070]
Goldschmidt, 1935, Biol. Zentbl. 55: 535--554
Gen und Aussencharakter. (Untersuchungen an Drosophila). [FBrf0002990]
Book
Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp
Genetic variations of Drosophila melanogaster. [FBrf0020044]
Bridges and Brehme, 1944, Publs Carnegie Instn 552: vii + 257pp
The mutants of Drosophila melanogaster. [FBrf0006100]
Morgan et al., 1925, Biblphia Genet. 2: 262pp
The genetics of Drosophila melanogaster. [FBrf0001379]