FlyBase Allele Report: Dmel\Bx[3]

General Information

Symbol

Dmel\Bx³

Species

D. melanogaster

Name

FlyBase ID

FBal0001433

Feature type

allele

Associated gene

Dmel\Bx

Associated Insertion(s)

roo{}Bx³

Carried in Construct

Key Links

Allele class

hypermorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypermorphic allele - genetic evidence

(Rabinow et al., 1993)

Mutagen

spontaneous

Progenitor genotype

Associated Insertion(s)

roo{}Bx³

Cytology

Description

Insertion of approximately 9kb into the 3' UTR.

(Shoresh et al., 1998)

Insertion of a roo element.

(Rabinow et al., 1993)

10.3 kb (roo).

(Waddington, 1940)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical resistant

(Tsai et al., 2004)

viable

visible

(Delanoue et al., 2002, Zeng et al., 1998)

visible | dominant

(Shoresh et al., 1998)

Phenotype Manifest In

wing

(Delanoue et al., 2002, Zeng et al., 1998)

wing margin

(Shoresh et al., 1998)

wing vein L5

Detailed Description

Statement

Reference

Mutant animals exhibit an decreased sensitivity to cocaine.

(Tsai et al., 2004)

Homozygotes have a scalloped wing phenotype.

(Delanoue et al., 2002)

Shows dominant wing scalloping.

(Shoresh et al., 1998)

Flies show disruption of the wing margin resulting in scalloping of the wing.

(Zeng et al., 1998)

Third-instar larvae show 20-40 degenerating cells in area of wing disk corresponding to future wing margin.

(Fristrom, 1969)

Scalloping visible in prepupal wing bud.

(Waddington, 1940)

Extreme allele usually without the bubbles in the wing; shortened L5 a constant character; wings more pointed than Bx² and hairs at tip of wing clumped. RK1.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Bx³ has visible phenotype, enhanceable by vg[+]/vg^null

(Delanoue et al., 2002)

NOT Enhanced by

Statement

Reference

Bx³ has visible phenotype, non-enhanceable by vg[+]/vg^83b27

(Delanoue et al., 2002)

Suppressed by

Statement

Reference

Bx³ has visible phenotype, suppressible by Dp(2;Y)G44

(Delanoue et al., 2002)

NOT suppressed by

Statement

Reference

Bx³ has visible phenotype, non-suppressible by vg[+]/vg^83b27

(Delanoue et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

Bx³ has wing phenotype, enhanceable by vg[+]/vg^null

(Delanoue et al., 2002)

Bx³ has phenotype, enhanceable by Chi^e5.5

(Shoresh et al., 1998)

Bx³ has phenotype, enhanceable by ap^56f

(Shoresh et al., 1998)

NOT Enhanced by

Statement

Reference

Bx³ has wing phenotype, non-enhanceable by vg[+]/vg^83b27

(Delanoue et al., 2002)

Suppressed by

Statement

Reference

Bx³ has wing phenotype, suppressible by Dp(2;Y)G44

(Delanoue et al., 2002)

NOT suppressed by

Statement

Reference

Bx³ has wing phenotype, non-suppressible by vg[+]/vg^83b27

(Delanoue et al., 2002)

Bx³ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Other

Statement

Reference

Bx³, Dp(2;Y)G44 has wing phenotype

(Delanoue et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The scalloped wing phenotype seen in Bx³ homozygotes is enhanced by vg^null/+.

The scalloped wing phenotype seen in Bx³ homozygotes is unaffected by vg^83b27/+.

The scalloped wing phenotype seen in Bx³ homozygotes is rescued by Dp(2;Y)G44, although the wings have rigidity defects.

(Delanoue et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (1)

Kyoto

105678

Bx³/C(1)DX, y¹ w¹ f¹

Notes on Origin

Discoverer

Gershenson, 1927.

Comments

Bx³/+ fully separable from wild-type.

Alleles fall into an allelic series based on cocaine resistance phenotype. Bx^J > Bx¹ = Bx² = Bx³.

(Tsai et al., 2004)

Bx³ in heterozygous combination with a Bx deficiency or Bx has normal wing phenotype.

(Lifschytz and Green, 1979)

No interaction with Doa alleles is observed.

(Rabinow et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Bx³

(Delanoue et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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