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General Information
Symbol
Dmel\Bx3
Species
D. melanogaster
Name
FlyBase ID
FBal0001433
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of approximately 9kb into the 3' UTR.

Insertion of a roo element.

10.3 kb (roo).

Insertion components
roo{}Bx3
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutant animals exhibit an decreased sensitivity to cocaine.

Homozygotes have a scalloped wing phenotype.

Shows dominant wing scalloping.

Flies show disruption of the wing margin resulting in scalloping of the wing.

Third-instar larvae show 20-40 degenerating cells in area of wing disk corresponding to future wing margin.

Scalloping visible in prepupal wing bud.

Extreme allele usually without the bubbles in the wing; shortened L5 a constant character; wings more pointed than Bx2 and hairs at tip of wing clumped. RK1.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Bx3 has visible phenotype, enhanceable by vg[+]/vgnull

NOT Enhanced by
Statement
Reference

Bx3 has visible phenotype, non-enhanceable by vg[+]/vg83b27

Suppressed by
Statement
Reference

Bx3 has visible phenotype, suppressible by Dp(2;Y)G44

NOT suppressed by
Statement
Reference

Bx3 has visible phenotype, non-suppressible by vg[+]/vg83b27

Phenotype Manifest In
Enhanced by
Statement
Reference

Bx3 has wing phenotype, enhanceable by vg[+]/vgnull

Bx3 has phenotype, enhanceable by Chie5.5

Bx3 has phenotype, enhanceable by ap56f

NOT Enhanced by
Statement
Reference

Bx3 has wing phenotype, non-enhanceable by vg[+]/vg83b27

Suppressed by
Statement
Reference

Bx3 has wing phenotype, suppressible by Dp(2;Y)G44

NOT suppressed by
Statement
Reference

Bx3 has wing phenotype, non-suppressible by vg[+]/vg83b27

Bx3 has phenotype, non-suppressible by su(Hw)2

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The scalloped wing phenotype seen in Bx3 homozygotes is enhanced by vgnull/+.

The scalloped wing phenotype seen in Bx3 homozygotes is unaffected by vg83b27/+.

The scalloped wing phenotype seen in Bx3 homozygotes is rescued by Dp(2;Y)G44, although the wings have rigidity defects.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (1)
Stocks (1)
Notes on Origin
Discoverer

Gershenson, 1927.

Comments
Comments

Bx3/+ fully separable from wild-type.

Alleles fall into an allelic series based on cocaine resistance phenotype. BxJ > Bx1 = Bx2 = Bx3.

Bx3 in heterozygous combination with a Bx deficiency or Bx has normal wing phenotype.

No interaction with Doa alleles is observed.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (11)