A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\ca1

General Information
SymbolDmel\ca1SpeciesD. melanogaster
NameFlyBase IDFBal0001461
Feature typealleleAssociated geneDmel\ca
Also Known Asca
Allele class
Mutagenspontaneous
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Description
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FB2013_03
FB2013_02
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hide Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
14bp deletion in the second coding exon that results in a frame shift after residue 194 and premature termination of translation after an additional 11 amino acids.
Carried on aberration
 
Cytology
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Statement
Reference
Mutant flies show a significant decrease in ommochrome pigment levels and some reduction in drosopterin pigment levels compared to wild type.
Mutant flies have reduced red pigment in the eye compared to controls.
The primary pigment cells in ca1 flies lack the large electron-lucent xanthommatin granules seen in wild type, while the granules in the secondary and tertiary pigment cells are fewer in number than normal and vary considerably in shape and density of their content. The small xanthommatin pigment granules seen in photoreceptor cells in wild-type animals appear to be normal in ca1 flies. and bwkΔ11 produces animals with an extra veins phenotype.
Considerable amounts of pigment are deposited in the eye but the ocelli remain colourless.
Uptake of radio-labeled kynurenine by larval Malpighian tubules greatly reduced; uptake by developing eyes nearly normal.
Presence of 4-0-glucosyl-N-acetyldopamine, possibly a detoxification product of dopamine.
Produce less v+ substance than wild type.
Malpighian tubule colour: colourless.
Eye color autonomous when larval optic disk from ca1 is transplanted into wild type or v hosts. Wild-type disk in ca1 not entirely autonomous.
RK1. Eye colour: ruby. Body slightly narrow; wings pointed.
 
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hideNOT Enhanced by
Statement
Reference
ca1 has eye color defective phenotype, non-enhanceable by blos1ex2
hideNOT suppressed by
Statement
Reference
ca1 has eye color defective phenotype, non-suppressible by blos1ex2
hideEnhancer of
Statement
Reference
ca1 is an enhancer of visible phenotype of Scer\GAL4GMR.PF, aosGD16463
hideOther
Statement
Reference
hide Phenotype Manifest In
hideNOT suppressed by
Statement
Reference
ca1 has phenotype, non-suppressible by su(Hw)2
hideEnhancer of
Statement
Reference
ca1 is an enhancer of eye phenotype of Scer\GAL4GMR.PF, aosGD16463
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Statement
Reference
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Statement
Reference
The reduction in drosopterin pigment levels seen in flies carrying w[dsRNA.GMR] is enhanced manyfold if they are also mutant for ca[1]. The mispatterning of the eye caused by expression of aos[GD16463] under the control of Scer\GAL4[GMR.PF] is enhanced in a ca[1] background.
The reduced red eye pigment phenotype of ca[1] blos1[ex2] double mutants is indistinguishable from that of ca[1] single mutants.
The level of pteridine eye pigments in ltd1 ; ca1 double mutant flies resembles that seen in ca1 single mutants.
Eye colour: deep reddish yellow, with cn1. Eye colour: translucent brownish yellow, with bw1.
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Statement
Reference
hide Complementation & Rescue Data
Fails to complement
Rescued by
Not rescued by
Comments
hide Stocks ( 454 )
Bloomington
459
Kyoto
105922
101584
105923
hide Notes on Origin
Discoverer
Bridges, 12th Dec. 1919.
hide Comments
Mutant does not affect ncd function.
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hide Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym
Name Synonym
Secondary FlyBase IDs
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hide Recent research papers ( 1 )
Harris et al., 2011, J. Cell Biol. 194(1): 77--87
Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing. [FBrf0214287]