A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Allele Dmel\ca1

General Information
SymbolDmel\ca1SpeciesD. melanogaster
NameFlyBase IDFBal0001461
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\ca
Allele class
Mutagenspontaneous
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Allele class
Mutagen
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
      14bp deletion in the second coding exon that results in a frame shift after residue 194 and premature termination of translation after an additional 11 amino acids.
      Assay mode
      Carried on aberration
       
      Cytology
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      hide Phenotype Manifest In
       
      hide Detailed Description
      Statement
      Reference
      RK1. Eye colour: ruby. Body slightly narrow; wings pointed.
       
      Eye color autonomous when larval optic disk from ca1 is transplanted into wild type or v hosts. Wild-type disk in ca1 not entirely autonomous.
      Malpighian tubule colour: colourless.
      Produce less v+ substance than wild type.
      Presence of 4-0-glucosyl-N-acetyldopamine, possibly a detoxification product of dopamine.
      Uptake of radio-labeled kynurenine by larval Malpighian tubules greatly reduced; uptake by developing eyes nearly normal.
      Considerable amounts of pigment are deposited in the eye but the ocelli remain colourless.
      The primary pigment cells in ca1 flies lack the large electron-lucent xanthommatin granules seen in wild type, while the granules in the secondary and tertiary pigment cells are fewer in number than normal and vary considerably in shape and density of their content. The small xanthommatin pigment granules seen in photoreceptor cells in wild-type animals appear to be normal in ca1 flies. and bwkΔ11 produces animals with an extra veins phenotype.
      hide Interactions
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      hideEnhancer of
      Statement
      Reference
      ca1/ca[+] is an enhancer of visible phenotype of Scer\GAL4GMR.PF, bchsEP2299
      hideOther
      Statement
      Reference
      hide Phenotype Manifest In
      hideNOT suppressed by
      Statement
      Reference
      ca1 has phenotype, non-suppressible by su(Hw)2
      hideEnhancer of
      Statement
      Reference
      ca1/ca[+] is an enhancer of eye phenotype of Scer\GAL4GMR.PF, bchsEP2299
      hideOther
      Statement
      Reference
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      Eye colour: deep reddish yellow, with cn1. Eye colour: translucent brownish yellow, with bw1.
      The level of pteridine eye pigments in ltd1 ; ca1 double mutant flies resembles that seen in ca1 single mutants.
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Fails to complement
      Rescued by
      Not rescued by
      Comments
      hide Stocks ( 460 )
      Bloomington
      459
      Kyoto
      105922
      101584
      105923
      hide Notes on Origin
      Discoverer
      Bridges, 12th Dec. 1919.
      hide Comments
      Mutant does not affect ncd function.
      hide Synonyms & Secondary IDs ( 4 )
      Reported As
      Symbol Synonym
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 33 )
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        hide Recent research papers ( 1 )
        Simonsen et al., 2007, Genetics 176(2): 1283--1297
        Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles. [FBrf0201586]