A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Allele Dmel\ca1

General Information
SymbolDmel\ca1SpeciesD. melanogaster
NameFlyBase IDFBal0001461
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\ca
Allele class
Mutagenspontaneous
hide Nature of the Allele
Allele class
Mutagen
spontaneous
 
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
      14bp deletion in the second coding exon that results in a frame shift after residue 194 and premature termination of translation after an additional 11 amino acids.
      (Ma et al., 2004)
      Assay mode
      Carried on aberration
      TM6B-P{HZ2.7}3
      (Beitel, 2004.9.21)
      TM6B-P{Dfd-EYFP}3
      (FlyBase Curators, 2006-, Beitel, 2005.3.25)
      TM6C-ca1
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      Df(3R)BSC47
      (Andrade et al., 2004.1.19)
      TM6B-Tb+ca1
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      Dp(3;3)Cam36
      (Roote, 2000.3.14, Roote, 2004.6.24)
      Df(3R)BSC38
      (Andrade et al., 2003.7.4)
      Payne-Dc
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 1998.8.25)
      Df(3R)BSC48
      (Andrade and Cook, 2004.1.19)
      C(3)EN-Z170-vNh
      (Novitski et al., 1981)
      TM6C-cSc
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      Df(3R)BSC56
      (Andrade et al., 2004.9.20)
      C(3)EN-W96-vNe
      (Novitski et al., 1981)
      F(3R)2
       
      C(3)EN-W96-vNg
      (Novitski et al., 1981)
      TM6B-rTc
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      Df(3R)BSC24
      (Deal-Herr and Cook, 2002.11.8)
      C(3R)RM-SH4b
       
      C(3)EN-W96-vNf
      (Novitski et al., 1981)
      Df(3R)BSC43
      (Bloomington Drosophila Stock Center, 2003.12.2)
      Df(3R)BSC42
      (Bloomington Drosophila Stock Center, 2003.12.2)
      TM6B-Tc
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      TM6B-Sb1
      (FlyBase Curators, 2006-, Kennison, 1999.2.11)
      TM6B-P{Dfd-GMR-nvYFP}4
      (Beitel, 2007.4.20)
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      visible | recessive
       
      eye color defective
      (Silva and Mensua, 1985, )
      eye color defective | recessive
      (Yamamoto et al., 1989)
      hide Phenotype Manifest In
      pigment cell
      (Silva and Mensua, 1985, Yamamoto et al., 1989, )
      eye
      (Yamamoto et al., 1989)
      wing
       
      abdomen
       
      primary pigment cell pigment granule
      (Ma et al., 2004)
      secondary pigment cell pigment granule
      (Ma et al., 2004)
      tertiary pigment cell pigment granule
      (Ma et al., 2004)
      hide Detailed Description
      Statement
      Reference
      RK1. Eye colour: ruby. Body slightly narrow; wings pointed.
       
      Eye color autonomous when larval optic disk from ca1 is transplanted into wild type or v hosts. Wild-type disk in ca1 not entirely autonomous.
      (Beadle and Ephrussi, 1936)
      Malpighian tubule colour: colourless.
      (Beadle, 1937)
      Produce less v+ substance than wild type.
      (Clancy, 1942)
      Presence of 4-0-glucosyl-N-acetyldopamine, possibly a detoxification product of dopamine.
      (Okubo, 1958)
      Uptake of radio-labeled kynurenine by larval Malpighian tubules greatly reduced; uptake by developing eyes nearly normal.
      (Sullivan and Sullivan, 1975)
      Considerable amounts of pigment are deposited in the eye but the ocelli remain colourless.
      (Tearle, 1991)
      The primary pigment cells in ca1 flies lack the large electron-lucent xanthommatin granules seen in wild type, while the granules in the secondary and tertiary pigment cells are fewer in number than normal and vary considerably in shape and density of their content. The small xanthommatin pigment granules seen in photoreceptor cells in wild-type animals appear to be normal in ca1 flies. and bwkΔ11 produces animals with an extra veins phenotype.
      (Ma et al., 2004)
      hide Interactions
      hide Phenotypic Class
      hideEnhancer of
      Statement
      Reference
      ca1/ca[+] is an enhancer of visible phenotype of Scer\GAL4GMR.PF, bchsEP2299
      (Simonsen et al., 2007)
      hideOther
      Statement
      Reference
      ca1, cic1 has wild-type phenotype
      (Ma et al., 2004)
      hide Phenotype Manifest In
      hideNOT suppressed by
      Statement
      Reference
      ca1 has phenotype, non-suppressible by su(Hw)2
      (Lindsley and Grell, 1968)
      hideEnhancer of
      Statement
      Reference
      ca1/ca[+] is an enhancer of eye phenotype of Scer\GAL4GMR.PF, bchsEP2299
      (Simonsen et al., 2007)
      hideOther
      Statement
      Reference
      ca1, cicD49 has wing vein | ectopic phenotype
      (Ma et al., 2004)
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      Eye colour: deep reddish yellow, with cn1. Eye colour: translucent brownish yellow, with bw1.
      (Mainx, 1938)
      The level of pteridine eye pigments in ltd1 ; ca1 double mutant flies resembles that seen in ca1 single mutants.
      (Ma et al., 2004)
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Fails to complement
      ca32
      (Yamamoto et al., 1989)
      ca33
      (Yamamoto et al., 1989)
      ca34
      (Yamamoto et al., 1989)
      cand5
      (Yamamoto et al., 1989)
      cand6
      (Yamamoto et al., 1989)
      cand7
      (Yamamoto et al., 1989)
      cand8
      (Yamamoto et al., 1989)
      Rescued by
      ca1 is rescued by ca1-1273.Scer\UAS.T:Ivir\HA1/Scer\GAL4αTub84B.PL
      (Ma et al., 2004)
      ca1 is rescued by caScer\UAS.T:Ivir\HA1/Scer\GAL4αTub84B.PL
      (Ma et al., 2004)
      Not rescued by
      ca1 is not rescued by ca1-1132.Scer\UAS.T:Ivir\HA1/Scer\GAL4αTub84B.PL
      (Ma et al., 2004)
      Comments
      hide Stocks ( 460 )
      Bloomington
      459
      ca1
      1226
      TM6C, ca1
      460
      ca1 bv1
      461
      ca1 awdK
      465
      cmp1 ca1/TM6
      3115
      spz2 ca1/TM1
      1348
      Dp(3;1)67N; ca1 bv1
      Kyoto
      105922
      ca1
      101584
      ca1 awdK
      105923
      ca1 awdK
      106855
      spz2 ca1/TM1
      106282
      Dp(3;1)67N; ca1 bv1
      hide Notes on Origin
      Discoverer
      Bridges, 12th Dec. 1919.
      hide Comments
      Mutant does not affect ncd function.
      (Yamamoto et al., 1989)
      hide Synonyms & Secondary IDs ( 4 )
      Reported As
      Symbol Synonym
      ca
      (Endow et al., 1990, Yamamoto et al., 1989, Novitski et al., 1981)
      ca1
      (Christensen et al., 2008.6.11)
      claret1
      (Simonsen et al., 2007)
      unnamed
      (Silva and Mensua, 1985, Roote, 2004.6.24)
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 33 )
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        hide Recent research papers ( 1 )
        Simonsen et al., 2007, Genetics 176(2): 1283--1297
        Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles. [FBrf0201586]
        Show all research papers ...