Allele Dmel\ca¹

General Information
Symbol	Dmel\ca¹	Species	D. melanogaster
Name		FlyBase ID	FBal0001461
Feature type	allele	Associated gene	Dmel\ca
Also Known As	ca

Allele class
Mutagen	spontaneous
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	spontaneous
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference 14bp deletion in the second coding exon that results in a frame shift after residue 194 and premature termination of translation after an additional 11 amino acids. (Ma et al., 2004)
Carried on aberration	C(3)EN-W96-vNe (Novitski et al., 1981) C(3)EN-W96-vNf (Novitski et al., 1981) C(3)EN-W96-vNg (Novitski et al., 1981) C(3)EN-Z170-vNh (Novitski et al., 1981) C(3R)RM-SH4b Df(3R)BSC24 (Deal-Herr and Cook, 2002.11.8) Df(3R)BSC38 (Andrade et al., 2003.7.4) Df(3R)BSC42 (Bloomington Drosophila Stock Center, 2003.12.2) Df(3R)BSC43 (Bloomington Drosophila Stock Center, 2003.12.2) Df(3R)BSC47 (Andrade et al., 2004.1.19) Df(3R)BSC48 (Andrade and Cook, 2004.1.19) Df(3R)BSC56 (Andrade et al., 2004.9.20) Dp(3;3)Cam36 (Roote, 2000.3.14, Roote, 2004.6.24) F(3R)2 Payne-Dc (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 1998.8.25) TM6B-P{Dfd-EYFP}3 (FlyBase Curators, 2006-, Beitel, 2005.3.25) TM6B-P{Dfd-GMR-nvYFP}4 (Beitel, 2007.4.20) TM6B-P{HZ2.7}3 (Beitel, 2004.9.21) TM6B-rTc (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28) TM6B-Sb¹ (FlyBase Curators, 2006-, Kennison, 1999.2.11) TM6B-Tb⁺ca¹ (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28) TM6B-Tc (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28) TM6C-ca¹ (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28) TM6C-cSc (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
Cytology
Phenotypic Data
Phenotypic Class
	eye color defective (Silva and Mensua, 1985, Cheli et al., 2010) eye color defective \| recessive (Yamamoto et al., 1989) visible \| recessive
Phenotype Manifest In
	abdomen eye (Yamamoto et al., 1989) pigment cell (Silva and Mensua, 1985, Yamamoto et al., 1989, ) primary pigment cell pigment granule (Ma et al., 2004) secondary pigment cell pigment granule (Ma et al., 2004) tertiary pigment cell pigment granule (Ma et al., 2004) wing
Detailed Description
	Statement Reference Mutant flies show a significant decrease in ommochrome pigment levels and some reduction in drosopterin pigment levels compared to wild type. (Harris et al., 2011) Mutant flies have reduced red pigment in the eye compared to controls. (Cheli et al., 2010) The primary pigment cells in ca¹ flies lack the large electron-lucent xanthommatin granules seen in wild type, while the granules in the secondary and tertiary pigment cells are fewer in number than normal and vary considerably in shape and density of their content. The small xanthommatin pigment granules seen in photoreceptor cells in wild-type animals appear to be normal in ca¹ flies. and bwk^Δ11 produces animals with an extra veins phenotype. (Ma et al., 2004) Considerable amounts of pigment are deposited in the eye but the ocelli remain colourless. (Tearle, 1991) Uptake of radio-labeled kynurenine by larval Malpighian tubules greatly reduced; uptake by developing eyes nearly normal. (Sullivan and Sullivan, 1975) Presence of 4-0-glucosyl-N-acetyldopamine, possibly a detoxification product of dopamine. (Okubo, 1958) Produce less v⁺ substance than wild type. (Clancy, 1942) Malpighian tubule colour: colourless. (Beadle, 1937) Eye color autonomous when larval optic disk from ca¹ is transplanted into wild type or v hosts. Wild-type disk in ca¹ not entirely autonomous. (Beadle and Ephrussi, 1936) RK1. Eye colour: ruby. Body slightly narrow; wings pointed.
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement Reference ca¹ has eye color defective phenotype, non-enhanceable by blos1^ex2 (Cheli et al., 2010)
NOT suppressed by
Statement Reference ca¹ has eye color defective phenotype, non-suppressible by blos1^ex2 (Cheli et al., 2010)
Enhancer of
Statement Reference ca¹/ca[+] is an enhancer of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 (Simonsen et al., 2007) ca¹ is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, aos^GD16463 (Harris et al., 2011)
Other
Statement Reference ca¹, cic¹ has wild-type phenotype (Ma et al., 2004)
Phenotype Manifest In
NOT suppressed by
Statement Reference ca¹ has phenotype, non-suppressible by su(Hw)² (Lindsley and Grell, 1968)
Enhancer of
Statement Reference ca¹/ca[+] is an enhancer of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, bchs^EP2299 (Simonsen et al., 2007) ca¹ is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, aos^GD16463 (Harris et al., 2011)
Other
Statement Reference ca¹, cic^D49 has wing vein \| ectopic phenotype (Ma et al., 2004)
Additional Comments
Genetic Interactions
Statement Reference The reduction in drosopterin pigment levels seen in flies carrying w[dsRNA.GMR] is enhanced manyfold if they are also mutant for ca[1]. The mispatterning of the eye caused by expression of aos[GD16463] under the control of Scer\GAL4[GMR.PF] is enhanced in a ca[1] background. (Harris et al., 2011) The reduced red eye pigment phenotype of ca[1] blos1[ex2] double mutants is indistinguishable from that of ca[1] single mutants. (Cheli et al., 2010) The level of pteridine eye pigments in ltd¹ ; ca¹ double mutant flies resembles that seen in ca¹ single mutants. (Ma et al., 2004) Eye colour: deep reddish yellow, with cn¹. Eye colour: translucent brownish yellow, with bw¹. (Mainx, 1938)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	ca³² (Yamamoto et al., 1989) ca³³ (Yamamoto et al., 1989) ca³⁴ (Yamamoto et al., 1989) ca^nd5 (Yamamoto et al., 1989) ca^nd6 (Yamamoto et al., 1989) ca^nd7 (Yamamoto et al., 1989) ca^nd8 (Yamamoto et al., 1989)
Rescued by	ca¹ is rescued by ca^{1-1273.Scer\UAS.T:Ivir\HA1}/Scer\GAL4^αTub84B.PL (Ma et al., 2004) ca¹ is rescued by ca^{Scer\UAS.T:Ivir\HA1}/Scer\GAL4^αTub84B.PL (Ma et al., 2004)
Not rescued by	ca¹ is not rescued by ca^{1-1132.Scer\UAS.T:Ivir\HA1}/Scer\GAL4^αTub84B.PL (Ma et al., 2004)
Comments
Stocks ( 454 )
Bloomington	459 ca¹ 1226 TM6C, ca¹ 461 ca¹ awd^K 465 cmp¹ ca¹/TM6 3115 spz² ca¹/TM1 27330 Qajjem²¹¹ ca¹ 1348 Dp(3;1)67N; ca¹ bv¹
Kyoto	105922 ca¹ 101584 ca¹ awd^K 105923 ca¹ awd^K 106855 spz² ca¹/TM1 106282 Dp(3;1)67N; ca¹ bv¹
	More stocks available...
Notes on Origin
Discoverer	Bridges, 12th Dec. 1919.

Comments
	Mutant does not affect ncd function. (Yamamoto et al., 1989)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	ca (Endow et al., 1990, Yamamoto et al., 1989, Novitski et al., 1981) ca¹ (Harris et al., 2011, Christensen et al., 2008.6.11, Cheli et al., 2010) claret¹ (Simonsen et al., 2007) unnamed (Silva and Mensua, 1985, Roote, 2004.6.24)
Name Synonym
Secondary FlyBase IDs

References ( 35 )

Generate a list of	All references relating to this allele ( 35 )

List References by type	Research paper ( 16 ) Personal communication to FlyBase ( 17 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers ( 1 )
	Harris et al., 2011, J. Cell Biol. 194(1): 77--87 Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing. [FBrf0214287] Show all research papers ...

Allele Dmel\ca1

Allele Dmel\ca¹