Allele Dmel\cact⁴

General Information
Symbol	Dmel\cact⁴	Species	D. melanogaster
Name		FlyBase ID	FBal0001510
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\cact

Allele class
Mutagen	ethyl methanesulfonate
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Tearle and Nusslein-Volhard, 1987, Roth et al., 1991, Ashburner et al., 1999.10.12)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Assay mode
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Tearle and Nusslein-Volhard, 1987, ) lethal \| embryonic stage (with cact¹) (Gordon et al., 2005)
Phenotype Manifest In
	embryo \| dorsal (with cact¹) (Gordon et al., 2005) embryonic dorsal epidermis (Roth et al., 1991) melanotic mass (Minakhina and Steward, 2006) larval digestive system (Minakhina and Steward, 2006)
Detailed Description
	Statement Reference Strong ventralizing phenotype: lack of all dorsally and laterally derived structures and the expansion of the ventral epidermis around the entire circumference. Expansion of twi expression in terminal regions. (Roth et al., 1991) cact¹/cact⁴ mutant embryos exhibit a strong ventralised phenotype. (Gordon et al., 2005) Mutant third instar larvae have melanotic nodules found in the hemocoel or in association with He-positive lymph glands. They also show gut melanisation not accompanied by tissue overgrowth or hemocyte encapsulation. (Minakhina and Steward, 2006)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference cact⁴/cact[+] is a suppressor of visible \| conditional - heat sensitive phenotype of peb¹ (Wilk et al., 2004)
Phenotype Manifest In
NOT Enhancer of
Statement Reference cact⁴/cact¹ is a non-enhancer of embryo \| ventral phenotype of Scer\GAL4^{nos.UTR.T:Hsim\VP16}, wntD^Scer\UAS.cGa (Gordon et al., 2005)
Suppressor of
Statement Reference cact⁴/cact[+] is a suppressor of eye \| conditional - heat sensitive phenotype of peb¹ (Wilk et al., 2004)
Additional Comments
Genetic Interactions
Statement Reference wntD^Scer\UAS.cGa,Scer\GAL4^{nos.UTR.T:Hsim\VP16} cact⁴/cact¹ mutant embryos exhibit a strongly dorsalised phenotype identical to wntD^Scer\UAS.cGa,Scer\GAL4^{nos.UTR.T:Hsim\VP16} alone. (Gordon et al., 2005)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	564 cact⁴ pr¹/CyO, P{elav-lacZ.H}YH2
Notes on Origin
Discoverer

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	cact⁴ cact^G8 (Roth et al., 1991, Tearle and Nusslein-Volhard, 1987, Minakhina and Steward, 2006)
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Minakhina and Steward, 2006, Genetics 174(1): 253--263 Melanotic mutants in Drosophila: pathways and phenotypes. [FBrf0194475] Gordon et al., 2005, Nature 437(7059): 746--749 WntD is a feedback inhibitor of Dorsal/NF-kappaB in Drosophila development and immunity. [FBrf0188139] Wilk et al., 2004, Genetics 168(1): 281--300 Dose-sensitive autosomal modifiers identify candidate genes for tissue autonomous and tissue nonautonomous regulation by the Drosophila nuclear zinc-finger protein, hindsight. [FBrf0180294] Roth et al., 1991, Development 112: 371--388 cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos. [FBrf0053786]
Personal communication to FlyBase	Ashburner et al., 1999.10.12, Adh. Adh. [FBrf0112153]
Stock list	Tearle and Nusslein-Volhard, 1987, D. I. S. 66: 209--269 Tubingen mutants and stock list. [FBrf0045941]

Allele Dmel\cact4

Allele Dmel\cact⁴