Allele Dmel\cbd¹

General Information
Symbol	Dmel\cbd¹	Species	D. melanogaster
Name		FlyBase ID	FBal0001557
Feature type	allele	Associated gene	Dmel\cbd
Also Known As	cbd^KS96

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	behavior defective \| larval stage (Varnam and Sokolowski, 1995) behavior defective \| recessive (Heisenberg et al., 1985) learning defective \| recessive (Heisenberg et al., 1985) locomotor behavior defective \| larval stage \| recessive (Varnam et al., 1996) memory defective (Liu et al., 2006)
Phenotype Manifest In
	adult central complex (Strauss and Heisenberg, 1993, Heisenberg et al., 1985, Renn et al., 1999) ellipsoid body (Strauss and Heisenberg, 1993) fan-shaped body (Strauss and Heisenberg, 1993) mushroom body (Heisenberg et al., 1985) mushroom body beta-lobe (Heisenberg et al., 1985) mushroom body gamma-lobe (Heisenberg et al., 1985) ring neuron R4 (Renn et al., 1999)
Detailed Description
	Statement Reference Mutants have impaired visual pattern memory. (Liu et al., 2006) Mutants show severe disruption of the central complex, including a failure of neuropils from the two hemispheres to fuse at the midline. On either side of the midline, axons form ellipsoid body-like structures which vary widely in shape. In most cases, R4d axons remain within the neuropil mass on the ipsilateral side, but occasionally they appear to cross the midline. (Renn et al., 1999) Homozygous larvae show reduced locomotor behaviour (shorter path lengths) on agar (non-foraging surface) and yeast (foraging surface) compared to controls. Larvae perform normally in a roll over test. (Varnam et al., 1996) Abnormal position and internal structure of optic lobes. (Strauss and Heisenberg, 1993) Central complex is dissociated into two fibre masses of variable shape. β,γ lobes of mushroom bodies are reduced. (Heisenberg et al., 1985) Entire central complex of brain (with exception of protocerebral bridge) dissociated into two fiber masses of variable shape; some of dorsal brain's mushroom body lobes reduced in size; inter-hemispheric commissure of brain reduced in size (in white pupae); abnormal learning in adult and larvae tests using olfactory stimuli; subnormal locomotor activity.
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	cbd¹ cbd^KS96 (Liu et al., 2006, Renn et al., 1999, Ferrus and Canal, 1994, Heisenberg et al., 1985, )
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Liu et al., 2006, Nature 439(7076): 551--556 Distinct memory traces for two visual features in the Drosophila brain. [FBrf0191247] Hitier et al., 2000, Mech. Dev. 99(1-2): 93--100 no-bridge and linotte act jointly at the interhemispheric junction to build up the adult central brain of Drosophila melanogaster. [FBrf0131314] Renn et al., 1999, J. Neurobiol. 41(2): 189--207 Genetic analysis of the Drosophila ellipsoid body neuropil: Organization and development of the central complex. [FBrf0111476] Varnam et al., 1996, J. Neurogenet. 11(1-2): 99--115 Larval behavior of Drosophila central complex mutants: interactions between no bridge, foraging, and chaser. [FBrf0108418] Strauss and Heisenberg, 1993, J. Neurosci. 13(5): 1852--1861 A higher control center of locomotor behavior in the Drosophila brain. [FBrf0058917] Heisenberg et al., 1985, J. Neurogenet. 2(1): 1--30 Drosophila mushroom body mutants are deficient in olfactory learning. [FBrf0043042]
Review	Ferrus and Canal, 1994, Trends Neurosci. 17(11): 479--486 The behaving brain of a fly. [FBrf0078379]
Abstract	Varnam and Sokolowski, 1995, J. Neurogenet. 10(1): 61 Larval locomotion in central complex mutants. [FBrf0082743]

Allele Dmel\cbd1

Allele Dmel\cbd¹