Open Close
General Information
Symbol
Dmel\cd1
Species
D. melanogaster
Name
FlyBase ID
FBal0001565
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous cd1 mutant flies show increased levels of 3-hydroxykynurenine (3-HK) compared to controls. No rhabdomere degeneration is seen in homozygous cd1 mutant flies.

Mutant flies show a significant reduction in ommochrome pigment levels compared to wild type.

Eye colour: pale brown. Ocellus colour: white. Eyes are pale brown. Blocks pigmentation of the secondary pigment cells and causes excessive pigmentation of the primary pigment cells.

Accumulates a blue-fluorescent compound termed cardinalic acid (xantherenic acid 8-O-β-O-glucoside).

Phenoxazinone synthetase activity about 39% wild type; accumulates 3-hydroxykinurenine.

Drosopterin content of eyes about 85% normal.

Eye color autonomous in transplant of larval optic disk into wild type, ca, cn, st, or vlarval host.

Eye colour: yellowish vermilion, darkening to wild-type with age. Ocellus colour: white; not darkening with age. Malpighian tubule colour: bright yellow; not distinguishable from wild type. RK2.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

cd1 partially suppresses the rhabdomere degeneration seen when Hsap\HTTQ93.ex1p.Scer\UAS is expressed under the control of Scer\GAL4elav-C155 at both one day and seven days post-eclosion. 3-hydroxykynurenine (3-HK) levels are unchanged but kynurenic acid (KYNA) levels are significantly increased, resulting in a significant increase in the 3-HK/KYNA ratio.

Complementation and Rescue Data
Comments
Images (2)
Stocks (22)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)