FlyBase Allele Report: Dmel\Cdk1[216A]

General Information

Symbol

Dmel\Cdk1^216A

Species

D. melanogaster

Name

FlyBase ID

FBal0001571

Feature type

allele

Associated gene

Dmel\Cdk1

Associated Insertion(s)

Carried in Construct

Also Known As

cdc2²¹⁶

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Stern et al., 1993)

Mutagen

ethyl methanesulfonate

(Clegg et al., 1993, Stern et al., 1993)

Progenitor genotype

Cytology

Description

Amino acid replacement: A145V. Nucleotide substitution: C?T.

(Clegg et al., 1993)

Missense mutation: alanine replaced by valine.

(Stern et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:10,385,359..10,385,359 [-]

Nucleotide change:

C10385359T

Reported nucleotide change:

C?T

Amino acid change:

A145V | Cdk1-PA

Reported amino acid change:

A145V

Comment:

The Cdk1^216A sequence is in GB:S66801.

(Clegg et al., 1993, Stern et al., 1993)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

S66801

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | larval stage

(Stern et al., 1993)

abnormal size | larval stage

(Stern et al., 1993)

lethal | recessive

(Stern et al., 1993)

lethal - all die before end of pupal stage | recessive

(Clegg et al., 1993)

some die during pupal stage | recessive

(Clegg et al., 1993)

Phenotype Manifest In

imaginal disc

(Stern et al., 1993)

larva

(Stern et al., 1993)

Detailed Description

Statement

Reference

Die after pupariation at the larval-pupal interface. Larvae take 1-2 days longer than wild type to reach the wandering stage. Imaginal discs are missing or rudimentary and larval brains are reduced in size. Endoreplication and polytenization of larval cells is normal, as are salivary gland size and intensity of DNA staining of their polytene nuclei.

(Stern et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Cdk1^216A is a non-enhancer of visible phenotype of Dp^GMR.PD, E2f1^GMR.PD

(Staehling-Hampton et al., 1999)

NOT Suppressor of

Statement

Reference

Cdk1^216A is a non-suppressor of visible phenotype of Dp^GMR.PD, E2f1^GMR.PD

(Staehling-Hampton et al., 1999)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Cdk1^216A/Df(2L)J27 is rescued by Cdk1^+t5.8

(Stern et al., 1993)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

S66801

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Cdk1^216A

cdc2²¹⁶

(Staehling-Hampton et al., 1999, Clegg et al., 1993)

cdc2^216A

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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