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General Information
Symbol
Dmel\cg1
Species
D. melanogaster
Name
FlyBase ID
FBal0001596
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of approximately 6kb in cg.

Insertion components
?{}cg1
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous and cg1/cg07659 flies have gaps in wing vein L4. Homozygous and cg1/cg07659 males have extra sex comb teeth.

cg1/cgk11504 transheterozygotes show pleiotropic defects in bristle number, wing venation and oogenesis.

Homozygotes have phenotypes in the wing, leg and antenna. Approximately 10% of cg1/cg07659 and 50% of cg1/cg3 animals eclose to adult stages, with most of the remaining animals dying as pharate adults. cg1/cg1, cg1/cg07659 and cg1/cg3 flies have defects in some combination of the posterior compartment longitudinal veins L4 and L5. Defects in vein L4, ranging from a slight thinning of the vein to gaps of increasing size are seen in 100% of wings of all three allelic combinations. Defects in wing vein L5 are seen in approximately 40% of cg1/cg1 wings, while less than 25% of cg1/cg07659 and cg1/cg3 flies have wing vein L5 defects. 40% of cg1/cg07659 flies have truncations of wing vein L2. This is rarely seen in cg1/cg1 or cg1/cg3 flies. Rarely (less than 1%), all three genotypes show outgrowths in the costal region of the anterior wing margin. Homozygous males have a few extra sex comb bristles. Bifurcated mesothoracic legs are occasionally seen. cg1/cg07659 leg discs show overgrowth in the anterior/posterior axis. cg1/cg07659 flies have expanded transverse rows and sex combs.

Terminal gaps in wing vein L4 and homozygotes have intercalary gaps in wing vein L5. Also abnormalities in legs and in oogenesis.

Oogenesis highly irregular.

Sex combs of male extremely large. Number of sex comb teeth increased from 10 to 18; number of bractless bristles increased; width of distal portion of basitarsus increased 1.6 fold; total number of bristles on basitarsus increased in both sexes (FBrf0065640; FBrf0063395). Some distortion and shortening of legs. Wings show gap in vein L4 between posterior crossvein and margin. Wings slightly curved. Effects result from a combination of overgrowth and irregular folding of imaginal rudiments during the pupal period. RK2.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

cg1 has phenotype, enhanceable by dunspecified

cg1 has phenotype, enhanceable by fjunspecified

cg1 has phenotype, enhanceable by dsunspecified

cg1 has phenotype, enhanceable by ssa

Suppressed by
NOT suppressed by
Statement
Reference

cg1 has phenotype, non-suppressible by su(Hw)2

Enhancer of
Statement
Reference

cg1 is an enhancer of phenotype of ciW

Other
Additional Comments
Genetic Interactions
Statement
Reference

Df(2R)en-11/+ ; cg1/+ double heterozygotes have a gap in wing vein L4. The abnormal leg disc morphology of cg1/cg07659 animals is substantially rescued by ciScer\UAS.T:Ivir\HA1 expressed under the control of Scer\GAL4ptc-559.1. The adult transverse row and sex comb phenotypes are also partially rescued.

Wing discs from l(2)gd11, cg1 double mutants show a variety of extra folds and extensive overgrowth. The second and third leg, haltere, female genital and eye-antenna discs all show duplication of various structures. These animals fail to form pharate adults and die as larvae or pupae.

Enhanced when homozygous by homozygous mutant alleles of d, fj, ds and by ssa. Double heterozygote with ci often shows gap in wing vein L4.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (5)
Notes on Origin
Discoverer
Comments
Comments

Double heterozygote en1 cg1/++ has slight degree of L4 interruption and thinning at low temperature. Triple heterozygote en1 cg1/++; ciunspecified/+ has L4 interruption in half the flies.

Sex-comb phenotype enhanced by sn or Pc/Scr.

ciW interacts strongly with cg1. cg1/+; ciW/+ resembles ciW/ciW.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (13)