FlyBase Allele Report: Dmel\cg[1]

General Information

Symbol

Dmel\cg¹

Species

D. melanogaster

Name

FlyBase ID

FBal0001596

Feature type

allele

Associated gene

Dmel\cg

Associated Insertion(s)

?{}cg¹

Carried in Construct

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

Progenitor genotype

Associated Insertion(s)

?{}cg¹

Cytology

Description

Insertion of approximately 6kb in cg.

(Svendsen et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | recessive

hyperplasia | recessive

viable

(Svendsen et al., 2000)

visible (with cg³)

(Svendsen et al., 2000)

visible (with cg⁰⁷⁶⁵⁹)

(Campbell and Tomlinson, 2000, Svendsen et al., 2000)

visible | recessive

(Campbell and Tomlinson, 2000, Svendsen et al., 2000, Diaz-Benjumea and Garcia-Bellido, 1990)

Phenotype Manifest In

antenna

(Svendsen et al., 2000)

leg

(Svendsen et al., 2000, Diaz-Benjumea and Garcia-Bellido, 1990)

leg disc (with cg⁰⁷⁶⁵⁹)

(Svendsen et al., 2000)

macrochaeta (with cg^k11504)

(Song et al., 2000)

mesothoracic leg

(Svendsen et al., 2000)

prothoracic tibial transverse row bristle | increased number (with cg⁰⁷⁶⁵⁹)

(Svendsen et al., 2000)

sex comb

sex comb | increased number

(Campbell and Tomlinson, 2000, Svendsen et al., 2000)

sex comb | increased number (with cg⁰⁷⁶⁵⁹)

(Campbell and Tomlinson, 2000, Svendsen et al., 2000)

wing

(Svendsen et al., 2000)

wing blade posterior compartment (with cg³)

(Svendsen et al., 2000)

wing blade posterior compartment (with cg⁰⁷⁶⁵⁹)

(Svendsen et al., 2000)

wing margin | anterior

(Svendsen et al., 2000)

wing margin | anterior (with cg³)

(Svendsen et al., 2000)

wing margin | anterior (with cg⁰⁷⁶⁵⁹)

(Svendsen et al., 2000)

wing vein (with cg^k11504)

(Song et al., 2000)

wing vein L2 (with cg⁰⁷⁶⁵⁹)

(Svendsen et al., 2000)

wing vein L4

(Campbell and Tomlinson, 2000, Svendsen et al., 2000, Diaz-Benjumea and Garcia-Bellido, 1990)

wing vein L4 (with cg³)

(Svendsen et al., 2000)

wing vein L4 (with cg⁰⁷⁶⁵⁹)

(Campbell and Tomlinson, 2000, Svendsen et al., 2000)

wing vein L5

(Svendsen et al., 2000, Diaz-Benjumea and Garcia-Bellido, 1990)

wing vein L5 (with cg³)

(Svendsen et al., 2000)

wing vein L5 (with cg⁰⁷⁶⁵⁹)

(Svendsen et al., 2000)

Detailed Description

Statement

Reference

Homozygous and cg¹/cg⁰⁷⁶⁵⁹ flies have gaps in wing vein L4. Homozygous and cg¹/cg⁰⁷⁶⁵⁹ males have extra sex comb teeth.

(Campbell and Tomlinson, 2000)

cg¹/cg^k11504 transheterozygotes show pleiotropic defects in bristle number, wing venation and oogenesis.

(Song et al., 2000)

Homozygotes have phenotypes in the wing, leg and antenna. Approximately 10% of cg¹/cg⁰⁷⁶⁵⁹ and 50% of cg¹/cg³ animals eclose to adult stages, with most of the remaining animals dying as pharate adults. cg¹/cg¹, cg¹/cg⁰⁷⁶⁵⁹ and cg¹/cg³ flies have defects in some combination of the posterior compartment longitudinal veins L4 and L5. Defects in vein L4, ranging from a slight thinning of the vein to gaps of increasing size are seen in 100% of wings of all three allelic combinations. Defects in wing vein L5 are seen in approximately 40% of cg¹/cg¹ wings, while less than 25% of cg¹/cg⁰⁷⁶⁵⁹ and cg¹/cg³ flies have wing vein L5 defects. 40% of cg¹/cg⁰⁷⁶⁵⁹ flies have truncations of wing vein L2. This is rarely seen in cg¹/cg¹ or cg¹/cg³ flies. Rarely (less than 1%), all three genotypes show outgrowths in the costal region of the anterior wing margin. Homozygous males have a few extra sex comb bristles. Bifurcated mesothoracic legs are occasionally seen. cg¹/cg⁰⁷⁶⁵⁹ leg discs show overgrowth in the anterior/posterior axis. cg¹/cg⁰⁷⁶⁵⁹ flies have expanded transverse rows and sex combs.

(Svendsen et al., 2000)

Terminal gaps in wing vein L4 and homozygotes have intercalary gaps in wing vein L5. Also abnormalities in legs and in oogenesis.

(Diaz-Benjumea and Garcia-Bellido, 1990)

Oogenesis highly irregular.

(Beatty, 1949)

Sex combs of male extremely large. Number of sex comb teeth increased from 10 to 18; number of bractless bristles increased; width of distal portion of basitarsus increased 1.6 fold; total number of bristles on basitarsus increased in both sexes (FBrf0065640; FBrf0063395). Some distortion and shortening of legs. Wings show gap in vein L4 between posterior crossvein and margin. Wings slightly curved. Effects result from a combination of overgrowth and irregular folding of imaginal rudiments during the pupal period. RK2.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Df(2R)en-11/+, cg¹ has visible | dominant phenotype

(Svendsen et al., 2000)

cg¹, l(2)gd1¹ has lethal | recessive phenotype

(Buratovich and Bryant, 1997)

cg¹, l(2)gd1¹ has hyperplasia | recessive phenotype

(Buratovich and Bryant, 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

cg¹ has phenotype, enhanceable by dachs^unspecified

(Waddington, 1953)

cg¹ has phenotype, enhanceable by fj^unspecified

(Waddington, 1953)

cg¹ has phenotype, enhanceable by ds^unspecified

(Waddington, 1953)

cg¹ has phenotype, enhanceable by ss^a

(Waddington, 1953)

Suppressed by

Statement

Reference

cg⁰⁷⁶⁵⁹/cg¹ has prothoracic tibial transverse row bristle | increased number phenotype, suppressible | partially by Scer\GAL4^ptc-559.1/ci^UAS.Tag:HA

(Svendsen et al., 2000)

cg⁰⁷⁶⁵⁹/cg¹ has sex comb | increased number phenotype, suppressible | partially by Scer\GAL4^ptc-559.1/ci^UAS.Tag:HA

(Svendsen et al., 2000)

cg⁰⁷⁶⁵⁹/cg¹ has leg disc phenotype, suppressible by Scer\GAL4^ptc-559.1/ci^UAS.Tag:HA

(Svendsen et al., 2000)

NOT suppressed by

Statement

Reference

cg¹ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Enhancer of

Statement

Reference

cg¹ is an enhancer of phenotype of ci^W

(House, 1953)

Other

Statement

Reference

Df(2R)en-11/+, cg¹ has wing vein L4 phenotype

(Svendsen et al., 2000)

cg¹, l(2)gd1¹ has metathoracic leg disc phenotype

(Buratovich and Bryant, 1997)

cg¹, l(2)gd1¹ has female genital disc phenotype

(Buratovich and Bryant, 1997)

cg¹, l(2)gd1¹ has eye-antennal disc phenotype

(Buratovich and Bryant, 1997)

cg¹, l(2)gd1¹ has wing disc phenotype

(Buratovich and Bryant, 1997)

cg¹, l(2)gd1¹ has mesothoracic leg disc phenotype

(Buratovich and Bryant, 1997)

cg¹, l(2)gd1¹ has haltere disc phenotype

(Buratovich and Bryant, 1997)

cg¹, en¹ has wing vein L4 phenotype

(House, 1961)

cg¹, ci^unspecified has wing vein L4 phenotype

(Waddington, 1953)

Additional Comments

Genetic Interactions

Statement

Reference

Df(2R)en-11/+ ; cg¹/+ double heterozygotes have a gap in wing vein L4. The abnormal leg disc morphology of cg¹/cg⁰⁷⁶⁵⁹ animals is substantially rescued by ci^{Scer\UAS.T:Ivir\HA1} expressed under the control of Scer\GAL4^ptc-559.1. The adult transverse row and sex comb phenotypes are also partially rescued.

(Svendsen et al., 2000)

Wing discs from l(2)gd1¹, cg¹ double mutants show a variety of extra folds and extensive overgrowth. The second and third leg, haltere, female genital and eye-antenna discs all show duplication of various structures. These animals fail to form pharate adults and die as larvae or pupae.

(Buratovich and Bryant, 1997)

Enhanced when homozygous by homozygous mutant alleles of d, fj, ds and by ss^a. Double heterozygote with ci often shows gap in wing vein L4.

(Waddington, 1953)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

cg³

(Svendsen et al., 2000)

Rescued by

cg¹ is rescued by cg^+t103

(Svendsen et al., 2000)

cg¹ is rescued by cg^+t111

(Svendsen et al., 2000)

cg¹ is rescued by cg^+t104

(Svendsen et al., 2000)

cg¹ is rescued by cg^+t105

(Svendsen et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (5)

Bloomington

252

cg¹ c¹/SM5

253

cg¹ c¹/In(2LR)U, U¹

292

dw-24E¹ l(2)cg¹ cg¹/SM5

Kyoto

105816

cg¹ c¹/In(2LR)U, U¹

105838

dw-24E¹ l(2)cg¹ cg¹/SM5

Notes on Origin

Discoverer

Comments

Double heterozygote en¹ cg¹/++ has slight degree of L4 interruption and thinning at low temperature. Triple heterozygote en¹ cg¹/++; ci^unspecified/+ has L4 interruption in half the flies.

(House, 1961)

Sex-comb phenotype enhanced by sn or Pc/Scr.

(Datta and Mukherjee, 1968)

ci^W interacts strongly with cg¹. cg¹/+; ci^W/+ resembles ci^W/ci^W.

(House, 1953)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

cg¹

(Hitrik et al., 2016, Pilgram et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (13)

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