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General Information
Symbol
Dmel\perClk
Species
D. melanogaster
Name
FlyBase ID
FBal0001708
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Clk
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C2691336T

Reported nucleotide change:

C5928T

Amino acid change:

A969V | per-PA; A969V | per-PB

Reported amino acid change:

A969V

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: C5928T (numbering system of FBrf0047067). Amino acid replacement: A969V. 3bp are deleted from the 3' UTR with respect to the sequence published in FBrf0049579.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

22.5hr clock mutant.

The mean period of locomotor activity is shorter than wild-type (average value is 22.8 +/- 0.1 hours).

Short cycle duration, the evening peak of activity is shifted to an earlier time than wild type.

The activity rhythm period of perClk/Y flies is lengthened by CkII╬▓And, by 1.1 hours.

The period of the free-running locomotor activity rhythm is shortened to approximately 22.5 hours in hemizygous males. The periodicity is slightly temperature sensitive, becoming shorter over a range of 17-28oC. The phase response curve is similarly shortened. Heterozygous females have an periodicity intermediate between that of hemizygous males and wild-type. Eclosion peaks of perClk cultures are separated by only 22.5 hours. per01/perClk flies have statistically indistinguishable rhythms from perClk/per+ flies. Male perClk flies have an essentially normal courtship song.

1.5 hour shortening of the circadian rhythms of locomotor activity. Hemizygous males have essentially normal one minute song rhythm.

The normal 24 hour period of the circadian rhythms of adult locomotor activity and of eclosion are shortened by approximately 1.5 hours. Clk/+ heterozygotes have a period phenotype intermediate between wild-type and mutant homozygotes. The period of the phase-resetting response of the activity rhythm is shortened by 1-2 hours per cycle; adults entrain well to 12 hour light: twelve hour dark cycles, but evening peak of locomotor activity is advanced relative to wild-type; courtship song rhythms of mutant males have essentially normal one-minute periods. Temperature compensation of circadian period is normal (Q10 approximately equal to 1.0), in tests of locomotor activity rhythms.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments

Clk/per01 indistinguishable from Clk/+.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Konopka and Orr.

Comments
Comments

per01 and perClk map approximately 0.015 map units apart from each other.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (11)