Allele Dmel\cm¹

General Information
Symbol	Dmel\cm¹	Species	D. melanogaster
Name		FlyBase ID	FBal0001720
Feature type	allele	Created / Updated	2006-05-15/2006-05-15
Associated gene	Dmel\cm

Allele class
Mutagen	spontaneous
Nature of the Allele
Allele class
Mutagen	spontaneous
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion of 5kb into the cm open reading frame. (Mullins et al., 1999)
Assay mode
Caused by insertion	?{}cm¹ (Mullins et al., 1999)
Cytology
Phenotypic Data
Phenotypic Class
	visible \| recessive (Mullins et al., 1999) eye color defective \| recessive (Mullins et al., 1999, ) short lived \| male (Simonsen et al., 2007)
Phenotype Manifest In
	pigment cell (Mullins et al., 1999, ) secondary pigment cell pigment granule (Mullins et al., 1999) tertiary pigment cell pigment granule (Mullins et al., 1999) rhabdomere (Mullins et al., 1999) Malpighian tubule
Detailed Description
	Statement Reference Eye colour: translucent dark ruby. Eye colour: deep orange, with st¹. Eye colour: lighter than bw¹, with bw¹. Malpighian tubule colour: very pale yellow. RK1. Eye colour: darker than wild type. Dramatic reduction in number of secondary and tertiary pigment granules surrounding the ommatidium. Outer rhabdomeres are also occasionally missing. (Mullins et al., 1999) Mutant males have a shortened adult life span compared to controls, with a mean life span of 21.97 days at 25[o]. (Simonsen et al., 2007)
Interactions
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Statement Reference cm¹ has phenotype, non-suppressible by su(Hw)² (Lindsley and Grell, 1968)
Additional Comments
Genetic Interactions
Statement Reference cm[1] is a complex modifier of the eye phenotype caused by expression of bchs[EP2299] under the control of Scer\GAL4[GMR.PF]. (Simonsen et al., 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 26 )
Bloomington	21 cm¹ 22 cm¹ ct⁶ 4679 cm¹ l(1)7Dd⁴/FM7a 3169 cm¹ ct⁶ mys^ts1 1282 cm¹ m^74f sd¹ os^s 1277 cm¹ ct⁶ v¹ m^74f/C(1)M4, y²
Kyoto	105681 cm¹ 105682 cm¹ ct⁶ 106890 cm¹ ct⁶ mys^ts1 106261 cm¹ m^74f sd¹ os^s 106259 cm¹ ct⁶ v¹ m^74f/C(1)M4, y² 101017 C(1)DX, y¹ w¹ f¹ / cm¹ ct⁶ sn³
	More stocks available...
Notes on Origin
Discoverer	Mohr, 27th April 1927.

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	carmine¹ (Simonsen et al., 2007) cm¹
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Simonsen et al., 2007, Genetics 176(2): 1283--1297 Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles. [FBrf0201586] Mullins et al., 1999, Molec. gen. Genet. 262(3): 401--412 Defective expression of the 3 subunit of the AP-3 adaptor complex in the Drosophila pigmentation mutant carmine. [FBrf0112254] Tearle, 1991, Genet. Res. 57: 257--266 Tissue specific effects of ommochrome pathway mutations in Drosophila melanogaster. [FBrf0054090] Mohr, 1927, Z. indukt. Abstamm.- u. VererbLehre 45: 403--405 Carmine, a new sex-linked eye color in Drosophila melanogaster. [FBrf0001640]
Review	Boehm and Bonifacino, 2002, Gene 286(2): 175--186 Genetic analyses of adaptin function from yeast to mammals. [FBrf0148996]
Book	Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp Genetic variations of Drosophila melanogaster. [FBrf0020044]

Allele Dmel\cm1

Allele Dmel\cm¹