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General Information
Symbol
Dmel\cm1
Species
D. melanogaster
Name
FlyBase ID
FBal0001720
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
carmine1
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of 5kb into the cm open reading frame.

Insertion components
?{}cm1
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Upon 6 days of exposure to continuous white light, cm1 mutant photoreceptor cells show degenerative features, including a loss of rhabdomeres and disruption of ommatidial organization. cm1 mutant photoreceptor cells exhibit decreased ERG amplitudes.

The glue granules in the salivary gland cells of cm1 mutant third instar larvae are similar in size to wild type.

Mutant flies have reduced red pigment in the eye compared to controls.

Mutant males have a shortened adult life span compared to controls, with a mean life span of 21.97 days at 25o.

Eye colour: darker than wild type. Dramatic reduction in number of secondary and tertiary pigment granules surrounding the ommatidium. Outer rhabdomeres are also occasionally missing.

Eye colour: translucent dark ruby. Eye colour: deep orange, with st1. Eye colour: lighter than bw1, with bw1. Malpighian tubule colour: very pale yellow. RK1.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

cm1 has eye color defective phenotype, enhanceable by Blos1ex2

Enhancer of
Statement
Reference

cm1 is an enhancer of eye color defective phenotype of Blos1ex2

Phenotype Manifest In
Suppressed by
NOT suppressed by
Statement
Reference

cm1 has phenotype, non-suppressible by su(Hw)2

Additional Comments
Genetic Interactions
Statement
Reference

Overexpression of Vps35Scer\UAS.T:Ivir\HA1 in a Scer\GAL4Act5C.PU wJF01901 background, significantly restores rhabdomere number and suppresses the ERG amplitude defects found in cm1 mutants that have been continuously exposed to white light for 6 days.

Overexpression of Vps26Scer\UAS.T:SV5\V5 in a Scer\GAL4Act5C.PU wJF01901 background, significantly restores rhabdomere number and suppresses the ERG amplitude defects found in cm1 mutants that have been continuously exposed to white light for 6 days.

cm1 is a complex modifier of the eye phenotype caused by expression of bchsEP2299 under the control of Scer\GAL4GMR.PF.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (2)
Stocks (30)
Notes on Origin
Discoverer

Mohr, 27th April 1927.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (11)