Allele Dmel\cora¹

General Information
Symbol	Dmel\cora¹	Species	D. melanogaster
Name		FlyBase ID	FBal0001766
Feature type	allele	Associated gene	Dmel\cora
Also Known As	cor¹

Map ( GBrowse )
Allele class	loss of function allele
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Fehon et al., 1994)
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2R:15,126,435..15,126,435 evidence=experimental pr_change=Q529@\|cora-PA reported_na_change=C?T reported_pr_change=Q529@ na_change=C15126435T (Ward et al., 1998)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name L27467 AAB59187

UniProtKB/Swiss-Prot	Q9V8R9
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: Q529@. Nucleotide substitution: C?T. (Fehon et al., 1994)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Fehon et al., 1994, Lamb et al., 1998)
Phenotype Manifest In
	embryonic/first instar larval cuticle (Lamb et al., 1998) embryonic/first instar larval cuticle \| dorsal (Lamb et al., 1998) embryonic/larval salivary gland \| embryonic stage (Lamb et al., 1998) embryonic dorsal epidermis (Fehon et al., 1994)
Detailed Description
	Statement Reference Embryos show defects in paracellular barrier function in the trachea in a dextran injection assay. (Ile et al., 2012) cora¹ homozygous mutants have an effective paracellular diffusion barrier in the embryonic salivary gland. (Genova and Fehon, 2003) Homozygous embryos have a faint cuticle and a dorsal scab. The remains of the salivary glands are present as necrotic material. No adult escapers are produced. (Lamb et al., 1998) Abnormality in dorsal closure, leaving a small scab on the dorsal side. (Fehon et al., 1994)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference cora¹ is a suppressor of visible \| dominant phenotype of Egfr^E1 (Lamb et al., 1998)
Phenotype Manifest In
Suppressor of
Statement Reference cora[+]/cora¹ is a suppressor \| partially of eye phenotype of Egfr^E1 (Fehon et al., 1994) cora¹ is a suppressor of eye phenotype of Egfr^E1 (Lamb et al., 1998)
Other
Statement Reference Atpα^unspecified, cora¹/cora² has embryonic salivary gland & epithelial cell phenotype (Genova and Fehon, 2003) Atpα^unspecified/Atpalpha[+], cora¹/cora² has embryonic salivary gland & epithelial cell phenotype (Genova and Fehon, 2003) cora¹/cora², nrv2[+]/nrv2^unspecified has embryonic salivary gland & epithelial cell phenotype (Genova and Fehon, 2003) cora¹/cora², nrv2^unspecified has embryonic salivary gland & epithelial cell phenotype (Genova and Fehon, 2003) Nrx-IV¹⁴, cora¹/cora² has embryonic salivary gland & epithelial cell phenotype (Genova and Fehon, 2003) Nrx-IV¹⁴/Nrx-IV[+], cora¹/cora² has embryonic salivary gland & epithelial cell phenotype (Genova and Fehon, 2003)
Additional Comments
Genetic Interactions
Statement Reference cora¹/cora² mutant embryos have an effective diffusion barrier in the embryonic salivary glands that is disrupted when Nrx-IV¹⁴/+, nrv2^unspecified/+ or Atpα^unspecified/+ is present. (Genova and Fehon, 2003) Dominantly suppresses the rough eye phenotype of Egfr^E1/+ heterozygotes; the eye is wild type in size with some roughening. (Lamb et al., 1998) Partially suppresses Egfr^E1 eye phenotype. (Fehon et al., 1994)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	cora³ (Lamb et al., 1998) cora⁴ (Lamb et al., 1998) cora⁵ (Lamb et al., 1998) cora⁶ (Lamb et al., 1998) cora⁷ (Lamb et al., 1998) cora⁸ (Lamb et al., 1998) cora⁹ (Lamb et al., 1998) cora¹⁰ (Lamb et al., 1998) cora¹¹ (Lamb et al., 1998) cora¹² (Lamb et al., 1998) cora¹³ (Lamb et al., 1998) cora¹⁴ (Lamb et al., 1998) cora¹⁵ (Lamb et al., 1998)
Rescued by	cora¹ is rescued by cora^1.Ubi-p63E (Fehon et al., 1994, Lamb et al., 1998)
Comments	cora¹/cora² mutant embryos have an effective diffusion barrier in the embryonic salivary glands. (Genova and Fehon, 2003) Lethality rescued by cora^1.Ubi-p63E. (Fehon et al., 1994)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	cor¹ (Genova and Fehon, 2003, Lamb et al., 1998) cora¹ (Tonning et al., 2005)
Name Synonym	coracle¹ (Ile et al., 2012)
Secondary FlyBase IDs

References ( 6 )
Research paper	Ile et al., 2012, Development 139(14): 2535--2546 Wunen, a Drosophila lipid phosphate phosphatase, is required for septate junction-mediated barrier function. [FBrf0218686] Tonning et al., 2005, Dev. Cell 9(3): 423--430 A transient luminal chitinous matrix is required to model epithelial tube diameter in the Drosophila trachea. [FBrf0187412] Genova and Fehon, 2003, J. Cell Biol. 161(5): 979--989 Neuroglian, Gliotactin, and the Na+/K+ ATPase are essential for septate junction function in Drosophila. [FBrf0160546] Lamb et al., 1998, Mol. Biol. Cell 9(12): 3505--3519 Drosophila coracle, a member of the protein 4.1 superfamily, has essential structural functions in the septate junctions and developmental functions in embryonic and adult epithelial cells. [FBrf0105869] Ward et al., 1998, J. Cell Biol. 140(6): 1463--1473 A conserved functional domain of Drosophila coracle is required for localization at the septate junction and has membrane-organizing activity. [FBrf0102020] Fehon et al., 1994, Development 120(3): 545--557 A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene. [FBrf0073060]

Allele Dmel\cora1

Allele Dmel\cora¹