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General Information
Symbol
Dmel\cora2
Species
D. melanogaster
Name
FlyBase ID
FBal0001767
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
cor2
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    C19238975T

    Reported nucleotide change:

    C?T

    Amino acid change:

    R544term | cora-PA; R554term | cora-PF; R544term | cora-PG

    Reported amino acid change:

    R544term

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Nucleotide substitution: C?T.

    Amino acid replacement: R544term.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    cora2 mutants die as embryos and frequently display cuticular phenotypes such as dorsal openings.

    cora2 homozygous mutants have an effective diffusion paracellular barrier in the embryonic salivary glands.

    Homozygous embryos have a faint cuticle and a dorsal hole. No adult escapers are produced. Hemizygous embryos show delamination of the cuticle at the anterior end of the embryo. The remains of the salivary glands are present as necrotic material. cora2/cora15 adults have eyes which show roughening across the equator.

    Failure of dorsal closure, leaving a large dorsal opening, and incomplete head involution.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Suppressor of
    Statement
    Reference

    cora2 is a suppressor of visible | dominant phenotype of EgfrE1

    Phenotype Manifest In
    Enhanced by
    Enhancer of
    Suppressor of
    Statement
    Reference

    cora2 is a suppressor of eye phenotype of EgfrE1

    Other
    Statement
    Reference

    Atpαunspecified/Atpalpha[+], cora1/cora2 has embryonic salivary gland & epithelial cell phenotype

    cora1/cora2, nrv2[+]/nrv2unspecified has embryonic salivary gland & epithelial cell phenotype

    Nrx-IV14/Nrx-IV[+], cora2 has embryonic salivary gland & epithelial cell phenotype

    cora2, nrv2[+]/nrv2unspecified has embryonic salivary gland & epithelial cell phenotype

    Nrx-IV14/Nrx-IV[+], cora1/cora2 has embryonic salivary gland & epithelial cell phenotype

    cora1/cora2, nrv2unspecified has embryonic salivary gland & epithelial cell phenotype

    cora2, nrv2unspecified has embryonic salivary gland & epithelial cell phenotype

    Nrx-IV14, cora1/cora2 has embryonic salivary gland & epithelial cell phenotype

    Nrx-IV14, cora2 has embryonic salivary gland & epithelial cell phenotype

    Atpαunspecified, cora1/cora2 has embryonic salivary gland & epithelial cell phenotype

    Atpαunspecified, cora2 has embryonic salivary gland & epithelial cell phenotype

    Atpαunspecified/Atpalpha[+], cora2 has embryonic salivary gland & epithelial cell phenotype

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The frequency and severity of cuticular defects observed in both cora2 and chem1 homozygous embryos are significantly increased by combination with a single copy of either chem1 or cora2, respectively, as well as in cora2;chem1 double homozygotes compared to the single homozygotes.

    cora1/cora2 or cora2/cora2 mutant embryos have an effective diffusion barrier in the embryonic salivary glands that is disrupted when Nrx-IV14/+, nrv2unspecified/+ or Atpαunspecified/+ is present.

    Dominantly suppresses the rough eye phenotype of EgfrE1/+ heterozygotes; the eye is wild type in size with some roughening.

    Completely suppresses EgfrE1 eye phenotype.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 2 )
    Crossreferences
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    Synonyms and Secondary IDs (4)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (7)