Open Close
General Information
Symbol
Dmel\csw1
Species
D. melanogaster
Name
FlyBase ID
FBal0001920
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
cswC114
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

euchromatic aberration

Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In the larval eye discs of csw1 mutants only a few photoreceptors develop along the morphogenetic furrow. The residual photoreceptors are mostly R8 cells.

csw1/Y third larval instar eye discs show an increase in the number of apoptotic cells compared to wild type. There is also a zone of apoptotic cells anterior to the morphogenetic furrow, which is not seen in wild-type discs.

Has no "Enhancer of sev" activity. Clones of mutant cells induced during the first larval instar only rarely develop photoreceptors.

csw1 germline clone mosaics cause maternal effect lethality. There is slight paternal rescue of the germline clone phenotype; 74% embryos progress further through embryogenesis, complete germband shortening, often complete head involution and exhibit the corkscrew shape. Embryos that do not receive a wild type copy from their father (26%) die in the shape of a 'U' when the germband is fully extended or as it is shortening, often do not complete head involution.

Abnormal development of terminal internal structures. Syncytial and cellular blastoderm embryos show reduced posterior tll domain. hb remains as a posterior cap and the seventh ftz stripe expands posteriorly, both due to lack of hkb repressing activity.

Lethality occurs during larval and pupal stages. Phenotype of homozygous germ line clones is maternal effect lethal.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Expression of Zzzz\cagAScer\UAS.T:Ivir\HA1 under the control of either Scer\GAL4GMR.PF or Scer\GAL4hs.PB does not significantly increase the number of photoreceptors seen in csw1 mutant larval eye discs.

Complementation and Rescue Data
Partially rescued by
Comments

Expression of cswScer\UAS.T:Zzzz\FLAG under the control of either Scer\GAL4GMR.PF or Scer\GAL4hs.PB significantly increases the number of photoreceptors seen in csw1 mutant larval eye discs.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Lefevre.

Comments
Comments

Maternal germline clonal analysis demonstrates there is a maternal effect lethal phenotype, twisted embryos.

Phenotypic series of csw mutant embryos derived from homozygous germline clones, classified according to cuticular phenotype: csw5 = cswLE120 > csw1 = csw13-87 > cswe13d.3 > csw7 = csw6.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (8)