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General Information
Symbol
Dmel\csw6
Species
D. melanogaster
Name
FlyBase ID
FBal0001925
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The extent to which posterior pattern elements are formed directly reflects the magnitude of tor signal. Thus mutants derived from germ line clones can be ordered with respect to increasing posterior abnormalities thus: phl1 (normal posterior patterning) - csw6 - csw6,phl1 - csw5,phlPB26 (deletion of A8).

csw6 germline clone mosaics cause maternal effect lethality. Embryos derived from mothers with germline clones that exhibit a corkscrew cuticle phenotype (6%) have slight paternal rescue of the germline clone phenotype, embryos that do not receive a wild type copy from their father (94%), null embryos, die with a 'U'-shaped cuticle phenotype. In mutant embryos ventral cells undergo cell fate changes to that of more lateral epidermal cell fates. Migration of tracheal precursor cells is defective in embryos, the mature trachea shows disruption of the major anterioposterior tracheal branch. Pupal lethality can be rescued by heat induced expression of P{hs-SHP-2} during larval and pupal stages but not by expression of P{hs-SHP-1}.

Abnormal development of terminal internal structures.

csw6 is viable and fertile with rough eyes. fertile viable

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

csw6 has lethal | pupal stage phenotype, suppressible by Hsap\PTPN11hs.PP

NOT suppressed by
Statement
Reference

csw6 has lethal | pupal stage phenotype, non-suppressible by Hsap\PTPN6hs.PP

Enhancer of
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference

csw6 has phenotype, suppressible by csw::Src64BC583S.hs.2sev

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Scer\GAL4sca-C253 mediated expression of EgfrDN.Scer\UAS.cBa generates flies with reduced eyes and females carrying Scer\GAL4T155 and EgfrDN.Scer\UAS.cBa lay partially to completely ventralised eggs. These phenotypes are enhanced in a csw6 mutant background.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Not rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Phenotypic series of csw mutant embryos derived from homozygous germline clones, classified according to cuticular phenotype: csw5 = cswLE120 > csw1 = csw13-87 > cswe13d.3 > csw7 = csw6. Weak csw allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
l(1)15086
Name Synonyms
Secondary FlyBase IDs
    References (7)