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General Information
Symbol
Dmel\ctK
Species
D. melanogaster
Name
of Krivshenko
FlyBase ID
FBal0002000
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Insertion of gypsy element 6kb upstream of the 5'-most identified exon, in orientation opposite to that of cut. The gypsy element has a 129bp deletion that extends from the 1st to the 6th octamer repeat (proposed to interact with the su(Hw) product), spanning total of 5 repeats.

Insertion of gypsy element at nucleotide position -48.

DNA coordinates (FBrf0042060) (0 is gypsy site in ct6): +70.8 to +73.3

Insertion components
gypsy{}ctK
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

ctK wings have a notched edge.

There is a partial loss of the adult wing margin.

ctK mutant flies show an intermediate "cut" wing phenotype, with partial loss of the wing margin.

ctK mutant flies exhibit a scalloped wing phenotype with margin nicks.

Hemizygotes have a decreased number of wing margin bristles and show some incision of wing blade tissue.

Mutants have a wing nicking phenotype.

Shows no interaction with pb mutations.

Adult survivors exhibit wing margin defects.

Homozygous embryos lack Malpighian tubules and the gut wall is 3--4 fold thicker than wild type at the junction of the posterior and anterior midgut.

Flies have scalloped wing margins and fine scutellar bristles.

Scalloped wings. Bristles are finer than wild-type. Completely complemented by Df(1)R19.

Mutants have a number of cuts on the internal and external sides of the wing (resembling sd mutations). The macrochaetae of the mesonotum and especially the scutellum are of the Minute type.

cut wings fine bristles Classified as a group-I lethal because homozygotes show reduced viability and only 10% of fewer heterozygotes with other lethal alleles survive; survivors have weakly cut wings, as well as fine bristles and enlarged and deformed humeral callus, not seen in other cut-wing mutants.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
NOT Enhanced by
Statement
Reference

ctK has visible phenotype, non-enhanceable by +/Df(3L)brm11

ctK has visible phenotype, non-enhanceable by Df(3R)Exel7327/+

ctK has visible phenotype, non-enhanceable by +/Df(3R)slo8

ctK has visible phenotype, non-enhanceable by Snr101319/Snr1[+]

ctK has visible phenotype, non-enhanceable by brm[+]/brm2

ctK has visible phenotype, non-enhanceable by Df(1)18.1.15/+

ctK has visible phenotype, non-enhanceable by Scer\GAL4bbg-C96/osaRD.UAS

ctK has visible phenotype, non-enhanceable by osa2/osa[+]

ctK has visible phenotype, non-enhanceable by Scer\GAL4bbg-C96/osaVP16.AD.UAS

ctK has visible phenotype, non-enhanceable by osaUAS.cCa/Scer\GAL4bbg-C96

ctK has visible phenotype, non-enhanceable by Df(1)N12/+

ctK has visible phenotype, non-enhanceable by +/Df(2R)ED1552

ctK has visible phenotype, non-enhanceable by +/Df(2R)Exel7147

Suppressed by
Statement
Reference

ctK has visible phenotype, suppressible | partially by mod(mdg4)[+]/mod(mdg4)ul

ctK has visible phenotype, suppressible by mod(mdg4)ul/mod(mdg4)ul

ctK has visible phenotype, suppressible by mod(mdg4)T6

ctK has visible phenotype, suppressible | partially by Scer\GAL4[-]/Vha68-2GS-A1548

ctK has visible phenotype, suppressible | partially by mRpL4GS-A961/Scer\GAL4[-]

ctK has visible phenotype, suppressible | partially by mor[+]/mor1

ctK has visible phenotype, suppressible | partially by Scer\GAL4[-]/morGS-A897

ctK has visible phenotype, suppressible | partially by staiGS-A1533/Scer\GAL4[-]

ctK has visible phenotype, suppressible by Df(2L)Prl/+

ctK has visible phenotype, suppressible by Df(3L)Cat/+

ctK has visible phenotype, suppressible by Df(3R)p25/Df(3R)P2

ctK has visible phenotype, suppressible by Scer\GAL4bbg-C96/aptGS-A960

ctK has visible phenotype, suppressible by Scer\GAL4bbg-C96/hGS-A1546

ctK has visible phenotype, suppressible | partially by CG6907GS-A945/Scer\GAL4[-]

ctK has visible phenotype, suppressible | partially by CG9270GS-A839/Scer\GAL4[-]

ctK has visible phenotype, suppressible | partially by Df(3R)sbd105/+

ctK has visible phenotype, suppressible | partially by Trx-2GS-A866/Scer\GAL4[-]

ctK has visible phenotype, suppressible by mod(mdg4)ul

NOT suppressed by
Statement
Reference

ctK has visible phenotype, non-suppressible by +/Df(2R)Exel7147

ctK has visible phenotype, non-suppressible by +/Df(3L)brm11

ctK has visible phenotype, non-suppressible by Df(3R)Exel7327/+

ctK has visible phenotype, non-suppressible by +/Df(3R)slo8

ctK has visible phenotype, non-suppressible by Snr101319/Snr1[+]

ctK has visible phenotype, non-suppressible by brm[+]/brm2

ctK has visible phenotype, non-suppressible by Scer\GAL4bbg-C96/osaRD.UAS

ctK has visible phenotype, non-suppressible by osa2/osa[+]

ctK has visible phenotype, non-suppressible by Scer\GAL4bbg-C96/osaVP16.AD.UAS

ctK has visible phenotype, non-suppressible by osaUAS.cCa/Scer\GAL4bbg-C96

ctK has visible phenotype, non-suppressible by Df(2R)vg-B/+

ctK has visible phenotype, non-suppressible by Df(3R)P2/+

ctK has visible phenotype, non-suppressible by Df(3R)e-N19/+

ctK has visible phenotype, non-suppressible by Df(3R)p25/+

ctK has visible phenotype, non-suppressible by Df(3R)red1/+

ctK has visible phenotype, non-suppressible by Df(1)18.1.15/+

ctK has visible phenotype, non-suppressible by In(2LR)Px4/+

ctK has visible phenotype, non-suppressible by Df(1)N12/+

ctK has visible phenotype, non-suppressible by +/Df(2R)ED1552

Enhancer of
Statement
Reference

ctK/ct[+] is an enhancer of lethal | recessive | partially phenotype of mir-bft6

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

ctK has wing margin phenotype, enhanceable by Nipped-B[+]/Nipped-BNC6

ctK has wing margin phenotype, enhanceable by Nipped-B[+]/Nipped-BNC7

ctK has wing margin phenotype, enhanceable by Nipped-BNC23/Nipped-B[+]

ctK has wing margin phenotype, enhanceable by Nipped-B[+]/Nipped-BNC39

ctK has wing margin phenotype, enhanceable by Nipped-BNC41/Nipped-B[+]

ctK has wing margin phenotype, enhanceable by Nipped-B[+]/Nipped-BNC59

ctK has wing margin phenotype, enhanceable by Nipped-B[+]/Nipped-BNC71

ctK has wing margin phenotype, enhanceable by Nipped-BNC77/Nipped-B[+]

ctK has wing margin phenotype, enhanceable by Nipped-B[+]/Nipped-BNC78

ctK has wing margin phenotype, enhanceable by pds5[+]/pds5e3

ctK has triple row phenotype, enhanceable by Df(2R)nap1/+

NOT Enhanced by
Statement
Reference

ctK has wing margin phenotype, non-enhanceable by Sse13m/Sse[+]

ctK has wing margin phenotype, non-enhanceable by san[+]/sanKG04816

ctK has wing margin phenotype, non-enhanceable by eco1/eco[+]

ctK has triple row phenotype, non-enhanceable by +/Df(3L)brm11

ctK has triple row phenotype, non-enhanceable by Df(3R)Exel7327/+

ctK has triple row phenotype, non-enhanceable by +/Df(3R)slo8

ctK has triple row phenotype, non-enhanceable by Snr101319/Snr1[+]

ctK has triple row phenotype, non-enhanceable by brm[+]/brm2

ctK has triple row phenotype, non-enhanceable by Scer\GAL4bbg-C96/osaRD.UAS

ctK has triple row phenotype, non-enhanceable by osa2/osa[+]

ctK has triple row phenotype, non-enhanceable by osaUAS.cCa/Scer\GAL4bbg-C96

ctK has triple row phenotype, non-enhanceable by Df(1)18.1.15/+

ctK has triple row phenotype, non-enhanceable by Df(1)N12/+

ctK has triple row phenotype, non-enhanceable by +/Df(2R)ED1552

ctK has triple row phenotype, non-enhanceable by +/Df(2R)Exel7147

Suppressed by
Statement
Reference

ctK has wing margin phenotype, suppressible | partially by ToporsZ4522/nbl[+]

ctK has wing margin phenotype, suppressible | partially by ToporsZ1837/nbl[+]

ctK has wing margin phenotype, suppressible | partially by mod(mdg4)[+]/mod(mdg4)ul

ctK has wing margin phenotype, suppressible by mod(mdg4)T6

ctK has wing margin phenotype, suppressible by SMC1exc46/SMC1[+]

ctK has wing margin phenotype, suppressible by pds5[+]/pds5e6

ctK has triple row phenotype, suppressible | partially by Scer\GAL4[-]/Vha68-2GS-A1548

ctK has triple row phenotype, suppressible | partially by mRpL4GS-A961/Scer\GAL4[-]

ctK has triple row phenotype, suppressible | partially by mor[+]/mor1

ctK has triple row phenotype, suppressible | partially by Scer\GAL4[-]/morGS-A897

ctK has triple row phenotype, suppressible | partially by staiGS-A1533/Scer\GAL4[-]

ctK has triple row phenotype, suppressible by Df(2L)Prl/+

ctK has triple row phenotype, suppressible by Df(3L)Cat/+

ctK has triple row phenotype, suppressible by Df(3R)p25/Df(3R)P2

ctK has triple row phenotype, suppressible | partially by CG6907GS-A945/Scer\GAL4[-]

ctK has triple row phenotype, suppressible | partially by CG9270GS-A839/Scer\GAL4[-]

ctK has triple row phenotype, suppressible | partially by Df(3R)sbd105/+

ctK has triple row phenotype, suppressible | partially by Trx-2GS-A866/Scer\GAL4[-]

ctK has phenotype, suppressible by su(Hw)7

NOT suppressed by
Statement
Reference

ctK has wing margin phenotype, non-suppressible by Sse13m/Sse[+]

ctK has wing margin phenotype, non-suppressible by san[+]/sanKG04816

ctK has wing margin phenotype, non-suppressible by eco1/eco[+]

ctK has triple row phenotype, non-suppressible by +/Df(2R)Exel7147

ctK has triple row phenotype, non-suppressible by +/Df(3L)brm11

ctK has triple row phenotype, non-suppressible by Df(3R)Exel7327/+

ctK has triple row phenotype, non-suppressible by +/Df(3R)slo8

ctK has triple row phenotype, non-suppressible by Snr101319/Snr1[+]

ctK has triple row phenotype, non-suppressible by brm[+]/brm2

ctK has triple row phenotype, non-suppressible by Scer\GAL4bbg-C96/osaRD.UAS

ctK has triple row phenotype, non-suppressible by osa2/osa[+]

ctK has triple row phenotype, non-suppressible by osaUAS.cCa/Scer\GAL4bbg-C96

ctK has triple row phenotype, non-suppressible by Df(2R)vg-B/+

ctK has triple row phenotype, non-suppressible by Df(3R)P2/+

ctK has triple row phenotype, non-suppressible by Df(3R)e-N19/+

ctK has triple row phenotype, non-suppressible by Df(3R)p25/+

ctK has triple row phenotype, non-suppressible by Df(3R)red1/+

ctK has triple row phenotype, non-suppressible by In(2LR)Px4/+

ctK has triple row phenotype, non-suppressible by Df(1)18.1.15/+

ctK has triple row phenotype, non-suppressible by Df(1)N12/+

ctK has triple row phenotype, non-suppressible by +/Df(2R)ED1552

Additional Comments
Genetic Interactions
Statement
Reference

Heterozygosity for ToporsZ4522 or ToporsZ1837 only slightly suppresses the wing margin phenotype of ctK flies.

The "cut" wing phenotype observed in ctK mutant animals is almost entirely rescued by one copy of mod(mdg4)ul, and completely rescued in animals carrying two copies of mod(mdg4)ul.

The "cut" wing phenotype observed in ctK mutant animals is suppressed in a mod(mdg4)T6 mutant background.

ctK SMC1exc46 heterozygous double mutants exhibit a reduced number of wing margin nicks compared to ctK mutants.

Sse13m heterozygosity does not affect the wing margin nick phenotype of ctK mutants.

sanKG04816 heterozygosity does not affect the wing margin nick phenotype of ctK mutants.

eco1 heterozygosity does not affect the wing margin nick phenotype of ctK mutants.

ctK mutants heterozygous for pds5e3 exhibit a slightly increased number of wing margin nicks compared to ctK heterozygotes, although this is not significantly different from that seen in ctK single mutants.

ctK mutants heterozygous for pds5e6 exhibit a significantly decreased level of wing margin nicking compared to ctK single mutants.

Expression of wgScer\UAS.cLa under the control of Scer\GAL4C96 suppresses the loss of wing blade tissue, including the slender recurved chemosensory wing margin bristles, seen in ctK flies, but does not rescue the loss of the stout mechanosensory wing margin bristles.

The wing nicking phenotype seen in ctK mutant males is not affected by expression of CG4203dsRNA.Sym.Scer\UAS under the control of Scer\GAL4hs.PB.

The severity of the wing nicking phenotype seen in ctK mutant males is increased by expression of Nipped-BdsRNA.Sym.Scer\UAS under the control of Scer\GAL4hs.PB.

The severity of the wing nicking phenotype seen in ctK mutant males is decreased by expression of SAdsRNA.Sym.Scer\UAS under the control of Scer\GAL4hs.PB.

ctK/+ ; bft6/bft6 animals do not survive to adulthood. ctK/+ ; bft6/bft24 females can survive to adulthood and they show the bft mutant eye phenotype. Adult ctK/Y ; bft6/bft24 males are never seen.

Dominantly suppressed by su(Hw). Suppression more complete for su(Hw)V than for su(Hw)7.

ctK phenotype is completely suppressed by mod(mdg4)ul.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

Expression of mod(mdg4)Scer\UAS.cGa or mod(mdg4)ΔQ.Scer\UAS under the control of Scer\GAL4Act5C in a ctK,mod(mdg4)ul mutant background suppresses the effect that mod(mdg4)ul has on ctK wings, and the wings that form lack regions of the wing margin and are similar to ctK wings.

The factor causing the cutting of wings is allelic to ct. The reduction in size of the macrochaetae is perhaps caused by another factor independent from the first, but which cannot be separated from ct.

Images (1)
Stocks (2)
Notes on Origin
Discoverer

Krivshenko.

Comments
Comments

Weak lethal class I ct allele.

A cut lethal I phenotypic class allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (25)