A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\ctK

General Information
SymbolDmel\ctKSpeciesD. melanogaster
Nameof KrivshenkoFlyBase IDFBal0002000
Feature typealleleAssociated geneDmel\ct
Allele class
Mutagenspontaneous
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Description
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FB2013_03
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
Insertion of gypsy element 6kb upstream of the 5'-most identified exon, in orientation opposite to that of cut. The gypsy element has a 129bp deletion that extends from the 1st to the 6th octamer repeat (proposed to interact with the su(Hw) product), spanning total of 5 repeats.
Insertion of gypsy element at nucleotide position -48.
DNA coordinates (FBrf0042060) (0 is gypsy site in ct6): +70.8 to +73.3
 
Caused by insertion
Cytology
Polytene chromosomes normal.
 
Polytene chromosomes normal.
hide Phenotypic Data
hide Phenotypic Class
hide Phenotype Manifest In
scutellum & macrochaeta
scutum & macrochaeta
hide Detailed Description
Statement
Reference
There is a partial loss of the adult wing margin.
ct[K] mutant flies show an intermediate "cut" wing phenotype, with partial loss of the wing margin.
ctK mutant flies exhibit a scalloped wing phenotype with margin nicks.
Hemizygotes have a decreased number of wing margin bristles and show some incision of wing blade tissue.
Mutants have a wing nicking phenotype.
Shows no interaction with pb mutations.
Adult survivors exhibit wing margin defects.
Homozygous embryos lack Malpighian tubules and the gut wall is 3--4 fold thicker than wild type at the junction of the posterior and anterior midgut.
Flies have scalloped wing margins and fine scutellar bristles.
Scalloped wings. Bristles are finer than wild-type. Completely complemented by Df(1)R19.
Mutants have a number of cuts on the internal and external sides of the wing (resembling sd mutations). The macrochaetae of the mesonotum and especially the scutellum are of the Minute type.
cut wings fine bristles Classified as a group-I lethal because homozygotes show reduced viability and only 10% of fewer heterozygotes with other lethal alleles survive; survivors have weakly cut wings, as well as fine bristles and enlarged and deformed humeral callus, not seen in other cut-wing mutants.
 
hide External Data
Linkouts
hide Interactions
hide Phenotypic Class
hideEnhanced by
Statement
Reference
ctK has visible phenotype, enhanceable by Df(2R)nap1/+
hideNOT Enhanced by
Statement
Reference
ctK has visible phenotype, non-enhanceable by +/Df(2R)ED1552
ctK has visible phenotype, non-enhanceable by +/Df(2R)Exel7147
ctK has visible phenotype, non-enhanceable by +/Df(3L)brm11
ctK has visible phenotype, non-enhanceable by +/Df(3R)slo8
ctK has visible phenotype, non-enhanceable by brm[+]/brm2
ctK has visible phenotype, non-enhanceable by Df(1)18.1.15/+
ctK has visible phenotype, non-enhanceable by Df(1)N12/+
ctK has visible phenotype, non-enhanceable by Df(3R)Exel7327/+
ctK has visible phenotype, non-enhanceable by osa2/osa[+]
ctK has visible phenotype, non-enhanceable by Snr101319/Snr1[+]
hideSuppressed by
Statement
Reference
ctK has visible phenotype, suppressible | partially by CG6907GS-A945/Scer\GAL4[-]
ctK has visible phenotype, suppressible | partially by CG9270GS-A839/Scer\GAL4[-]
ctK has visible phenotype, suppressible | partially by Df(3R)sbd105/+
ctK has visible phenotype, suppressible | partially by mod(mdg4)[+]/mod(mdg4)ul
ctK has visible phenotype, suppressible | partially by mor[+]/mor1
ctK has visible phenotype, suppressible | partially by mRpL4GS-A961/Scer\GAL4[-]
ctK has visible phenotype, suppressible | partially by Scer\GAL4[-]/morGS-A897
ctK has visible phenotype, suppressible | partially by Scer\GAL4[-]/Vha68-2GS-A1548
ctK has visible phenotype, suppressible | partially by staiGS-A1533/Scer\GAL4[-]
ctK has visible phenotype, suppressible | partially by Trx-2GS-A866/Scer\GAL4[-]
ctK has visible phenotype, suppressible by Df(2L)Prl/+
ctK has visible phenotype, suppressible by Df(3L)Cat/+
ctK has visible phenotype, suppressible by Df(3R)p25/Df(3R)P2
ctK has visible phenotype, suppressible by mod(mdg4)T6
ctK has visible phenotype, suppressible by mod(mdg4)ul
ctK has visible phenotype, suppressible by mod(mdg4)ul/mod(mdg4)ul
ctK has visible phenotype, suppressible by Scer\GAL4bbg-C96/aptGS-A960
ctK has visible phenotype, suppressible by Scer\GAL4bbg-C96/hGS-A1546
hideNOT suppressed by
Statement
Reference
ctK has visible phenotype, non-suppressible by +/Df(2R)ED1552
ctK has visible phenotype, non-suppressible by +/Df(2R)Exel7147
ctK has visible phenotype, non-suppressible by +/Df(3L)brm11
ctK has visible phenotype, non-suppressible by +/Df(3R)slo8
ctK has visible phenotype, non-suppressible by brm[+]/brm2
ctK has visible phenotype, non-suppressible by Df(1)18.1.15/+
ctK has visible phenotype, non-suppressible by Df(1)N12/+
ctK has visible phenotype, non-suppressible by Df(2R)vg-B/+
ctK has visible phenotype, non-suppressible by Df(3R)e-N19/+
ctK has visible phenotype, non-suppressible by Df(3R)Exel7327/+
ctK has visible phenotype, non-suppressible by Df(3R)P2/+
ctK has visible phenotype, non-suppressible by Df(3R)p25/+
ctK has visible phenotype, non-suppressible by Df(3R)red1/+
ctK has visible phenotype, non-suppressible by In(2LR)Px4/+
ctK has visible phenotype, non-suppressible by osa2/osa[+]
ctK has visible phenotype, non-suppressible by osaScer\UAS.cCa/Scer\GAL4bbg-C96
ctK has visible phenotype, non-suppressible by Snr101319/Snr1[+]
hideEnhancer of
Statement
Reference
ctK/ct[+] is an enhancer of lethal | recessive | partially phenotype of bft6
hideOther
Statement
Reference
hide Phenotype Manifest In
hideEnhanced by
Statement
Reference
ctK has triple row phenotype, enhanceable by Df(2R)nap1/+
ctK has wing margin phenotype, enhanceable by Nipped-B[+]/Nipped-BNC6
ctK has wing margin phenotype, enhanceable by Nipped-B[+]/Nipped-BNC7
ctK has wing margin phenotype, enhanceable by Nipped-B[+]/Nipped-BNC39
ctK has wing margin phenotype, enhanceable by Nipped-B[+]/Nipped-BNC59
ctK has wing margin phenotype, enhanceable by Nipped-B[+]/Nipped-BNC71
ctK has wing margin phenotype, enhanceable by Nipped-B[+]/Nipped-BNC78
ctK has wing margin phenotype, enhanceable by Nipped-BNC23/Nipped-B[+]
ctK has wing margin phenotype, enhanceable by Nipped-BNC41/Nipped-B[+]
ctK has wing margin phenotype, enhanceable by Nipped-BNC77/Nipped-B[+]
ctK has wing margin phenotype, enhanceable by pds5[+]/pds5e3
hideNOT Enhanced by
Statement
Reference
ctK has triple row phenotype, non-enhanceable by +/Df(2R)ED1552
ctK has triple row phenotype, non-enhanceable by +/Df(2R)Exel7147
ctK has triple row phenotype, non-enhanceable by +/Df(3L)brm11
ctK has triple row phenotype, non-enhanceable by +/Df(3R)slo8
ctK has triple row phenotype, non-enhanceable by brm[+]/brm2
ctK has triple row phenotype, non-enhanceable by Df(1)18.1.15/+
ctK has triple row phenotype, non-enhanceable by Df(1)N12/+
ctK has triple row phenotype, non-enhanceable by Df(3R)Exel7327/+
ctK has triple row phenotype, non-enhanceable by osa2/osa[+]
ctK has triple row phenotype, non-enhanceable by Snr101319/Snr1[+]
ctK has wing margin phenotype, non-enhanceable by eco1/eco[+]
ctK has wing margin phenotype, non-enhanceable by san[+]/sanKG04816
ctK has wing margin phenotype, non-enhanceable by Sse13m/Sse[+]
hideSuppressed by
Statement
Reference
ctK has phenotype, suppressible by su(Hw)7
ctK has triple row phenotype, suppressible | partially by CG6907GS-A945/Scer\GAL4[-]
ctK has triple row phenotype, suppressible | partially by CG9270GS-A839/Scer\GAL4[-]
ctK has triple row phenotype, suppressible | partially by Df(3R)sbd105/+
ctK has triple row phenotype, suppressible | partially by mor[+]/mor1
ctK has triple row phenotype, suppressible | partially by mRpL4GS-A961/Scer\GAL4[-]
ctK has triple row phenotype, suppressible | partially by Scer\GAL4[-]/morGS-A897
ctK has triple row phenotype, suppressible | partially by Scer\GAL4[-]/Vha68-2GS-A1548
ctK has triple row phenotype, suppressible | partially by staiGS-A1533/Scer\GAL4[-]
ctK has triple row phenotype, suppressible | partially by Trx-2GS-A866/Scer\GAL4[-]
ctK has triple row phenotype, suppressible by Df(2L)Prl/+
ctK has triple row phenotype, suppressible by Df(3L)Cat/+
ctK has triple row phenotype, suppressible by Df(3R)p25/Df(3R)P2
ctK has wing margin phenotype, suppressible | partially by mod(mdg4)[+]/mod(mdg4)ul
ctK has wing margin phenotype, suppressible by mod(mdg4)T6
ctK has wing margin phenotype, suppressible by pds5[+]/pds5e6
ctK has wing margin phenotype, suppressible by SMC1exc46/SMC1[+]
hideNOT suppressed by
Statement
Reference
ctK has triple row phenotype, non-suppressible by +/Df(2R)ED1552
ctK has triple row phenotype, non-suppressible by +/Df(2R)Exel7147
ctK has triple row phenotype, non-suppressible by +/Df(3L)brm11
ctK has triple row phenotype, non-suppressible by +/Df(3R)slo8
ctK has triple row phenotype, non-suppressible by brm[+]/brm2
ctK has triple row phenotype, non-suppressible by Df(1)18.1.15/+
ctK has triple row phenotype, non-suppressible by Df(1)N12/+
ctK has triple row phenotype, non-suppressible by Df(2R)vg-B/+
ctK has triple row phenotype, non-suppressible by Df(3R)e-N19/+
ctK has triple row phenotype, non-suppressible by Df(3R)Exel7327/+
ctK has triple row phenotype, non-suppressible by Df(3R)P2/+
ctK has triple row phenotype, non-suppressible by Df(3R)p25/+
ctK has triple row phenotype, non-suppressible by Df(3R)red1/+
ctK has triple row phenotype, non-suppressible by In(2LR)Px4/+
ctK has triple row phenotype, non-suppressible by osa2/osa[+]
ctK has triple row phenotype, non-suppressible by Snr101319/Snr1[+]
ctK has wing margin phenotype, non-suppressible by eco1/eco[+]
ctK has wing margin phenotype, non-suppressible by san[+]/sanKG04816
ctK has wing margin phenotype, non-suppressible by Sse13m/Sse[+]
hide Additional Comments
hide Genetic Interactions
Statement
Reference
The "cut" wing phenotype observed in ct[K] mutant animals is almost entirely rescued by one copy of mod(mdg4)[ul], and completely rescued in animals carrying two copies of mod(mdg4)[ul]. The "cut" wing phenotype observed in ct[K] mutant animals is suppressed in a mod(mdg4)[T6] mutant background.
ctK SMC1exc46 heterozygous double mutants exhibit a reduced number of wing margin nicks compared to ctK mutants. Sse13m heterozygosity does not affect the wing margin nick phenotype of ctK mutants. sanKG04816 heterozygosity does not affect the wing margin nick phenotype of ctK mutants. eco1 heterozygosity does not affect the wing margin nick phenotype of ctK mutants. ctK mutants heterozygous for pds5e3 exhibit a slightly increased number of wing margin nicks compared to ctK heterozygotes, although this is not significantly different from that seen in ctK single mutants. ctK mutants heterozygous for pds5e6 exhibit a significantly decreased level of wing margin nicking compared to ctK single mutants.
Expression of wgScer\UAS.cLa under the control of Scer\GAL4C96 suppresses the loss of wing blade tissue, including the slender recurved chemosensory wing margin bristles, seen in ctK flies, but does not rescue the loss of the stout mechanosensory wing margin bristles.
The wing nicking phenotype seen in ct[K] mutant males is not affected by expression of CG4203[dsRNA.Sym.Scer\UAS] under the control of Scer\GAL4[hs.PB]. The severity of the wing nicking phenotype seen in ct[K] mutant males is increased by expression of Nipped-B[dsRNA.Sym.Scer\UAS] under the control of Scer\GAL4[hs.PB]. The severity of the wing nicking phenotype seen in ct[K] mutant males is decreased by expression of SA[dsRNA.Sym.Scer\UAS] under the control of Scer\GAL4[hs.PB].
ctK/+ ; bft6/bft6 animals do not survive to adulthood. ctK/+ ; bft6/bft24 females can survive to adulthood and they show the bft mutant eye phenotype. Adult ctK/Y ; bft6/bft24 males are never seen.
Dominantly suppressed by su(Hw). Suppression more complete for su(Hw)V than for su(Hw)7.
ctK phenotype is completely suppressed by mod(mdg4)ul.
hide Xenogenetic Interactions
Statement
Reference
hide Complementation & Rescue Data
Partially rescued by
Comments
Expression of mod(mdg4)[Scer\UAS.cGa] or mod(mdg4)[ΔQ.Scer\UAS] under the control of Scer\GAL4[Act5C] in a ct[K],mod(mdg4)[ul] mutant background suppresses the effect that mod(mdg4)[ul] has on ct[K] wings, and the wings that form lack regions of the wing margin and are similar to ct[K] wings.
The factor causing the cutting of wings is allelic to ct. The reduction in size of the macrochaetae is perhaps caused by another factor independent from the first, but which cannot be separated from ct.
hide Stocks ( 2 )
Bloomington
Kyoto
hide Notes on Origin
Discoverer
Krivshenko.
hide Comments
Weak lethal class I ct allele.
A cut lethal I phenotypic class allele.
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Other Crossreferences
Linkouts
hide Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym
Name Synonym
of Krivshenko
 
Secondary FlyBase IDs
  • FBal0064921
hide References ( 23 )
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