Allele Dmel\ct^MR2

General Information
Symbol	Dmel\ct^MR2	Species	D. melanogaster
Name		FlyBase ID	FBal0002042
Feature type	allele	Associated gene	Dmel\ct

Allele class
Mutagen	MRh12
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	MRh12
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion of gypsy element at nucleotide position -118. (Tchurikov et al., 1989) DNA coordinates (Jack, 1985) (0 is gypsy site in ct⁶): 0
Caused by insertion	gypsy{}ct^MR2 (Hoover et al., 1992, Tchurikov et al., 1989, Georgiev and Gerasimova, 1989)
Cytology
Phenotypic Data
Phenotypic Class
	visible (Georgiev and Gerasimova, 1989) visible \| recessive
Phenotype Manifest In
	wing (Georgiev and Gerasimova, 1989, )
Detailed Description
	Statement Reference Wings are cut to points, and the wing margins are scalloped. (Georgiev and Gerasimova, 1989) Strong ct⁶-like wing phenotype.
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference ct^MR2 has visible phenotype, suppressible \| heat sensitive by mod(mdg4)^ul (Georgiev and Gerasimova, 1989)
Phenotype Manifest In
Suppressed by
Statement Reference ct^MR2 has phenotype, suppressible by su(Hw)² (Georgiev and Gerasimova, 1989) ct^MR2 has phenotype, suppressible by su(Hw)^u1 (Georgiev and Gerasimova, 1989) ct^MR2 has phenotype, suppressible by su(Hw)^u2 (Georgiev and Gerasimova, 1989) ct^MR2 has phenotype, suppressible by su(Hw)^unspecified/su(Hw)^unspecified (Hoover et al., 1992)
Additional Comments
Genetic Interactions
Statement Reference Phenotype is partially suppressed by mod(mdg4)^ul at 25^oC, and completely suppressed by mod(mdg4)^ul at 18^oC. (Georgiev and Gerasimova, 1989)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	su(Hw) binding site in gypsy insertion in ct is full length. (Hoover et al., 1992) ct^MR2 can revert or partially revert by excision of, or insertion of other elements (e.g. jockey or Hercules), into the gypsy insert responsible for ct^MR2. (Leigh Brown et al., 1989) Unstable revertants are able to generate new ct derivatives, retain the gypsy LTR of ct^MR2. (Mizrokhi et al., 1985) Other types of transposing elements also appear to be mobilized in the ct^MR2 unstable system. (Gerasimova et al., 1984) Highly unstable; mutates to either stable, unstable (most frequent, --> 10^-4 mutations to ct), or superunstable (least frequent, --> around 50% ct mutants) alleles and to other ct alleles, which in turn may be unstable or superunstable. The gypsy sequence appears to be mobilized and transposed into other parts of the ct locus to produce new ct alleles or, when ct undergoes reversion, to other positions on the chromosomes where new mutants arise.
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	ct^MR2
Name Synonym
Secondary FlyBase IDs

References ( 13 )
Research paper	Hoover et al., 1992, Genetics 132: 691--697 Dominant effects of suppressor of Hairy-wing mutations on gypsy-induced alleles of forked and cut in Drosophila melanogaster. [FBrf0056247] Flavell et al., 1990, Mol. Gen. Genet. 220: 181--185 Complete reversions of a gypsy retrotransposon-induced cut locus mutation in Drosophila melanogaster involving jockey transposon insertions and flanking gypsy sequence deletions. [FBrf0052591] Georgiev and Gerasimova, 1989, Mol. Gen. Genet. 220: 121--126 Novel genes influencing the expression of the yellow locus and mdg4 (gypsy) in Drosophila melanogaster. [FBrf0050555] Georgiev et al., 1989, Genome 31: 920--928 Mobile genetic elements in Drosophila melanogaster (recent experiments). [FBrf0050015] Leigh Brown et al., 1989, Mol. Gen. Genet. 218: 208--213 Instability in the ct^MR2 strain of Drosophila melanogaster: role of P-element functions and structure of revertants. [FBrf0050559] Tchurikov et al., 1989, Mol. Gen. Genet. 219: 241--248 Mobile elements and transposition events in the cut locus of Drosophila melanogaster. [FBrf0050561] Tchurikov et al., 1988, Lambert, McDonald, Weinstein, 1988: 103--113 Concerted transposition in Drosophila melanogaster. [FBrf0098741] Mizrokhi et al., 1985, EMBO J. 4: 3781--3787 The nature of unstable insertion mutations and reversions in the locus cut of Drosophila melanogaster: Molecular mechanism of transposition. [FBrf0042441] Gerasimova et al., 1984, Mol. Gen. Genet. 194: 517--522 Simultaneous transposition of different mobile elements: Relation to multiple mutagenesis in Drosophila melanogaster. [FBrf0041499] Gerasimova and Ilyin, 1984, D. I. S. 60: 111--112 Transpositions of various mobile elements and their relation of unstable mutagenesis in Drosophila melanogaster. [FBrf0040568] Gerasimova et al., 1984, Mol. Gen. Genet. 193: 488--492 Mobilization of the transposable element mdg4 by hybrid dysgenesis generates a family of unstable cut mutations in Drosophila melanogaster. [FBrf0041498] Gerasimova, 1983, Mol. Gen. Genet. 190: 390--393 Superunstable alleles at the cut locus in Drosophila melanogaster. [FBrf0039958] Gerasimova, 1981, Mol. Gen. Genet. 184(3): 544--547 Genetic instability at the cut locus of Drosophila melanogaster induced by the Mr-h12 chromosome. [FBrf0037079]

Allele Dmel\ctMR2

Allele Dmel\ct^MR2