FlyBase Allele Report: Dmel\cv[1]

General Information

Symbol

Dmel\cv¹

Species

D. melanogaster

Name

FlyBase ID

FBal0002184

Feature type

allele

Associated gene

Dmel\cv

Associated Insertion(s)

412{}cv¹

Carried in Construct

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Contains a 412 insertion in intron 2.

(Shimmi et al., 2005)

Insertion components

412{}cv¹

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Vilmos et al., 2005)

visible | recessive

Phenotype Manifest In

anterior crossvein

(Vilmos et al., 2005)

crossvein

muscle cell of mesothoracic extracoxal depressor muscle 66

(Jaramillo et al., 2009)

muscle cell of mesothoracic extracoxal depressor muscle 66 (with cv⁴³)

(Jaramillo et al., 2009)

muscle cell of mesothoracic extracoxal depressor muscle 66 (with Df(1)C149)

(Jaramillo et al., 2009)

posterior crossvein

(Vilmos et al., 2005)

wing vein

wing vein L3

(Vilmos et al., 2005)

wing vein L4

(Vilmos et al., 2005)

Detailed Description

Statement

Reference

The number of fibers in the tergal depressor of trochanter (TDT) muscles is reduced in addition to the morphology of these muscles being abnormal in hemizygous cv¹ males and cv¹/cv⁴³ females.

cv¹/Df(1)C149 animals have a reduced number of fibres in the tergal depressor of the trochanter (TDT) muscles.

(Jaramillo et al., 2009)

Both the anterior and posterior crossveins are missing in the wings of cv¹ flies.

(Shimmi et al., 2005)

cv¹ mutants exhibit an absence of crossveins and a delta at the tips of the L3 and L4 veins. The longitudinal veins in cv¹ mutants show poorly defined edges and trajectories often broadening and meandering along their length in a manner similar to that seen in sog mutant wing tissue.

(Vilmos et al., 2005)

Wing effects due to excessive contraction in the pupal period, obliterating the cavity which should normally remain between the epithelia to form the vein.

(Waddington, 1940)

Crossveins absent or traces only present. Veins L3 and L4 slightly δ at tips. Classifiable in unexpanded wings. RK1.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

cv¹ has visible phenotype, non-suppressible by Scer\GAL4^ptc-559.1/tsg^UAS.cYa

(Vilmos et al., 2005)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

cv¹ has anterior crossvein phenotype, non-suppressible by Scer\GAL4^ptc-559.1/tsg^UAS.cYa

(Vilmos et al., 2005)

cv¹ has posterior crossvein phenotype, non-suppressible by Scer\GAL4^ptc-559.1/tsg^UAS.cYa

(Vilmos et al., 2005)

cv¹ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Enhancer of

Statement

Reference

cv¹/cv[+] is an enhancer of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of tsg^Scer\UAS.cYa under the regulation of Scer\GAL4^ptc-559.1 does not suppress the anterior and posterior crossvein phenotype observed in cv¹ mutants.

(Vilmos et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

cv⁶⁰

(Shimmi et al., 2005)

cv⁷⁰

(Shimmi et al., 2005)

Rescued by

cv¹ is rescued by Scer\GAL4^arm.PS/cv^{UAS.Tag:polyHis}

(Shimmi et al., 2005)

cv¹ is rescued by Scer\GAL4^ptc-559.1/cv^UAS.cVa

(Vilmos et al., 2005)

Comments

cv¹ hemizygotes can be rescued by the expression of cv^Scer\UAS.cVa under the control of Scer\GAL4^ptc-559.1 along the anterior-posterior border, rescues both the anterior crossvein and the posterior crossvein in cv mutants.

(Vilmos et al., 2005)

Images (0)

Mutant

Wild-type

Stocks (130)

Bloomington

4497

cv¹ v¹ run²⁹/FM6

9165

y¹ cv¹ rux⁴/FM7c

9242

y¹ cv¹ rux⁸/FM7c