Allele Dmel\cv¹

General Information
Symbol	Dmel\cv¹	Species	D. melanogaster
Name		FlyBase ID	FBal0002184
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\cv

Allele class
Mutagen	spontaneous
Nature of the Allele
Allele class
Mutagen	spontaneous
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Contains a 412 insertion in intron 2. (Shimmi et al., 2005)
Assay mode
Caused by insertion	412{}cv¹ (Shimmi et al., 2005)
Carried on aberration	Df(1)ras203 (Nash and Janca, 1983) FM0 (Lindsley and Zimm, 1992)
Cytology
Phenotypic Data
Phenotypic Class
	visible (Vilmos et al., 2005) visible \| recessive
Phenotype Manifest In
	crossvein wing vein wing vein L3 (Vilmos et al., 2005) wing vein L4 (Vilmos et al., 2005) anterior crossvein (Vilmos et al., 2005) posterior crossvein (Vilmos et al., 2005)
Detailed Description
	Statement Reference Crossveins absent or traces only present. Veins L3 and L4 slightly δ at tips. Classifiable in unexpanded wings. RK1. Wing effects due to excessive contraction in the pupal period, obliterating the cavity which should normally remain between the epithelia to form the vein. (Waddington, 1940) cv¹ mutants exhibit an absence of crossveins and a delta at the tips of the L3 and L4 veins. The longitudinal veins in cv¹ mutants show poorly defined edges and trajectories often broadening and meandering along their length in a manner similar to that seen in sog mutant wing tissue. (Vilmos et al., 2005) Both the anterior and posterior crossveins are missing in the wings of cv¹ flies. (Shimmi et al., 2005)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement Reference cv¹ has visible phenotype, non-suppressible by Scer\GAL4^ptc-559.1/tsg^Scer\UAS.cYa (Vilmos et al., 2005)
Phenotype Manifest In
NOT suppressed by
Statement Reference cv¹ has phenotype, non-suppressible by su(Hw)² (Lindsley and Grell, 1968) cv¹ has anterior crossvein phenotype, non-suppressible by Scer\GAL4^ptc-559.1/tsg^Scer\UAS.cYa (Vilmos et al., 2005) cv¹ has posterior crossvein phenotype, non-suppressible by Scer\GAL4^ptc-559.1/tsg^Scer\UAS.cYa (Vilmos et al., 2005)
Enhancer of
Statement Reference cv¹/cv[+] is an enhancer of wing vein \| ectopic phenotype of Snr1^E1 (Marenda et al., 2004)
Additional Comments
Genetic Interactions
Statement Reference Expression of tsg^Scer\UAS.cYa under the regulation of Scer\GAL4^ptc-559.1 does not suppress the anterior and posterior crossvein phenotype observed in cv¹ mutants. (Vilmos et al., 2005)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	cv⁶⁰ (Shimmi et al., 2005) cv⁷⁰ (Shimmi et al., 2005)
Rescued by	cv¹ is rescued by Scer\GAL4^arm.PS/cv^{Scer\UAS.T:Zzzz\His6} (Shimmi et al., 2005) cv¹ is rescued by Scer\GAL4^ptc-559.1/cv^Scer\UAS.cVa (Vilmos et al., 2005)
Comments	cv¹ hemizygotes can be rescued by the expression of cv^Scer\UAS.cVa under the control of Scer\GAL4^ptc-559.1 along the anterior-posterior border, rescues both the anterior crossvein and the posterior crossvein in cv mutants. (Vilmos et al., 2005)
Stocks ( 157 )
Bloomington	4182 y¹ cv¹ 4493 cv¹ f¹ 4497 cv¹ v¹ run²⁹/FM6 9165 y¹ cv¹ rux⁴/FM7c 9242 y¹ cv¹ rux⁸/FM7c 9167 y¹ cv¹ shtd¹/FM7c 5284 cv¹ fs(1)h¹ v¹/FM7c
Kyoto	107616 y¹ cv¹ 101197 w¹ cv¹ sn³ 107761 cv¹ v¹ run²⁹/FM6 101095 FM3 / y¹ cv¹ otu¹² 101240 y¹ cv¹ otu^PΔ5 / FM7
	More stocks available...
Notes on Origin
Discoverer

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	cv¹
Name Synonym
Secondary FlyBase IDs

References ( 10 )
Research paper	Shimmi et al., 2005, Dev. Biol. 282(1): 70--83 The crossveinless gene encodes a new member of the Twisted gastrulation family of BMP-binding proteins which, with Short gastrulation, promotes BMP signaling in the crossveins of the Drosophila wing. [FBrf0187398] Vilmos et al., 2005, EMBO Rpts 6(3): 262--267 crossveinless defines a new family of Twisted-gastrulation-like modulators of bone morphogenetic protein signalling. [FBrf0183951] Marenda et al., 2004, Dev. Biol. 267(2): 279--293 The Drosophila Brahma (SWI/SNF) chromatin remodeling complex exhibits cell-type specific activation and repression functions. [FBrf0174517] Marcus, 2003, Genetics 163(2): 591--597 Female site-specific transposase-induced recombination: a high-efficiency method for fine mapping mutations on the X chromosome in Drosophila. [FBrf0157240] Johannes and Preiss, 2002, Mech. Dev. 115(1-2): 3--14 Wing vein formation in Drosophila melanogaster: hairless is involved in the cross-talk between Notch and EGF signaling pathways. [FBrf0149093] Nash and Janca, 1983, Genetics 105: 957--968 Hypomorphic lethal mutations and their implications for the interpretation of lethal complementation studies in Drosophila. [FBrf0039488] Waddington, 1940, J. Genet. 41: 75--139 The genetic control of wing development in Drosophila. [FBrf0005070]
Supplementary material	Vilmos, 2005, EMBO Rpts 6(3): 1--8 Supplementary Online Material. [FBrf0188586]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905] Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp Genetic variations of Drosophila melanogaster. [FBrf0020044]

Allele Dmel\cv1

Allele Dmel\cv¹